| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José L Venero, El-Hadi Absi, Josefina Cano, Alberto Machad. Melatonin induces tyrosine hydroxylase mRNA expression in the ventral mesencephalon but not in the hypothalamus. Journal of pineal research. vol 32. issue 1. 2002-05-20. PMID:11841594. |
we have evaluated the effect of chronic administration of melatonin in terms of mrna expression for tyrosine hydroxylase (th), the rate-limiting enzyme in catecholamine biosynthesis, and in the terms of dopamine (da) transporter (dat) by means of in situ hybridization. |
2002-05-20 |
2023-08-12 |
rat |
| Niklas Lindgren, Michel Goiny, Mario Herrera-Marschitz, John W Haycock, Tomas Hökfelt, Gilberto Fison. Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain. The European journal of neuroscience. vol 15. issue 4. 2002-05-10. PMID:11886455. |
activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain. |
2002-05-10 |
2023-08-12 |
rat |
| Niklas Lindgren, Michel Goiny, Mario Herrera-Marschitz, John W Haycock, Tomas Hökfelt, Gilberto Fison. Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain. The European journal of neuroscience. vol 15. issue 4. 2002-05-10. PMID:11886455. |
production of dopamine is regulated via phosphorylation of tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of catecholamines. |
2002-05-10 |
2023-08-12 |
rat |
| Karen J Maloney, Lynda Mainville, Barbara E Jone. c-Fos expression in dopaminergic and GABAergic neurons of the ventral mesencephalic tegmentum after paradoxical sleep deprivation and recovery. The European journal of neuroscience. vol 15. issue 4. 2002-05-10. PMID:11886456. |
here, we examined whether dopamine (da) and adjacent gamma-aminobutyric acid (gaba)-synthesizing neurons are active in association with ps recovery as compared to ps deprivation or control conditions in different groups of rats by using c-fos expression as a reflection of neural activity, combined with dual immunostaining for tyrosine hydroxylase (th) or glutamic acid decarboxylase (gad). |
2002-05-10 |
2023-08-12 |
rat |
| M Najimi, E Hermans, W Rostène, P Forge. Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells. Metabolic brain disease. vol 16. issue 3-4. 2002-05-03. PMID:11769329. |
based on the functional interactions between neurotensin and dopamine transmission, we have used this cell line to investigate the short- and long-term modulation of tyrosine hydroxylase gene expression by the stable neurotensin agonist jmv 449. |
2002-05-03 |
2023-08-12 |
human |
| M Najimi, E Hermans, W Rostène, P Forge. Transcriptional regulation of the tyrosine hydroxylase gene by neurotensin in human neuroblastoma CHP212 cells. Metabolic brain disease. vol 16. issue 3-4. 2002-05-03. PMID:11769329. |
these results indicate that modulation of tyrosine hydroxylase gene expression may constitute one of the mechanisms involved in the control of dopamine transmission by neurotensin. |
2002-05-03 |
2023-08-12 |
human |
| Isabel Lastres-Becker, Henrik H Hansen, Fernando Berrendero, Rosario De Miguel, Alberto Pérez-Rosado, Jorge Manzanares, José A Ramos, Javier Fernández-Rui. Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease. Synapse (New York, N.Y.). vol 44. issue 1. 2002-05-03. PMID:11842443. |
analysis of gaba, dopamine, and their related enzymes, glutamic acid decarboxylase and tyrosine hydroxylase, in the basal ganglia proved marked decreases compatible with the motor hyperkinesia. |
2002-05-03 |
2023-08-12 |
mouse |
| Min An, Rushu Luo, Paul D Henio. Differentiation and maturation of zebrafish dorsal root and sympathetic ganglion neurons. The Journal of comparative neurology. vol 446. issue 3. 2002-05-01. PMID:11932942. |
after undergoing overt neuronal differentiation, sympathetic neurons subsequently express the adrenergic differentiation markers dopamine beta-hydroxylase and tyrosine hydroxylase. |
2002-05-01 |
2023-08-12 |
zebrafish |
| R K Sharm. Development and survival of tyrosine hydroxylase containing neurons in RCS rat retinae. Current eye research. vol 23. issue 4. 2002-04-22. PMID:11852426. |
dopaminergic amacrine cells respond to light by increasing their tyrosine hydroxylase (th) activity and the rate of dopamine turnover. |
2002-04-22 |
2023-08-12 |
rat |
| Ruth G Perez, Jack C Waymire, Eva Lin, Jen J Liu, Fengli Guo, Michael J Zigmon. A role for alpha-synuclein in the regulation of dopamine biosynthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943812. |
because 14-3-3 binds to and activates tyrosine hydroxylase, the rate-limiting enzyme in dopamine (da) biosynthesis, we explored whether alpha-synuclein also bound to tyrosine hydroxylase and influenced its activity. |
2002-04-22 |
2023-08-12 |
Not clear |
| Ruth G Perez, Jack C Waymire, Eva Lin, Jen J Liu, Fengli Guo, Michael J Zigmon. A role for alpha-synuclein in the regulation of dopamine biosynthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943812. |
however, overexpressing cell lines had significantly reduced tyrosine hydroxylase activity and a corresponding reduction in dopamine synthesis. |
2002-04-22 |
2023-08-12 |
Not clear |
| Ruth G Perez, Jack C Waymire, Eva Lin, Jen J Liu, Fengli Guo, Michael J Zigmon. A role for alpha-synuclein in the regulation of dopamine biosynthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 8. 2002-04-22. PMID:11943812. |
these data suggest that alpha-synuclein plays a role in the regulation of dopamine biosynthesis, acting to reduce the activity of tyrosine hydroxylase. |
2002-04-22 |
2023-08-12 |
Not clear |
| Deniz Kirik, Carl Rosenblad, Corinna Burger, Cecilia Lundberg, Teit E Johansen, Nicholas Muzyczka, Ronald J Mandel, Anders Björklun. Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 7. 2002-04-08. PMID:11923443. |
the degenerative changes were accompanied by a loss of 30-80% of the nigral dopamine neurons, a 40-50% reduction of striatal dopamine, and tyrosine hydroxylase levels that was fully developed by 8 weeks. |
2002-04-08 |
2023-08-12 |
human |
| Sophie Callier, Maryvonne Le Saux, Anne-Marie Lhiaubet, Thérèse Di Paolo, William Rostène, Didier Pelapra. Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture. Journal of neurochemistry. vol 80. issue 2. 2002-04-04. PMID:11902121. |
the efficiency of both toxins and oestradiol was evaluated by tyrosine hydroxylase (th) immunocytochemistry, [3h]dopamine ([3h]da) uptake, length of dopaminergic processes and lactate dehydrogenase (ldh) release measurement. |
2002-04-04 |
2023-08-12 |
Not clear |
| C Themann, D Alvarez Fischer, S Gross, R Westermann, E Weihe, K Kuschinsky, H Schäfer, B Ferge. Effect of repeated treatment with high doses of selegiline on behaviour, striatal dopaminergic transmission and tyrosine hydroxylase mRNA levels. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 1. 2002-04-02. PMID:11862330. |
we investigated the effects of acute and repeated treatment with a high dose of selegiline on dopamine overflow in the striatum as well as on behaviour and on tyrosine hydroxylase (th) mrna levels in midbrain. |
2002-04-02 |
2023-08-12 |
rat |
| C Themann, D Alvarez Fischer, S Gross, R Westermann, E Weihe, K Kuschinsky, H Schäfer, B Ferge. Effect of repeated treatment with high doses of selegiline on behaviour, striatal dopaminergic transmission and tyrosine hydroxylase mRNA levels. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 1. 2002-04-02. PMID:11862330. |
in addition, it leads to a decrease, probably due to a down-regulation, of dopamine turnover and tyrosine hydroxylase. |
2002-04-02 |
2023-08-12 |
rat |
| Elisa Mengual, Virginia M Picke. Ultrastructural immunocytochemical localization of the dopamine D2 receptor and tyrosine hydroxylase in the rat ventral pallidum. Synapse (New York, N.Y.). vol 43. issue 3. 2002-03-21. PMID:11793420. |
ultrastructural immunocytochemical localization of the dopamine d2 receptor and tyrosine hydroxylase in the rat ventral pallidum. |
2002-03-21 |
2023-08-12 |
rat |
| Alberto Ricci, Francesco Amenta, Elena Bronzetti, Laura Felici, Tahir Hussain, Mustafa F Lokhandwal. Age-related changes of dopamine receptor protein immunoreactivity in the rat mesenteric vascular tree. Mechanisms of ageing and development. vol 123. issue 5. 2002-03-19. PMID:11796139. |
dopamine d1-d5 receptor protein immunoreactivity and tyrosine hydroxylase (th) immunoreactivity were investigated on the mesenteric arterial tree by immunohistochemistry. |
2002-03-19 |
2023-08-12 |
rat |
| Vincent Joseph, Jorge Soliz, Ruddy Soria, Jacqueline Pequignot, Roland Favier, Hilde Spielvogel, Jean Marc Pequigno. Dopaminergic metabolism in carotid bodies and high-altitude acclimatization in female rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 282. issue 3. 2002-03-15. PMID:11832397. |
at high altitude (3,600 m, bolivian institute for high-altitude biology-ibba, la paz, bolivia), neutered females had higher carotid body tyrosine hydroxylase activity (the rate-limiting enzyme for catecholamine synthesis: +129%) and dopamine utilization (+150%), lower minute ventilation (-30%) and hypoxic ventilatory response (-57%), and higher hematocrit (+18%) and hb concentration (+21%) than intact female rats. |
2002-03-15 |
2023-08-12 |
rat |
| T Nakahara, T Yamamoto, K Endo, H Kayam. Neuronal ectopic expression of tyrosine hydroxylase in the mouse striatum by combined administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 3-nitropropionic acid. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738497. |
these neurons were also immunoreactive to aromatic l-amino acid decarboxylase.we conclude that the combined administration of mptp and 3-npa caused a more profound damage to the nigro-striatal dopaminergic system, and thus some striatal neurons capable of up-regulating tyrosine hydroxylase were induced to produce dopamine, probably to compensate for the dopamine depletion. |
2002-03-14 |
2023-08-12 |
mouse |