| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L J Freedman, C Sh. Monoaminergic innervation of the macaque extended amygdala. Neuroscience. vol 104. issue 4. 2001-09-13. PMID:11457591. |
thus, we mapped the distribution of fibers immunoreactive for tyrosine hydroxylase, dopamine beta-hydroxylase, serotonin, dopamine transporter, and serotonin transporter in the brains of macaque monkeys. |
2001-09-13 |
2023-08-12 |
monkey |
| A Storch, G Paul, M Csete, B O Boehm, P M Carvey, A Kupsch, J Schwar. Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells. Experimental neurology. vol 170. issue 2. 2001-09-13. PMID:11476598. |
following incubation in differentiation media containing interleukin (il)-1b (il-1b), il-11, leukemia inhibitory factor (lif), and glial cell line-derived neurotrophic factor (gdnf), up to 1% of the precursor cells converted into cells immunoreactive for tyrosine hydroxylase (th), a marker for dopamine neurons. |
2001-09-13 |
2023-08-12 |
human |
| R Sánchez-Pernaute, L Studer, K S Bankiewicz, E O Major, R D McKa. In vitro generation and transplantation of precursor-derived human dopamine neurons. Journal of neuroscience research. vol 65. issue 4. 2001-09-13. PMID:11494363. |
transplantation of midbrain precursor-derived dopamine neurons into parkinsonian rats resulted in grafts rich in tyrosine hydroxylase positive neurons 6 weeks after transplantation. |
2001-09-13 |
2023-08-12 |
human |
| R Sánchez-Pernaute, L Studer, K S Bankiewicz, E O Major, R D McKa. In vitro generation and transplantation of precursor-derived human dopamine neurons. Journal of neuroscience research. vol 65. issue 4. 2001-09-13. PMID:11494363. |
no surviving tyrosine hydroxylase positive neurons could be detected when dopamine neurons derived from cortical precursors were grafted. |
2001-09-13 |
2023-08-12 |
human |
| G D Zeevalk, L P Bernard, L Manzino, P K Sonsall. Differential sensitivity of mesencephalic neurons to inhibition of phosphatase 2A. The Journal of pharmacology and experimental therapeutics. vol 298. issue 3. 2001-09-13. PMID:11504786. |
acutely, oka increased tyrosine hydroxylase activity, a phosphatase 2a substrate, and increased dopamine turnover. |
2001-09-13 |
2023-08-12 |
rat |
| D R Grattan, J Xu, M J McLachlan, I C Kokay, S J Bunn, R C Hovey, H W Dave. Feedback regulation of PRL secretion is mediated by the transcription factor, signal transducer, and activator of transcription 5b. Endocrinology. vol 142. issue 9. 2001-09-13. PMID:11517172. |
despite this hyperprolactinemia, mrna levels and immunoreactivity of tyrosine hydroxylase, the key enzyme in dopamine synthesis, were significantly lower in the tuberoinfundibular dopamine neurons of these signal transducer and activator of transcription 5b-deficient mice. |
2001-09-13 |
2023-08-12 |
mouse |
| N Drandarevski, A Marburger, D Walther, T Reum, G Uh, R Morgenster. Dopaminergic mRNA expression in the intact substantia nigra of unilaterally 6-OHDA-lesioned and grafted rats: an in situ hybridization study. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 2. 2001-08-30. PMID:11314769. |
the expression of dopamine transporter mrna, synaptic vesicular monoamine transporter mrna and tyrosine hydroxylase mrna was assessed in adjacent cryostat sections using in situ hybridization. |
2001-08-30 |
2023-08-12 |
rat |
| N Drandarevski, A Marburger, D Walther, T Reum, G Uh, R Morgenster. Dopaminergic mRNA expression in the intact substantia nigra of unilaterally 6-OHDA-lesioned and grafted rats: an in situ hybridization study. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 2. 2001-08-30. PMID:11314769. |
mean grain densities overlying labeled neurons in the substantia nigra pars compacta of grafted rats were compared to those of shamgrafted rats and revealed differential expression of dopamine transporter mrna, whereas synaptic vesicular monoamine transporter mrna and tyrosine hydroxylase mrna expression showed no difference. |
2001-08-30 |
2023-08-12 |
rat |
| E Rodríguez-Martín, S Canals, M J Casarejos, S de Bernardo, A Handler, M A Men. L-DOPA and glia-conditioned medium have additive effects on tyrosine hydroxylase expression in human catecholamine-rich neuroblastoma NB69 cells. Journal of neurochemistry. vol 78. issue 3. 2001-08-30. PMID:11483656. |
the aim of this study was to investigate the effect of l-dopa and glia-conditioned medium (gcm) on cell viability, tyrosine hydroxylase (th) expression, dopamine (da) metabolism and glutathione (gsh) levels of nb69 cells. |
2001-08-30 |
2023-08-12 |
human |
| F Amenta, E Bronzetti, F Cantalamessa, D El-Assouad, L Felici, A Ricci, S K Tayebat. Identification of dopamine plasma membrane and vesicular transporters in human peripheral blood lymphocytes. Journal of neuroimmunology. vol 117. issue 1-2. 2001-08-23. PMID:11431013. |
plasma membrane dopamine transporter (dat), vesicular monoamine transporters (vmat) type-1 and -2 and the expression of the dopaminergic markers dopamine and tyrosine hydroxylase were assessed in membranes and/or in cytospin centrifuged human peripheral blood lymphocytes. |
2001-08-23 |
2023-08-12 |
human |
| A Payton, J Holmes, J H Barrett, T Hever, H Fitzpatrick, A L Trumper, R Harrington, P McGuffin, M O'Donovan, M Owen, W Ollier, J Worthington, A Thapa. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. American journal of medical genetics. vol 105. issue 5. 2001-08-16. PMID:11449400. |
we tested polymorphisms in genes encoding three dopamine receptors (drd3, drd4, and drd5) and four dopamine-relevant enzymes: tyrosine hydroxylase [tyrosine hydroxylase (th)], dopamine beta hydroxylase (dbetah), catechol-o-methyltransferase (comt), and monoamine oxidase a (maoa). |
2001-08-16 |
2023-08-12 |
Not clear |
| D S Rothblat, E Rubin, J S Schneide. Effects of chronic alcohol ingestion on the mesostriatal dopamine system in the rat. Neuroscience letters. vol 300. issue 2. 2001-08-09. PMID:11207375. |
western blotting revealed a mean 20% decrease in tyrosine hydroxylase protein levels in the dorsal and ventral striatum of alcohol-fed animals while dopamine transporter protein levels from the same animals were significantly increased compared to controls (mean 60% increase for the dorsal and ventral striatum). |
2001-08-09 |
2023-08-12 |
rat |
| P Teismann, M Schwaninger, F Weih, B Ferge. Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease. Neuroreport. vol 12. issue 5. 2001-08-09. PMID:11303744. |
furthermore, p50-deficient mice showed only minor differences in striatal dopamine and metabolite levels as well as tyrosine hydroxylase immunoreactivity after mptp administration in comparison to wildtype mice. |
2001-08-09 |
2023-08-12 |
mouse |
| M Z Guimarães, J N Hokoç, R Duvoisin, R A Reis, F G De Mell. Dopaminergic retinal cell differentiation in culture: modulation by forskolin and dopamine. The European journal of neuroscience. vol 13. issue 10. 2001-08-09. PMID:11403686. |
we examined the effects of dopamine and camp on the differentiation of dopaminergic retinal cells in the chick retina, using an in vitro system and tyrosine hydroxylase immunocytochemistry. |
2001-08-09 |
2023-08-12 |
chicken |
| M Ota, A Nakashima, K Ikemoto, S Nojima, M Tanaka, M Okuda, H Koga, K Mori, Y S Kaneko, K Fujiwara, H Yamamoto, T Nagatsu, A Ot. Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients. Molecular psychiatry. vol 6. issue 3. 2001-07-26. PMID:11326301. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine (da) biosynthesis. |
2001-07-26 |
2023-08-12 |
human |
| J D Adams, M L Chang, L Klaidma. Parkinson's disease--redox mechanisms. Current medicinal chemistry. vol 8. issue 7. 2001-07-26. PMID:11375751. |
tyrosine hydroxylase is present in all dopaminergic neurons and is responsible for the synthesis of dopamine. |
2001-07-26 |
2023-08-12 |
Not clear |
| E Küppers, T Ivanova, M Karolczak, C Beye. Estrogen: a multifunctional messenger to nigrostriatal dopaminergic neurons. Journal of neurocytology. vol 29. issue 5-6. 2001-07-26. PMID:11424954. |
precisely, we found that dopaminergic neurons are direct targets for estrogen and that estrogen stimulates neurite extension/branching and the expression of tyrosine hydroxylase, the key enzyme in dopamine synthesis. |
2001-07-26 |
2023-08-12 |
Not clear |
| M S Szczypka, K Kwok, M D Brot, B T Marck, A M Matsumoto, B A Donahue, R D Palmite. Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice. Neuron. vol 30. issue 3. 2001-07-26. PMID:11430814. |
dopamine-deficient (dd) mice cannot synthesize dopamine (da) in dopaminergic neurons due to selective inactivation of the tyrosine hydroxylase gene in those neurons. |
2001-07-26 |
2023-08-12 |
mouse |
| S Theofilopoulos, J Goggi, S S Riaz, E Jauniaux, G M Stern, H F Bradfor. Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor. Brain research. Developmental brain research. vol 127. issue 2. 2001-07-19. PMID:11334998. |
parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor. |
2001-07-19 |
2023-08-12 |
human |
| S Theofilopoulos, J Goggi, S S Riaz, E Jauniaux, G M Stern, H F Bradfor. Parallel induction of the formation of dopamine and its metabolites with induction of tyrosine hydroxylase expression in foetal rat and human cerebral cortical cells by brain-derived neurotrophic factor and glial-cell derived neurotrophic factor. Brain research. Developmental brain research. vol 127. issue 2. 2001-07-19. PMID:11334998. |
brain-derived neurotrophic factor (bdnf; 50 ng/ml), dopamine (da; 10 microm) and forskolin (fsk; 10 microm) have previously been shown by this and other laboratories to induce the tyrosine hydroxylase (th) enzyme in foetal human and rat cerebral cortex during specified sensitive developmental periods. |
2001-07-19 |
2023-08-12 |
human |