| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Lebel, Y Gauthier, A Moreau, J Droui. Pitx3 activates mouse tyrosine hydroxylase promoter via a high-affinity binding site. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299318. |
tyrosine hydroxylase (th) is the rate-limiting enzyme of dopamine and (nor)adrenaline biosynthesis. |
2001-05-17 |
2023-08-12 |
mouse |
| J K Phillips, R Dubey, E Sesiashvilvi, M Takeda, D L Christie, J Lipsk. Differential expression of the noradrenaline transporter in adrenergic chromaffin cells, ganglion cells and nerve fibres of the rat adrenal medulla. Journal of chemical neuroanatomy. vol 21. issue 1. 2001-05-10. PMID:11173223. |
immunoreactivity for the catecholamine biosynthetic enzymes tyrosine hydroxylase (th), aromatic-l-amino-acid decarboxylase (aadc) and dopamine beta-hydroxylase (dbh) was present in all chromaffin cells, while phenylethanolamine n-methyltransferase (pnmt) was used to determine adrenergic chromaffin cell groups. |
2001-05-10 |
2023-08-12 |
rat |
| P S MohanKumar, S M MohanKumar, S K Quadri, J L Voog. Effects of chronic bromocriptine treatment on tyrosine hydroxylase (TH) mRNA expression, TH activity and median eminence dopamine concentrations in ageing rats. Journal of neuroendocrinology. vol 13. issue 3. 2001-05-03. PMID:11207940. |
effects of chronic bromocriptine treatment on tyrosine hydroxylase (th) mrna expression, th activity and median eminence dopamine concentrations in ageing rats. |
2001-05-03 |
2023-08-12 |
rat |
| E Grünblatt, S Mandel, G Maor, M B Youdi. Effects of R- and S-apomorphine on MPTP-induced nigro-striatal dopamine neuronal loss. Journal of neurochemistry. vol 77. issue 1. 2001-05-03. PMID:11279270. |
both s-apo (0.5-1 mg/kg, subcutaneous) and r-apo (10 mg/kg) pretreatment of c57-bl mice, protected against mptp (24 mg/kg, intraperitoneally) induced dopamine (da) depletion and reduction in tyrosine hydroxylase (th) activity. |
2001-05-03 |
2023-08-12 |
mouse |
| N Kinor, R Geffen, E Golomb, T Zinman, G Yadi. Dopamine increases glial cell line-derived neurotrophic factor in human fetal astrocytes. Glia. vol 33. issue 2. 2001-04-26. PMID:11180511. |
thus, if implanted into a brain region rich in dopamine, or if transfected with the tyrosine hydroxylase gene, fetal astrocytes may serve as paracrine/autocrine cells capable of supplying critical growth factors to diseased brain tissue. |
2001-04-26 |
2023-08-12 |
human |
| P Teismann, B Ferge. Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease. Synapse (New York, N.Y.). vol 39. issue 2. 2001-04-19. PMID:11180504. |
as markers of protection we determined the effects on mptp-induced striatal dopamine depletion, locomotor activity, cell loss, and tyrosine hydroxylase immunoreactivity (th-ir) in the substantia nigra pars compacta. |
2001-04-19 |
2023-08-12 |
mouse |
| P V Ershov, M V Ugriumov, A Cala. [Quantitative evaluation of populations of neurons expressing dopamine synthesis enzymes in the arcuate nucleus neurons in developing rats]. Izvestiia Akademii nauk. Seriia biologicheskaia. issue 1. 2001-04-05. PMID:11236583. |
the ratio of neuron populations expressing either tyrosine hydroxylase or aromatic l-amino acid decarboxylase, which are enzymes of dopamine synthesis, was estimated quantitatively in the arcuate nucleus of male and female rats on 21st day of intrauterine development, the 9th day of postnatal development, and in adult animals. |
2001-04-05 |
2023-08-12 |
rat |
| J S Shin, J J Lee, Y Kim, C K Lee, Y P Yun, M K Le. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biological & pharmaceutical bulletin. vol 24. issue 1. 2001-03-29. PMID:11201237. |
the decreased dopamine level was maintained up to 48 h and then recovered to the control level at about 72 h. tyrosine hydroxylase (th) was inhibited at 6 h following treatment with ethaverine in pc12 cells and the activity was maintained at a reduced level up to 36 h (12-22% inhibition at 2.0 microm). |
2001-03-29 |
2023-08-12 |
Not clear |
| J F Bowye. Neuronal degeneration in the limbic system of weanling rats exposed to saline, hyperthermia or d-amphetamine. Brain research. vol 885. issue 2. 2001-03-01. PMID:11102570. |
neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreactivity in the caudate-putamen (cpu) and decreases in cpu tissue dopamine levels in weanlings was much less than those previously observed in adults. |
2001-03-01 |
2023-08-12 |
rat |
| M Romero-Ramos, J L Venero, M Santiago, J A Rodriguez-Gómez, M L Vizuete, J Cano, A Machad. Decreased messenger RNA expression of key markers of the nigrostriatal dopaminergic system following vitamin E deficiency in the rat. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113352. |
after 15 days of deficient diet, the amount and activity of striatal and nigral tyrosine hydroxylase increased, which contrasted with a decreased messenger rna expression for tyrosine hydroxylase and the dopamine transporter in the ventral mesencephalon. |
2001-03-01 |
2023-08-12 |
rat |
| M Romero-Ramos, J L Venero, M Santiago, J A Rodriguez-Gómez, M L Vizuete, J Cano, A Machad. Decreased messenger RNA expression of key markers of the nigrostriatal dopaminergic system following vitamin E deficiency in the rat. Neuroscience. vol 101. issue 4. 2001-03-01. PMID:11113352. |
in contrast, messenger rna levels for tyrosine hydroxylase and the dopamine transporter were markedly reduced in 30-day deficient rats. |
2001-03-01 |
2023-08-12 |
rat |
| T González-Hernández, P Barroso-Chinea, A Acevedo, E Salido, M Rodrígue. Colocalization of tyrosine hydroxylase and GAD65 mRNA in mesostriatal neurons. The European journal of neuroscience. vol 13. issue 1. 2001-03-01. PMID:11135004. |
in this study, we used the combination of immunocytochemistry for tyrosine hydroxylase (th; a marker of dopaminergic neurons), in situ hybridization (ish) for two different isoforms of glutamic acid decarboxylase (gad65 and gad67, the rate-limiting enzyme in gaba synthesis) and retrograde tracing techniques to investigate the possible existence of nigrostriatal neurons containing both neurotransmitters (dopamine and gaba) in the rat. |
2001-03-01 |
2023-08-12 |
rat |
| S N Ebert, R P Thompso. Embryonic epinephrine synthesis in the rat heart before innervation: association with pacemaking and conduction tissue development. Circulation research. vol 88. issue 1. 2001-03-01. PMID:11139483. |
using antibodies that selectively recognize the catecholamine biosynthetic enzymes, tyrosine hydroxylase, dopamine ss-hydroxylase, and phenylethanolamine n-methyltransferase, we used coimmunofluorescent staining techniques to identify cardiac cells that have the capability of producing catecholamines. |
2001-03-01 |
2023-08-12 |
rat |
| L I Tsao, T Hayashi, T P S. Blockade of dopamine transporter and tyrosine hydroxylase activity loss by [D-Ala(2), D-Leu(5)]enkephalin in methamphetamine-treated CD-1 mice. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980266. |
blockade of dopamine transporter and tyrosine hydroxylase activity loss by [d-ala(2), d-leu(5)]enkephalin in methamphetamine-treated cd-1 mice. |
2001-02-22 |
2023-08-12 |
mouse |
| L I Tsao, T Hayashi, T P S. Blockade of dopamine transporter and tyrosine hydroxylase activity loss by [D-Ala(2), D-Leu(5)]enkephalin in methamphetamine-treated CD-1 mice. European journal of pharmacology. vol 404. issue 1-2. 2001-02-22. PMID:10980266. |
here, we show that dadle was able to block the protein as well as the functional loss of dopamine transporter (dat) and tyrosine hydroxylase (th) induced by methamphetamine. |
2001-02-22 |
2023-08-12 |
mouse |
| S Iwata, M Nomoto, S Kaseda, S Tanoue, M Shimosaka, T Fukud. TH protein and mRNA in nigrostriatal dopaminergic neurons are down-regulated by continuous but not intermittent apomorphine. Brain research. Molecular brain research. vol 82. issue 1-2. 2001-02-22. PMID:11042366. |
levels of tyrosine hydroxylase (th) and th mrna were measured after administration of dopamine agonists for a long period of time to elucidate the long-term feedback inhibition of dopamine synthesis in nigrostriatal dopaminergic neurons. |
2001-02-22 |
2023-08-12 |
Not clear |
| T Arinami, H Ishiguro, E S Onaiv. Polymorphisms in genes involved in neurotransmission in relation to smoking. European journal of pharmacology. vol 410. issue 2-3. 2001-02-22. PMID:11134671. |
these include genes encoding the dopamine d(3) and d(5) receptors, serotonin receptors, tyrosine hydroxylase, trytophan 2,3-dioxygenase, opioid receptors, and cannabinoid receptors. |
2001-02-22 |
2023-08-12 |
Not clear |
| P C Waldmeier, W P Spooren, B Hengere. CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 362. issue 6. 2001-02-22. PMID:11138845. |
cgp 3466 or its hydrogen maleate salt, cgp 3466b, at concentrations between 10(-11) m and 10(-7) m, protected rat embryonic mesencephalic dopaminergic neurons in free-floating or dispersed cell culture from death inflicted by treatment with 1-methyl-4-phenyl pyridinium ion (mpp+) as measured by different readouts such as dopamine uptake, tyrosine hydroxylase activity, and counts of tyrosine hydroxylase-positive cells. |
2001-02-22 |
2023-08-12 |
mouse |
| M V Ugriumov, V I Mel'nikova, P V Ershov, I Balan, A Cala. [Non-dopaminergic neurons expressing dopamine synthesis enzymes: differentiation and functional importance]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 86. issue 10. 2001-02-22. PMID:11200326. |
the study has evaluated in vivo, ex vivo and in vitro ontogenesis and functional significance of the arcuate nucleus neurons expressing either individual enzymes of dopamine synthesis, tyrosine hydroxylase or aromatic l-amino acid decarboxylase as well as both of them (dopaminergic neurons) in rats from the 17th embryonic day to adulthood. |
2001-02-22 |
2023-08-12 |
rat |
| M V Ugriumov, V I Mel'nikova, P V Ershov, I Balan, A Cala. [Non-dopaminergic neurons expressing dopamine synthesis enzymes: differentiation and functional importance]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 86. issue 10. 2001-02-22. PMID:11200326. |
the data suggest a possibility of the dopamine synthesis in the fetus arcuate nucleus by the monoenzymatic neurons containing either tyrosine hydroxylase or aromatic l-amino acid decarboxylase-expressing neurons in co-operation. |
2001-02-22 |
2023-08-12 |
rat |