| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Q Vu, Z D Ling, S Y Ma, H C Robie, C W Tong, E Y Chen, J W Lipton, P M Carve. Pramipexole attenuates the dopaminergic cell loss induced by intraventricular 6-hydroxydopamine. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 2. 2000-09-21. PMID:10847557. |
in the preliminary study, 6-hydroxydopamine produced a 68% reduction in striatal dopamine and a 62% loss in tyrosine hydroxylase immunoreactive (thir) cell counts in the substantia nigra. |
2000-09-21 |
2023-08-12 |
rat |
| M Y Jung, P R Hof, C Schmaus. Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k). Neuroscience. vol 97. issue 3. 2000-09-14. PMID:10828532. |
the present study used mice deficient for dopamine d(2) and d(3) receptors to test whether the expression of these two members of the d(2) class of receptors is essential for the normal expression of three markers that characterize the neurochemical differentiation of the striatum: the calcium-binding protein calbindin, tyrosine hydroxylase and acetylcholinesterase. |
2000-09-14 |
2023-08-12 |
mouse |
| M Y Jung, P R Hof, C Schmaus. Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k). Neuroscience. vol 97. issue 3. 2000-09-14. PMID:10828532. |
results from these experiments revealed that the expression of striatal tyrosine hydroxylase (the rate-limiting enzyme of dopamine synthesis) and acetylcholinesterase is unaffected even by the combined knockout of d(2) and d(3) receptors. |
2000-09-14 |
2023-08-12 |
mouse |
| I S Shim, J S Won, J K Lee, D K Song, S E Kim, S O Huh, Y H Kim, H W Su. Modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat. Journal of ethnopharmacology. vol 70. issue 2. 2000-09-01. PMID:10771206. |
modulatory effect of ginseng total saponin on dopamine release and tyrosine hydroxylase gene expression induced by nicotine in the rat. |
2000-09-01 |
2023-08-12 |
rat |
| L R Lucas, P Pompei, B S McEwe. Salt appetite in salt-replete rats: involvement of mesolimbic structures in deoxycorticosterone-induced salt craving behavior. Neuroendocrinology. vol 71. issue 6. 2000-09-01. PMID:10878500. |
in addition, there were decreases in dopamine transporter binding in the acbsh and decreases in tyrosine hydroxylase immunoreactivity throughout the striatum in the 24h vs. 24hx group. |
2000-09-01 |
2023-08-12 |
rat |
| P C Das, W K McElroy, R L Coope. Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12) cells in vitro. Toxicological sciences : an official journal of the Society of Toxicology. vol 56. issue 2. 2000-08-24. PMID:10910990. |
these data indicate that both atrazine and simazine inhibit the cellular synthesis of da mediated by the tyrosine hydroxylase (th), and ne mediated by dopamine beta-hydroxylase (dbetah), and, as a result, there is a partial or significant inhibition of ne release. |
2000-08-24 |
2023-08-12 |
Not clear |
| M L Vizuete, M Merino, J L Venero, M Santiago, J Cano, A Machad. Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899929. |
injection of 100 and 250 nmol of histamine in substantia nigra produced a selective damage in dopaminergic neurons evidenced by the loss of tyrosine hydroxylase mrna-expressing cells, tyrosine hydroxylase-immunolabeled-positive cell bodies, and dopamine and 3,4-dihydroxyphenylacetic acid levels. |
2000-08-17 |
2023-08-12 |
rat |
| R F Castilho, O Hansson, P Brundi. FK506 and cyclosporin A enhance the survival of cultured and grafted rat embryonic dopamine neurons. Experimental neurology. vol 164. issue 1. 2000-08-16. PMID:10877919. |
we examined the effects of the immunophilin ligands and calcineurin inhibitors fk506 and cyclosporin a on the survival of rat embryonic dopamine (tyrosine hydroxylase (th)-immunoreactive) neurons. |
2000-08-16 |
2023-08-12 |
rat |
| C L Barr, K G Wigg, S Bloom, R Schachar, R Tannock, W Roberts, M Malone, J L Kenned. Further evidence from haplotype analysis for linkage of the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898896. |
we extend our study of the dopamine d4 gene and adhd by testing for linkage using two additional polymorphisms in the dopamine d4 receptor gene and a polymorphism in the closely linked gene, tyrosine hydroxylase. |
2000-08-10 |
2023-08-12 |
Not clear |
| B B Nankova, M Rivkin, M Kelz, E J Nestler, E L Sabba. Fos-related antigen 2: potential mediator of the transcriptional activation in rat adrenal medulla evoked by repeated immobilization stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908602. |
we investigated dna protein interactions at the ap1-like promoter elements of two stress-responsive genes, tyrosine hydroxylase and dopamine beta-hydroxylase. |
2000-08-10 |
2023-08-12 |
rat |
| B B Nankova, M Rivkin, M Kelz, E J Nestler, E L Sabba. Fos-related antigen 2: potential mediator of the transcriptional activation in rat adrenal medulla evoked by repeated immobilization stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908602. |
the induction of fra2 and increased ap1-like binding activity was reflected in sustained transcriptional activation of tyrosine hydroxylase and dopamine beta-hydroxylase genes after repeated episodes of stress. |
2000-08-10 |
2023-08-12 |
rat |
| B B Nankova, M Rivkin, M Kelz, E J Nestler, E L Sabba. Fos-related antigen 2: potential mediator of the transcriptional activation in rat adrenal medulla evoked by repeated immobilization stress. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 15. 2000-08-10. PMID:10908602. |
the functional link between fra2 and regulation of tyrosine hydroxylase and dopamine beta-hydroxylase transcription was confirmed in pc12 cells coexpressing this factor and the corresponding promoter-reporter gene constructs. |
2000-08-10 |
2023-08-12 |
rat |
| A K Pani, R P Crol. Catechol concentrations in the hemolymph of the scallop, Placopecten magellanicus. General and comparative endocrinology. vol 118. issue 1. 2000-08-02. PMID:10753566. |
scallops incubated in 10(-5) m alpha-methyl-p-tyrosine, a blocker of tyrosine hydroxylase, for 1 day followed by a 3-day wash in artificial seawater had significantly reduced concentrations of dopa, dopamine, and dopac in the hemolymph. |
2000-08-02 |
2023-08-12 |
Not clear |
| D D Song, S N Habe. Striatal responses to partial dopaminergic lesion: evidence for compensatory sprouting. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 13. 2000-07-26. PMID:10864967. |
furthermore, normal preproenkephalin mrna expression was maintained despite severe overall loss of tyrosine hydroxylase fibers in striatal regions with abundant branching, whereas preproenkephalin mrna expression increased in severely depleted regions that lacked branched fibers, indicating that branching or sprouting was involved in the compensation for dopamine depletion and the maintenance of normal preproenkephalin expression. |
2000-07-26 |
2023-08-12 |
Not clear |
| S J Augood, Z R Hollingsworth, D G Standaert, P C Emson, J B Penne. Localization of dopaminergic markers in the human subthalamic nucleus. The Journal of comparative neurology. vol 421. issue 2. 2000-07-24. PMID:10813785. |
the potential role for dopamine in the subthalamic nucleus was investigated in human postmortem tissue sections by examining; (1) immunostaining for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine synthesis; (2) binding of [(3)h]-sch23390 (d1-like), [(3)h]-ym-09151-2 (d2-like), and [(3)h]-mazindol (dopamine uptake); and (3) expression of dopamine d1 and d2 receptor mrnas. |
2000-07-24 |
2023-08-12 |
human |
| P Klivenyi, O A Andreassen, R J Ferrante, E Lancelot, D Reif, M F Bea. Inhibition of neuronal nitric oxide synthase protects against MPTP toxicity. Neuroreport. vol 11. issue 6. 2000-07-17. PMID:10817604. |
arr17338 produced dose-dependent significant protection against mptp induced depletion of dopamine and protected against mptp induced depletions of tyrosine hydroxylase immunostained neurons in the substantia nigra. |
2000-07-17 |
2023-08-12 |
Not clear |
| K Czaj. Distribution of primary afferent neurons innervating the porcine oviduct and their immunohistochemical characterization. Cells, tissues, organs. vol 166. issue 3. 2000-06-30. PMID:10765023. |
we also investigated the existence and coexistence of immunoreactivities to tyrosine hydroxylase (th) and dopamine beta-hydroxylase within the neurons because in some mammals, dorsal root ganglia (drg) were previously found to contain perikarya immunoreactive (ir) to th. |
2000-06-30 |
2023-08-12 |
Not clear |
| K C Lim, G Lakshmanan, S E Crawford, Y Gu, F Grosveld, J D Enge. Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nature genetics. vol 25. issue 2. 2000-06-29. PMID:10835639. |
we find here that null mutation of gata3 leads to reduced accumulation of th (encoding tyrosine hydroxylase, th) and dbh (dopamine beta-hydroxylase, dbh) mrna, whereas several other sns genes are unaffected. |
2000-06-29 |
2023-08-12 |
mouse |
| U Ernsberger, E Reissmann, I Mason, H Rohre. The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. Mechanisms of development. vol 92. issue 2. 2000-06-16. PMID:10727856. |
the expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. |
2000-06-16 |
2023-08-12 |
chicken |
| U Ernsberger, E Reissmann, I Mason, H Rohre. The expression of dopamine beta-hydroxylase, tyrosine hydroxylase, and Phox2 transcription factors in sympathetic neurons: evidence for common regulation during noradrenergic induction and diverging regulation later in development. Mechanisms of development. vol 92. issue 2. 2000-06-16. PMID:10727856. |
during differentiation of sympathetic neurons in chick embryos, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) mrnas become detectable during the same developmental period and are both induced by bmp 4. |
2000-06-16 |
2023-08-12 |
chicken |