| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Swanson, M Adachi, E J Lewi. The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein. The Journal of biological chemistry. vol 275. issue 4. 2000-02-29. PMID:10644760. |
for the noradrenergic phenotype, these influences combine to activate the expression of the catecholaminergic biosynthetic enzymes tyrosine hydroxylase and dopamine beta-hydroxylase (dbh). |
2000-02-29 |
2023-08-12 |
rat |
| J A Morón, V Pérez, M Pastó, J M Lizcano, M Unzet. FA-70, a novel selective and irreversible monoamine oxidase-A inhibitor: effect on monoamine metabolism in mouse cerebral cortex. The Journal of pharmacology and experimental therapeutics. vol 292. issue 2. 2000-02-22. PMID:10640319. |
the ex vivo effect of fa70 on dopamine content was correlated with the activation effect on tyrosine hydroxylase activity, the enzyme responsible for the regulation of the limiting step in catecholamine synthesis. |
2000-02-22 |
2023-08-12 |
mouse |
| N Y Choksi, W B Nix, S D Wyrick, R G Boot. A novel phenylaminotetralin (PAT) recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661506. |
furthermore, certain pats stimulate tyrosine hydroxylase and dopamine synthesis in guinea pig and rat brain in vitro. |
2000-02-22 |
2023-08-12 |
rat |
| N Y Choksi, W B Nix, S D Wyrick, R G Boot. A novel phenylaminotetralin (PAT) recognizes histamine H1 receptors and stimulates dopamine synthesis in vivo in rat brain. Brain research. vol 852. issue 1. 2000-02-22. PMID:10661506. |
we propose that pats represent a novel class of ligands for h1 receptors that can modulate tyrosine hydroxylase activity and dopamine synthesis in the limbic region of mammalian forebrain. |
2000-02-22 |
2023-08-12 |
rat |
| B Y Zeng, B Dass, A Owen, S Rose, C Cannizzaro, B C Tel, P Jenne. Chronic L-DOPA treatment increases striatal cannabinoid CB1 receptor mRNA expression in 6-hydroxydopamine-lesioned rats. Neuroscience letters. vol 276. issue 2. 2000-02-15. PMID:10624794. |
a 6-ohda lesion of nigrostriatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mrna, did not alter cb1r mrna levels in the dopamine depleted striatum. |
2000-02-15 |
2023-08-12 |
rat |
| M A Mena, M J Casarejos, J García de Yébene. The effect of glia-conditioned medium on dopamine neurons in culture. Modulation of apoptosis, tyrosine hydroxylase expression and 1-methyl-4-phenylpyridinium toxicity. Journal of neural transmission (Vienna, Austria : 1996). vol 106. issue 11-12. 2000-02-15. PMID:10651107. |
in this study we have investigated the effect of gcm on the number of tyrosine hydroxylase (th) immunoreactive neurons, levels of dopamine, number of high affinity dopamine uptake sites, and percentage of apoptotic cells in midbrain neuronal cultures, before and after exposure to 1-methyl-4-phenylpyridinium (mpp+). |
2000-02-15 |
2023-08-12 |
Not clear |
| D M Donovan, L L Miner, M P Perry, R S Revay, L G Sharpe, S Przedborski, V Kostic, R M Philpot, C L Kirstein, R B Rothman, C W Schindler, G R Uh. Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581396. |
to study possible influences of variant dat expression on these processes, we have constructed transgenic mice (thdat) in which tyrosine hydroxylase (th) promoter sequences drive expression of a rat dat cdna variant, increase striatal dat expression by 20-30%, and provide modest alterations in striatal levels of dopamine and its metabolites. |
2000-02-14 |
2023-08-12 |
mouse |
| D S Latchman, R S Coffi. Viral vectors in the treatment of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 15. issue 1. 2000-02-10. PMID:10634236. |
parkinson's disease is an obvious target for the development of gene therapy procedures which could involve both the delivery of the gene encoding tyrosine hydroxylase to boost dopamine production or the delivery of genes encoding neurotrophic factors such as gdnf to promote the survival of dopaminergic neurons. |
2000-02-10 |
2023-08-12 |
Not clear |
| S J Oh, I B Kim, E J Lee, K Y Kim, H I Kim, M H Chu. Immunocytological localization of dopamine in the guinea pig retina. Cell and tissue research. vol 298. issue 3. 2000-02-09. PMID:10639746. |
we examined dopaminergic neurons in the guinea pig retina; antisera against tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt) and an antiserum against gamma-aminobutyric acid (gaba) were used. |
2000-02-09 |
2023-08-12 |
Not clear |
| S Nishikawa, S Goto, T Hamasaki, M Ogawa, Y Ushi. Transient and compartmental expression of the reeler gene product reelin in the developing rat striatum. Brain research. vol 850. issue 1-2. 2000-02-03. PMID:10629770. |
furthermore, reelin protein is differentially concentrated in the two distinct compartments showing a mosaic-like fashion in the early postnatal period: the compartments of heightened cr-50-immunolabeling correspond to so-called "dopamine islands" (i.e., developing striosomes) visualized by tyrosine hydroxylase (th)-immunostaining. |
2000-02-03 |
2023-08-12 |
rat |
| Y S Lee, G Raia, C Tönshoff, M J Evinge. Neural regulation of phenylethanolamine N-methyltransferase (PNMT) gene expression in bovine chromaffin cells differs from other catecholamine enzyme genes. Journal of molecular neuroscience : MN. vol 12. issue 1. 2000-02-03. PMID:10636470. |
because the 5'-upstream regions of the pnmt do not contain sequences analogous to those demonstrated to convey neural regulation to the tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) catecholamine-synthesizing enzyme genes, functional and biochemical analyses have been utilized to characterize pnmt promoter responses to cholinergic and depolarizing agents. |
2000-02-03 |
2023-08-12 |
cattle |
| V Kalia, C Fenske, D R Hole, C A Wilso. Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats. Journal of reproduction and fertility. vol 117. issue 1. 2000-02-03. PMID:10645260. |
at the same time, the progesterone treatment increased tyrosine hydroxylase activity in the zona incerta as indicated by an increase in l-dihydroxyphenylalanine (l-dopa) accumulation after 100 mg 3-hydroxybenzylhydrazine hydrochloric acid (nsd1015) kg-1 and an increase in dopamine release as indicated by a increase in dihydroxyphenylacetic acid (dopac) concentrations (one of the major metabolites of dopamine). |
2000-02-03 |
2023-08-12 |
rat |
| V Kalia, C Fenske, D R Hole, C A Wilso. Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats. Journal of reproduction and fertility. vol 117. issue 1. 2000-02-03. PMID:10645260. |
this treatment had no effect on the ratio of tyrosine hydroxylase:beta-actin mrna but decreased l-dopa accumulation and dopac concentrations in the zona incerta, indicating a post-translational inhibition of dopamine synthesis and release. |
2000-02-03 |
2023-08-12 |
rat |
| V Kalia, C Fenske, D R Hole, C A Wilso. Effect of gonadal steroids and gamma-aminobutyric acid on LH release and dopamine expression and activity in the zona incerta in rats. Journal of reproduction and fertility. vol 117. issue 1. 2000-02-03. PMID:10645260. |
in conclusion, the steroids act to increase dopamine activity in different ways: oestrogen increases tyrosine hydroxylase mrna expression and progesterone acts after translation to increase tyrosine hydroxylase activity and dopamine release (as indicated by increases in dopac concentrations). |
2000-02-03 |
2023-08-12 |
rat |
| A Nakashima, N Hayashi, K Mori, Y S Kaneko, T Nagatsu, A Ot. Positive charge intrinsic to Arg(37)-Arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1. FEBS letters. vol 465. issue 1. 2000-01-31. PMID:10620706. |
positive charge intrinsic to arg(37)-arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1. |
2000-01-31 |
2023-08-12 |
human |
| A Nakashima, N Hayashi, K Mori, Y S Kaneko, T Nagatsu, A Ot. Positive charge intrinsic to Arg(37)-Arg(38) is critical for dopamine inhibition of the catalytic activity of human tyrosine hydroxylase type 1. FEBS letters. vol 465. issue 1. 2000-01-31. PMID:10620706. |
tyrosine hydroxylase (th), which converts l-tyrosine to l-3, 4-dihydroxyphenylalanine, is a rate-limiting enzyme in the biosynthesis of catecholamines; its activity is regulated by the feedback inhibition of the catecholamine products including dopamine. |
2000-01-31 |
2023-08-12 |
human |
| B Alston-Mills, A C Parker, E J Eisen, R Wilson, S Fletche. Factors influencing maternal behavior in the hubb/hubb mutant mouse. Physiology & behavior. vol 68. issue 1-2. 2000-01-31. PMID:10627055. |
tyrosine hydroxylase, the rate-determining step in dopamine synthesis, was localized in the brain by immunohistochemistry. |
2000-01-31 |
2023-08-12 |
mouse |
| J S Dixon, P Y Jen, J A Goslin. Tyrosine hydroxylase and vesicular acetylcholine transporter are coexpressed in a high proportion of intramural neurons of the human neonatal and child urinary bladder. Neuroscience letters. vol 277. issue 3. 2000-01-24. PMID:10626837. |
previous studies have used the immunocytochemical demonstration of tyrosine hydroxylase (th), either alone or in combination with dopamine beta-hydroxylase, to identify noradrenergic neurons in these ganglia. |
2000-01-24 |
2023-08-12 |
human |
| R Lints, S W Emmon. Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene. Development (Cambridge, England). vol 126. issue 24. 2000-01-21. PMID:10572056. |
we used expression of a tyrosine hydroxylase reporter transgene as well as direct assays for dopamine to study the genetic requirements for adoption of the dopaminergic cell fate. |
2000-01-21 |
2023-08-12 |
caenorhabditis_elegans |
| F Marsais, A Cala. Ectopic expression of non-catecholaminergic tyrosine hydroxylase in rat hypothalamic magnocellular neurons. Neuroscience. vol 94. issue 1. 2000-01-14. PMID:10613505. |
in lactating and salt-loaded rats, magnocellular neurons were devoid of the catecholamine biosynthesis markers aromatic l-amino acid decarboxylase, l-3,4 dihydroxyphenylalanine, dopamine and gtp-cyclohydrolase i. tyrosine hydroxylase expression did not increase after rats were injected with reserpine. |
2000-01-14 |
2023-08-12 |
rat |