| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Steiner, M Blum, S T Kitai, P Fed. Differential expression of ErbB3 and ErbB4 neuregulin receptors in dopamine neurons and forebrain areas of the adult rat. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506520. |
immunostaining for tyrosine hydroxylase and dopamine depletion by 6-hydroxydopamine indicate that erbb4 is expressed in dopamine neurons in the latter two nuclei. |
1999-11-19 |
2023-08-12 |
rat |
| G T Liberatore, D I Finkelstein, J Y Wong, M K Horne, M J Porritt, G A Donnan, D W Howell. Sprouting of dopaminergic axons after striatal injury: confirmation by markers not dependent on dopamine metabolism. Experimental neurology. vol 159. issue 2. 1999-11-19. PMID:10506529. |
striatal injury increases dopamine metabolism in the nigrostriatal system but it is unclear whether this response is due to increased synthesis and activation of tyrosine hydroxylase within existing dopamine terminals and/or branching and sprouting of new terminals. |
1999-11-19 |
2023-08-12 |
mouse |
| A Parsian, Z H Zhan. Human chromosomes 11p15 and 4p12 and alcohol dependence: possible association with the GABRB1 gene. American journal of medical genetics. vol 88. issue 5. 1999-11-17. PMID:10490712. |
to determine the role of genes in the chromosomal regions 11p15 and 4p12 in the development of alcohol dependence, a sample of alcoholics (n = 133) and normal controls (n = 89) were screened using polymorphisms in the dopamine d4 receptor (drd4), tyrosine hydroxylase (th), and gaba receptor beta1 (gabrbeta1) genes. |
1999-11-17 |
2023-08-12 |
human |
| B Husemann, N Andreeva, J Gao, J Heldt, K Andersson, J Gros. Early hypoxia modulates the phenotype of dopaminergic cells in rat di- and mesencephalic cell cultures and induces a higher vulnerability of non-dopaminergic neurons to a second hypoxic exposure. Neuroscience letters. vol 275. issue 1. 1999-11-15. PMID:10554983. |
the numbers of neuron-specific enolase immuno-reactive (nse-ir) and tyrosine hydroxylase immuno-reactive (th-ir) neurons and the levels of dopamine, its main metabolites and the spontaneous and potassium-stimulated da release were determined on div 15. |
1999-11-15 |
2023-08-12 |
rat |
| S Cho, O Hwang, H Baker, H H Baik, B T Volpe, J H Son, T H Jo. Altered presynaptic gene expression in transgenic mice producing dopamine in the pineal gland. Synapse (New York, N.Y.). vol 34. issue 2. 1999-11-09. PMID:10502312. |
we recently generated transgenic mice that ectopically express tyrosine hydroxylase (th) and thereby produce dopamine (da) de novo in pinealocytes of the pineal gland (pg). |
1999-11-09 |
2023-08-12 |
mouse |
| E Grünblatt, S Mandel, T Berkuzki, M B Youdi. Apomorphine protects against MPTP-induced neurotoxicity in mice. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 4. 1999-11-02. PMID:10435498. |
pretreatment with 5-10 mg/kg r-apomorphine administered subcutaneously in c57bl mice protects against mptp (24 mg/kg administered intraperitoneally) induced loss of nigrostriatal dopamine neurons as indicated by striatal dopamine content, tyrosine hydroxylase content, and tyrosine hydroxylase activity. |
1999-11-02 |
2023-08-12 |
mouse |
| J Peyronnet, L Poncet, L Denoroy, J M Pequignot, H Lagercrantz, Y Dalma. Plasticity in the phenotypic expression of catecholamines and vasoactive intestinal peptide in adult rat superior cervical and stellate ganglia after long-term hypoxia in vivo. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391493. |
in the intact superior cervical ganglion, hypoxia increased the dopamine level as well as the density of small intensely fluorescent cells immunolabelled for tyrosine hydroxylase and vasoactive intestinal peptide. |
1999-10-08 |
2023-08-12 |
rat |
| J S Baffi, M Palkovits, S O Castillo, E Mezey, V M Nikode. Differential expression of tyrosine hydroxylase in catecholaminergic neurons of neonatal wild-type and Nurr1-deficient mice. Neuroscience. vol 93. issue 2. 1999-10-07. PMID:10465447. |
subsequent analysis revealed the absence of neurotransmitter dopamine and tyrosine hydroxylase immunoreactivity in the central dopaminergic area of newborn pups. |
1999-10-07 |
2023-08-12 |
mouse |
| S E Leff, S K Spratt, R O Snyder, R J Mande. Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392841. |
unlike previous approaches involving delivery of either tyrosine hydroxylase, or tyrosine hydroxylase and l-aromatic amino acid decarboxylase transgenes together to accomplish unregulated dopamine delivery, the current study proposes a pro-drug strategy (peripheral l-dihydroxyphenylalanine administration after l-aromatic amino acid decarboxylase transduction). |
1999-10-06 |
2023-08-12 |
rat |
| J N Nobrega, M Gernert, W Löscher, R Raymond, T Belej, A Richte. Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392843. |
tyrosine hydroxylase immunoreactivity and [3h]win 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. |
1999-10-06 |
2023-08-12 |
Not clear |
| J N Nobrega, M Gernert, W Löscher, R Raymond, T Belej, A Richte. Tyrosine hydroxylase immunoreactivity and [3H]WIN 35,428 binding to the dopamine transporter in a hamster model of idiopathic paroxysmal dystonia. Neuroscience. vol 92. issue 1. 1999-10-06. PMID:10392843. |
in order to further characterize the nature of dopamine alterations, the present study investigated possible changes in the number of dopaminergic neurons, as defined by tyrosine hydroxylase immunohistochemistry, as well as binding to the dopamine transporter labelled with [3h]win 35,428 in dystonic hamsters. |
1999-10-06 |
2023-08-12 |
Not clear |
| W S Neckameye. Dopamine and mushroom bodies in Drosophila: experience-dependent and -independent aspects of sexual behavior. Learning & memory (Cold Spring Harbor, N.Y.). vol 5. issue 1-2. 1999-09-23. PMID:10454380. |
depletion of dopamine in drosophila melanogaster adult males, accomplished through systemic introduction of the tyrosine hydroxylase inhibitor 3-iodo-tyrosine, severely impaired the ability of these flies to modify their courtship responses to immature males. |
1999-09-23 |
2023-08-12 |
drosophila_melanogaster |
| A Trefilov, M Krawczak, J Berard, J Schmidtk. DNA sequence polymorphisms in genes involved in the regulation of dopamine and serotonin metabolism in rhesus macaques. Electrophoresis. vol 20. issue 8. 1999-09-22. PMID:10435447. |
these genes included dopamine and serotonin receptors and transporters, and tyrosine hydroxylase. |
1999-09-22 |
2023-08-12 |
human |
| D M Kuhn, R E Arthur, D M Thomas, L A Elferin. Tyrosine hydroxylase is inactivated by catechol-quinones and converted to a redox-cycling quinoprotein: possible relevance to Parkinson's disease. Journal of neurochemistry. vol 73. issue 3. 1999-09-14. PMID:10461926. |
quinone derivatives of dopa, dopamine, and n-acetyldopamine inactivate tyrosine hydroxylase, the initial and rate-limiting enzyme in the biosynthesis of the catecholamine neurotransmitters. |
1999-09-14 |
2023-08-12 |
Not clear |
| K Takekoshi, K Isobe, F Nomura, M Motooka, T Nanmoku, T Naka. Effects of PAMP on mRNAs coding for catecholamine-synthesizing enzymes in PC12 cells. Life sciences. vol 65. issue 8. 1999-09-14. PMID:10466743. |
to gain new insight into the anticholinergic actions of pamp, we determined the effects of pamp on the tyrosine hydroxylase (th)- and dopamine beta-hydroxylase (dbh) mrna expression in the rat pheochromocytoma cell line pc12 stimulated by nicotine. |
1999-09-14 |
2023-08-12 |
rat |
| V M Goettl, T A Wemlinger, A M Duchemin, N H Neff, M Hadjiconstantino. GM1 ganglioside restores dopaminergic neurochemical and morphological markers in aged rats. Neuroscience. vol 92. issue 3. 1999-09-09. PMID:10426539. |
gm1 administered to aged sprague-dawley rats for 30 days reversed the decreased activity of tyrosine hydroxylase in the midbrain and striatum, elevated the reduced protein content and mrna levels of the enzyme in the midbrain, and reversed the decrements of dopamine and 3,4-dihydroxyphenylacetic acid content in both the midbrain and striatum. |
1999-09-09 |
2023-08-12 |
rat |
| E C Bucholtz, R L Brown, A Tropsha, R G Booth, S D Wyric. Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors. Journal of medicinal chemistry. vol 42. issue 16. 1999-09-02. PMID:10447948. |
a series of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes (1-phenyl-3-aminotetralins, pats) previously was found to modulate tyrosine hydroxylase activity and dopamine synthesis in rodent forebrain through interaction with a binding site labeled by [(3)h]-(-)-(1r,3s)-trans-h(2)-pat. |
1999-09-02 |
2023-08-12 |
rat |
| J S Shin, H S Yun-Choi, E I Kim, M K Le. Inhibitory effects of higenamine on dopamine content in PC12 cells. Planta medica. vol 65. issue 5. 1999-08-19. PMID:10418335. |
these results suggest that the inhibition of tyrosine hydroxylase activity by higenamine might partially contribute to the decrease in dopamine content in pc12 cells. |
1999-08-19 |
2023-08-12 |
Not clear |
| R Hernandez-Rauda, G Rozas, P Rey, J Otero, M Aldegund. Changes in the pituitary metabolism of monoamines (dopamine, norepinephrine, and serotonin) in female and male rainbow trout (Oncorhynchus mykiss) during gonadal recrudescence. Physiological and biochemical zoology : PBZ. vol 72. issue 3. 1999-08-17. PMID:10222329. |
in female rainbow trout, the turnover of dopamine (calculated using the inhibitor of tyrosine hydroxylase alpha-methyl-p-tyrosine methyl-ester hcl), serotonin metabolism, and norepinephrine levels decreased in the advanced stage of exogenous vitellogenesis with respect to the initial stage. |
1999-08-17 |
2023-08-12 |
Not clear |
| M Merino, M L Vizuete, J Cano, A Machad. The non-NMDA glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione and 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline, but not NMDA antagonists, block the intrastriatal neurotoxic effect of MPP+. Journal of neurochemistry. vol 73. issue 2. 1999-08-13. PMID:10428073. |
different doses of glutamate receptor antagonists were coinfused with 1.5 microg of mpp+ into the striatum; kynurenic acid, a nonselective antagonist of glutamate receptors (30 and 60 nmol), partially protected dopaminergic terminal degeneration in terms of rescue of dopamine levels and tyrosine hydroxylase immunohistochemistry. |
1999-08-13 |
2023-08-12 |
rat |