| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M V Ugryumo. The differentiation of dopaminergic neurons in situ, in vivo, and in transplants. Neuroscience and behavioral physiology. vol 30. issue 1. 2000-06-02. PMID:10768370. |
as regards the dopaminergic neurons of the substantia nigra, expression of their specific phenotype in human fetuses started with the synthesis of tyrosine hydroxylase and co-maturation of the specific dopamine reuptake mechanism during the sixth week of development. |
2000-06-02 |
2023-08-12 |
human |
| N Lindgren, Z Q Xu, M Lindskog, M Herrera-Marschitz, M Goiny, J Haycock, M Goldstein, T Hökfelt, G Fison. Regulation of tyrosine hydroxylase activity and phosphorylation at Ser(19) and Ser(40) via activation of glutamate NMDA receptors in rat striatum. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820208. |
the activity of tyrosine hydroxylase, the rate-limiting enzyme in the biosynthesis of dopamine, is stimulated by phosphorylation. |
2000-06-02 |
2023-08-12 |
rat |
| N Lindgren, Z Q Xu, M Lindskog, M Herrera-Marschitz, M Goiny, J Haycock, M Goldstein, T Hökfelt, G Fison. Regulation of tyrosine hydroxylase activity and phosphorylation at Ser(19) and Ser(40) via activation of glutamate NMDA receptors in rat striatum. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820208. |
they also provide a mechanism for the demonstrated ability of nmda to decrease tyrosine hydroxylase activity and dopamine synthesis. |
2000-06-02 |
2023-08-12 |
rat |
| J Niquet, J Charl. In vitro expression of tyrosine hydroxylase by a subpopulation of rat melanotrophs is down-regulated by dopamine. Brain research bulletin. vol 51. issue 6. 2000-05-31. PMID:10758337. |
in vitro expression of tyrosine hydroxylase by a subpopulation of rat melanotrophs is down-regulated by dopamine. |
2000-05-31 |
2023-08-12 |
rat |
| J Niquet, J Charl. In vitro expression of tyrosine hydroxylase by a subpopulation of rat melanotrophs is down-regulated by dopamine. Brain research bulletin. vol 51. issue 6. 2000-05-31. PMID:10758337. |
bromocryptine (2.5 x 10(-7) m), a d2 dopamine agonist, down-regulated melanotroph tyrosine hydroxylase expression in a time-dependent manner; initial effect was detected at 15 h and maximum at 3 days treatment (reduction to about 40% of control values). |
2000-05-31 |
2023-08-12 |
rat |
| J Niquet, J Charl. In vitro expression of tyrosine hydroxylase by a subpopulation of rat melanotrophs is down-regulated by dopamine. Brain research bulletin. vol 51. issue 6. 2000-05-31. PMID:10758337. |
these data suggest tyrosine hydroxylase expression in melanotrophs being under tonic inhibitory control by dopamine innervation in vivo. |
2000-05-31 |
2023-08-12 |
rat |
| S M Pearl, M D Antion, G D Stanwood, J D Jaumotte, G Kapatos, M J Zigmon. Effects of NADH on dopamine release in rat striatum. Synapse (New York, N.Y.). vol 36. issue 2. 2000-05-12. PMID:10767056. |
nicotinamide adenine dinucleotide (nadh) may be utilized for the synthesis and regeneration of tetrahydrobiopterin (bh(4)), which in turn is an essential cofactor for tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of dopamine (da). |
2000-05-12 |
2023-08-12 |
rat |
| J Zhang, D G Graham, T J Montine, Y S H. Enhanced N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in mice deficient in CuZn-superoxide dismutase or glutathione peroxidase. Journal of neuropathology and experimental neurology. vol 59. issue 1. 2000-04-07. PMID:10744035. |
littermate control and homozygous deficient mice were injected intraperitoneally with a total cumulative dose of 0, 75, or 150 mg/kg of mptp delivered over 5 d. all mice were killed 5 d after the last injection and the brains were processed for immunohistological analysis for tyrosine hydroxylase (th) in the striatum and the substantia nigra pars compacta (snc), as well as for direct measurements of dopamine concentrations in the striatum. |
2000-04-07 |
2023-08-12 |
mouse |
| N Yukimasa, K Isobe, H Nagai, Y Takuwa, T Naka. Successive occupancy by immediate early transcriptional factors of the tyrosine hydroxylase gene TRE and CRE sites in PACAP-stimulated PC12 pheochromocytoma cells. Neuropeptides. vol 33. issue 6. 2000-04-04. PMID:10657527. |
we previously demonstrated that pituitary adenylate cyclase-activating polypeptide (pacap) coordinately upregulates the expression of the tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) genes by activating the cyclic amp (camp) and protein kinase c (pkc) signaling pathways. |
2000-04-04 |
2023-08-12 |
rat |
| C Rosenblad, M Grønborg, C Hansen, N Blom, M Meyer, J Johansen, L Dagø, D Kirik, U A Patel, C Lundberg, D Trono, A Björklund, T E Johanse. In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. Molecular and cellular neurosciences. vol 15. issue 2. 2000-03-28. PMID:10673327. |
addition of nbn/art to cultures of fetal mesencephalic dopamine (da) neurons increased the number of surviving tyrosine hydroxylase (th)-immunoreactive neurons by approximately 70%, similar to the maximal effect obtained with gdnf. |
2000-03-28 |
2023-08-12 |
Not clear |
| P T Bywood, S M Johnso. Dendrite loss is a characteristic early indicator of toxin-induced neurodegeneration in rat midbrain slices. Experimental neurology. vol 161. issue 1. 2000-03-23. PMID:10683296. |
the slices were fixed and recut into thin sections (30 micrometer) and substantia nigra dopamine neurons were immunolabeled for tyrosine hydroxylase coupled to diaminobenzidine. |
2000-03-23 |
2023-08-12 |
rat |
| P Padungchaichot, J Y Wong, A L Natoli, J S Massalas, D I Finkelstein, A L Lawrence, J Drag. Early direct and transneuronal effects in mice with targeted expression of a toxin gene to D1 dopamine receptor neurons. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682709. |
the nigrostriatal pathway in the mutant pups was intact with a normal number of dopaminergic neurons in the substantia nigra and the ventral tegmental area in addition to a normal pattern of striatal dopamine transporter and tyrosine hydroxylase immunoreactivity. |
2000-03-21 |
2023-08-12 |
mouse |
| E Lorenc-Koci, M Smiałowska, L Antkiewicz-Michaluk, K Gołembiowska, M Bajkowska, S Wolfart. Effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine in the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats. Neuroscience. vol 95. issue 4. 2000-03-21. PMID:10682712. |
effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine in the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats. |
2000-03-21 |
2023-08-12 |
rat |
| L Cao, Y C Zhao, Z H Jiang, D H Xu, Z G Liu, S D Chen, X Y Liu, Z C Zhen. Long-term phenotypic correction of rodent hemiparkinsonism by gene therapy using genetically modified myoblasts. Gene therapy. vol 7. issue 5. 2000-03-20. PMID:10694827. |
rat myoblasts were genetically modified to express tyrosine hydroxylase (th) and produce dopamine in culture. |
2000-03-20 |
2023-08-12 |
rat |
| D A Berkowicz, P Q Tromble. Dopaminergic modulation at the olfactory nerve synapse. Brain research. vol 855. issue 1. 2000-03-17. PMID:10650134. |
in the olfactory bulb (ob), the dopamine synthetic enzyme, tyrosine hydroxylase, is largely confined to neurons in the glomerular layer. |
2000-03-17 |
2023-08-12 |
Not clear |
| G Zauli, P Secchiero, L Rodella, D Gibellini, P Mirandola, M Mazzoni, D Milani, D R Dowd, S Capitani, M Vital. HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells. The Journal of biological chemistry. vol 275. issue 6. 2000-03-16. PMID:10660577. |
treatment of dopaminergic rat pc12 cells with human immunodeficiency virus, type 1 (hiv-1) tat protein or tat cdna inhibited the expression of tyrosine hydroxylase (th), the rate-limiting enzyme for the dopamine biosynthetic pathway, as well as the production and release of dopamine into the culture medium. |
2000-03-16 |
2023-08-12 |
human |
| I Lamensdorf, L He, A Nechushtan, J Harvey-White, G Eisenhofer, R Milan, E Rojas, I J Kopi. Effect of glipizide on dopamine synthesis, release and metabolism in PC12 cells. European journal of pharmacology. vol 388. issue 2. 2000-03-16. PMID:10666506. |
the cellular accumulation of dopac was accompanied by reduced tyrosine hydroxylase activity and reduced formation of dopamine and its metabolites presumably by a negative feedback effect of the increased cytoplasmic concentrations of dopac. |
2000-03-16 |
2023-08-12 |
cattle |
| P T Bywood, S M Johnso. Loss of tyrosine hydroxylase immunoreactivity in dendrites is a sensitive index of kainic acid-induced damage in rat substantia nigra neurons in vivo. Neuroscience letters. vol 280. issue 1. 2000-03-13. PMID:10696798. |
), the brain fixed and substantia nigra (sn) dopamine neurons and their dendrites labeled using an antibody to tyrosine hydroxylase (th). |
2000-03-13 |
2023-08-12 |
rat |
| V Depaepe, L Cuvelier, B Thöny, A Résiboi. Pterin-4alpha-carbinolamine dehydratase in rat brain. I. Patterns of co-localization with tyrosine hydroxylase. Brain research. Molecular brain research. vol 75. issue 1. 2000-03-07. PMID:10648890. |
in association with brain tyrosine hydroxylase (th), which is required for dopamine synthesis, pcd catalyses dehydration and thus recycling of the cofactor tetrahydrobiopterin (bh(4)). |
2000-03-07 |
2023-08-12 |
rat |
| C Winter, J Schenkel, E Bürger, C Eickmeier, M Zimmermann, T Herdege. The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle. Neuroscience. vol 95. issue 3. 2000-03-01. PMID:10670442. |
in contrast, application of fk506 resulted in survival of 46%, 44% and 28% of the axotomized nigral neurons, and the majority of these surviving neurons showed continuous expression of tyrosine hydroxylase, the pacemaker enzyme for dopamine synthesis. |
2000-03-01 |
2023-08-12 |
rat |