| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A D Rabinovic, D A Lewis, T G Hasting. Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine. Neuroscience. vol 101. issue 1. 2001-02-15. PMID:11068137. |
a previous report from this laboratory showed that intrastriatal injection of dopamine resulted in the selective reduction of tyrosine hydroxylase immunoreactivity, accompanied by an increase in indices of dopamine oxidation. |
2001-02-15 |
2023-08-12 |
Not clear |
| A D Rabinovic, D A Lewis, T G Hasting. Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine. Neuroscience. vol 101. issue 1. 2001-02-15. PMID:11068137. |
however, conclusive proof that decreased tyrosine hydroxylase immunoreactivity represented a loss of dopamine terminals was lacking. |
2001-02-15 |
2023-08-12 |
Not clear |
| M Romero-Ramos, J L Venero, J Cano, A Machad. Low selenium diet induces tyrosine hydroxylase enzyme in nigrostriatal system of the rat. Brain research. Molecular brain research. vol 84. issue 1-2. 2001-02-15. PMID:11113527. |
as a further step, we measured the levels of activity and mrna expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2001-02-15 |
2023-08-12 |
rat |
| J Diaz, C Pilon, B Le Foll, C Gros, A Triller, J C Schwartz, P Sokolof. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 23. 2001-02-08. PMID:11102473. |
d(3)r-immunoreactivity was also found in all tyrosine hydroxylase (th)-positive neurons observed in sn, vta and a8 retrorubral fields, where it could represent d(3) autoreceptors controlling dopamine neuron activities, in agreement with the elevated dopamine extracellular levels in projection areas of these neurons found in d(3)r-deficient mice. |
2001-02-08 |
2023-08-12 |
mouse |
| S Canals, M J Casarejos, E Rodríguez-Martín, S de Bernardo, M A Men. Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures. Journal of neurochemistry. vol 76. issue 1. 2001-02-08. PMID:11145978. |
dea-no, at doses of 25 and 50 microm, exerted neurotrophic effects on dopamine cells, increasing the number of tyrosine hydroxylase positive (th(+)) cells, th(+) neurite processes, da levels and [(3)h]da uptake. |
2001-02-08 |
2023-08-12 |
Not clear |
| H S Kim, S J Hong, M S LeDoux, K S Ki. Regulation of the tyrosine hydroxylase and dopamine beta-hydroxylase genes by the transcription factor AP-2. Journal of neurochemistry. vol 76. issue 1. 2001-02-08. PMID:11146001. |
regulation of the tyrosine hydroxylase and dopamine beta-hydroxylase genes by the transcription factor ap-2. |
2001-02-08 |
2023-08-12 |
Not clear |
| H S Kim, S J Hong, M S LeDoux, K S Ki. Regulation of the tyrosine hydroxylase and dopamine beta-hydroxylase genes by the transcription factor AP-2. Journal of neurochemistry. vol 76. issue 1. 2001-02-08. PMID:11146001. |
in this study, transcriptional regulation of tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) genes by ap-2 was investigated. |
2001-02-08 |
2023-08-12 |
Not clear |
| M Herrera-Marschitz, C Kohlhauser, S Gomez-Urquijo, R Ubink, M Goiny, T Hökfel. Excitatory amino acids, monoamine, and nitric oxide synthase systems in organotypic cultures: biochemical and immunohistochemical analysis. Amino acids. vol 19. issue 1. 2001-02-01. PMID:11026471. |
immunohistochemistry confirmed the impressions obtained from microscopic and biochemical analysis along the in vitro development, revealing apparently healthy neuronal systems with characteristics similar to those observed in vivo, when tyrosine hydroxylase and nitric oxide synthase, markers for dopamine and nitric oxide containing neurons, respectively, were analysed. |
2001-02-01 |
2023-08-12 |
rat |
| N P Hyland, T P Abrahams, K Fuchs, M A Burmeister, P J Hornb. Organization and neurochemistry of vagal preganglionic neurons innervating the lower esophageal sphincter in ferrets. The Journal of comparative neurology. vol 430. issue 2. 2001-02-01. PMID:11135258. |
the neurochemistry of les-projecting neurons was also investigated using two markers of "nontraditional" neurotransmitters in vagal preganglionic neurons, nitric oxide synthase (nos), and dopamine (tyrosine hydroxylase: th). |
2001-02-01 |
2023-08-12 |
Not clear |
| F J Wan, I S Shiah, H C Lin, S Y Huang, C S Tun. Nomifensine attenuates d-amphetamine-induced dopamine terminal neurotoxicity in the striatum of rats. The Chinese journal of physiology. vol 43. issue 2. 2001-01-18. PMID:10994696. |
this phenomenon includes depletion of dopamine content, decreased activity of tyrosine hydroxylase and diminish in the number of dopamine reuptake transporter. |
2001-01-18 |
2023-08-12 |
rat |
| T B Freeman, F Cicchetti, R A Hauser, T W Deacon, X J Li, S M Hersch, G M Nauert, P R Sanberg, J H Kordower, S Saporta, O Isacso. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 25. 2001-01-18. PMID:11106399. |
selective markers of both striatal projection and interneurons such as dopamine and c-amp-related phosphoprotein, calretinin, acetylcholinesterase, choline acetyltransferase, tyrosine hydroxylase, calbindin, enkephalin, and substance p showed positive transplant regions clearly innervated by host tyrosine hydroxylase fibers. |
2001-01-18 |
2023-08-12 |
human |
| U Ernsberge. Evidence for an evolutionary conserved role of bone morphogenetic protein growth factors and phox2 transcription factors during noradrenergic differentiation of sympathetic neurons. Induction of a putative synexpression group of neurotransmitter-synthesizing enzymes. European journal of biochemistry. vol 267. issue 24. 2001-01-18. PMID:11106406. |
the simultaneous expression of tyrosine hydroxylase and dopamine beta-hydroxylase, enzymes of the noradrenaline biosynthesis pathway, indicates that different genes contributing to the noradrenergic transmitter phenotype are regulated as a synexpression group. |
2001-01-18 |
2023-08-12 |
Not clear |
| U Ernsberge. Evidence for an evolutionary conserved role of bone morphogenetic protein growth factors and phox2 transcription factors during noradrenergic differentiation of sympathetic neurons. Induction of a putative synexpression group of neurotransmitter-synthesizing enzymes. European journal of biochemistry. vol 267. issue 24. 2001-01-18. PMID:11106406. |
this conclusion is supported by the demonstration of bone morphogenetic protein (bmp) growth factors and phox2 transcription factors being necessary for the expression of both tyrosine hydroxylase and dopamine beta-hydroxylase in differentiating sympathetic neurons. |
2001-01-18 |
2023-08-12 |
Not clear |
| H Matsuda, Y Li, M Yoshikaw. Possible involvement of dopamine and dopamine2 receptors in the inhibitions of gastric emptying by escin Ib in mice. Life sciences. vol 67. issue 24. 2001-01-18. PMID:11133004. |
was attenuated after pretreatment with a single bolus of dl-alpha-methyl-p-tyrosine methyl ester (400 mg/kg, s.c., an inhibitor of tyrosine hydroxylase), reserpine (5 mg/kg, p.o., a catecholamine depletor), 6-hydroxydopamine (80 mg/kg, i.p., a dopamine depletor). |
2001-01-18 |
2023-08-12 |
mouse |
| K Pong, S R Doctrow, M Baudr. Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain research. vol 881. issue 2. 2001-01-04. PMID:11036157. |
exposure of cultures to 10 microm mpp(+) reduced dopamine (da) uptake and the number of tyrosine hydroxylase immunoreactive (thir) neurons to 56 and 52% of control, while exposure to 30 microm 6-ohda reduced da uptake and the number of thir neurons to 58 and 59% of control, respectively. |
2001-01-04 |
2023-08-12 |
Not clear |
| L H Miner, S Schroeter, R D Blakely, S R Sesac. Ultrastructural localization of the serotonin transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to dopamine terminals. The Journal of comparative neurology. vol 427. issue 2. 2001-01-04. PMID:11054690. |
the present study sought to examine the distribution of immunogold-silver labeling for sert (sert-ir) in the rat prelimbic pfc and to describe its ultrastructural spatial relationship to dopamine axons labeled by immunoperoxidase staining for tyrosine hydroxylase (th-ir). |
2001-01-04 |
2023-08-12 |
rat |
| J Gross, N Leclere, J Heldt, I Müller, T Kietzmann, N Andreev. Differential effects of hypoxia on untreated and NGF treated PC12 cells. Life sciences. vol 67. issue 21. 2001-01-04. PMID:11104361. |
in order to understand the cellular mechanism of these changes, we studied the effects of hypoxia on the levels of dopamine (da) and tyrosine hydroxylase (th) mrna in untreated and ngf treated pc12 cells. |
2001-01-04 |
2023-08-12 |
Not clear |
| D C Harvey, G Laćan, W P Melega. Regional heterogeneity of dopaminergic deficits in vervet monkey striatum and substantia nigra after methamphetamine exposure. Experimental brain research. vol 133. issue 3. 2000-12-28. PMID:10958525. |
decreases in ir for tyrosine hydroxylase (th), dopamine transporter (dat), and the vesicular monoamine transporter (vmat2) were observed 1 week after meth hci (2x2 mg/kg; 24 h apart). |
2000-12-28 |
2023-08-12 |
monkey |
| M F Kritze. Effects of acute and chronic gonadectomy on the catecholamine innervation of the cerebral cortex in adult male rats: insensitivity of axons immunoreactive for dopamine-beta-hydroxylase to gonadal steroids, and differential sensitivity of axons immunoreactive for tyrosine hydroxylase to ovarian and testicular hormones. The Journal of comparative neurology. vol 427. issue 4. 2000-12-21. PMID:11056468. |
previous studies have shown that gonadectomy in adult male rats induces a complex series of region- and time-specific changes in the density of presumed cerebral cortical dopamine axons that are immunoreactive for tyrosine hydroxylase. |
2000-12-21 |
2023-08-12 |
rat |
| Y Shen, S I Muramatsu, K Ikeguchi, K I Fujimoto, D S Fan, M Ogawa, H Mizukami, M Urabe, A Kume, I Nagatsu, F Urano, T Suzuki, H Ichinose, T Nagatsu, J Monahan, I Nakano, K Ozaw. Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Human gene therapy. vol 11. issue 11. 2000-12-15. PMID:10945765. |
we previously showed that the coexpression of tyrosine hydroxylase (th) and aromatic-l-amino-acid decarboxylase (aadc), using two separate adeno-associated virus (aav) vectors, resulted in more effective dopamine production and more remarkable behavioral recovery in 6-hydroxydopamine-lesioned parkinsonian rats, compared with the expression of th alone. |
2000-12-15 |
2023-08-12 |
rat |