| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J B Eells, J E Rives, S K Yeung, V M Nikode. In vitro regulated expression of tyrosine hydroxylase in ventral midbrain neurons from Nurr1-null mouse pups. Journal of neuroscience research. vol 64. issue 4. 2001-07-19. PMID:11340638. |
disruption of the nurr1 gene in mice by homologous recombination abolishes synthesis of dopamine (da) and expression of da biosynthetic enzymes, including tyrosine hydroxylase (th), in the ventral midbrain without affecting the synthesis of da in other areas of the brain. |
2001-07-19 |
2023-08-12 |
mouse |
| K Sawamoto, N Nakao, K Kobayashi, N Matsushita, H Takahashi, K Kakishita, A Yamamoto, T Yoshizaki, T Terashima, F Murakami, T Itakura, H Okan. Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 11. 2001-07-19. PMID:11353855. |
to visualize and isolate live dopamine (da)-producing neurons in the embryonic ventral mesencephalon, we generated transgenic mice expressing green fluorescent protein (gfp) under the control of the rat tyrosine hydroxylase gene promoter. |
2001-07-19 |
2023-08-12 |
mouse |
| A J Jiménez, P Fernández-Llebrez, J M Pérez-Fígare. Neural input and neural control of the subcommissural organ. Microscopy research and technique. vol 52. issue 5. 2001-07-12. PMID:11241862. |
in the bovine sco, an important number of fibers containing tyrosine hydroxylase are present, indicating that in this species dopamine and/or noradrenaline-containing fibers are an important neural input. |
2001-07-12 |
2023-08-12 |
rat |
| Y H Zhang, L H Fan. Inhibitory effect of tetrandrine on dopamine biosynthesis and tyrosine hydroxylase in PC12 cells. Planta medica. vol 67. issue 1. 2001-07-12. PMID:11270728. |
inhibitory effect of tetrandrine on dopamine biosynthesis and tyrosine hydroxylase in pc12 cells. |
2001-07-12 |
2023-08-12 |
Not clear |
| Y H Zhang, L H Fan. Inhibitory effect of tetrandrine on dopamine biosynthesis and tyrosine hydroxylase in PC12 cells. Planta medica. vol 67. issue 1. 2001-07-12. PMID:11270728. |
tetrandrine at a concentration of 3.0 microm decreased dopamine content by 59.4% (ic50 = 2.4 microm) and intracellular tyrosine hydroxylase (th) activity was inhibited by the treatment of tetrandrine (49.8% inhibition at 3.0 microm) compared with control. |
2001-07-12 |
2023-08-12 |
Not clear |
| S J Kish, K S Kalasinsky, P Derkach, G A Schmunk, M Guttman, L Ang, V Adams, Y Furukawa, J W Haycoc. Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282256. |
in nucleus accumbens, levels of tyrosine hydroxylase protein (-25%) and those of the dopamine metabolite homovanillic acid (-33%) were reduced significantly together with a trend for decreased dopamine (-32%) concentration. |
2001-07-12 |
2023-08-12 |
human |
| S J Kish, K S Kalasinsky, P Derkach, G A Schmunk, M Guttman, L Ang, V Adams, Y Furukawa, J W Haycoc. Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 24. issue 5. 2001-07-12. PMID:11282256. |
these changes could reflect either a compensatory downregulation of dopamine biosynthesis in response to prolonged dopaminergic stimulation caused by heroin, or reduced axoplasmic transport of tyrosine hydroxylase. |
2001-07-12 |
2023-08-12 |
human |
| C Sánchez-Camacho, O Marín, W J Smeets, H J Ten Donkelaar, A Gonzále. Descending supraspinal pathways in amphibians. II. Distribution and origin of the catecholaminergic innervation of the spinal cord. The Journal of comparative neurology. vol 434. issue 2. 2001-07-12. PMID:11331525. |
immunohistochemical studies with antibodies against tyrosine hydroxylase, dopamine, and noradrenaline have revealed that the spinal cord of anuran, urodele, and gymnophionan (apodan) amphibians is abundantly innervated by catecholaminergic (ca) fibers and terminals. |
2001-07-12 |
2023-08-12 |
xenopus_laevis |
| W J Smeets, J M Lopez, A Gonzále. Immunohistochemical localization of DARPP-32 in the brain of the lizard, Gekko gecko: co-occurrence with tyrosine hydroxylase. The Journal of comparative neurology. vol 435. issue 2. 2001-07-12. PMID:11391641. |
to assess the relationship between dopaminergic neuronal structures and dopaminoceptive structures in a reptile, single and double immunohistochemical procedures with antibodies directed against darpp-32 (dopamine- and camp-regulated phosphoprotein with an apparent molecular mass of 32,000 daltons),a phosphoprotein related to the dopamine d(1)-receptor, and tyrosine hydroxylase (th) were applied to the brain of the lizard, gekko gecko. |
2001-07-12 |
2023-08-12 |
Not clear |
| T Hayashi, H Hirata, M Asanuma, B Ladenheim, L I Tsao, J L Cadet, T P S. Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage caused by a single high dose of methamphetamine: examining the role of p53. Synapse (New York, N.Y.). vol 39. issue 4. 2001-07-05. PMID:11169780. |
the levels of dopamine transporter (dat), tyrosine hydroxylase (th), major biogenic amines including da, 5-hydroxytryptamine (5-ht), and their metabolites were examined. |
2001-07-05 |
2023-08-12 |
mouse |
| J Holzschuh, S Ryu, F Aberger, W Drieve. Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mechanisms of development. vol 101. issue 1-2. 2001-07-05. PMID:11231083. |
to characterize the formation of the dopaminergic system in the developing zebrafish cns, we cloned cdnas encoding tyrosine hydroxylase (th), an enzyme in dopamine synthesis, and the dopamine transporter (dat), a membrane transport protein which terminates dopamine action by re-uptake. |
2001-07-05 |
2023-08-12 |
zebrafish |
| W Neckameyer, J O'Donnell, Z Huang, W Star. Dopamine and sensory tissue development in Drosophila melanogaster. Journal of neurobiology. vol 47. issue 4. 2001-07-05. PMID:11351339. |
the current study demonstrates that males depleted of dopamine as third instar larvae (via inhibition of the biosynthetic enzyme tyrosine hydroxylase) demonstrated abnormalities in courtship behavior as adults. |
2001-07-05 |
2023-08-12 |
drosophila_melanogaster |
| W Neckameyer, J O'Donnell, Z Huang, W Star. Dopamine and sensory tissue development in Drosophila melanogaster. Journal of neurobiology. vol 47. issue 4. 2001-07-05. PMID:11351339. |
to establish that dopamine was synthesized in tissues destined to become part of the adult sensory apparatus, transgenic lines were generated containing 1 or 4 kb of 5' upstream sequences from the drosophila tyrosine hydroxylase gene (dth) fused to the e. coli beta-galactosidase reporter. |
2001-07-05 |
2023-08-12 |
drosophila_melanogaster |
| N Lindgren, Z Q Xu, M Herrera-Marschitz, J Haycock, T Hökfelt, G Fison. Dopamine D(2) receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum. The European journal of neuroscience. vol 13. issue 4. 2001-06-28. PMID:11207812. |
dopamine d(2) receptors regulate tyrosine hydroxylase activity and phosphorylation at ser40 in rat striatum. |
2001-06-28 |
2023-08-12 |
rat |
| N Lindgren, Z Q Xu, M Herrera-Marschitz, J Haycock, T Hökfelt, G Fison. Dopamine D(2) receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum. The European journal of neuroscience. vol 13. issue 4. 2001-06-28. PMID:11207812. |
changes in dopamine release have been attributed to changes in the synthesis of dopamine, which is regulated via phosphorylation of tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of catecholamines. |
2001-06-28 |
2023-08-12 |
rat |
| M Barrot, D N Abrous, M Marinelli, F Rougé-Pont, M Le Moal, P V Piazz. Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum. The European journal of neuroscience. vol 13. issue 4. 2001-06-28. PMID:11207816. |
), but not the release of dopamine induced by morphine (2 mg/kg, s.c.) or the density of the limiting enzyme of dopamine synthesis, tyrosine hydroxylase. |
2001-06-28 |
2023-08-12 |
rat |
| D S Melchitzky, D A Lewi. Dopamine transporter-immunoreactive axons in the mediodorsal thalamic nucleus of the macaque monkey. Neuroscience. vol 103. issue 4. 2001-06-28. PMID:11301210. |
axons immunoreactive for tyrosine hydroxylase were distributed in a pattern very similar to that of dopamine transporter-labeled axons. |
2001-06-28 |
2023-08-12 |
monkey |
| N Tümer, H A Demirel, L Serova, E L Sabban, C S Broxson, S K Power. Gene expression of catecholamine biosynthetic enzymes following exercise: modulation by age. Neuroscience. vol 103. issue 3. 2001-06-21. PMID:11274789. |
we examined the effect of short-term exercise training on tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in adrenals and specific brain regions with aging. |
2001-06-21 |
2023-08-12 |
rat |
| D S Latchman, R S Coffi. Viral vectors for gene therapy in Parkinson's disease. Reviews in the neurosciences. vol 12. issue 1. 2001-06-14. PMID:11236066. |
this approach could involve both the delivery of the gene encoding tyrosine hydroxylase to boost dopamine production or the delivery of genes encoding neurotrophic factors such as gdnf to promote the survival of dopaminergic neurons. |
2001-06-14 |
2023-08-12 |
Not clear |
| D Sutoo, K Akiyama, K Yab. Quantitative imaging of tyrosine hydroxylase and calmodulin in the human brain. Journal of neuroscience research. vol 63. issue 5. 2001-05-17. PMID:11223911. |
previously it was shown that tyrosine hydroxylase was activated and dopamine synthesis was enhanced in the neostriatum region in mice and rats by the intracerebroventricular administration of calcium through a calmodulin-dependent system. |
2001-05-17 |
2023-08-12 |
mouse |