| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Layla Azam, Ursula H Winzer-Serhan, Yiling Chen, Frances M Lesli. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. The Journal of comparative neurology. vol 444. issue 3. 2002-03-05. PMID:11840479. |
the purpose of this study was to use double-labeling in situ hybridization to identify nachr subunit mrnas expressed within dopamine neurons of the sn/vta, by using a digoxigenin-labeled riboprobe for tyrosine hydroxylase as the dopamine cell marker and (35)s-labeled riboprobes for nachr subunits. |
2002-03-05 |
2023-08-12 |
Not clear |
| Kengo Funakoshi, Masato Nakano, Yoshitoshi Atobe, Tetsuo Kadota, Richard C Goris, Reiji Kishid. Catecholaminergic innervation of the sympathetic preganglionic cell column of the filefish Stephanolepis cirrhifer. The Journal of comparative neurology. vol 442. issue 3. 2002-02-25. PMID:11774336. |
fluorescent double labeling distinguished noradrenergic nerve fibers immunoreactive for both tyrosine hydroxylase and dopamine beta hydroxylase, and dopaminergic fibers immunoreactive only for tyrosine hydroxylase. |
2002-02-25 |
2023-08-12 |
Not clear |
| Kengo Funakoshi, Masato Nakano, Yoshitoshi Atobe, Tetsuo Kadota, Richard C Goris, Reiji Kishid. Catecholaminergic innervation of the sympathetic preganglionic cell column of the filefish Stephanolepis cirrhifer. The Journal of comparative neurology. vol 442. issue 3. 2002-02-25. PMID:11774336. |
double labeling of tyrosine hydroxylase and dopamine beta hydroxylase showed that the neurons in the locus coeruleus were all noradrenergic, and those in the caudal dorsomedial medulla were mostly noradrenergic, whereas the area postrema contained both noradrenergic and dopaminergic neurons. |
2002-02-25 |
2023-08-12 |
Not clear |
| R W Rodrigues, V C Gomide, G Chad. Astroglial and microglial reaction after a partial nigrostriatal degeneration induced by the striatal injection of different doses of 6-hydroxydopamine. The International journal of neuroscience. vol 109. issue 1-2. 2002-02-21. PMID:11699344. |
following, animals were sacrificed and the tyrosine hydroxylase (th) positive dopamine cells, the glial fibrillary acidic protein (gfap) immunolabeled astrocytes and the ox42 immunoreactive microglia were visualized by mean of immunohistochemistry and quantified by stereologic method employing the optical disector and the point intercepts. |
2002-02-21 |
2023-08-12 |
rat |
| M L Filipenko, O V Alekseyenko, A G Beilina, T P Kamynina, N N Kudryavtsev. Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience. Brain research. Molecular brain research. vol 96. issue 1-2. 2002-02-14. PMID:11731011. |
increase of tyrosine hydroxylase and dopamine transporter mrna levels in ventral tegmental area of male mice under influence of repeated aggression experience. |
2002-02-14 |
2023-08-12 |
mouse |
| M L Filipenko, O V Alekseyenko, A G Beilina, T P Kamynina, N N Kudryavtsev. Increase of tyrosine hydroxylase and dopamine transporter mRNA levels in ventral tegmental area of male mice under influence of repeated aggression experience. Brain research. Molecular brain research. vol 96. issue 1-2. 2002-02-14. PMID:11731011. |
tyrosine hydroxylase (th) and dopamine transporter (dat) mrna levels in the ventral tegmental area (vta) of midbrain were measured by multiplex rt-pcr in male mice with repeated experience of social victories (winners) and social defeats (losers) in 10 daily agonistic confrontations. |
2002-02-14 |
2023-08-12 |
mouse |
| J C Williams, D Stone, J R Smith-Arica, I D Morris, P R Lowenstein, M G Castr. Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas. Molecular therapy : the journal of the American Society of Gene Therapy. vol 4. issue 6. 2002-02-06. PMID:11735344. |
as an alternative, we have developed a gene therapy strategy in which the rate-limiting enzyme in dopamine synthesis, tyrosine hydroxylase (th), is overexpressed in the anterior pituitary (ap) gland. |
2002-02-06 |
2023-08-12 |
rat |
| M B O'Byrne, J P Bolam, J J Hanley, K F Tipto. Tyrosine-hydroxylase immunoreactive cells in the rat striatum following treatment with MPP+. Advances in experimental medicine and biology. vol 483. 2002-01-29. PMID:11787621. |
tyrosine hydroxylase is the rate-limiting enzyme in the synthesis of dopamine, and as such, it is widely used as a marker of dopaminergic cells. |
2002-01-29 |
2023-08-12 |
rat |
| Rao Muralikrishna Adibhatla, J F Hatcher, R J Dempse. Citicoline: neuroprotective mechanisms in cerebral ischemia. Journal of neurochemistry. vol 80. issue 1. 2002-01-29. PMID:11796739. |
citicoline also provides choline for synthesis of neurotransmitter acetylcholine, stimulation of tyrosine hydroxylase activity and dopamine release. |
2002-01-29 |
2023-08-12 |
Not clear |
| T Barrett, T Xie, Y Piao, O Dillon-Carter, G J Kargul, M K Lim, F J Chrest, R Wersto, D L Rowley, M Juhaszova, L Zhou, M P Vawter, K G Becker, C Cheadle, W H Wood, U D McCann, W J Freed, M S Ko, G A Ricaurte, D M Donova. A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicity. Neurobiology of disease. vol 8. issue 5. 2002-01-23. PMID:11592851. |
ventral mesencephalic dopamine neurons were purified by fluorescent-activated cell sorting from embryonic day 13.5 transgenic mice harboring a 4.5-kb rat tyrosine hydroxylase promoter-lacz fusion. |
2002-01-23 |
2023-08-12 |
mouse |
| B Caronti, G Antonini, C Calderaro, S Ruggieri, G Palladini, F E Pontieri, C Colosim. Dopamine transporter immunoreactivity in peripheral blood lymphocytes in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 7. 2002-01-22. PMID:11515746. |
previous studies indicate changes of dopamine content, tyrosine hydroxylase immunoreactivity and dopamine receptors in peripheral blood lymphocytes (pbl) in pd. |
2002-01-22 |
2023-08-12 |
Not clear |
| H Ishiguro, T Ohtsuki, Y Okubo, A Kurumaji, T Arinam. Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 7. 2002-01-22. PMID:11515750. |
pacap appears to play a role in up-regulation of tyrosine hydroxylase and dopamine beta-hydroxylase via protein kinase c and/or protein kinase a. |
2002-01-22 |
2023-08-12 |
Not clear |
| S C Woolley, J T Sakata, A Gupta, D Crew. Evolutionary changes in dopaminergic modulation of courtship behavior in Cnemidophorus whiptail lizards. Hormones and behavior. vol 40. issue 4. 2002-01-22. PMID:11716577. |
however, while the anatomical distributions of the dopamine synthesizing enzyme tyrosine hydroxylase are similar among vertebrates, evolutionary changes in the functional role of dopamine are poorly understood. |
2002-01-22 |
2023-08-12 |
Not clear |
| C P Pontin. Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders? Human molecular genetics. vol 10. issue 17. 2002-01-15. PMID:11532994. |
these include, as fe(ii), facilitating the production of dopamine from phenylalanine by tyrosine hydroxylase, and as heme, assisting the recycling of ascorbate by cytochrome b-561 required for the generation of norepinephrine from dopamine by dopamine beta-hydroxylase. |
2002-01-15 |
2023-08-12 |
mouse |
| K P Datla, M Christidou, W W Widmer, H K Rooprai, D T Dexte. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport. vol 12. issue 17. 2002-01-11. PMID:11726811. |
unilateral infusion of the dopaminergic neurotoxin, 6-hydroxydopamine (6-ohda; 8 microg), onto medial forebrain bundle significantly reduced the number of tyrosine hydroxylase positive (th+) cells in the substantia nigra and decreased striatal dopamine content in the vehicle treated rats. |
2002-01-11 |
2023-08-12 |
rat |
| C Deransart, G B Landwehrmeyer, T J Feuerstein, C H Lückin. Up-regulation of D3 dopaminergic receptor mRNA in the core of the nucleus accumbens accompanies the development of seizures in a genetic model of absence-epilepsy in the rat. Brain research. Molecular brain research. vol 94. issue 1-2. 2002-01-03. PMID:11597777. |
when compared to non-epileptic control rats, epileptic rats displayed no change in the expression of mrnas coding for the neuronal dopaminergic markers (tyrosine hydroxylase, membraneous and vesicular dopamine transporters). |
2002-01-03 |
2023-08-12 |
rat |
| E B Gauda, R Cooper, P K Akins, G W. Prenatal nicotine affects catecholamine gene expression in newborn rat carotid body and petrosal ganglion. Journal of applied physiology (Bethesda, Md. : 1985). vol 91. issue 5. 2002-01-03. PMID:11641357. |
we used in situ hybridization histochemistry to determine the effect of prenatal and early postnatal nicotine exposure on tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah), preproenkephalin (ppe), and d2-dopamine receptor mrna levels in the rat carotid body and petrosal ganglion during postnatal development. |
2002-01-03 |
2023-08-12 |
rat |
| L M Gerhold, T L Horvath, M E Freema. Vasoactive intestinal peptide fibers innervate neuroendocrine dopaminergic neurons. Brain research. vol 919. issue 1. 2002-01-03. PMID:11689162. |
using antibodies directed against vasoactive intestinal peptide (vip) and tyrosine hydroxylase (th) the rate-limiting enzyme in dopamine synthesis, fine vip fibers in close apposition to th-immunoreactive (ir) soma and proximal dendrites were revealed. |
2002-01-03 |
2023-08-12 |
rat |
| J F Bowyer, R R Holson, D B Miller, J P O'Callagha. Phenobarbital and dizocilpine can block methamphetamine-induced neurotoxicity in mice by mechanisms that are independent of thermoregulation. Brain research. vol 919. issue 1. 2002-01-03. PMID:11689178. |
body temperature profiles observed during methamphetamine (meth) exposure are known to affect dopamine and tyrosine hydroxylase (th) levels in the striatum of mice; hyperthermia potentiates depletion while hypothermia is protective against depletions. |
2002-01-03 |
2023-08-12 |
mouse |
| A Kurumaji, T Kuroda, K Yamada, T Yoshikawa, M Tor. An association of the polymorphic repeat of tetranucleotide (TCAT) in the first intron of the human tyrosine hydroxylase gene with schizophrenia in a Japanese sample. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 4. 2001-12-12. PMID:11475015. |
tyrosine hydroxylase (th) is the rate limiting enzyme in the synthesis of dopamine and norepinephrine. |
2001-12-12 |
2023-08-12 |
human |