| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Desiree Böck, Maria Wilhelm, Jonas Mumenthaler, Daniel Fabio Carpanese, Peter I Kulcsár, Simon d'Aquin, Alessio Cremonesi, Anahita Rassi, Johannes Häberle, Tommaso Patriarchi, Gerald Schwan. Base editing of eLife. vol 13. 2024-12-23. PMID:39714464. |
while ptbp1 downregulation in astrocytes had no effect, ptbp1 downregulation in neurons of the striatum resulted in the expression of the dan marker tyrosine hydroxylase (th) in non-dividing neurons, which was associated with an increase in striatal dopamine concentrations and a rescue of forelimb akinesia and spontaneous rotations. |
2024-12-23 |
2024-12-25 |
mouse |
| Khang-Yen Pham, Shristi Khanal, Ganesh Bohara, Nikesh Rimal, Sang-Hoon Song, Thoa Thi Kim Nguyen, In-Sun Hong, Jinkyung Cho, Jong-Sun Kang, Sooyeun Lee, Dong-Young Choi, Simmyung Yoo. HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease. Redox biology. vol 79. 2024-12-19. PMID:39700694. |
additionally, plga@cay@lf nps treatment normalized dopamine and tyrosine hydroxylase levels, reduced neuroinflammation, and improved behavioral impairments. |
2024-12-19 |
2024-12-22 |
Not clear |
| Nehal Shawky Nagy, Mohamed Helal, Eman Sheta Alsawy, Mohamad Moustafa Ali, Soheir Salem Al-Sherif, Amina Essawy Essaw. Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson's disease. PloS one. vol 19. issue 12. 2024-12-18. PMID:39693313. |
molecularly, it increased tyrosine hydroxylase and dopa decarboxylase gene expression, essential for dopamine synthesis. |
2024-12-18 |
2024-12-21 |
rat |
| Yunqing Cao, Oliver Popp, Niccolo Milani, Fatimunnisa Qadri, Ralf Kühn, Philipp Mertins, Michael Bader, Natalia Alenin. Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice. Communications biology. vol 7. issue 1. 2024-12-18. PMID:39695187. |
it is generated by two different tryptophan hydroxylase enzymes, tph1 and tph2, in the periphery and in the brain, respectively, which are members of the aromatic amino acid hydroxylase (aaah) family together with phenylalanine hydroxylase (pah), degrading phenylalanine, and tyrosine hydroxylase (th), generating dopamine. |
2024-12-18 |
2024-12-21 |
mouse |
| Babita Singh, Shivani Pandey, Mohammad Rumman, Mrinal Gupta, Abbas Ali Mahd. Bacopaside-I ameliorates motor dysfunction and neurodegeneration in rat model of Parkinson's disease. Naunyn-Schmiedeberg's archives of pharmacology. 2024-12-10. PMID:39656222. |
furthermore, chronic administration of bs-i increased the expression levels of dopamine transporter (dat) and vesicular monoamine transporter (vmat) genes and the numbers of tyrosine hydroxylase (th)-positive neurons as compared to rotenone-exposed animals. |
2024-12-10 |
2024-12-12 |
rat |
| Wessam Z Ghaith, Walaa Wadie, Mohammed F El-Yaman. Crosstalk between SIRT1/Nrf2 signaling and NLRP3 inflammasome/pyroptosis as a mechanistic approach for the neuroprotective effect of linagliptin in Parkinson's disease. International immunopharmacology. vol 145. 2024-12-06. PMID:39642562. |
linagliptin decreased α-synuclein immunoreactivity along with an increase in tyrosine hydroxylase immunoreactivity and striatal dopamine content. |
2024-12-06 |
2024-12-10 |
rat |
| Jae-Won Jung, Yukiori Goto, Young-A Le. Dopamine-mediated behavioral alterations following exposure to a social video in socially isolated mice during the developmental period. Behavioral neuroscience. 2024-12-05. PMID:39636608. |
furthermore, the sve group exhibited elevated levels of tyrosine hydroxylase and dopamine transporter in key social cognition regions-namely the prefrontal cortex, retrosplenial cortex, and hippocampus. |
2024-12-05 |
2024-12-08 |
mouse |
| Kielen R Zuurbier, Rene Solano Fonseca, Sonja L B Arneaud, Jordan M Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M Dougla. Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy. Nature communications. vol 15. issue 1. 2024-12-05. PMID:39632864. |
to bolster stress resilience and mitigate dopamine toxicity, yy1 increases expression of the vesicular monoamine transporter 2, vmat2, while coordinately inhibiting dopamine synthesis through stabilization of a guanine quadruplex in intron 10 of tyrosine hydroxylase, th. |
2024-12-05 |
2024-12-07 |
mouse |
| Zhigang Chen, Shaoyi Duan, Jialu Li, Jianming Su, Hongyu Le. T-2 toxin triggers depression-like behaviors via upregulation of dopamine transporter in nucleus accumbens of male mice. Ecotoxicology and environmental safety. vol 289. 2024-12-01. PMID:39616663. |
in addition, the reduced dopamine (da) level and elevated dopamine transporter (dat) level were found in reward center nucleus accumbens (nac) receiving daergic projection from ventral tegmental area (vta) in brain after t-2 toxin administration, while there was no significant alteration in da synthesis-related tyrosine hydroxylase (th) and aromatic l-amino acid decarboxylase (aadc) in vta and da storage-related vesicle monoamine transporter 2 (vmat2) in nac. |
2024-12-01 |
2024-12-06 |
mouse |
| Marcello Serra, Gaia Faustini, Viviana Brembati, Maria Antonietta Casu, Marina Pizzi, Micaela Morelli, Annalisa Pinna, Arianna Bellucc. Early α-synuclein/synapsin III co-accumulation, nigrostriatal dopaminergic synaptopathy and denervation in the MPTPp mouse model of Parkinson's Disease. Experimental neurology. 2024-11-05. PMID:39500391. |
this was accompanied by marked co-accumulation of synapsin iii (syn iii), a synaptic protein previously identified as a component of α-syn fibrils in post-mortem pd brains and as a main stabilizer of α-syn aggregates, as well as very early and severe reduction of vesicular monoamine transporter 2 (vmat2), dopamine transporter (dat) and tyrosine hydroxylase (th) immunoreactivity in nigrostriatal neurons. |
2024-11-05 |
2024-11-08 |
mouse |
| Nicolas C Galinelli, Nicholas J Bamford, Madison L Erdody, Tobias Warnken, Melody A de Laat, Martin N Sillence, Patricia A Harris, Simon R Baile. Effect of short-term dopamine reduction on insulin sensitivity and post-prandial insulin and glucose responses in Standardbred horses. Domestic animal endocrinology. vol 90. 2024-11-01. PMID:39486097. |
the aim of this study was to investigate the effects of alpha-methyl-para-tyrosine (ampt), a tyrosine hydroxylase inhibitor that reduces dopamine production, on insulin sensitivity and the post-prandial insulin response to a glucose-containing meal. |
2024-11-01 |
2024-11-05 |
Not clear |
| Suzuna Hayashi, Miki Fujiuchi, Mei Oshiden, Akira Honda, Nao Kagaw. Opioid receptor and dopaminergic gene expression increase in the brains of dominant medaka Oryzias latipes males after repeated fights. Journal of fish biology. 2024-10-27. PMID:39462145. |
repeated positive fighting experiences enhance the gene expression levels of μ-type opioid receptor (mor), tyrosine hydroxylase (th), an enzyme involved in dopamine synthesis, and dopamine receptor type 2 (d2r) in the reward-related brain regions of aggressive mice. |
2024-10-27 |
2024-10-30 |
mouse |
| Erik H Douma, Jesse Stoop, Matthijs V R Lingl, Marten P Smidt, Lars P van der Heid. Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits. Cell & bioscience. vol 14. issue 1. 2024-10-25. PMID:39456033. |
this study explores an alternative approach by investigating the activation of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2024-10-25 |
2024-10-29 |
Not clear |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
dopamine is synthesized in the dopaminergic neurons of the sn by the actions of tyrosine hydroxylase (th) and dihydroxyphenylalanine decarboxylase (ddc). |
2024-10-16 |
2024-10-19 |
mouse |
| Hiroki Saito, Takuya Yokoyama, Nobuaki Nakamuta, Yoshio Yamamot. Immunohistochemical distribution of cannabinoid receptor type 1 (CB1) and type 2 (CB2) in the rat carotid body. Acta histochemica. vol 126. issue 8. 2024-10-15. PMID:39405990. |
dot-like cb1 immunoreactivity was distributed in the perinuclear cytoplasm of chemoreceptor cells immunoreactive for the catecholamine-synthesizing enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase. |
2024-10-15 |
2024-10-18 |
rat |
| Patrick D Worhunsky, Marcella M Mignosa, Jean-Dominique Gallezot, Brian Pittman, Nabeel B Nabulsi, Adam Stryjewski, Laya Jalilian-Khave, Richard Trinko, Ralph J DiLeone, Richard E Carson, Robert T Malison, Marc N Potenza, Gustavo A Angarit. Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [ Biological psychiatry. 2024-10-12. PMID:39395473. |
preclinical research suggests that the active form of vitamin d, calcitriol, increases subcortical tyrosine hydroxylase, d2/3 receptors, and amphetamine-stimulated dopamine release in rodents. |
2024-10-12 |
2024-10-15 |
Not clear |
| Nicolas C Galinelli, Nicholas J Bamford, Madison L Erdody, Tobias Warnken, Melody A de Laat, Martin N Sillence, Patricia A Harris, Simon R Baile. Physiological and metabolic effects of short-term dopamine reduction in healthy horses using a tyrosine hydroxylase inhibitor (alpha-methyl-para-tyrosine). Domestic animal endocrinology. vol 90. 2024-10-10. PMID:39388740. |
physiological and metabolic effects of short-term dopamine reduction in healthy horses using a tyrosine hydroxylase inhibitor (alpha-methyl-para-tyrosine). |
2024-10-10 |
2024-10-13 |
Not clear |
| Daria S Gorina, Anastasiya V Lastovka, Artem D Rogachev, Alexandra V Podturkina, Alla V Pavlova, Oleg V Ardashov, Nikolai S Li-Zhulanov, Tatyana G Tolstikova, Konstantin P Volcho, Nariman F Salakhutdino. Pharmacokinetics and Dose Proportionality Study of a Novel Antiparkinsonian Agent, a 1 Molecules (Basel, Switzerland). vol 29. issue 18. 2024-09-28. PMID:39339493. |
pa-96 supported the survival of cultured naïve dopamine neurons, alleviated motor deficits in mptp and haloperidol-based mice models of parkinson's disease, and increased the density of tyrosine hydroxylase positive neurons and dopamine concentration in the midbrain of an mptp-damaged brain. |
2024-09-28 |
2024-10-01 |
mouse |
| Takuya Yokoyama, Sayed Sharif Abdali, Nobuaki Nakamuta, Yoshio Yamamot. Distribution and morphology of serotonin transporter-immunoreactive type I cells in the rat carotid body. Anatomical record (Hoboken, N.J. : 2007). 2024-09-27. PMID:39327891. |
of sert-immunoreactive type i cells, 14.6% and 32.6% were immunoreactive for tyrosine hydroxylase (th) and dopamine beta-hydroxylase, respectively, while 75.9% were immunoreactive for serotonin (5-ht). |
2024-09-27 |
2024-09-29 |
rat |
| Min Shao, Chen Zhao, Zhijian Pan, Xuanjun Yang, Cheng Gao, Gloria Hio-Cheng Kam, Hefeng Zhou, Simon Ming-Yuen Le. Oxyphylla A exerts antiparkinsonian effects by ameliorating 6-OHDA-induced mitochondrial dysfunction and dyskinesia in vitro and in vivo. Chemico-biological interactions. 2024-09-05. PMID:39233265. |
pre-treatment mitigated loss of tyrosine hydroxylase (th)-positive neurons in the substantia nigra and striatal dopaminergic fibers, restoring dopamine levels and ameliorating motor deficits in pd mice. |
2024-09-05 |
2024-09-08 |
mouse |