| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Kolacheva, Ekaterina Pavlova, Alyona Bannikova, Vsevolod Bogdanov, Michael Ugrumo. Initial Molecular Mechanisms of the Pathogenesis of Parkinson's Disease in a Mouse Neurotoxic Model of the Earliest Preclinical Stage of This Disease. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279354. |
it was shown that the content of tyrosine hydroxylase (th), the first enzyme in dopamine synthesis, does not change within 6 h after the administration of mptp, but decreases after 24 h. in turn, th activity increases after 1 h, decreases after 3 h, remains at the control level after 6 h, and decreases 24 h after the administration of mptp. |
2024-01-27 |
2024-01-29 |
mouse |
| Adedamola Bayo-Olugbami, AbdulRazaq Bidemi Nafiu, Abdulbasit Amin, Olalekan Michael Ogundele, Charles C Lee, Bamidele Victor Owoyel. Cholecalciferol (VD3) Attenuates L-DOPA-Induced Dyskinesia in Parkinsonian Mice Via Modulation of Microglia and Oxido-Inflammatory Mechanisms. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243560. |
using western blot, striatum was assessed for expression of dopamine metabolic enzymes: tyrosine hydroxylase (th) and monoamine oxidase-b (mao-b); cd11b, bax, p47phox, and il-1β. |
2024-01-20 |
2024-01-22 |
mouse |
| A C Akinmoladun, Ibrahim Saliu, Olaoluwa Abilogun, Omotola Helen Ajibola, Zainab Abiola Amoo, Olubukola Benedicta Ojo, Ebenezer O Farombi, Mary Tolulope Olaley. Comparative influence of kolaviron and coenzyme Q10 on complex I activity, glutamate clearance, 3,4-dihydroxyphenethylamine metabolism, and redox stress in rotenone-induced neurotoxicity. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 37. issue 2. 2024-01-20. PMID:38243568. |
in all brain regions examined, kv and coenzyme q10 pretreatment modulated complex i activity, ameliorated redox imbalance, and enhanced dopamine metabolism via increasing the activity of tyrosine hydroxylase and decreasing monoamine oxidase activity. |
2024-01-20 |
2024-01-22 |
rat |
| A C Akinmoladun, Bidemi Sikirat Jiddah Kazeem, Morenikejimi Bello, M Tolulope Olaley. Effect of standardized Eucalyptus globulus leaf extract on brain oxidative stress and aberrant neurochemistry of fructose-streptozotocin-induced diabetic rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. vol 38. issue 1. 2024-01-19. PMID:38243358. |
the brains of animals in the untreated diabetic group with increased blood glucose level showed oxidative stress (increased level of mda and myeloperoxidase but decreased level of reduced glutathione and superoxide dismutase) and disturbed neurochemistry (increased level of acetylcholinesterase and monoamine oxidase but decreased level of na+k+atpase, tyrosine hydroxylase and dopamine). |
2024-01-19 |
2024-01-22 |
rat |
| Kunwar Jung-Kc, Alba Tristán-Noguero, Altanchimeg Altankhuyag, David Piñol Belenguer, Karina S Prestegård, Irene Fernandez-Carasa, Arianna Colini Baldeshi, Maria Sigatulina Bondarenko, Angeles García-Cazorla, Antonella Consiglio, Aurora Martine. Tetrahydrobiopterin (BH Journal of inherited metabolic disease. 2024-01-10. PMID:38196161. |
tetrahydrobiopterin (bh proteostatic regulation of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis, is crucial for maintaining proper brain neurotransmitter homeostasis. |
2024-01-10 |
2024-01-13 |
Not clear |
| John Tyler, Madeline Podaras, Brittany Richardson, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A Baron, Panayotis K Thano. High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling. Frontiers in public health. vol 11. 2024-01-09. PMID:38192549. |
the present study examined the effects of chronic hiit exercise on dopamine signaling as measured by dopamine type 1-like receptor (d1r)-like, dopamine type 2-like receptor (d2r)-like, and tyrosine hydroxylase (th) quantification in the brains of male and female rats as measured by [ |
2024-01-09 |
2024-01-10 |
rat |
| Jun Sung Park, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park, Myeong Ok Ki. Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson's Disease-Associated Pathology. Vaccines. vol 11. issue 12. 2023-12-23. PMID:38140224. |
furthermore, vaccinated groups, especially ova and klh groups, showed decrease in α-syn levels and increased dopamine-related markers, i.e., tyrosine hydroxylase (th), vesicle monoamine transporter 2 (vmat2), and dopamine transporter (dat), and autophagy activities in the striatum and snpc. |
2023-12-23 |
2023-12-25 |
mouse |
| Luca Lo Piccolo, Ranchana Yeewa, Sureena Pohsa, Titaree Yamsri, Daniel Calovi, Jutarop Phetcharaburanin, Manida Suksawat, Thanaporn Kulthawatsiri, Vorasuk Shotelersuk, Salinee Jantrapiro. FAME4-associating YEATS2 knockdown impairs dopaminergic synaptic integrity and leads to seizure-like behaviours in Drosophila melanogaster. Progress in neurobiology. 2023-12-21. PMID:38128822. |
additionally, reducing dyeats2 expression negatively affected tyrosine hydroxylase (th) gene expression, resulting in decreased dopamine biosynthesis. |
2023-12-21 |
2023-12-24 |
drosophila_melanogaster |
| Yahong Zhang, Tsung-Huang Tsai, Michael Ezrokhi, Carl Stoelzel, Anthony H Cincott. Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary Nucleus Area Induces Obesity and Glucose Intolerance. Neuroendocrinology. 2023-12-21. PMID:38128505. |
this study investigated the effect of sumn tyrosine hydroxylase (rate-limiting enzyme in dopamine synthesis) knockdown (thx) on peripheral fuel metabolism. |
2023-12-21 |
2023-12-24 |
Not clear |
| Sabine Jung-Klawitter, Petra Richter, Yuheng Yuan, Karin Welzel, Marie Kube, Stella Bähr, Alexander Leibner, Egbert Flory, Thomas Oplade. Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1. Journal of inherited metabolic disease. 2023-12-12. PMID:38084654. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine biosynthesis catalyzing the tetrahydrobiopterin (bh |
2023-12-12 |
2023-12-17 |
Not clear |
| Ichiro Kawahata, Kohji Fukunag. Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease-Potential Biomarkers and Therapeutic Targets. International journal of molecular sciences. vol 24. issue 23. 2023-12-09. PMID:38069360. |
in particular, fabp3, abundant in nigrostriatal dopaminergic neurons, is responsible for α-synuclein propagation into neurons and intracellular accumulation, affecting the loss of mesencephalic tyrosine hydroxylase protein, a rate-limiting enzyme of dopamine biosynthesis. |
2023-12-09 |
2023-12-17 |
Not clear |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). |
2023-12-01 |
2023-12-10 |
mouse |
| Noha Nabil Mohammed, Mariane G Tadros, Mina Y Georg. Empagliflozin repurposing in Parkinson's disease; modulation of oxidative stress, neuroinflammation, AMPK/SIRT-1/PGC-1α, and wnt/β-catenin pathways. Inflammopharmacology. 2023-12-01. PMID:38038781. |
moreover, rotenone induced alpha-synuclein accumulation, reduced tyrosine hydroxylase expression, dopamine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid concentrations. |
2023-12-01 |
2023-12-10 |
rat |
| Priyanshu Sharma, Payal Mitta. Paraquat (herbicide) as a cause of Parkinson's Disease. Parkinsonism & related disorders. 2023-11-26. PMID:38008593. |
the endoplasmic reticulum's stress, decreased levels of neurotrophic factors, oxidative stress, mitochondrial dysfunction, catabolic alterations in dopamine, and decreased activity of tyrosine hydroxylase are some of these causes. |
2023-11-26 |
2023-11-28 |
Not clear |
| Shejil Kumar, Katherine Wu, Natassia Rodrigo, Anthony Glove. Massive Biochemically Silent Pheochromocytoma Masquerading as Nonfunctioning Adrenocortical Cancer. JCEM case reports. vol 1. issue 3. 2023-11-01. PMID:37908587. |
tumor cells stained positive for tyrosine hydroxylase and negative for dopamine β hydroxylase. |
2023-11-01 |
2023-11-08 |
Not clear |
| Sally Hamdon, Pol Fernandez-Gonzalez, Muhammad Yusof Omar, Marta González-Sepúlveda, Jordi Ortiz, Carles Gi. CHIR99021 causes inactivation of Tyrosine Hydroxylase and depletion of dopamine in rat brain striatum. Neuropharmacology. 2023-10-16. PMID:37844866. |
chir99021 causes inactivation of tyrosine hydroxylase and depletion of dopamine in rat brain striatum. |
2023-10-16 |
2023-11-08 |
rat |
| Maddison Reed, Wen Pan, Lina Musa, Stefania Arlotta, Jan A Mennigen, Michael G Jon. A role for dopamine in control of the hypoxic ventilatory response via D The Journal of comparative neurology. 2023-10-14. PMID:37837632. |
we used immunohistochemistry and confocal microscopy to map the distribution of tyrosine hydroxylase (th), an enzyme necessary for dopamine synthesis, in the gills of zebrafish. |
2023-10-14 |
2023-11-08 |
zebrafish |
| Marcos Fernandes Gregnani, Alexandre Budu, Rogério Oliveira Batista, Fábio Henrique Ornellas, Gabriel Rufino Estrela, Adriano Cleis Arruda, Leandro Ceotto Freitas Lima, Jean Lucas Kremer, Lys Angela Favaroni Mendes, Dulce Elena Casarini, Claudimara Ferini Pacicco Lotfi, Lila Missae Oyama, Michael Bader, Ronaldo Carvalho Araúj. Kinin B1 receptor modulates glucose homeostasis and physical exercise capacity by altering adrenal catecholamine synthesis and secretion. Molecular and cellular endocrinology. 2023-10-12. PMID:37827227. |
this phenotype was related to alterations in adrenal catecholamine synthesis: increased basal epinephrine concentration and reduced norepinephrine content in response to exercise, as well decreased gene expression and protein content of tyrosine hydroxylase and decreased gene expression of dopamine beta hydroxylase and kinin b2 receptor. |
2023-10-12 |
2023-10-15 |
mouse |
| Celia Garau, Jessica Hayes, Giulia Chiacchierini, James E McCutcheon, John Apergis-Schout. Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat. Current biology : CB. 2023-10-10. PMID:37816347. |
tyrosine hydroxylase (th)-containing neurons of the dopamine (da) cell group a13 are well positioned to impact known da-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. |
2023-10-10 |
2023-10-15 |
rat |
| Qun Wang, Yuqian Wang, Yaoyao Tian, Yanyan Li, Jing Han, Fadao Tai, Rui Ji. Social environment enrichment alleviates anxiety-like behavior in mice: Involvement of the dopamine system. Behavioural brain research. 2023-10-01. PMID:37778421. |
cr group also showed significantly higher expression of tyrosine hydroxylase in the ventral tegmental area and dopamine 1 receptor mrna in the nucleus accumbens shell than control group. |
2023-10-01 |
2023-10-07 |
mouse |