| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesse Stoop, Erik H Douma, Marc van der Vlag, Marten P Smidt, Lars P van der Heid. Tyrosine hydroxylase phosphorylation is under the control of serine 40. Journal of neurochemistry. 2023-09-30. PMID:37776259. |
tyrosine hydroxylase catalyzes the initial and rate-limiting step in the biosynthesis of the neurotransmitter dopamine. |
2023-09-30 |
2023-10-07 |
mouse |
| Mitchell T Ringuet, Ada Koo, Sebastian G B Furness, Stuart J McDougall, John B Furnes. Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre. The Journal of physiology. 2023-09-29. PMID:37772438. |
we show that dopamine, serotonin and ghrelin receptor transcripts are contained in the same pgns and that these neurons have closely associated tyrosine hydroxylase and serotonin boutons. |
2023-09-29 |
2023-10-07 |
mouse |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| Sai Teja Meka, Sree Lalitha Bojja, Gautam Kumar, Sumit Raosaheb Birangal, C Mallikarjuna Ra. Novel HDAC inhibitors provide neuroprotection in MPTP-induced Parkinson's disease model of rats. European journal of pharmacology. 2023-09-26. PMID:37751833. |
mptp administration resulted in a marked rise in lipid peroxidation, and interleukin-1β concentration accompanied by reduced tyrosine hydroxylase and dopamine levels in the striatum compared to the sham group. |
2023-09-26 |
2023-10-07 |
rat |
| R Schumacher, M F Rossetti, G Canesini, L Gaydou, A P Garcia, G P Lazzarino, P R Fernandez, C Stoker, M J Carrió, M F Andreoli, J G Ramo. Neonatal overfeeding alters the functioning of the mesolimbic dopaminergic circuitry involving changes in DNA methylation and effects on feeding behavior. The Journal of nutritional biochemistry. 2023-09-25. PMID:37748623. |
sl-pnd21 animals presented increased expression levels of tyrosine hydroxylase and dopamine receptor d2 in vta, decreased expression levels of dopamine active transporter (dat) in vta, and higher expression levels of dat in nacc. |
2023-09-25 |
2023-10-07 |
rat |
| Julia Sepel Loreto, Sabrina Antunes Ferreira, Pâmela de Almeida, João Batista Teixeira da Rocha, Nilda Vargas Barbos. Screening for Differentially Expressed Memory Genes on a Diabetes Model Induced by High-Sugar Diet in Drosophila melanogaster: Potential Markers for Memory Deficits. Molecular neurobiology. 2023-09-12. PMID:37698834. |
interestingly, the flies fed on hsd presented a decreased expression of the tyrosine hydroxylase (ple) and dopa decarboxylase (ddc) genes, signals of a possible dopamine deficiency. |
2023-09-12 |
2023-10-07 |
drosophila_melanogaster |
| Toshiharu Nagats. Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview. Journal of neural transmission (Vienna, Austria : 1996). 2023-08-28. PMID:37638996. |
the author identified the genes and proteins of human enzymes involved in the biosynthesis of catecholamines (dopamine, norepinephrine, epinephrine) and tetrahydrobiopterin (bh4): tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), dopamine β-hydroxylase (dbh), phenylethanolamine n-methyltransferase (pnmt), and gtp cyclohydrolase i (gch1). |
2023-08-28 |
2023-09-07 |
human |
| Ella A Kasanga, Yoonhee Han, Marla K Shifflet, Walter Navarrete, Robert McManus, Caleb Parry, Arturo Barahona, Vicki A Nejtek, Fredric P Manfredsson, Jeffrey H Kordower, Jason R Richardson, Michael F Salvator. Nigral-specific increase in ser31 phosphorylation compensates for tyrosine hydroxylase protein and nigrostriatal neuron loss: Implications for delaying parkinsonian signs. Experimental neurology. 2023-08-27. PMID:37634696. |
compensatory mechanisms that augment dopamine (da) signaling are thought to mitigate onset of hypokinesia prior to major loss of tyrosine hydroxylase (th) in striatum that occurs in parkinson's disease. |
2023-08-27 |
2023-09-07 |
rat |
| Xingxia Wang, Wei Hu, Liqun Qu, Jian Wang, Anguo Wu, Hang Hong Lo, Jerome P L Ng, Yong Tang, Xiaoyun Yun, Jianhui Wu, Vincent Kam Wai Wong, Sookja Kim Chung, Linna Wang, Weidan Luo, Xiang Ji, Betty Yuen Kwan La. Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's disease. Pharmacological research. 2023-08-16. PMID:37586619. |
besides, the pharmacological effects on neurotransmitters (tyrosine hydroxylase and dopamine), inflammatory cytokines (ifn γ, tnfα, mcp-1, il-10, il-6 and il-17a), histology (hematoxylin & eosin and nissl staining) and behavioural pathology (open-field test, hindlimb clasping, y-maze, morris water-maze and nest building test) were also confirmed in the a53t-α-transgenic pd mouse model. |
2023-08-16 |
2023-09-07 |
mouse |
| Luis Fernando Narváez-Pérez, Francisco Paz-Bermúdez, José Arturo Avalos-Fuentes, Aurelio Campos-Romo, Benjamín Florán-Garduño, José Segovi. CRISPR/sgRNA-directed synergistic activation mediator (SAM) as a therapeutic tool for Parkinson´s disease. Gene therapy. 2023-08-04. PMID:37542151. |
as a proof-of-concept for the treatment of pd, we used sam, a crispr gene activation system, to activate the endogenous tyrosine hydroxylase gene (th) of astrocytes to produce dopamine (da) in the striatum of 6-ohda-lesioned rats. |
2023-08-04 |
2023-08-14 |
rat |
| Tanya Denne, Lila C Winfrey, Cindy Moore, Chase Whitner, Theresa D'Silva, Amala Soumyanath, Lynne Shinto, Amie Hiller, Charles K Meshu. Recovery of motor function is associated with rescue of glutamate biomarkers in the striatum and motor cortex following treatment with Mucuna pruriens in a murine model of Parkinson's disease. Molecular and cellular neurosciences. 2023-08-01. PMID:37527694. |
the goal of this study was to determine if daily oral treatment with an extract of mucuna pruriens, starting after the mptp-induced loss of nigrostriatal dopamine in male mice, would result in recovery/restoration of motor function, tyrosine hydroxylase (th) protein expression in the nigrostriatal pathway, or glutamate biomarkers in both the striatum and motor cortex. |
2023-08-01 |
2023-08-14 |
mouse |
| Ella A Kasanga, Isabel Soto, Ashley Centner, Robert McManus, Marla K Shifflet, Walter Navarrete, Yoonhee Han, Jerome Lisk, Ken Wheeler, Isha Mhatre-Winters, Jason R Richardson, Christopher Bishop, Vicki A Nejtek, Michael F Salvator. Moderate intensity aerobic exercise in 6-OHDA-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502851. |
moderate intensity aerobic exercise in 6-ohda-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein. |
2023-07-28 |
2023-08-14 |
rat |
| Ella A Kasanga, Isabel Soto, Ashley Centner, Robert McManus, Marla K Shifflet, Walter Navarrete, Yoonhee Han, Jerome Lisk, Ken Wheeler, Isha Mhatre-Winters, Jason R Richardson, Christopher Bishop, Vicki A Nejtek, Michael F Salvator. Moderate intensity aerobic exercise in 6-OHDA-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502851. |
alleviation of motor impairment by aerobic exercise (ae) in parkinson's disease (pd) points to a cns response that could be targeted by therapeutic approaches, but recovery of striatal dopamine (da) or tyrosine hydroxylase (th) has been inconsistent in rodent studies. |
2023-07-28 |
2023-08-14 |
rat |
| N A Santiago, B He, S L Howard, S Beaudin, B J Strupp, D R Smit. Developmental Manganese Exposure Causes Lasting Attention Deficits Accompanied by Dysregulation of mTOR Signaling and Catecholaminergic Gene Expression in Brain Prefrontal Cortex. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37503220. |
results show that developmental mn exposure causes lasting focused attention deficits that are associated with reduced gene expression of tyrosine hydroxylase, dopamine transporter, and dna methyltransferase 3a. |
2023-07-28 |
2023-08-14 |
rat |
| Alexandra A Naumova, Ekaterina A Oleynik, Anna V Khramtsova, Svetlana D Nikolaeva, Elena V Chernigovskaya, Margarita V Glazov. Short-term hindlimb unloading negatively affects dopaminergic transmission in the nigrostriatal system of mice. Developmental neurobiology. 2023-07-25. PMID:37489016. |
our data showed a significant decrease in the expression and phosphorylation of tyrosine hydroxylase (th) in the sn and dorsal striatum of hu mice that suggested attenuation of dopamine synthesis in response to hu. |
2023-07-25 |
2023-08-14 |
mouse |
| Guobao Wang, Xiang Ji, Lei Nie, Ruirui X. Exploring the proteins and metabolites associated with male antennae responses to female exposure of Antheraea pernyi (Lepidoptera: Saturniidae) moths. Journal of economic entomology. 2023-07-17. PMID:37459048. |
a number of deps and dems related to neural transmission of female pheromone signals in the male antennae of a. pernyi were screened, including tyrosine hydroxylase, cryptochrome-1, tachykinin, arylalkylamine n-acetyltransferase, cadherin-23, glutathione s-transferase delta 3, tyramine, tryptamine, n-oleoyl dopamine, n-stearoyl dopamine, and n-stearoyl tyrosine. |
2023-07-17 |
2023-08-14 |
human |
| Xu Cao, Zhong-Rui Du, Xin Liu, Xiong Wang, Chong Li, Sai-Nan Zhou, Jia-Rui Liu, Ping-Yi Xu, Jun-Li Ye, Qing Zhao, Fang Zhao, Ka-Hing Wong, Xiao-Li Don. Low and high doses of oral maslinic acid protect against Parkinson's disease via distinct gut microbiota-related mechanisms. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-07. PMID:37418977. |
the present study found both low and high dose ma treatment significantly prevented dopaminergic neuronal loss in a classical chronic pd mouse model by ameliorating motor functions and improving tyrosine hydroxylase expressions in the substantia nigra pars compacta (snpc) and increasing dopamine and its metabolite homovanillic acid levels in the striatum. |
2023-07-07 |
2023-08-14 |
mouse |
| K N Rose, M Zorlu, X Xue, W Cai, S Lin, M A Schwarzschild, X Chen, S N Gompert. Low-dose carbon monoxide is neuroprotective in rodent models of Parkinson's disease. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398030. |
administration of hbi-002 in the asyn model reduced ipsilateral loss of both striatal dopamine and tyrosine hydroxylase (th)-positive neurons in the substantia nigra and reduced asyn aggregates and s129 phosphorylation. |
2023-07-03 |
2023-08-14 |
mouse |
| Heba M Mansour, Ahmed F Mohamed, Mahmoud M Khattab, Aiman S El-Khati. Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease. European journal of pharmacology. 2023-06-29. PMID:37385578. |
in the current study, administration of 100 mg/kg lap in rotenone-treated rats for 21 days ameliorates motor impairment, debilitated histopathological alterations, and revived dopaminergic neurons by increasing tyrosine hydroxylase (th) expression in sn, along with increased dopamine level. |
2023-06-29 |
2023-08-14 |
rat |
| Abubakar Atiq, Hyeon Jin Lee, Amjad Khan, Min Hwa Kang, Inayat Ur Rehman, Riaz Ahmad, Muhammad Tahir, Jawad Ali, Kyonghwan Choe, Jun Sung Park, Myeong Ok Ki. Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson's Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment. International journal of molecular sciences. vol 24. issue 12. 2023-06-28. PMID:37373089. |
our study showed that mptp increased the expression of α-synuclein, decreased tyrosine hydroxylase (th) and dopamine transporter (dat) levels in the striatum and substantia nigra pars compacta (snpc), and impaired motor function. |
2023-06-28 |
2023-08-14 |
mouse |