| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Sienkiewicz, G J Molenaar, J Kaleczyc, J Falkowski, M Lakom. Has active immunization against gonadotrophin-releasing hormone any effect on testis innervation in the pig? An immunohistochemical study. Anatomia, histologia, embryologia. vol 29. issue 4. 2000-12-07. PMID:11008373. |
the innervation of porcine testes was studied in intact animals and in boars undergoing active immunization against gonadotrophin-releasing hormone (gnrh) by means of immunohistochemistry using antibodies to tyrosine hydroxylase (th), dopamine beta-hydroxylase (d beta h), vasoactive intestinal polypolypeptide (vip), neuropeptide y (npy), synaptosome-associated protein of 25 kda (snap-25) and protein gene product 9.5 (pgp 9.5). |
2000-12-07 |
2023-08-12 |
Not clear |
| V M Goettl, T A Wemlinger, T G Fong, N H Neff, M Hadjiconstantino. Retinal cholinergic and dopaminergic deficits of aged rats are improved following treatment with GM1 ganglioside. Brain research. vol 877. issue 1. 2000-11-28. PMID:10980236. |
the dopaminergic markers, tyrosine hydroxylase, aromatic l-amino acid decarboxylase, dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid were comparable in the young and aged animals and gm1 treatment did not alter them. |
2000-11-28 |
2023-08-12 |
rat |
| V D Gueorguiev, R J Zeman, E M Meyer, E L Sabba. Involvement of alpha7 nicotinic acetylcholine receptors in activation of tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in PC12 cells. Journal of neurochemistry. vol 75. issue 5. 2000-11-09. PMID:11032889. |
involvement of alpha7 nicotinic acetylcholine receptors in activation of tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in pc12 cells. |
2000-11-09 |
2023-08-12 |
Not clear |
| V D Gueorguiev, R J Zeman, E M Meyer, E L Sabba. Involvement of alpha7 nicotinic acetylcholine receptors in activation of tyrosine hydroxylase and dopamine beta-hydroxylase gene expression in PC12 cells. Journal of neurochemistry. vol 75. issue 5. 2000-11-09. PMID:11032889. |
nicotine treatment increases intracellular free ca(2+) concentration [ca(2+)](i), stimulates catecholamine release, and elevates gene expression for the catecholamine biosynthetic enzymes tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
2000-11-09 |
2023-08-12 |
Not clear |
| M Park, K Kitahama, M Geffard, T Maed. Postnatal development of the dopaminergic neurons in the rat mesencephalon. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984659. |
the two mesencephalic dopaminergic systems in the developing rat brain were investigated immunohistochemically by dopamine and tyrosine hydroxylase and the results were quantitatively analyzed with a computer. |
2000-11-07 |
2023-08-12 |
rat |
| V Fauchey, M Jaber, B Bloch, C Le Moin. Dopamine control of striatal gene expression during development: relevance to knockout mice for the dopamine transporter. The European journal of neuroscience. vol 12. issue 9. 2000-11-07. PMID:10998124. |
we detected tyrosine hydroxylase, by immunohistochemistry, in the ventral mesencephalon and the striatal anlage in both genotypes at g13, whereas the dopamine transporter appeared in the striatum of normal mice at g14. |
2000-11-07 |
2023-08-12 |
mouse |
| J M Campbell, D P Gilmore, D Russell, C A Growney, G Favor, A K Kennedy, R W Davies, A P Payne, T W Ston. Pharmacological analysis of extracellular dopamine and metabolites in the striatum of conscious as/agu rats, mutants with locomotor disorder. Neuroscience. vol 100. issue 1. 2000-11-06. PMID:10996457. |
the as/agu rat is a spontaneously occurring mutation which exhibits locomotor abnormalities, reduced tyrosine hydroxylase levels in the substantia nigra and lower extracellular levels of dopamine. |
2000-11-06 |
2023-08-12 |
human |
| J M Campbell, D P Gilmore, D Russell, C A Growney, G Favor, A K Kennedy, R W Davies, A P Payne, T W Ston. Pharmacological analysis of extracellular dopamine and metabolites in the striatum of conscious as/agu rats, mutants with locomotor disorder. Neuroscience. vol 100. issue 1. 2000-11-06. PMID:10996457. |
the results show reduced extracellular dopamine in as/agu rats when the locomotor disorder is apparent, but there has been little loss of tyrosine hydroxylase. |
2000-11-06 |
2023-08-12 |
human |
| E Rodríguez-Martín, M J Casarejos, E Bazán, S Canals, A S Herranz, M A Men. Nitric oxide induces differentiation in the NB69 human catecholamine-rich cell line. Neuropharmacology. vol 39. issue 11. 2000-11-03. PMID:10963752. |
the nitric oxide (no) donor, s-nitroso-n-acetyl-d,l-penicillamine (snap), induced differentiation of human neuroblastoma nb69 cells to a dopamine phenotype, as shown by phase-contrast microscopy and tyrosine hydroxylase (th) immunocytochemistry. |
2000-11-03 |
2023-08-12 |
human |
| J Zhou, Y Shen, Z Tang, L Xu, H F Bradford, Y Y. Striatal extracts promote the survival and phenotypic expression of rat fetal dopaminergic neurons in vitro. Neuroscience letters. vol 292. issue 1. 2000-10-25. PMID:10996436. |
the striatal extract was found to be able to induce expression of tyrosine hydroxylase in cultured striatal cells in the presence of dopamine. |
2000-10-25 |
2023-08-12 |
rat |
| E Bezard, M Jaber, F Gonon, A Boireau, B Bloch, C E Gros. Adaptive changes in the nigrostriatal pathway in response to increased 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration in the mouse. The European journal of neuroscience. vol 12. issue 8. 2000-10-19. PMID:10971632. |
our results demonstrate the sequential activation of two compensatory mechanisms: (i) an increase in striatal tyrosine hydroxylase (th) protein content attested by the persistence of th immunolabelling up to d15, contrasting with the decrease observed in both the number of nigral th-immunoreactive neurons (-70.2%) and striatal dopamine content (-38.4%); (ii) a downregulation of da uptake in surviving terminals at d20 (73.4% of nigral degeneration). |
2000-10-19 |
2023-08-12 |
mouse |
| H M Haughey, A E Fleckenstein, R R Metzger, G R Hanso. The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987842. |
a role for dopamine (da) was suggested by findings that pretreatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine, the d1 antagonist sch-23390, or the d2 antagonist eticlopride attenuated the meth-induced decrease in striatal, but not hippocampal, sert activity. |
2000-10-05 |
2023-08-12 |
rat |
| Y Higashi, M Asanuma, I Miyazaki, N Ogaw. Inhibition of tyrosinase reduces cell viability in catecholaminergic neuronal cells. Journal of neurochemistry. vol 75. issue 4. 2000-10-05. PMID:10987861. |
the biosynthesis of dopamine (da) in catecholaminergic neurons is regulated by tyrosine hydroxylase, which converts tyrosine into 3, 4-dihydroxyphenylalanine (l-dopa). |
2000-10-05 |
2023-08-12 |
Not clear |
| D C Harvey, G Lacan, S P Tanious, W P Meleg. Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain research. vol 871. issue 2. 2000-10-04. PMID:10899292. |
a post-mortem characterization of other meth subjects at 1 month showed extensive decreases in immunoreactivity (ir) profiles of tyrosine hydroxylase (th), dat and vesicular monoamine transporter-2 (vmat) in the striatum, medial forebrain bundle and the ventral midbrain dopamine (vmd) cell region. |
2000-10-04 |
2023-08-12 |
human |
| Z Y Tong, A E Kingsbury, O J Foste. Up-regulation of tyrosine hydroxylase mRNA in a sub-population of A10 dopamine neurons in Parkinson's disease. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925142. |
up-regulation of tyrosine hydroxylase mrna in a sub-population of a10 dopamine neurons in parkinson's disease. |
2000-10-04 |
2023-08-12 |
human |
| J Gross, I Müller, Y Chen, M Elizalde, N Leclere, M Herrera-Marschitz, K Andersso. Perinatal asphyxia induces region-specific long-term changes in mRNA levels of tyrosine hydroxylase and dopamine D(1) and D(2) receptors in rat brain. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925148. |
perinatal asphyxia induces region-specific long-term changes in mrna levels of tyrosine hydroxylase and dopamine d(1) and d(2) receptors in rat brain. |
2000-10-04 |
2023-08-12 |
rat |
| J Gross, I Müller, Y Chen, M Elizalde, N Leclere, M Herrera-Marschitz, K Andersso. Perinatal asphyxia induces region-specific long-term changes in mRNA levels of tyrosine hydroxylase and dopamine D(1) and D(2) receptors in rat brain. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925148. |
to study the effects of neonatal asphyxia on gene expression of the dopaminergic systems, we determined quantitatively the mrna levels of tyrosine hydroxylase, dopamine transporter, dopamine d(1) and d(2) receptors in substantia nigra/ventral tegmental area, striatum and limbic area. |
2000-10-04 |
2023-08-12 |
rat |
| J Gross, I Müller, Y Chen, M Elizalde, N Leclere, M Herrera-Marschitz, K Andersso. Perinatal asphyxia induces region-specific long-term changes in mRNA levels of tyrosine hydroxylase and dopamine D(1) and D(2) receptors in rat brain. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925148. |
these observations indicate that neonatal asphyxia triggers a cascade of gene expressions for tyrosine hydroxylase and d(1) and d(2) dopamine receptors. |
2000-10-04 |
2023-08-12 |
rat |
| E Aliaga, C Cárcamo, J Abarca, L Tapia-Arancibia, G Busto. Transient increase of brain derived neurotrophic factor mRNA expression in substantia nigra reticulata after partial lesion of the nigrostriatal dopaminergic pathway. Brain research. Molecular brain research. vol 79. issue 1-2. 2000-10-04. PMID:10925152. |
these changes correlate with a partial reduction of dopamine (da) content in the striatum but with a normal tyrosine hydroxylase immunoreactivity in substantia nigra pars compacta. |
2000-10-04 |
2023-08-12 |
Not clear |
| M Thiruchelvam, B J Brockel, E K Richfield, R B Baggs, D A Cory-Slecht. Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? Brain research. vol 873. issue 2. 2000-09-28. PMID:10930548. |
concurrently, levels of dopamine and metabolites and dopamine turnover were increased immediately post-injection only by combined exposures, and returned to control levels or below within 48 h. reductions in tyrosine hydroxylase immunoreactivity, measured 3 days after the last injection, resulted only from combined exposure and were detected in dorsal striatum, but not in the nucleus accumbens. |
2000-09-28 |
2023-08-12 |
mouse |