| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone M Smits, Tiia Ponnio, Orla M Conneely, J Peter H Burbach, Marten P Smid. Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. The European journal of neuroscience. vol 18. issue 7. 2003-12-19. PMID:14622207. |
nurr1, a member of the nuclear hormone receptor superfamily of transcription factors, is essential for establishing the dopaminergic phenotype, because expression of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, requires nurr1. |
2003-12-19 |
2023-08-12 |
mouse |
| Iwona E Misiuta, Lynn Anderson, Michael P McGrogan, Paul R Sanberg, Alison E Willing, Tanja Zigov. The transcription factor Nurr1 in human NT2 cells and hNT neurons. Brain research. Developmental brain research. vol 145. issue 1. 2003-12-16. PMID:14519498. |
our previous in vitro experiments showed that hnt cells possess immunocytochemically detectable markers typical of dopaminergic (da) ventral mesencephalic (vm) neurons, including tyrosine hydroxylase (th), dopamine transporter (dat), dopamine receptor (d2), and aldehyde dehydrogenase (ahd-2). |
2003-12-16 |
2023-08-12 |
human |
| Peter D Alfinito, Sheng-Ping Wang, Lawrence Manzino, Sonia Rijhsinghani, Gail D Zeevalk, Patricia K Sonsall. Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 34. 2003-12-16. PMID:14645494. |
damage was assessed 1 week later by measuring striatal dopamine, tyrosine hydroxylase (th), and gaba content. |
2003-12-16 |
2023-08-12 |
mouse |
| Patrick Berenguer, Christophe Soulage, David Perrin, Jean-Marc Pequignot, Jacques H Abrain. Behavioral and neurochemical effects induced by subchronic exposure to 40 ppm toluene in rats. Pharmacology, biochemistry, and behavior. vol 74. issue 4. 2003-12-15. PMID:12667915. |
to test this hypothesis, we investigated the neurobehavioral and neurochemical effects of 40 ppm inhaled toluene in a rat model of 16-week subchronic exposure, examining locomotor and rearing activities; adaptation/sensitization to narcosis produced by acute exposure to toluene at high concentration; and tyrosine hydroxylase and tryptophan hydroxylase activities, and dopamine (da) and serotonin (5-ht) turnovers in the caudate-putamen, nucleus accumbens, hippocampus, prefrontal cortex, and cerebellum. |
2003-12-15 |
2023-08-12 |
rat |
| Guillaume Hébert, Josette Arsaut, Robert Dantzer, Jacques Demotes-Mainar. Time-course of the expression of inflammatory cytokines and matrix metalloproteinases in the striatum and mesencephalon of mice injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, a dopaminergic neurotoxin. Neuroscience letters. vol 349. issue 3. 2003-12-04. PMID:12951201. |
the time-course of denervation/reorganization was assessed through [(3)h]gbr-12935 binding on dopamine transporter and tyrosine hydroxylase immunohistochemistry. |
2003-12-04 |
2023-08-12 |
mouse |
| Zhizhong Dong, Boris Ferger, Jean-Charles Paterna, Denise Vogel, Sven Furler, Maribel Osinde, Joram Feldon, Hansruedi Büele. Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 21. 2003-12-04. PMID:14530399. |
furthermore, cdcrel-1 inhibits the release of dopamine from stably-transfected pc12 cells, and pharmacological inhibition of tyrosine hydroxylase and dopamine synthesis in rats prevents cdcrel-1-induced nigral neurodegeneration. |
2003-12-04 |
2023-08-12 |
rat |
| Florence Friggi-Grelin, Magali Iché, Serge Birma. Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms. Genesis (New York, N.Y. : 2000). vol 35. issue 3. 2003-11-26. PMID:12640623. |
drosophila tyrosine hydroxylase (dth) is a key enzyme in dopamine (da) biosynthesis, which is expressed in neural and hypodermal da-synthesizing cells. |
2003-11-26 |
2023-08-12 |
drosophila_melanogaster |
| John W Haycock, Laurence Becker, Lee Ang, Yoshiaki Furukawa, Oleh Hornykiewicz, Stephen J Kis. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. Journal of neurochemistry. vol 87. issue 3. 2003-11-24. PMID:14535941. |
because age-related changes in brain dopaminergic innervation are assumed to influence human disorders involving dopamine (da), we measured the levels of several presynpatic daergic markers [da, homovanillic acid, tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), vesicular monoamine transporter 2 (vmat2), and dopamine transporter (dat)] in post-mortem human striatum (caudate and putamen) from 56 neurologically normal subjects aged 1 day to 103 years. |
2003-11-24 |
2023-08-12 |
human |
| Den'etsu Sutoo, Kayo Akiyam. The significance of increase in striatal D(2) receptors in epileptic EL mice. Brain research. vol 980. issue 1. 2003-11-12. PMID:12865156. |
the immunohistochemical levels of d(2) receptors in the medial area of the neostriatum were significantly higher in el mice than in ddy mice (mother strain of el mice), while there were no differences in the levels of tyrosine hydroxylase, calcium/calmodulin-dependent protein kinase ii, calmodulin, d(1) receptors, and dopamine transporters. |
2003-11-12 |
2023-08-12 |
mouse |
| Anya M Y Lin, C H Yang, Y-F Ueng, T Y Luh, T Y Liu, Y P Lay, L T H. Differential effects of carboxyfullerene on MPP+/MPTP-induced neurotoxicity. Neurochemistry international. vol 44. issue 2. 2003-11-12. PMID:12971912. |
furthermore, dopamine content and tyrosine hydroxylase (th)-positive axons were reduced in the ipsilateral striatum. |
2003-11-12 |
2023-08-12 |
mouse |
| Parikshit C Das, William K McElroy, Ralph L Coope. Potential mechanisms responsible for chlorotriazine-induced alterations in catecholamines in pheochromocytoma (PC12) cells. Life sciences. vol 73. issue 24. 2003-11-05. PMID:14550852. |
in this study we evaluated the effect of atrazine, simazine and cyanazine on the protein expression of the enzymes responsible for the synthesis of dopamine [tyrosine hydroxylase (th)] and norepinephrine [dopamine-beta-hydroxylase (dbetah)]. |
2003-11-05 |
2023-08-12 |
Not clear |
| Giovana Seno Di Marco, Maria da Graça Naffah-Mazzacoratti Md, Carlos P Vio, Oscar Fernando Pavão Dos Santos, Nestor Schor, Dulce Elena Casarin. Mesangial cells are able to produce catecholamines in vitro. Journal of cellular biochemistry. vol 89. issue 1. 2003-10-30. PMID:12682915. |
for this evaluation, the levels of norepinephrine, epinephrine, dopamine, and biopterin, the enzymatic cofactor of tyrosine hydroxylase (th), were analyzed by hplc in the intracellular compartment and in the medium of primary cultured mc. |
2003-10-30 |
2023-08-12 |
Not clear |
| D Stanic, D I Finkelstein, D W Bourke, J Drago, M K Horn. Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat. The European journal of neuroscience. vol 18. issue 5. 2003-10-23. PMID:12956716. |
density of dopamine transporter and tyrosine hydroxylase immunoreactive axonal varicosities (terminals) decreased up to 80% 4 weeks after lesioning but returned to normal by 16 weeks, unless snpc lesions were greater than 75%. |
2003-10-23 |
2023-08-12 |
rat |
| Donald M Kuhn, Timothy J Gedde. Tetrahydrobiopterin prevents nitration of tyrosine hydroxylase by peroxynitrite and nitrogen dioxide. Molecular pharmacology. vol 64. issue 4. 2003-10-16. PMID:14500751. |
tyrosine hydroxylase (th) is the initial and rate-limiting enzyme in the synthesis of the neurotransmitter dopamine. |
2003-10-16 |
2023-08-12 |
Not clear |
| S de Bernardo, S Canals, M J Casarejos, E Rodriguez-Martin, M A Men. Glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways. Journal of neuroscience research. vol 73. issue 6. 2003-10-14. PMID:12949908. |
glia-conditioned medium induces de novo synthesis of tyrosine hydroxylase and increases dopamine cell survival by differential signaling pathways. |
2003-10-14 |
2023-08-12 |
Not clear |
| Hitoshi Matsumoto, Kohjiro Tanaka, Hirofumi Noguchi, Yoichi Hayakaw. Cause of mortality in insects under severe stress. European journal of biochemistry. vol 270. issue 16. 2003-10-06. PMID:12899705. |
injection of 3-iodotyrosine (a tyrosine hydroxylase inhibitor) before mpli completely prevented the increase in hemolymph dopamine in test larvae and their following death. |
2003-10-06 |
2023-08-12 |
Not clear |
| Mona Thiruchelvam, Alison McCormack, Eric K Richfield, Raymond B Baggs, A William Tank, Donato A Di Monte, Deborah A Cory-Slecht. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. The European journal of neuroscience. vol 18. issue 3. 2003-10-03. PMID:12911755. |
increased tyrosine hydroxylase enzyme activity compensated for striatal tyrosine hydroxylase protein and/or dopamine loss following treatment in 6-week-old and 5-month-old, but not 18-month-old paraquat and paraquat + maneb mice. |
2003-10-03 |
2023-08-12 |
mouse |
| H Sershen, A Hashim, C Vadas. Strain and sex differences in repeated ethanol treatment-induced motor activity in quasi-congenic mice. Genes, brain, and behavior. vol 1. issue 3. 2003-09-26. PMID:12884971. |
these rqi strains were derived from mouse lines selectively bred for high activity of mesencephalic tyrosine hydroxylase (th/mes), therefore genetic variation in dopamine system-related behaviours, such as ethanol-induced motor activity, can be expected. |
2003-09-26 |
2023-08-12 |
mouse |
| Anna M S Kindlundh, Jonas Lindblom, Fred Nyber. Chronic administration with nandrolone decanoate induces alterations in the gene-transcript content of dopamine D(1)- and D(2)-receptors in the rat brain. Brain research. vol 979. issue 1-2. 2003-09-25. PMID:12850568. |
the aim of the present study was to investigate if these effects could be attributed to altered mrna content for tyrosine hydroxylase, l-amino acid decarboxylase, dopamine d(1)- and dopamine d(2)-receptor as measured by in situ hybridisation. |
2003-09-25 |
2023-08-12 |
rat |
| Giuseppe Battaglia, Carla L Busceti, Fabrizio Pontarelli, Francesca Biagioni, Francesco Fornai, Antonio Paparelli, Valeria Bruno, Stefano Ruggieri, Ferdinando Nicolett. Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Neuropharmacology. vol 45. issue 2. 2003-09-16. PMID:12842121. |
in control mice, high doses of mptp (20 mg/kg, i.p., injected four times with 2 h of interval) induced a nearly total degeneration of the nigro-striatal pathway, as shown by measurements of striatal dopamine (da) levels and by immunohistochemical analysis of tyrosine hydroxylase, high affinity dopamine transporter, and glial fibrillary acidic protein in the corpus striatum and substantia nigra. |
2003-09-16 |
2023-08-12 |
mouse |