| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George J Yohrling, George C-T Jiang, Molly M DeJohn, David W Miller, Anne B Young, Kent E Vrana, Jang-Ho J Ch. Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology. Brain research. Molecular brain research. vol 119. issue 1. 2004-02-19. PMID:14597227. |
we report that the enzymatic activity of tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine biosynthesis, is decreased in a transgenic mouse model of hd. |
2004-02-19 |
2023-08-12 |
mouse |
| Frédéric Moret, Jean-Claude Guilland, Sophie Coudouel, Luc Rochette, Philippe Vernie. Distribution of tyrosine hydroxylase, dopamine, and serotonin in the central nervous system of amphioxus (Branchiostoma lanceolatum): implications for the evolution of catecholamine systems in vertebrates. The Journal of comparative neurology. vol 468. issue 1. 2004-02-18. PMID:14648696. |
distribution of tyrosine hydroxylase, dopamine, and serotonin in the central nervous system of amphioxus (branchiostoma lanceolatum): implications for the evolution of catecholamine systems in vertebrates. |
2004-02-18 |
2023-08-12 |
Not clear |
| Frédéric Moret, Jean-Claude Guilland, Sophie Coudouel, Luc Rochette, Philippe Vernie. Distribution of tyrosine hydroxylase, dopamine, and serotonin in the central nervous system of amphioxus (Branchiostoma lanceolatum): implications for the evolution of catecholamine systems in vertebrates. The Journal of comparative neurology. vol 468. issue 1. 2004-02-18. PMID:14648696. |
we isolated a gene transcript encoding tyrosine hydroxylase (th), the limiting enzyme of catecholamine biosynthesis, and studied its distribution together with that of dopamine and serotonin. |
2004-02-18 |
2023-08-12 |
Not clear |
| Y Muramatsu, R Kurosaki, H Watanabe, M Michimata, M Matsubara, Y Imai, T Arak. Cerebral alterations in a MPTP-mouse model of Parkinson's disease--an immunocytochemical study. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 10. 2004-02-12. PMID:14523625. |
we investigated the immunohistochemical alterations of neuronal nitric oxide synthase (nnos), endothelial nos (enos), tyrosine hydroxylase (th), microtubule-associated protein 2a,b (map 2), glial fibrillary acidic protein (gfap), parvalbumin (pv), and dopamine transporter (dat) in the striatum and substantia nigra following the application of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in mice. |
2004-02-12 |
2023-08-12 |
mouse |
| Nobuhide Kobori, Jack C Waymire, John W Haycock, Guy L Clifton, Pramod K Das. Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor. The Journal of biological chemistry. vol 279. issue 3. 2004-02-12. PMID:14570886. |
tyrosine hydroxylase (th) is the rate-limiting enzyme for dopamine biosynthesis, and its activity is regulated by phosphorylation on three seryl residues: ser-19, ser-31, and ser-40. |
2004-02-12 |
2023-08-12 |
human |
| Maria Concetta Morale, Pier Andrea Serra, Maria Rosaria Delogu, Rossana Migheli, Gaia Rocchitta, Cataldo Tirolo, Salvo Caniglia, Nuccio Testa, Francesca L'Episcopo, Florinda Gennuso, Giovanna M Scoto, Nicholas Barden, Egidio Miele, Maria Speranza Desole, Bianca Marchett. Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 1. 2004-02-09. PMID:14630699. |
the gr deficiency of tg mice exacerbates mptp-induced toxicity to dopaminergic neurons, as revealed by both severe loss of tyrosine hydroxylase positive nigral neurons and sharp decreases in striatal levels of dopamine and its metabolites. |
2004-02-09 |
2023-08-12 |
mouse |
| Jonathan D Hommel, Robert M Sears, Dan Georgescu, Diana L Simmons, Ralph J DiLeon. Local gene knockdown in the brain using viral-mediated RNA interference. Nature medicine. vol 9. issue 12. 2004-02-05. PMID:14634645. |
here we use viral-mediated rna interference (rnai) to generate a specific knockdown of th, the gene encoding the dopamine synthesis enzyme tyrosine hydroxylase, within midbrain neurons of adult mice. |
2004-02-05 |
2023-08-12 |
mouse |
| Peter Klivenyi, Gabrielle Gardian, Noel Y Calingasan, Lichuan Yang, M Flint Bea. Additive neuroprotective effects of creatine and a cyclooxygenase 2 inhibitor against dopamine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Journal of molecular neuroscience : MN. vol 21. issue 3. 2004-01-29. PMID:14645986. |
both rofecoxib and creatine administered alone protected against striatal dopamine depletions and loss of substantia nigra tyrosine hydroxylase immunoreactive neurons. |
2004-01-29 |
2023-08-12 |
mouse |
| Barbara K Lipska, Daniel N Lerman, Zin Z Khaing, Daniel R Weinberge. The neonatal ventral hippocampal lesion model of schizophrenia: effects on dopamine and GABA mRNA markers in the rat midbrain. The European journal of neuroscience. vol 18. issue 11. 2004-01-29. PMID:14656305. |
we used in situ hybridization histochemistry to assess expression of mrnas for dopamine transporter (dat), tyrosine hydroxylase (th) and glutamate decarboxylase-67 (gad67) in the midbrain of adult rats with neonatal and adult ibotenic acid lesions of the ventral hippocampus. |
2004-01-29 |
2023-08-12 |
human |
| Krzysztof Wasowic. Changes in the expression of tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), galanin (GAL), vasoactive intestinal polypeptide (VIP) and substance P (SP) in the uterine cervix-projecting neurons located in the lumbar paravertebral ganglia of the pig. Folia morphologica. vol 62. issue 3. 2004-01-22. PMID:14507051. |
changes in the expression of tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), galanin (gal), vasoactive intestinal polypeptide (vip) and substance p (sp) in the uterine cervix-projecting neurons located in the lumbar paravertebral ganglia of the pig. |
2004-01-22 |
2023-08-12 |
Not clear |
| Michael J Hurley, Deborah C Mash, Peter Jenne. Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR. The European journal of neuroscience. vol 18. issue 9. 2004-01-16. PMID:14622169. |
dopamine d1-3 receptors, tyrosine hydroxylase and dopamine transporter mrna was detected in the uvula and nodulus (lobules 9 and 10, respectively) of the vermis of cerebellum from normal individuals. |
2004-01-16 |
2023-08-12 |
human |
| Michael J Hurley, Deborah C Mash, Peter Jenne. Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR. The European journal of neuroscience. vol 18. issue 9. 2004-01-16. PMID:14622169. |
in parkinson's disease, the level of dopamine d1 and d3 receptor mrna was significantly reduced in lobule 9 and the level of tyrosine hydroxylase mrna was significantly reduced in lobule 10. |
2004-01-16 |
2023-08-12 |
human |
| Michael J Hurley, Deborah C Mash, Peter Jenne. Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR. The European journal of neuroscience. vol 18. issue 9. 2004-01-16. PMID:14622169. |
the discrete changes in the levels of dopamine d1 and d3 receptors and tyrosine hydroxylase mrna in cerebellum from l-dopa treated parkinson's disease patients suggests that this brain area has a role in the symptoms of parkinson's disease and/or the beneficial/side-effects of treatment. |
2004-01-16 |
2023-08-12 |
human |
| Juan E Ferrario, Marina A Delfino, Andrea V Stefano, Virginia Zbarsky, Aicha Douhou, M Gustavo Murer, Rita Raisman-Vozari, Oscar S Gershani. Effects of orally administered levodopa on mesencephalic dopaminergic neurons undergoing a degenerative process. Neuroscience research. vol 47. issue 4. 2004-01-16. PMID:14630347. |
no significant differences between levodopa or vehicle-treated rats were found in: (i) striatal immunoautoradiographic labeling for tyrosine hydroxylase (th) and the membrane dopamine transporter (dat); (ii) cell counts of th-immunoreactive (th-ir) neurons remaining in the substantia nigra and ventral tegmental area (vta); (iii) surface area of remaining th-immunoreactive neurons in the substantia nigra. |
2004-01-16 |
2023-08-12 |
rat |
| Davide Viggiano, Lucia A Ruocco, Adolfo G Sadil. Dopamine phenotype and behaviour in animal models: in relation to attention deficit hyperactivity disorder. Neuroscience and biobehavioral reviews. vol 27. issue 7. 2004-01-15. PMID:14624807. |
therefore, the behavioural profile of dopamine transporter (dat), tyrosine hydroxylase (th), da and camp-regulated phosphoprotein (darpp 32), and d1, d2, d3, d4 and d5 dopamine receptors knockouts (and their combination) is reviewed.th, d1, d2, d4 ko mice exhibit decreased locomotor activity, perhaps due to decreased motivational level. |
2004-01-15 |
2023-08-12 |
mouse |
| Ferogh A Ahmadi, Daniel A Linseman, Tom N Grammatopoulos, Susan M Jones, Ron J Bouchard, Curt R Freed, Kim A Heidenreich, W Michael Zawad. The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons. Journal of neurochemistry. vol 87. issue 4. 2004-01-14. PMID:14622122. |
after 11 h of exposure to 30 nm rotenone, the number of dopamine neurons identified by tyrosine hydroxylase (th) immunostaining declined rapidly with only 23% of the neurons surviving. |
2004-01-14 |
2023-08-12 |
rat |
| A Vetillard, C Atteke, C Saligaut, P Jego, T Bailhach. Differential regulation of tyrosine hydroxylase and estradiol receptor expression in the rainbow trout brain. Molecular and cellular endocrinology. vol 199. issue 1-2. 2004-01-05. PMID:12581878. |
among the enzymes that regulate dopamine turnover, tyrosine hydroxylase (th), the rate-limiting anabolic enzyme, could be a target for endocrine feedback regulation. |
2004-01-05 |
2023-08-12 |
Not clear |
| Anna S Hui, Justin B Striet, Gary Gudelsky, Galia K Soukhova, Evelyne Gozal, Dana Beitner-Johnson, Shang-Z Guo, Leroy R Sachleben, John W Haycock, David Gozal, Maria F Czyzyk-Krzesk. Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons. Hypertension (Dallas, Tex. : 1979). vol 42. issue 6. 2004-01-05. PMID:14597643. |
expression of tyrosine hydroxylase and its phosphorylated forms, dopamine beta-hydroxylase, phenylethanolamine n-methyltransferase, and gtp cyclohydrolase-1 were determined by western blot analyses. |
2004-01-05 |
2023-08-12 |
rat |
| Masaya Segawa, Yoshiko Nomura, Nobuyoshi Nishiyam. Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease). Annals of neurology. vol 54 Suppl 6. 2003-12-24. PMID:12891652. |
neurohistochemical examination revealed a decrease of the tyrosine hydroxylase protein as well as its activity in the striatum and decrease of dopamine content, particularly in its ventral portion rich in d1 receptors (striatal direct pathways). |
2003-12-24 |
2023-08-12 |
Not clear |
| Georg F Hoffmann, Birgit Assmann, Christa Bräutigam, Carlo Dionisi-Vici, Martin Häussler, Johannes B C de Klerk, Markus Naumann, Gerry C H Steenbergen-Spanjers, Hans-Michael Strassburg, Ron A Wever. Tyrosine hydroxylase deficiency causes progressive encephalopathy and dopa-nonresponsive dystonia. Annals of neurology. vol 54 Suppl 6. 2003-12-24. PMID:12891655. |
tyrosine hydroxylase (th) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine. |
2003-12-24 |
2023-08-12 |
Not clear |