| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janice W Kansy, S Colette Daubner, Akinori Nishi, Naoki Sotogaku, Michael D Lloyd, Chan Nguyen, Lin Lu, John W Haycock, Bruce T Hope, Paul F Fitzpatrick, James A Bib. Identification of tyrosine hydroxylase as a physiological substrate for Cdk5. Journal of neurochemistry. vol 91. issue 2. 2004-11-15. PMID:15447670. |
here we report that cdk5 phosphorylates tyrosine hydroxylase (th), the key enzyme for synthesis of dopamine. |
2004-11-15 |
2023-08-12 |
mouse |
| K P Datla, R D Bennett, V Zbarsky, B Ke, Y-F Liang, T Higa, T Bahorun, O I Aruoma, D T Dexte. The antioxidant drink effective microorganism-X (EM-X) pre-treatment attenuates the loss of nigrostriatal dopaminergic neurons in 6-hydroxydopamine-lesion rat model of Parkinson's disease. The Journal of pharmacy and pharmacology. vol 56. issue 5. 2004-11-09. PMID:15142343. |
of tyrosine hydroxylase positive cells (th+ cells) in the substantia nigra pars compacta (snpc)) and functionality (dopamine and its metabolites dopac and hva content in the striata) of nigrostriatal dopaminergic neurons were assessed. |
2004-11-09 |
2023-08-12 |
rat |
| Evelien Huisman, Harry B M Uylings, Piet V Hooglan. A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 19. issue 6. 2004-10-28. PMID:15197709. |
to determine whether the olfactory dysfunctions, like the motor symptoms, are associated with a loss of dopamine, the number of dopaminergic cells in the olfactory bulb of parkinson's disease patients was studied using tyrosine hydroxylase immunohistochemistry. |
2004-10-28 |
2023-08-12 |
Not clear |
| Charlotte Marican, Line Duportets, Serge Birman, Jean Marc Jallo. Female-specific regulation of cuticular hydrocarbon biosynthesis by dopamine in Drosophila melanogaster. Insect biochemistry and molecular biology. vol 34. issue 8. 2004-10-22. PMID:15262286. |
the role of dopamine (da) is investigated in cuticular hydrocarbon biosynthesis in drosophila melanogaster with three different approaches: use of da-deficient mutants (dopa decarboxylase temperature sensitive mutants reared at restrictive temperature, and rescued by dopamine ingestion or by pale mutants partially rescued by a tyrosine hydroxylase construction), pharmacological treatments (tyrosine hydroxylase inhibitors) and topical application on decapitated flies. |
2004-10-22 |
2023-08-12 |
drosophila_melanogaster |
| Zenon Pidsudk. Distribution and chemical coding of neurons in intramural ganglia of the porcine urinary bladder trigone. Folia histochemica et cytobiologica. vol 42. issue 1. 2004-09-30. PMID:15046394. |
ten-microm-thick cryostat sections were processed for double-labelling immunofluorescence with antibodies against tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), neuropeptide y (npy), somatostatin (som), galanin (gal), vasoactive intestinal polypeptide (vip), nitric oxide synthase (nos), calcitonin gene-related peptide (cgrp), substance p (sp), leu5-enkephalin (lenk) and choline acetyltransferase (chat). |
2004-09-30 |
2023-08-12 |
Not clear |
| Richard J L Anney, Craig A Olsson, Mehrnoush Lotfi-Miri, George C Patton, Robert Williamso. Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. Pharmacogenetics. vol 14. issue 2. 2004-09-30. PMID:15077008. |
dopamine is a key neurotransmitter of the mesolimbic reward pathway in the human brain, and tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine biosynthesis. |
2004-09-30 |
2023-08-12 |
human |
| S Asai, R Ohta, M Shirota, A Tohei, G Watanabe, K Tay. Endocrinological responses during suckling in Hatano high- and low-avoidance rats. The Journal of endocrinology. vol 182. issue 2. 2004-09-20. PMID:15283687. |
since dopamine from the median eminence inhibits prolactin secretion from the lactotrophs of the anterior pituitary, and tuberoinfundibular dopaminergic neurones are partially regulated by the level of circulating prolactin, we evaluated the activity of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis. |
2004-09-20 |
2023-08-12 |
rat |
| Mian Zhou, H Hank Simms, Ping Wan. Increased gut-derived norepinephrine release in sepsis: up-regulation of intestinal tyrosine hydroxylase. Biochimica et biophysica acta. vol 1689. issue 3. 2004-09-16. PMID:15276647. |
although the gut has been demonstrated to be the major source of ne in sepsis, it remains unknown whether the increased ne is associated with up-regulation of intestinal ne biosynthesis enzymes such as tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
2004-09-16 |
2023-08-12 |
rat |
| Beth E Fisher, Giselle M Petzinger, Kerry Nixon, Elizabeth Hogg, Samuel Bremmer, Charles K Meshul, Michael W Jakowe. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. Journal of neuroscience research. vol 77. issue 3. 2004-09-09. PMID:15248294. |
the expression of proteins and genes involved in basal ganglia function including the dopamine transporter (dat), tyrosine hydroxylase (th), and the dopamine d1 and d2 receptors, as well as alterations on glutamate immunolabeling were determined. |
2004-09-09 |
2023-08-12 |
mouse |
| Raquel V Gallara, Salvador L Bellavia, Lidia L Serova, Esther L Sabba. Environmental light conditions alter gene expression of rat catecholamine biosynthetic enzymes and Neuropeptide Y: differential effect in superior cervical ganglia and adrenal gland. Brain research. Molecular brain research. vol 124. issue 2. 2004-08-26. PMID:15135223. |
the results of northern blot analysis show that ll exposure reduces mrna levels for tyrosine hydroxylase (th) the rate limiting catecholamine biosynthetic enzyme and also of dopamine beta-hydroxylase (dbh) as well as for npy in scg to about half the levels in control animals. |
2004-08-26 |
2023-08-12 |
rat |
| Esther L Sabban, Bistra B Nankova, Lidia I Serova, Richard Kvetnansky, Xiaoping Li. Molecular regulation of gene expression of catecholamine biosynthetic enzymes by stress: sympathetic ganglia versus adrenal medulla. Annals of the New York Academy of Sciences. vol 1018. 2004-08-18. PMID:15240392. |
stress induces tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) gene expression in sympathetic ganglia and adrenal medulla (am). |
2004-08-18 |
2023-08-12 |
rat |
| Stephanie C Licata, R Christopher Pierc. Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shell. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158168. |
the present study assessed the activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the nucleus accumbens following either acute or repeated cocaine administration. |
2004-08-17 |
2023-08-12 |
rat |
| Robert E McCullumsmith, Todd L Stincic, Smriti M Agrawal, James H Meador-Woodruf. Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat. European journal of pharmacology. vol 477. issue 2. 2004-08-11. PMID:14519413. |
thus, we treated rats with haloperidol-decanoate for 12 weeks, and assessed the effects of additional treatment with olanzapine, haloperidol, clozapine, or vehicle on vacuous chewing movements and expression of transcripts for dopamine receptors, tyrosine hydroxylase, delta-opioid receptor, prodynorphin, preproenkephalin, glutamic acid decarboxylase-65 (glutamic acid decarboxylase (gad)-65) and gad-67 and n-methyl-d-aspartate (nmda) receptor subunits in the striatum and its efferent pathways. |
2004-08-11 |
2023-08-12 |
rat |
| J S Lonstein, J D Blaustei. Immunocytochemical investigation of nuclear progestin receptor expression within dopaminergic neurones of the female rat brain. Journal of neuroendocrinology. vol 16. issue 6. 2004-08-06. PMID:15189328. |
dual-label immunocytochemistry was used to visualize cells having immunoreactivity (ir) for progestin receptors and tyrosine hydroxylase, a rate-limiting enzyme for dopamine synthesis. |
2004-08-06 |
2023-08-12 |
rat |
| Xuebing Cao, Shenggang Sun, E'tang Ton. Experimental study on heterograft of glomus cells of carotid body for hemiparkinsonian rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 22. issue 2. 2004-07-22. PMID:12658754. |
the striata were cut and examined for dopamine content by hplc and for immunohistochemical staining of tyrosine hydroxylase positive neurons (th+) at the end of the experiments. |
2004-07-22 |
2023-08-12 |
rat |
| Yue Su, Chun-Li Duan, Chun-Li Zhao, Huan-Ying Zhao, Qun-Yuan Xu, Hui Yan. [Expression and assessment of double genes of tyrosine hydroxylase gene and aromatic L-amino acid decarboxylase gene in vitro]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 5. 2004-07-22. PMID:14566408. |
since the expression of tyrosine hydroxylase (th) and aromatic l-amino acid decarboxylase (aadc) in the biosynthetic pathway for dopamine are low, a promising approach to the gene therapy of pd is to augment the gene expression of the enzymes in the biosynthetic pathway for dopamine. |
2004-07-22 |
2023-08-12 |
human |
| Ruth G Perez, Teresa G Hasting. Could a loss of alpha-synuclein function put dopaminergic neurons at risk? Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189334. |
while the function of alpha-synuclein is not entirely elucidated, one function appears to be as a normal regulatory protein that can bind to and inhibit tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2004-07-22 |
2023-08-12 |
Not clear |
| Ruth G Perez, Teresa G Hasting. Could a loss of alpha-synuclein function put dopaminergic neurons at risk? Journal of neurochemistry. vol 89. issue 6. 2004-07-22. PMID:15189334. |
the loss of functional alpha-synuclein may then result in dysregulation of tyrosine hydroxylase, dopamine transport and dopamine storage, resulting in excess cytosolic dopamine. |
2004-07-22 |
2023-08-12 |
Not clear |
| Stefan Lorenzl, Noel Calingasan, Lichuan Yang, David S Albers, Shuei Shugama, Jason Gregorio, H W Krell, Jason Chirichigno, Tong Joh, M Flint Bea. Matrix metalloproteinase-9 is elevated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuromolecular medicine. vol 5. issue 2. 2004-07-20. PMID:15075439. |
treatment with a hydroxamate-based mmp inhibitor, ro 28-2653 significantly reduced dopamine depletion and loss of tyrosine hydroxylase immunoreactive neurons in the substantia nigra pars compacta. |
2004-07-20 |
2023-08-12 |
mouse |
| Moussa B H Youdim, Zaher Arra. Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax. Neuropharmacology. vol 46. issue 8. 2004-07-13. PMID:15111020. |
with the diet containing the highest lithium concentration there was an almost complete prevention of striatal dopamine depletion and the reduction in tyrosine hydroxylase activity and protein and it prevented the increase in dopamine turnover (dopac + hva/da) normally observed in mptp treatment. |
2004-07-13 |
2023-08-12 |
mouse |