| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V C Gomide, G A Silveira, G Chad. Transient and widespread astroglial activation in the brain after a striatal 6-OHDA-induced partial lesion of the nigrostriatal system. The International journal of neuroscience. vol 115. issue 1. 2005-05-02. PMID:15768855. |
immunohistochemistry was employed for visualization of the tyrosine hydroxylase (th), marker for dopamine cells, and glial fibrillary acidic protein (gfap), marker for astrocytes. |
2005-05-02 |
2023-08-12 |
rat |
| Irmgard Paris, Pedro Martinez-Alvarado, Carolina Perez-Pastene, Marcelo N N Vieira, Claudio Olea-Azar, Rita Raisman-Vozari, Sergio Cardenas, Rebeca Graumann, Pablo Caviedes, Juan Segura-Aguila. Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715653. |
the role of dopamine in iron uptake into catecholaminergic neurons, and dopamine oxidation to aminochrome and its one-electron reduction in iron-mediated neurotoxicity, was studied in rcsn-3 cells, which express both tyrosine hydroxylase and monoamine transporters. |
2005-04-28 |
2023-08-12 |
Not clear |
| Mei Sun, Lingxin Kong, Xiaodan Wang, Courtney Holmes, Qingsheng Gao, Guo-Rong Zhang, Josef Pfeilschifter, David S Goldstein, Alfred I Gelle. Coexpression of tyrosine hydroxylase, GTP cyclohydrolase I, aromatic amino acid decarboxylase, and vesicular monoamine transporter 2 from a helper virus-free herpes simplex virus type 1 vector supports high-level, long-term biochemical and behavioral correction of a rat model of Parkinson's disease. Human gene therapy. vol 15. issue 12. 2005-04-21. PMID:15684695. |
the central hypothesis of this study is that coexpression of four dopamine biosynthetic and transporter genes in striatal neurons can support the efficient production and regulated, vesicular release of dopamine: tyrosine hydroxylase (th) converts tyrosine to l-3,4-dihydroxyphenylalanine (l-dopa), gtp cyclohydrolase i (gtp ch i) is the rate-limiting enzyme in the biosynthesis of the cofactor for th, aromatic amino acid decarboxylase (aadc) converts l-dopa to dopamine, and a vesicular monoamine transporter (vmat-2) transports dopamine into synaptic vesicles, thereby supporting regulated, vesicular release of dopamine and relieving feedback inhibition of th by dopamine. |
2005-04-21 |
2023-08-12 |
rat |
| M J Porritt, P E Batchelor, D W Howell. Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Experimental neurology. vol 192. issue 1. 2005-04-14. PMID:15698637. |
40% of substantia nigra pars compacta tyrosine hydroxylase immunoreactive neurons are lost (p < or = 0.00001) and dopamine uptake site density measured by (3)h-mazindol autoradiography is reduced by 34% (p < or = 0.005). |
2005-04-14 |
2023-08-12 |
rat |
| Philip Seeman, David Weinshenker, Remi Quirion, Lalit K Srivastava, Sanjeev K Bhardwaj, David K Grandy, Richard T Premont, Tatyana D Sotnikova, Patricia Boksa, Mufida El-Ghundi, Brian F O'dowd, Susan R George, Melissa L Perreault, Pekka T Männistö, Siobhan Robinson, Richard D Palmiter, Teresa Talleric. Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 9. 2005-04-13. PMID:15716360. |
dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of dbh (dopamine beta-hydroxylase), drd4 receptors, gprk6 (g protein-coupled receptor kinase 6), comt (catechol-o-methyltransferase), or th-/-, dbhth/+ (tyrosine hydroxylase), and in rats born by cesarean-section. |
2005-04-13 |
2023-08-12 |
rat |
| N Leclere, N Andreeva, J Fuchs, T Kietzmann, J Gros. Hypoxia-induced long-term increase of dopamine and tyrosine hydroxylase mRNA levels. Prague medical report. vol 105. issue 3. 2005-04-11. PMID:15782555. |
hypoxia-induced long-term increase of dopamine and tyrosine hydroxylase mrna levels. |
2005-04-11 |
2023-08-12 |
rat |
| N Leclere, N Andreeva, J Fuchs, T Kietzmann, J Gros. Hypoxia-induced long-term increase of dopamine and tyrosine hydroxylase mRNA levels. Prague medical report. vol 105. issue 3. 2005-04-11. PMID:15782555. |
the aim of the present study was to determine hypoxia-induced changes in the long-term expression of tyrosine hydroxylase (th) mrna and the steady-state dopamine (da) levels in rat mesencephalic cell cultures. |
2005-04-11 |
2023-08-12 |
rat |
| Sachiko Saino-Saito, Hayato Sasaki, Bruce T Volpe, Kazuto Kobayashi, Roseann Berlin, Harriet Bake. Differentiation of the dopaminergic phenotype in the olfactory system of neonatal and adult mice. The Journal of comparative neurology. vol 479. issue 4. 2005-04-08. PMID:15514978. |
to visualize spatiotemporal aspects of periglomerular dopamine (da) neuron differentiation, two independently derived transgenic mouse lines were analyzed with a 9-kb tyrosine hydroxylase (th) promoter to drive either a lacz or an enhanced green fluorescent protein (egfp) reporter gene. |
2005-04-08 |
2023-08-12 |
mouse |
| V I Mel'nikov, A V Lavrent'eva, V S Kudrin, K S Raevskiĭ, M V Ugriumo. [Dopamine synthesis by non-dopaminergic neurons of the rat fetus arquate nucleus]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 7. 2005-04-01. PMID:15462205. |
according to the hypothesis, l-dihydroxyphenylalanine (l-dopa) synthesised in tyrosine hydroxylase(th)-expressing neurons for conversion to dopamine. |
2005-04-01 |
2023-08-12 |
rat |
| Vincent Joseph, Aida Baira. Differential regulation of short and long dopamine D2 receptor mRNA levels by hypoxia in the adrenals of 1-day-old and adult rabbits. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519682. |
we tested the hypothesis that hypoxic exposure exerts distinct modulation on the mrna level of the short and long isoform of the d2 dopamine (da) receptor (d(2)r) and on tyrosine hydroxylase (th) in the adrenals and superior cervical ganglion (scg) of 1-day-old and adult rabbits. |
2005-03-30 |
2023-08-12 |
Not clear |
| Thomas Carlsson, Christian Winkler, Corinna Burger, Nicholas Muzyczka, Ronald J Mandel, Angela Cenci, Anders Björklund, Deniz Kiri. Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain : a journal of neurology. vol 128. issue Pt 3. 2005-03-28. PMID:15659429. |
in this study we used 33 rats with severe nigrostriatal dopamine depletion and showed that in vivo gene transfer of the da-synthetic enzymes tyrosine hydroxylase (th) and gtp cyclohydrolase 1 (gch1) using recombinant adeno-associated virus vectors can provide a constant source of dopa production locally in the striatum, at a level that is effective in reducing l-dopa-induced dyskinesias by >85%, and reverse lesion-induced motor impairments. |
2005-03-28 |
2023-08-12 |
rat |
| Yasuhide Mitsumoto, Atsushi Mori, Satoshi Ohashi, Masami Nakai, Tetsuji Moriizum. Differential effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the olfactory bulb and the striatum in mice. Neuroscience research. vol 51. issue 1. 2005-03-21. PMID:15596247. |
while a small reduction of tyrosine hydroxylase protein level was observed in the ob of mptp-treated mice, dopamine transporter (dat) was undetectable at the protein level in this region. |
2005-03-21 |
2023-08-12 |
mouse |
| Bin Liu, Jun Xia Xie, Dewi Kenneth Rowlands, Yu Lin Gou, Ching Cheong Leung, Yiu Wa Chung, Hsiao Chang Cha. Neuroprotective effects of Bak Foong Pill in 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease model mice. Biological & pharmaceutical bulletin. vol 27. issue 8. 2005-03-18. PMID:15305030. |
in the present study, we compared the effects of bak foong pill (bfp), a well-known gynaecological tonic in china, and 17beta-estradiol, on dopamine transporter (dat) and tyrosine hydroxylase (th) gene expression patterns in ovariectomized, 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (mptp)-induced parkinson's disease (pd) model mice, using multiplex reverse transcription-polymerase chain reaction (rt-pcr). |
2005-03-18 |
2023-08-12 |
mouse |
| Sabine Lemoine, Danièle Leroy, Maryvonne Warembour. Progesterone receptor and dopamine synthesizing enzymes in hypothalamic neurons of the guinea pig: an immunohistochemical triple-label analysis. Journal of chemical neuroanatomy. vol 29. issue 1. 2005-03-10. PMID:15589698. |
interactions among gonadal steroid hormones and the dopamine synthesizing enzymes, tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc), participate in hypothalamic functions. |
2005-03-10 |
2023-08-12 |
Not clear |
| Martine C J van der Elst, Michel M M Verheij, Eric W Roubos, Bart A Ellenbroek, Jan G Veening, Alexander R Cool. A single exposure to novelty differentially affects the accumbal dopaminergic system of apomorphine-susceptible and apomorphine-unsusceptible rats. Life sciences. vol 76. issue 12. 2005-03-08. PMID:15670618. |
in this study we have used microdialysis to measure extracellular concentrations of dopamine in vivo and immunocytochemistry for the enzyme tyrosine hydroxylase to assess the effect of a single exposure to novelty on the neurochemistry of the nucleus acc umbens in apomorphine-susceptible and apomorphine-unsusceptible rats. |
2005-03-08 |
2023-08-12 |
rat |
| Yasushi Kitaoka, Toshio Kuma. Modulation of retinal dopaminergic cells by nitric oxide. A protective effect on NMDA-induced retinal injury. In vivo (Athens, Greece). vol 18. issue 3. 2005-03-07. PMID:15341186. |
retinal dopaminergic cells can be detected by the immunohistochemical staining of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis. |
2005-03-07 |
2023-08-12 |
Not clear |
| Shu-Peng Li, Moon Seok Park, Jong Hun Kim, Myeong Ok Ki. Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the gamma-aminobutyric acid type B receptor expression of the rat prefrontal cortex. Journal of neuroscience research. vol 78. issue 6. 2005-03-07. PMID:15521060. |
to explore further the relationship between the mesencephalic dopaminergic neurons and pfc gabaergic neurons, we investigated the effects of nicotine and passive exposure to cigarette smoke on the regulation of tyrosine hydroxylase (th) in vta and substantia nigra (snc) and dopamine (da) d1 receptor levels in nucleus accumbens (nac) and caudate-putamen (cpu). |
2005-03-07 |
2023-08-12 |
rat |
| Sheila M Fleming, Yvon Delville, Timothy Schaller. An intermittent, controlled-rate, slow progressive degeneration model of Parkinson's disease: antiparkinson effects of Sinemet and protective effects of methylphenidate. Behavioural brain research. vol 156. issue 2. 2005-03-07. PMID:15582106. |
an immunocytochemical assay for tyrosine hydroxylase, a dopamine cell marker, revealed a partial loss of immunoreactive cells in the substantia nigra. |
2005-03-07 |
2023-08-12 |
Not clear |
| Bernard Le Foll, Jorge Diaz, Pierre Sokolof. Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice. Life sciences. vol 76. issue 11. 2005-03-07. PMID:15642598. |
d3r-deficient mice displayed other neuroadaptive changes, including decreased tyrosine hydroxylase, increased dopamine transporter mrnas and increased dopamine reuptake in striatum. |
2005-03-07 |
2023-08-12 |
mouse |
| Bernard Le Foll, Jorge Diaz, Pierre Sokolof. Neuroadaptations to hyperdopaminergia in dopamine D3 receptor-deficient mice. Life sciences. vol 76. issue 11. 2005-03-07. PMID:15642598. |
these results support a distinct role for d2r and d3r as autoreceptors: the d2r is the release-regulating and firing rate-regulating autoreceptor, whereas the d3r may control basal dopamine levels in the striatum, by an unknown mechanism, which does not involve regulation of dopamine transporters or tyrosine hydroxylase. |
2005-03-07 |
2023-08-12 |
mouse |