| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Don M Gash, Zhiming Zhang, Yi Ai, Richard Grondin, Robert Coffey, Greg A Gerhard. Trophic factor distribution predicts functional recovery in parkinsonian monkeys. Annals of neurology. vol 58. issue 2. 2005-10-31. PMID:16049934. |
significant increases were evident in the number of midbrain dopamine neurons immunopositive for tyrosine hydroxylase in both the substantia nigra and ventral tegmental area. |
2005-10-31 |
2023-08-12 |
monkey |
| Shengming Yin, Zhuo Guan, Yiyuan Tang, Jie Zhao, Jaushyong Hong, Wanqin Zhan. Abnormal expression of epilepsy-related gene ERG1/NSF in the spontaneous recurrent seizure rats with spatial learning memory deficits induced by kainic acid. Brain research. vol 1053. issue 1-2. 2005-10-27. PMID:16039622. |
moreover, in situ hybridization and immunohistochemistry showed that both erg1/nsf mrna and nsf immunoreactive expression were down-regulated in the ca1 and dorsal dentate gyrus cells (ddgcs) of the hippocampus, and interestingly, tyrosine hydroxylase (th) immunoreactive dopamine (da) neurons were lost in ventral tegmental area (vta) in the ka rats with srs. |
2005-10-27 |
2023-08-12 |
rat |
| Rocío M De Pablos, Antonio J Herrera, Ruth F Villarán, Josefina Cano, Alberto Machad. Dopamine-dependent neurotoxicity of lipopolysaccharide in substantia nigra. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 3. 2005-10-25. PMID:15625078. |
to test the involvement of dopamine (da) in this degeneration induced by lps, we treated albino wistar rats with different concentrations of alpha-methyl-p-tyrosine (alpha-mpt), an inhibitor of tyrosine hydroxylase (th) activity. |
2005-10-25 |
2023-08-12 |
rat |
| Judy P Q Zhu, Wenjing Xu, Jesus A Angul. Disparity in the temporal appearance of methamphetamine-induced apoptosis and depletion of dopamine terminal markers in the striatum of mice. Brain research. vol 1049. issue 2. 2005-10-19. PMID:16043139. |
exposure to meth induces long-term depletions of dopamine (da) terminal markers such as tyrosine hydroxylase (th) and da transporters (dat). |
2005-10-19 |
2023-08-12 |
mouse |
| A Serrano, J Menéndez, M J Casarejos, R M Solano, E Gallego, M Sánchez, M A Mena, J García de Yebene. Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice. Neuropharmacology. vol 49. issue 2. 2005-10-06. PMID:15993444. |
pk-ko mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. |
2005-10-06 |
2023-08-12 |
mouse |
| Yuen-Sum Lau, Lesya Novikova, Christina Roel. MPTP treatment in mice does not transmit and cause Parkinsonian neurotoxicity in non-treated cagemates through close contact. Neuroscience research. vol 52. issue 4. 2005-09-30. PMID:15936837. |
we detected a significant number of tunel-positive cells, loss of tyrosine hydroxylase immunoreactivity in the substantia nigra, and depletion of dopamine in the striatum of mptp-treated mice. |
2005-09-30 |
2023-08-12 |
mouse |
| Yong-Kyu Lee, Sung-Woo Park, Young-Kyung Kim, Dai-Jin Kim, Jaeseung Jeong, Hugh Myrick, Young-Hoon Ki. Effects of naltrexone on the ethanol-induced changes in the rat central dopaminergic system. Alcohol and alcoholism (Oxford, Oxfordshire). vol 40. issue 4. 2005-09-23. PMID:15897221. |
we assessed mrna levels of tyrosine hydroxylase (th), a major regulatory enzyme in the dopamine synthesis and levels of dopamine and its metabolites after chronic ethanol administration with and without concomitant naltrexone. |
2005-09-23 |
2023-08-12 |
rat |
| Mahdieh Sadidi, Timothy J Geddes, Donald M Kuh. S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione. Antioxidants & redox signaling. vol 7. issue 7-8. 2005-09-23. PMID:15998241. |
tyrosine hydroxylase (th) is the initial and rate-limiting enzyme in the biosynthesis of the neurotransmitter dopamine. |
2005-09-23 |
2023-08-12 |
Not clear |
| Heh-In Im, Wan Seok Joo, Eunjoo Nam, Eun-Sun Lee, Yu-Jin Hwang, Yong Sik Ki. Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice. Journal of pharmacological sciences. vol 98. issue 2. 2005-09-22. PMID:15942123. |
rotarod performance was assessed, tyrosine hydroxylase (th) western blotting was performed, and dopamine (da) levels and peroxidation were determined. |
2005-09-22 |
2023-08-12 |
mouse |
| Wendi S Neckameyer, Joshua S Weinstei. Stress affects dopaminergic signaling pathways in Drosophila melanogaster. Stress (Amsterdam, Netherlands). vol 8. issue 2. 2005-09-22. PMID:16019603. |
the stress paradigms also resulted in alterations in the activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine biosynthesis. |
2005-09-22 |
2023-08-12 |
drosophila_melanogaster |
| Guohua Jin, Xuefeng Tan, Meilin Tian, Jianbing Qin, Huixia Zhu, Zhen Huang, Huijun X. The controlled differentiation of human neural stem cells into TH-immunoreactive (ir) neurons in vitro. Neuroscience letters. vol 386. issue 2. 2005-09-22. PMID:16046065. |
the immunoreactivity to tyrosine hydroxylase (th), a distinctive marker for dopamine neurons was used to assess dopaminergic neuronal phenotype. |
2005-09-22 |
2023-08-12 |
human |
| Laura Mantoan, Nadia Stefanova, Karl E Egger, Kurt A Jellinger, Werner Poewe, Gregor K Wennin. Failure of caspase inhibition in the double-lesion rat model of striatonigral degeneration (multiple system atrophy). Acta neuropathologica. vol 109. issue 2. 2005-09-21. PMID:15549330. |
immunohistochemistry was performed with tyrosine hydroxylase, dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein and glial fibrillary acidic protein antibodies. |
2005-09-21 |
2023-08-12 |
rat |
| Yu Mi Kim, Mi Na Kim, Jae Joon Lee, Myung Koo Le. Inhibition of dopamine biosynthesis by tetrahydropapaveroline. Neuroscience letters. vol 386. issue 1. 2005-09-16. PMID:16026929. |
in this study, the inhibitory effects of thp on dopamine biosynthesis in pc12 cells and tyrosine hydroxylase (th) activity in bovine adrenal were investigated. |
2005-09-16 |
2023-08-12 |
cattle |
| Elisaveta Milusheva, Mária Baranyi, Agnes Kittel, Beáta Sperlágh, E Sylvester Viz. Increased sensitivity of striatal dopamine release to H2O2 upon chronic rotenone treatment. Free radical biology & medicine. vol 39. issue 1. 2005-08-31. PMID:15925285. |
the dopamine content in the rat striatum is decreased simultaneously with the progressive loss of tyrosine hydroxylase (th) immunoreactivity in response to chronic intravenous rotenone infusion. |
2005-08-31 |
2023-08-12 |
rat |
| P Mohapel, H Frielingsdorf, J Häggblad, O Zachrisson, P Brundi. Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions. Neuroscience. vol 132. issue 3. 2005-08-30. PMID:15837137. |
both in the striatum and in the substantia nigra there were no indications of any newly born cells differentiating into dopaminergic neurons following growth factor treatment, such that brdu-labeled cells never co-expressed tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2005-08-30 |
2023-08-12 |
rat |
| Bret A Morrow, D Eugene Redmond, Robert H Roth, John D Elswort. Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey. The Journal of comparative neurology. vol 488. issue 2. 2005-08-30. PMID:15924344. |
eleven fetal african green monkey midbrains were immunostained for tyrosine hydroxylase (th-ir) as a marker for dopamine neurons and quantified using stereological techniques (nucleator method). |
2005-08-30 |
2023-08-12 |
monkey |
| B Jakobsen, J B Gramsbergen, A Møller Dall, C Rosenblad, J Zimme. Characterization of organotypic ventral mesencephalic cultures from embryonic mice and protection against MPP toxicity by GDNF. The European journal of neuroscience. vol 21. issue 11. 2005-08-24. PMID:15978005. |
in one-week-old cultures (5 microm mpp(+), 2 days) gdnf provided potent neuroprotection with dopamine contents reaching control levels and number of tyrosine hydroxylase (th)(+) cells up to 80% of control, but in three-week-old cultures (10 microm mpp(+), 2 days) the protective potential of gdnf was markedly reduced. |
2005-08-24 |
2023-08-12 |
mouse |
| M Y Ryu, M A Lee, Y H Ahn, K S Kim, S H Yoon, E Y Snyder, K G Cho, S U Ki. Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian rats. Cell transplantation. vol 14. issue 4. 2005-08-17. PMID:15929554. |
to examine if genetically modified nscs are a suitable source for the cell and gene therapy of pd, an immortalized mouse nsc line, c17.2, was transduced with tyrosine hydroxylase (th) gene and with gtp cyclohydrolase 1 (gtpch1) gene, which are important enzymes in dopamine biosynthesis. |
2005-08-17 |
2023-08-12 |
mouse |
| Colleen A McClung, Kyriaki Sidiropoulou, Martha Vitaterna, Joseph S Takahashi, Francis J White, Donald C Cooper, Eric J Nestle. Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 26. 2005-08-11. PMID:15967985. |
these phenotypes are associated with increased expression and phosphorylation of tyrosine hydroxylase (the rate-limiting enzyme in dopamine synthesis), as well as changes in several genes known to regulate dopamine activity in the ventral tegmental area. |
2005-08-11 |
2023-08-12 |
mouse |
| Elena H Chartoff, Carrie L Heusner, Richard D Palmite. Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 7. 2005-08-09. PMID:15688082. |
we used dopamine-deficient (dd) mice in which tyrosine hydroxylase is selectively inactivated in dopaminergic neurons to determine whether dopamine is required for the locomotor and molecular effects of pcp and mk-801. |
2005-08-09 |
2023-08-12 |
mouse |