| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Norton H Neff, Trina A Wemlinger, Anne-Marie Duchemin, Maria Hadjiconstantino. Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16415089. |
chronically administered clozapine increased aaad activity and protein and dopamine metabolism in striatum without affecting tyrosine hydroxylase. |
2006-06-09 |
2023-08-12 |
mouse |
| Motoki Inaji, Takahito Yoshizaki, Takashi Okauchi, Jun Maeda, Yuji Nagai, Tadashi Nariai, Kikuo Ohno, Kiyoshi Ando, Hideyuki Okano, Shigeru Obayashi, Tetsuya Suhar. In vivo PET measurements with [11C]PE2I to evaluate fetal mesencephalic transplantations to unilateral 6-OHDA-lesioned rats. Cell transplantation. vol 14. issue 9. 2006-06-07. PMID:16405076. |
rotation behavior tests, in vitro autoradiography, measurements of da contents in the striatum by high-performance liquid chromatography (hplc), and tyrosine hydroxylase (th) immunohistological examinations were performed at the same time points and examined for their relationship to changes in the dopamine transporter. |
2006-06-07 |
2023-08-12 |
rat |
| H Yamaguchi, K Kajitani, Y Dan, M Furuichi, M Ohno, K Sakumi, D Kang, Y Nakabepp. MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Cell death and differentiation. vol 13. issue 4. 2006-06-05. PMID:16273081. |
in the present study, we found that levels of 8-oxog in cellular dna and rna increased in the mouse nigrostriatal system during the tyrosine hydroxylase (th)-positive dopamine neuron loss induced by the administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2006-06-05 |
2023-08-12 |
mouse |
| Kohei Kuribayashi, Yasushi Kitaoka, Toshio Kumai, Yasunari Munemasa, Yuka Kitaoka, Kazuyuki Isenoumi, Masamitsu Motoki, Jiro Kogo, Yasuhiro Hayashi, Shinichi Kobayashi, Satoki Uen. Neuroprotective effect of atrial natriuretic peptide against NMDA-induced neurotoxicity in the rat retina. Brain research. vol 1071. issue 1. 2006-06-05. PMID:16443199. |
it has also been reported that anp increases tyrosine hydroxylase (th) mrna levels and intracellular dopamine levels in pc12 cells. |
2006-06-05 |
2023-08-12 |
rat |
| Hyun Jin Choi, So Yeon Lee, Yuri Cho, Haja No, Seong Who Kim, Onyou Hwan. Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: implications for Parkinson's disease. Neurochemistry international. vol 48. issue 4. 2006-05-26. PMID:16343695. |
we have previously suggested tetrahydrobiopterin (bh4), an obligatory cofactor for the dopamine synthesis enzyme tyrosine hydroxylase and present selectively in monoaminergic neurons in the brain, as an endogenous molecule that contributes to the dopaminergic neurodegeneration. |
2006-05-26 |
2023-08-12 |
Not clear |
| Giselle M Petzinger, Beth Fisher, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Kerry Nixon, Michael W Jakowe. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16385585. |
behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. |
2006-05-25 |
2023-08-12 |
monkey |
| Giselle M Petzinger, Beth Fisher, Elizabeth Hogg, Avery Abernathy, Pablo Arevalo, Kerry Nixon, Michael W Jakowe. Behavioral motor recovery in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned squirrel monkey (Saimiri sciureus): changes in striatal dopamine and expression of tyrosine hydroxylase and dopamine transporter proteins. Journal of neuroscience research. vol 83. issue 2. 2006-05-25. PMID:16385585. |
brain tissue was harvested at 6 weeks or 9 months after the last injection and analyzed for dopamine and its metabolites by high performance liquid chromatography (hplc), and by immunohistochemical staining and western immunoblotting for the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and dopamine- and camp-responsive protein phosphatase of 32 kda (darpp-32), an effector molecule enriched in striatal medium spiny neurons. |
2006-05-25 |
2023-08-12 |
monkey |
| Paul E A Glaser, Stewart P Surgener, Richard Grondin, C R Gash, Mike Palmer, F Xavier Castellanos, Greg A Gerhard. Cerebellar neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in the cerebellar vermis? Journal of neuroscience methods. vol 151. issue 1. 2006-05-25. PMID:16451810. |
there is no well-characterized dopaminergic pathway that projects to the posterior-inferior cerebellar vermis, although the dopamine transporter (dat) and tyrosine hydroxylase (th) have been localized in the posterior-inferior vermis in the non-human primate by immunohistochemistry. |
2006-05-25 |
2023-08-12 |
human |
| Dimitra Mangoura, Spyros Theofilopoulos, Sophia Karouzaki, Emmanouella Tsirimonak. 12-O-tetradecanoyl-phorbol-13-acetate-dependent up-regulation of dopaminergic gene expression requires Ras and neurofibromin in human IMR-32 neuroblastoma. Journal of neurochemistry. vol 97 Suppl 1. 2006-05-23. PMID:16635257. |
gene expression of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, is known to be regulated by receptors that act through protein kinase c (pkc) or ras signalling. |
2006-05-23 |
2023-08-12 |
human |
| Sung Yul Kim, Kyou Chan Choi, Min Seok Chang, Myoung Hwan Kim, Sa Yong Kim, Young-Soon Na, Jong Eun Lee, Byung Kwan Jin, Bong-Hee Lee, Ja-Hyun Bai. The dopamine D2 receptor regulates the development of dopaminergic neurons via extracellular signal-regulated kinase and Nurr1 activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 17. 2006-05-23. PMID:16641236. |
in mice lacking the dopamine d2 receptor (d2r-/-), stereological cell counting analysis showed that the number of mesencephalic tyrosine hydroxylase (th) cells was significantly low during ontogeny, compared with that observed in wild-type (wt) mice, thereby indicating an alteration in dopaminergic neuronal development in the absence of d2r. |
2006-05-23 |
2023-08-12 |
mouse |
| Keiko Koga, Atsushi Mori, Satoshi Ohashi, Naoki Kurihara, Hisashi Kitagawa, Makoto Ishikawa, Yasuhide Mitsumoto, Masami Naka. H MRS identifies lactate rise in the striatum of MPTP-treated C57BL/6 mice. The European journal of neuroscience. vol 23. issue 4. 2006-05-09. PMID:16519673. |
neurochemical and western blot analyses revealed that dopamine contents and protein levels of tyrosine hydroxylase and dopamine transporter in the striatum were profoundly decreased at 3 days after mptp treatment. |
2006-05-09 |
2023-08-12 |
mouse |
| A Rivera, L F Agnati, T L Horvath, J J Valderrama, A de La Calle, K Fux. Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: relevance for volume transmission. Neuroscience. vol 137. issue 4. 2006-05-02. PMID:16387447. |
in particular, the relationships of tyrosine hydroxylase, dopamine beta-hydroxylase and uncoupling protein 2/3 immunoreactivity were assessed by double immunolabeling and confocal laser microscopy analysis associated with computer-assisted image analysis. |
2006-05-02 |
2023-08-12 |
rat |
| D S Kim, R D Palmiter, A Cummins, C R Gerfe. Reversal of supersensitive striatal dopamine D1 receptor signaling and extracellular signal-regulated kinase activity in dopamine-deficient mice. Neuroscience. vol 137. issue 4. 2006-05-02. PMID:16388913. |
dopamine-deficient mice, in which the tyrosine hydroxylase gene is specifically inactivated in dopaminergic neurons, were used to investigate dopamine d1-receptor-mediated activation of extracellular signal-regulated kinase. |
2006-05-02 |
2023-08-12 |
mouse |
| George K Tofaris, Pablo Garcia Reitböck, Trevor Humby, Sarah L Lambourne, Mark O'Connell, Bernardino Ghetti, Helen Gossage, Piers C Emson, Lawrence S Wilkinson, Michel Goedert, Maria Grazia Spillantin. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 15. 2006-05-02. PMID:16611810. |
here, we show that the expression of truncated human alpha-synuclein(1-120), driven by the rat tyrosine hydroxylase promoter on a mouse alpha-synuclein null background, leads to the formation of pathological inclusions in the substantia nigra and olfactory bulb and to a reduction in striatal dopamine levels. |
2006-05-02 |
2023-08-12 |
mouse |
| M B Arciszewski, K Wasowlc. Noradrenergic and cholinergic innervation of the accessory sexual glands in male sheep. Acta veterinaria Hungarica. vol 54. issue 1. 2006-05-01. PMID:16613028. |
immunohistochemistry was applied to determine the distribution patterns of nerve fibres containing tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah), neuropeptide y (npy), vasoactive intestinal peptide (vip) and vesicular acetylcholine transporter (vacht) in the prostate, seminal vesicle (sv) and bulbourethral glands (bu) of male sheep. |
2006-05-01 |
2023-08-12 |
Not clear |
| Hyerhan Jeong, Mi-Soo Kim, Jungsun Kwon, Kwang-Soo Kim, Wongi Seo. Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor. Neuroscience letters. vol 396. issue 1. 2006-04-28. PMID:16356647. |
to investigate the possibility that these two factors are functionally interrelated, we investigated the potential role of the androgen receptor (ar) on transcriptional activity of the tyrosine hydroxylase (th) gene that encodes the rate-limiting enzyme of the dopamine biosynthesis pathway. |
2006-04-28 |
2023-08-12 |
Not clear |
| Sarah W Lansing, Joseph S Lonstei. Tyrosine hydroxylase-synthesizing cells in the hypothalamus of prairie voles (Microtus ochrogaster): sex differences in the anteroventral periventricular preoptic area and effects of adult gonadectomy or neonatal gonadal hormones. Journal of neurobiology. vol 66. issue 3. 2006-04-21. PMID:16329116. |
the vertebrate hypothalamus and surrounding region contain a large population of cells expressing tyrosine hydroxylase (th), the rate limiting enzyme for synthesis of dopamine and other catecholamines. |
2006-04-21 |
2023-08-12 |
human |
| Robert E Drolet, Bahareh Behrouz, Keith J Lookingland, John L Goudrea. Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412098. |
substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein. |
2006-04-06 |
2023-08-12 |
mouse |
| Robert E Drolet, Bahareh Behrouz, Keith J Lookingland, John L Goudrea. Substrate-mediated enhancement of phosphorylated tyrosine hydroxylase in nigrostriatal dopamine neurons: evidence for a role of alpha-synuclein. Journal of neurochemistry. vol 96. issue 4. 2006-04-06. PMID:16412098. |
tyrosine hydroxylase (th) protein, phosphorylated at serine-40, serine-31 and serine-19, and enzyme catalytic activity were compared under basal conditions and in activated nigrostriatal dopamine (nsda) neurons of wild-type and homozygous alpha-synuclein knockout mice. |
2006-04-06 |
2023-08-12 |
mouse |
| Jonas Lindblom, Andreas Johansson, Andreas Holmgren, Elisabeth Grandin, Carina Nedergård, Robert Fredriksson, Helgi B Schiöt. Increased mRNA levels of tyrosine hydroxylase and dopamine transporter in the VTA of male rats after chronic food restriction. The European journal of neuroscience. vol 23. issue 1. 2006-04-06. PMID:16420427. |
increased mrna levels of tyrosine hydroxylase and dopamine transporter in the vta of male rats after chronic food restriction. |
2006-04-06 |
2023-08-12 |
rat |