| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip Seeman, Johannes Schwarz, Jiang-Fan Chen, Henry Szechtman, Melissa Perreault, G Stanley McKnight, John C Roder, Rémi Quirion, Patricia Boksa, Lalit K Srivastava, Kazuhiko Yanai, David Weinshenker, Tomiki Sumiyosh. Psychosis pathways converge via D2high dopamine receptors. Synapse (New York, N.Y.). vol 60. issue 4. 2006-09-20. PMID:16786561. |
mice born with gene knockouts of some possible schizophrenia susceptibility genes are dopamine supersensitive, and their striata reveal markedly elevated d2high states; suchgenes include dopamine-beta-hydroxylase, dopamine d4 receptors, g protein receptor kinase 6, tyrosine hydroxylase, catechol-o-methyltransferase, the trace amine-1 receptor, regulator of g protein signaling rgs9, and the riibeta form of camp-dependent protein kinase (pka). |
2006-09-20 |
2023-08-12 |
mouse |
| Laura Ezquerra, Gonzalo Herradon, Trang Nguyen, Inmaculada Silos-Santiago, Thomas F Deue. Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Life sciences. vol 79. issue 11. 2006-09-19. PMID:16643958. |
to discover regulatory pathways dependent on midkine (mk the gene, mk the protein) signaling, we compared the transcriptional profiles of aortae obtained from mk -/- and wild type (wt, +/+) mice; the comparison demonstrated an extraordinary high level expression of tyrosine hydroxylase (12-fold), the rate-limiting enzyme in catecholamine biosynthesis, dopa decarboxylase (73-fold), and dopamine beta-hydroxylase (75-fold) in aortae of mk -/- mice compared with aortae of wt (+/+) mice. |
2006-09-19 |
2023-08-12 |
mouse |
| Laura Ezquerra, Gonzalo Herradon, Trang Nguyen, Inmaculada Silos-Santiago, Thomas F Deue. Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Life sciences. vol 79. issue 11. 2006-09-19. PMID:16643958. |
the protein levels of tyrosine hydroxylase, dopa decarboxylase and dopamine beta-hydroxylase confirmed the analysis of the transcriptional profiles. |
2006-09-19 |
2023-08-12 |
mouse |
| Laura Ezquerra, Gonzalo Herradon, Trang Nguyen, Inmaculada Silos-Santiago, Thomas F Deue. Midkine is a potent regulator of the catecholamine biosynthesis pathway in mouse aorta. Life sciences. vol 79. issue 11. 2006-09-19. PMID:16643958. |
the remarkable increases in levels of expression of tyrosine hydroxylase, dopa decarboxylase and dopamine beta-hydroxylase suggest that mk together with ptn are very important regulators of the catecholamine pathway in mouse aorta and may critically regulate catecholamine biosynthesis and function in inflammatory and the other pathological conditions in which mk or ptn are upregulated. |
2006-09-19 |
2023-08-12 |
mouse |
| José Antonio Fuentealba, Katia Gysling, Karin Magendzo, María Estela André. Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens. Journal of neuroscience research. vol 84. issue 2. 2006-09-19. PMID:16676328. |
preexposure to u-69593 did not alter the expression of tyrosine hydroxylase or dopamine transporter in the ventral tegmental area. |
2006-09-19 |
2023-08-12 |
rat |
| Marina V Chuenkova, Mercio Pereiraperri. Enhancement of tyrosine hydroxylase expression and activity by Trypanosoma cruzi parasite-derived neurotrophic factor. Brain research. vol 1099. issue 1. 2006-09-19. PMID:16806115. |
because it is well established that neurotrophic factors regulate enzymes involved in the biosynthesis of neurotransmitters, we examined whether pdnf could also directly activate tyrosine hydroxylase (th), a rate-limiting enzyme in the synthesis of dopamine and other catecholamine neurotransmitters. |
2006-09-19 |
2023-08-12 |
rat |
| Monte A Gates, Eduardo M Torres, Anna White, Rosemary A Fricker-Gates, Stephen B Dunnet. Re-examining the ontogeny of substantia nigra dopamine neurons. The European journal of neuroscience. vol 23. issue 5. 2006-09-18. PMID:16553799. |
using a combination of bromodeoxyuridine (brdu) administration at e11, e12, e13 or e14 with immunocytochemical stainings for both brdu and tyrosine hydroxylase after 4 weeks of postnatal development, this characterization reveals that the vast majority (perhaps 80%) of snc dopamine neurons are probably born on e12 in sprague-dawley rats. |
2006-09-18 |
2023-08-12 |
rat |
| Nobuhide Kobori, Guy L Clifton, Pramod K Das. Enhanced catecholamine synthesis in the prefrontal cortex after traumatic brain injury: implications for prefrontal dysfunction. Journal of neurotrauma. vol 23. issue 7. 2006-09-14. PMID:16866622. |
using the cortical impact injury model of traumatic brain injury which reproducibly causes working memory deficits in rodents, we have measured the protein levels and activity of tyrosine hydroxylase (th), the rate-limiting enzyme for catecholamine biosynthesis, and tissue dopamine (da) and norepinephrine (ne) levels in microdissected pl/il tissues. |
2006-09-14 |
2023-08-12 |
Not clear |
| Annette Møller Dall, Jens Zimme. Development of DARPP-32-positive parts of fetal pig ganglionic eminence and ventral mesencephalon in organotypic slice co-cultures. Experimental neurology. vol 200. issue 1. 2006-09-05. PMID:16529743. |
this was used (a) to study the developmental expression of the striatal marker protein, dopamine and adenosine 3,5-monophosphate regulated phospho-protein (darpp-32) in the two parts and (b) to compare innervations of the two parts by tyrosine hydroxylase (th)-positive, dopaminergic fibers from co-cultured slices of the ventral mesencephalon. |
2006-09-05 |
2023-08-12 |
Not clear |
| Zane B Andrews, Alicia Rivera, John D Elsworth, Robert H Roth, Luigi Agnati, Belen Gago, Alfonso Abizaid, Michael Schwartz, Kjell Fuxe, Tamas L Horvat. Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function. The European journal of neuroscience. vol 24. issue 1. 2006-09-05. PMID:16882005. |
mice lacking ucp2 exhibited reduced dopamine turnover in the striatum as measured by the 3,4-dihydoxyphenylacetic acid/dopamine (dopac/da) ratio, reduced tyrosine hydroxylase immunoreactivity (th ir) in the substantia nigra pars compacta (snc) and reticulata, striatum and nucleus accumbens. |
2006-09-05 |
2023-08-12 |
mouse |
| Patricia Patterson-Buckendahl, Lucia Kubovcakova, Olga Krizanova, Larissa A Pohorecky, Richard Kvetnansk. Ethanol consumption increases rat stress hormones and adrenomedullary gene expression. Alcohol (Fayetteville, N.Y.). vol 37. issue 3. 2006-09-01. PMID:16713504. |
plasma epinephrine (epi); norepinephrine (ne); corticosterone (cort); prolactin (prl); adrenomedullary gene expression of catecholamine biosynthetic enzymes tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine-n-methyl transferase (pnmt); and th protein levels were measured. |
2006-09-01 |
2023-08-12 |
human |
| F-A Weltzien, C Pasqualini, N Le Belle, B Vidal, P Vernier, S Dufou. Brain expression of tyrosine hydroxylase and its regulation by steroid hormones in the European eel quantified by real-time PCR. Annals of the New York Academy of Sciences. vol 1040. 2006-08-29. PMID:15891106. |
to investigate the regulatory mechanisms involved, we developed a quantitative real-time rt-pcr assay for measurement of brain expression of tyrosine hydroxylase (th), the rate-limiting enzyme in the biosynthesis of dopamine. |
2006-08-29 |
2023-08-12 |
Not clear |
| Frederico Costa Pereira, Elita Santos Lourenço, Fernanda Borges, Teresa Morgadinho, Carlos Fontes Ribeiro, Tice Reis Macedo, Syed F Al. Single or multiple injections of methamphetamine increased dopamine turnover but did not decrease tyrosine hydroxylase levels or cleave caspase-3 in caudate-putamen. Synapse (New York, N.Y.). vol 60. issue 3. 2006-08-28. PMID:16739116. |
single or multiple injections of methamphetamine increased dopamine turnover but did not decrease tyrosine hydroxylase levels or cleave caspase-3 in caudate-putamen. |
2006-08-28 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Karuppagounder S Senthilkumar, Kochupurackal P Mohanakuma. L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochemistry international. vol 49. issue 1. 2006-08-24. PMID:16490285. |
unilateral stereotaxic intranigral infusion of rotenone caused significant decrease of striatal dopamine levels as measured employing hplc-electrochemistry, and loss of tyrosine hydroxylase immunoreactivity in the perikarya of ipsilateral substantia nigra (sn) neurons and their terminals in the striatum. |
2006-08-24 |
2023-08-12 |
rat |
| Karuppagounder S Saravanan, Kizhakke M Sindhu, Karuppagounder S Senthilkumar, Kochupurackal P Mohanakuma. L-deprenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochemistry international. vol 49. issue 1. 2006-08-24. PMID:16490285. |
treatment dose-dependently attenuated rotenone-induced reductions in complex-i activity and glutathione (gsh) levels in the sn, tyrosine hydroxylase immunoreactivity in the striatum or sn as well as striatal dopamine. |
2006-08-24 |
2023-08-12 |
rat |
| Yajie Liang, Shurong Li, Qiang Zou, Bingyin S. Potential neuroprotective effect of low dose whole-body gamma-irradiation against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity in C57 mice. Neuroscience letters. vol 400. issue 3. 2006-08-18. PMID:16540245. |
one week after the last mptp treatment, hplc determination of striatal dopamine and immunostaining for tyrosine hydroxylase (th), cd11b and gfap to detect dopamine neurons and associated glial reaction in the substantia nigra pars compacta (snpc) were performed. |
2006-08-18 |
2023-08-12 |
mouse |
| Ingo T Lehmann, Larisa Bobrovskaya, Sarah L Gordon, Peter R Dunkley, Phillip W Dickso. Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation. The Journal of biological chemistry. vol 281. issue 26. 2006-08-18. PMID:16644734. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. |
2006-08-18 |
2023-08-12 |
human |
| Janelle M Silvers, Michael Y Aksenov, Marina V Aksenova, Jacob Beckley, Petra Olton, Charles F Mactutus, Rosemarie M Booz. Dopaminergic marker proteins in the substantia nigra of human immunodeficiency virus type 1-infected brains. Journal of neurovirology. vol 12. issue 2. 2006-08-11. PMID:16798675. |
in this study, protein levels of tyrosine hydroxylase (th) and dopamine transporter (dat) in the substantia nigra of hiv-infected brains and -seronegative controls were determined by immunoblotting. |
2006-08-11 |
2023-08-12 |
human |
| L Novikova, B L Garris, D R Garris, Y-S La. Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease. Neuroscience. vol 140. issue 1. 2006-08-10. PMID:16533572. |
in the one-day and seven-day post-treated mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model for parkinson's disease, marked depression of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and striatum was observed, which was correlated with significant reductions of striatal dopamine content and uptake. |
2006-08-10 |
2023-08-12 |
mouse |
| Nobuhide Kobori, Anthony N Moore, Pramod K Das. GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activity. Brain research. vol 1086. issue 1. 2006-08-10. PMID:16626642. |
the synthesis of dopamine is regulated by phosphorylation of the rate-limiting enzyme tyrosine hydroxylase (th) under physiological conditions, with the phosphorylation of ser31 and ser40 directly increasing th activity. |
2006-08-10 |
2023-08-12 |
rat |