| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erica L Unger, Tessy Paul, Laura E Murray-Kolb, Barbara Felt, Byron C Jones, John L Bear. Early iron deficiency alters sensorimotor development and brain monoamines in rats. The Journal of nutrition. vol 137. issue 1. 2007-04-10. PMID:17182811. |
only g15 iron deficient rats had greater dopaminergic activity than controls as indicated by increased tyrosine hydroxylase levels, phosphorylated tyrosine hydroxylase levels, and cellular dopamine in prefrontal cortex and striatum at p15. |
2007-04-10 |
2023-08-12 |
human |
| Hong Qu Yan, Xiecheng Ma, Xiangbai Chen, Youming Li, Lifang Shao, C Edward Dixo. Delayed increase of tyrosine hydroxylase expression in rat nigrostriatal system after traumatic brain injury. Brain research. vol 1134. issue 1. 2007-04-05. PMID:17196177. |
tyrosine hydroxylase (th) is the key enzyme for synthesizing dopamine (da) in dopaminergic neurons and its terminals. |
2007-04-05 |
2023-08-12 |
rat |
| Gregory D Lyng, Abigail Snyder-Keller, Richard F Seega. Dopaminergic development of prenatal ventral mesencephalon and striatum in organotypic co-cultures. Brain research. vol 1133. issue 1. 2007-04-05. PMID:17196555. |
using organotypic co-cultures of rat embryonic day 14 (e14) ventral mesencephalon (vm) and e21 striatum, we have described the developmental changes in (i) dopamine (da) neurochemistry; (ii) numbers of da neurons; and (iii) protein expression of tyrosine hydroxylase (th), da transporter (dat), and glutamic acid decarboxylase (gad 65/67), over 17 days in vitro (div). |
2007-04-05 |
2023-08-12 |
rat |
| Meleik Hebert Goodwill, David A Lawrence, Richard F Seega. Polychlorinated biphenyls induce proinflammatory cytokine release and dopaminergic dysfunction: protection in interleukin-6 knockout mice. Journal of neuroimmunology. vol 183. issue 1-2. 2007-04-05. PMID:17229471. |
pcbs induced inflammatory responses in c57bl/6 adult male mice, significantly elevating serum levels of il-6 (31%), il-1beta (71%) and tnf-alpha (22%) and significantly reducing striatal dopamine (da, 21%), tyrosine hydroxylase (th, 26%), dopamine transporter (dat, 39%), and synaptophysin (29%) concentrations. |
2007-04-05 |
2023-08-12 |
mouse |
| Diane Stephenson, Andres Ramirez, Jill Long, Nestor Barrezueta, Eva Hajos-Korcsok, Curt Matherne, Dan Gallagher, Anne Ryan, Ricardo Ochoa, Frank Menniti, James Ya. Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16949674. |
to index the integrity of dopamine cell bodies, tyrosine hydroxylase (th) and beta-actin were quantified by western blot in lcm extracts. |
2007-03-27 |
2023-08-12 |
mouse |
| Evan P Sleipness, Barbara A Sorg, Heiko T Janse. Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. Brain research. vol 1129. issue 1. 2007-03-22. PMID:17156761. |
diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. |
2007-03-22 |
2023-08-12 |
rat |
| Evan P Sleipness, Barbara A Sorg, Heiko T Janse. Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. Brain research. vol 1129. issue 1. 2007-03-22. PMID:17156761. |
we used western blots to measure expression of dopamine transporter (dat) and tyrosine hydroxylase (th) proteins in the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate in sham and scn-lesioned (scnx) rats at zt4 (zeitgeber time 4, 4 h after lights-on) or zt20 (8 h after lights-off). |
2007-03-22 |
2023-08-12 |
rat |
| Simon McArthur, Hilary E Murray, Alihusein Dhankot, David T Dexter, Glenda E Gillie. Striatal susceptibility to a dopaminergic neurotoxin is independent of sex hormone effects on cell survival and DAT expression but is exacerbated by central aromatase inhibition. Journal of neurochemistry. vol 100. issue 3. 2007-03-20. PMID:17116232. |
contrary to our hypotheses, hormone manipulations (gonadectomy +/- oestrogen or androgen treatment) failed to alter survival of tyrosine hydroxylase immunoreactive cells in the substantia nigra pars compacta (snc) after lesioning; this indicates that, unlike inherent sex differences in toxin-induced striatal dopamine depletion, sex differences in cell loss were not hormonally generated, and that hormone-dependent changes in dopamine depletion can occur independently of cell survival. |
2007-03-20 |
2023-08-12 |
rat |
| Ralph Ankenman, Michael F Salvator. Low dose alpha-methyl-para-tyrosine (AMPT) in the treatment of dystonia and dyskinesia. The Journal of neuropsychiatry and clinical neurosciences. vol 19. issue 1. 2007-03-20. PMID:17308229. |
ampt (alpha-methyl-para-tyrosine) is an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in dopamine biosynthesis. |
2007-03-20 |
2023-08-12 |
Not clear |
| Lindsey Ferrie, Allan H Young, Richard McQuad. Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat. The international journal of neuropsychopharmacology. vol 9. issue 6. 2007-02-26. PMID:16313702. |
effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat. |
2007-02-26 |
2023-08-12 |
rat |
| Lindsey Ferrie, Allan H Young, Richard McQuad. Effect of lithium and lithium withdrawal on potassium-evoked dopamine release and tyrosine hydroxylase expression in the rat. The international journal of neuropsychopharmacology. vol 9. issue 6. 2007-02-26. PMID:16313702. |
in-situ hybridization histochemistry was used to study the abundance of mrna coding for dopamine's synthetic enzyme, tyrosine hydroxylase in the ventral tegmental area. |
2007-02-26 |
2023-08-12 |
rat |
| Yan Pan, Yemiliya Berman, Sandra Haberny, Emanuel Meller, Kenneth D Car. Synthesis, protein levels, activity, and phosphorylation state of tyrosine hydroxylase in mesoaccumbens and nigrostriatal dopamine pathways of chronically food-restricted rats. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17010321. |
synthesis, protein levels, activity, and phosphorylation state of tyrosine hydroxylase in mesoaccumbens and nigrostriatal dopamine pathways of chronically food-restricted rats. |
2007-01-30 |
2023-08-12 |
rat |
| V Anaya-Martinez, A Martinez-Marcos, D Martinez-Fong, J Aceves, D Erli. Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: implications for abnormal motor behavior. Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17008017. |
the projections of the substantia nigra pars compacta (snc) to the reticular thalamic nucleus (rtn) were assessed by measuring dopamine content and counting tyrosine hydroxylase positive (th (+)) cells in rats with unilateral lesions induced by 6-hydroxydopamine (6-ohda), and by using a fluorescent tract-tracing technique in rats without lesions. |
2007-01-26 |
2023-08-12 |
rat |
| Zbigniew K Binienda, Syed F Ali, Ashraf Virmani, Antonino Amato, Nadia Salem, Beata D Przybyl. Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitropropionic acid-induced neurotoxicity: neuroprotective role of L-carnitine. Neuroscience letters. vol 410. issue 1. 2007-01-23. PMID:17052844. |
total rna was isolated from the striatum and transcripts of ucp-2, ucp-4 and ucp-5 genes, as well as genes related to dopamine metabolism, such as da d(1) and d(2) receptors, tyrosine hydroxylase (th), monoamine oxidase-b (mao-b), and vesicular monoamine transporter-2 (vmat-2), were measured using real-time reverse transcription polymerase chain reaction (rt-pcr). |
2007-01-23 |
2023-08-12 |
rat |
| Yaping Chu, Jeffrey H Kordowe. Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease? Neurobiology of disease. vol 25. issue 1. 2007-01-23. PMID:17055279. |
the age-related increases in nigral alpha-synuclein were non-aggregated and strongly associated with age-related decreases in tyrosine hydroxylase (th), the rate limiting enzyme for dopamine production. |
2007-01-23 |
2023-08-12 |
monkey |
| Rebecca E Colebrooke, Trevor Humby, Patrick J Lynch, Daniel P McGowan, Jing Xia, Piers C Emso. Age-related decline in striatal dopamine content and motor performance occurs in the absence of nigral cell loss in a genetic mouse model of Parkinson's disease. The European journal of neuroscience. vol 24. issue 9. 2007-01-19. PMID:17100850. |
we report that evidence for cytosolic accumulation of dopamine in substantia nigra neurons in these mice is two-fold: firstly, there is reduced phosphorylation of tyrosine hydroxylase at the residue associated with catechol feedback inhibition; and, secondly, there are increased rates of dopamine turnover at 6, 12 and 24 months of age. |
2007-01-19 |
2023-08-12 |
mouse |
| Roya Tehranian, Susana E Montoya, Amber D Van Laar, Teresa G Hastings, Ruth G Pere. Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. Journal of neurochemistry. vol 99. issue 4. 2007-01-09. PMID:16981894. |
we previously discovered reduced tyrosine hydroxylase (th) activity and minimal dopamine synthesis in stably-transfected mn9d cells overexpressing either wild-type or a53t mutant (alanine to threonine at amino acid 53) alpha-synuclein. |
2007-01-09 |
2023-08-12 |
Not clear |
| Rui D S Prediger, Luciano C Batista, Rodrigo Medeiros, Pablo Pandolfo, Jorge C Florio, Reinaldo N Takahash. The risk is in the air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease. Experimental neurology. vol 202. issue 2. 2007-01-03. PMID:16908021. |
moreover, intranasal administration of mptp reduced the expression of the enzyme tyrosine hydroxylase in the olfactory bulb and substantia nigra of rats, resulting in a significant reduction of dopamine concentration in the olfactory bulb, prefrontal cortex and striatum, but not in the hippocampus. |
2007-01-03 |
2023-08-12 |
human |
| Ai Ling Fu, Shao Ping Wu, Zhao Hui Dong, Man Ji Su. A novel therapeutic approach to depression via supplement with tyrosine hydroxylase. Biochemical and biophysical research communications. vol 351. issue 1. 2006-12-22. PMID:17054915. |
tyrosine hydroxylase (tyrosine 3-monooxygenase, ec 1.14.16.2, th) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (da), noradrenaline (ne), and adrenaline, in the neurons. |
2006-12-22 |
2023-08-12 |
Not clear |
| Antoni Patsenka, Lucyna Antkiewicz-Michalu. Inhibition of rodent brain monoamine oxidase and tyrosine hydroxylase by endogenous compounds - 1,2,3,4-tetrahydro-isoquinoline alkaloids. Polish journal of pharmacology. vol 56. issue 6. 2006-12-21. PMID:15662085. |
four different noncatecholic and one catecholic tetrahydroisoquinolines (tiqs), cyclic condensation derivatives of beta-phenylethylamine and dopamine with aldehydes or keto acids, were examined for the inhibition of rat and mouse brain monoamine oxidase (mao) and rat striatum tyrosine hydroxylase (th) activity. |
2006-12-21 |
2023-08-12 |
mouse |