| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amjad Abuirmeileh, Alexander Harkavyi, Rebecca Lever, Christopher S Biggs, Peter S Whitto. Urocortin, a CRF-like peptide, restores key indicators of damage in the substantia nigra in a neuroinflammatory model of Parkinson's disease. Journal of neuroinflammation. vol 4. 2007-11-05. PMID:17659087. |
to do this we have measured restoration of normal motor behaviour, retention of nigral dopamine (da) and also tyrosine hydroxylase (th) activity. |
2007-11-05 |
2023-08-12 |
rat |
| Risa Sakai, Yoshifumi Irie, Takeshi Murata, Atsushi Ishige, Naoko Anjiki, Kenji Watanab. Toki-to protects dopaminergic neurons in the substantia nigra from neurotoxicity of MPTP in mice. Phytotherapy research : PTR. vol 21. issue 9. 2007-10-29. PMID:17486689. |
real-time rt-pcr analyses of mrna from sns demonstrated that expression of tyrosine hydroxylase (th) and dopamine transporter (dat) genes were decreased by mptp treatment and that these decreases were reversed by tkt administration prior to mptp treatment. |
2007-10-29 |
2023-08-12 |
mouse |
| Hideko Yamamoto, Etsuko Kamegaya, Yoko Hagino, Kazuhide Imai, Akihiro Fujikawa, Kohei Tamura, Tomoyuki Enokiya, Toshifumi Yamamoto, Takao Takeshima, Hisashi Koga, George R Uhl, Kazutaka Ikeda, Ichiro Sor. Genetic deletion of vesicular monoamine transporter-2 (VMAT2) reduces dopamine transporter activity in mesencephalic neurons in primary culture. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17664021. |
we examined mesencephalon dopaminergic cultures prepared from vmat2 wild-type, heterozygous or homozygous knockout (ko) 14-day-old mouse fetuses to determine the number of tyrosine hydroxylase (th)-positive cells and dopamine transporter activity. |
2007-10-25 |
2023-08-12 |
mouse |
| D Belin, V Deroche-Gamonet, M Jabe. Cocaine-induced sensitization is associated with altered dynamics of transcriptional responses of the dopamine transporter, tyrosine hydroxylase, and dopamine D2 receptors in C57Bl/6J mice. Psychopharmacology. vol 193. issue 4. 2007-10-23. PMID:17505818. |
cocaine-induced sensitization is associated with altered dynamics of transcriptional responses of the dopamine transporter, tyrosine hydroxylase, and dopamine d2 receptors in c57bl/6j mice. |
2007-10-23 |
2023-08-12 |
mouse |
| Shinji Kusakawa, Atsushi Tohei, Sukanya Jaroenporn, Gen Watanabe, Kazuyoshi Tay. Inhibition of stress-induced adrenocorticotropin and prolactin secretion mediating hypophysiotropic factors by antagonist of AMPA type glutamate receptor. The Journal of reproduction and development. vol 53. issue 3. 2007-10-19. PMID:17272925. |
however, nbqx had no significant effects on the activity of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis, as measured by the accumulation of 3, 4-dihydroxyphenylalanine (dopa). |
2007-10-19 |
2023-08-12 |
rat |
| Cecily E Hamill, W Michael Caudle, Jason R Richardson, Hongjie Yuan, Kurt D Pennell, James G Greene, Gary W Miller, Stephen F Trayneli. Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1. Molecular pharmacology. vol 72. issue 3. 2007-10-19. PMID:17596374. |
after mptp injection, par1-/- mice showed significantly higher residual levels of dopamine, dopamine transporter, and tyrosine hydroxylase and diminished microgliosis compared with wild-type mice. |
2007-10-19 |
2023-08-12 |
mouse |
| A K Wright, G W Arbuthnot. The influence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats. The European journal of neuroscience. vol 26. issue 3. 2007-10-17. PMID:17634067. |
an ibotenic acid injection into the gp in rats removes the cells of the gp and, over the following 6 weeks, a progressive loss of dopamine cells (counted stereologically in sections stained for tyrosine hydroxylase) develops in substantia nigra (sn). |
2007-10-17 |
2023-08-12 |
rat |
| Claudia Consales, Floriana Volpicelli, Dario Greco, Luigi Leone, Luca Colucci-D'Amato, Carla Perrone-Capano, Umberto di Porzi. GDNF signaling in embryonic midbrain neurons in vitro. Brain research. vol 1159. 2007-10-12. PMID:17574220. |
it modulates the expression of genes essential for da function (tyrosine hydroxylase, th and dopamine transporter, dat) and of da high affinity uptake. |
2007-10-12 |
2023-08-12 |
rat |
| Kazuto Shigematsu, Kan Toriyama, Kioko Kawai, Osamu Takahar. Ectopic adrenal tissue in the thorax: a case report with in situ hybridization and immunohistochemical studies. Pathology, research and practice. vol 203. issue 7. 2007-10-12. PMID:17590528. |
the centrally located cells showed immunoreactivities for tyrosine hydroxylase (th), dopamine beta hydroxylase (dbh), and phenylethanolamine-n-methyltransferase (pnmt). |
2007-10-12 |
2023-08-12 |
Not clear |
| Makoto Mizuno, Hidekazu Sotoyama, Eri Narita, Hiroki Kawamura, Hisaaki Namba, Yingjun Zheng, Takeyoshi Eda, Hiroyuki Naw. A cyclooxygenase-2 inhibitor ameliorates behavioral impairments induced by striatal administration of epidermal growth factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 38. 2007-10-11. PMID:17881518. |
intrastriatal egf infusion also increased cox-2 expression, elevated tyrosine hydroxylase activity, and upregulated the levels of dopamine and its metabolites. |
2007-10-11 |
2023-08-12 |
rat |
| Yu Mi Kim, Jae Joon Lee, Seung-Kook Park, Sung Cil Lim, Bang Yeon Hwang, Chong Kil Lee, Myung Koo Le. Effects of tributyltin acetate on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Archives of pharmacal research. vol 30. issue 7. 2007-10-09. PMID:17703738. |
tbta at concentrations of 0.1-0.2 microm inhibited dopamine biosynthesis by reducing tyrosine hydroxylase (th) activity and th gene expression in pc12 cells. |
2007-10-09 |
2023-08-12 |
Not clear |
| Phillip L Pearl, Jacob L Taylor, Stacey Trzcinski, Alex Sokoh. The pediatric neurotransmitter disorders. Journal of child neurology. vol 22. issue 5. 2007-10-02. PMID:17690069. |
the disorders of dopamine and serotonin synthesis are aromatic amino acid decarboxylase deficiency, tyrosine hydroxylase deficiency, and disorders of tetrahydrobiopterin synthesis. |
2007-10-02 |
2023-08-12 |
Not clear |
| Masami Miura, Sachiko Saino-Saito, Masao Masuda, Kazuto Kobayashi, Toshihiko Aosak. Compartment-specific modulation of GABAergic synaptic transmission by mu-opioid receptor in the mouse striatum with green fluorescent protein-expressing dopamine islands. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 36. 2007-10-02. PMID:17804632. |
we made patch-clamp recordings from medium spiny neurons in identified mor-immunoreactive "dopamine islands" as striosomes in a slice preparation taken from transgenic mice expressing green fluorescent protein in tyrosine hydroxylase mrna-containing neurons. |
2007-10-02 |
2023-08-12 |
mouse |
| Catherine R McMillan, Rohita Sharma, Tom Ottenhof, Lennard P Nile. Modulation of tyrosine hydroxylase expression by melatonin in human SH-SY5Y neuroblastoma cells. Neuroscience letters. vol 419. issue 3. 2007-09-28. PMID:17482356. |
we have previously reported in vivo preservation of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, following treatment with physiological doses of melatonin, in a 6-hydroxydopamine model of parkinson's disease. |
2007-09-28 |
2023-08-12 |
human |
| Leann P Quinn, Marion J Perren, Kim T Brackenborough, Peter L Woodhams, Martin Vidgeon-Hart, Helen Chapman, Menelas N Pangalos, Neil Upton, David J Virle. A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498809. |
in addition, mptp-treated mice were detected to have a marked depletion in striatal dopamine levels and a concomitant reduction in substantia nigra (sn) tyrosine hydroxylase (th) immunoreactivity, at 7 days post-mptp administration, indicative of dopaminergic neuronal loss. |
2007-09-27 |
2023-08-12 |
mouse |
| Jennifer Treweek, Sunmee Wee, George F Koob, Tobin J Dickerson, Kim D Jand. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 28. 2007-09-27. PMID:17592122. |
the powerfully rewarding effects of methamphetamine are attributed to multiple neuropharmacological actions such as its ability to block plasma membrane transporters of all monoamines, reduce dopamine transporter expression, and inhibit monoamine oxidase activity while increasing tyrosine hydroxylase activity. |
2007-09-27 |
2023-08-12 |
rat |
| Susana R Valdez, Alicia B Penissi, Ricardo P Deis, Graciela A Jah. Hormonal profile and reproductive performance in lactation deficient (OFA hr/hr) and normal (Sprague-Dawley) female rats. Reproduction (Cambridge, England). vol 133. issue 4. 2007-09-26. PMID:17504926. |
dopaminergic metabolism was assessed by determination of mediobasal hypothalamic dopamine and dihydroxyphenylacetic acid (dopac) concentrations by hplc and tyrosine hydroxylase expression by immunocytochemistry and western blot. |
2007-09-26 |
2023-08-12 |
rat |
| Emmanuelle Lagrue, Sylvie Chalon, Sylvie Bodard, Elie Saliba, Pierre Gressens, Pierre Castelna. Lamotrigine is neuroprotective in the energy deficiency model of MPTP intoxicated mice. Pediatric research. vol 62. issue 1. 2007-09-26. PMID:17515828. |
dopamine transporter (dat) density was assessed by quantitative autoradiography, tyrosine hydroxylase (th) was evaluated by immunohistochemistry and dopamine (da) levels by hplc-ed whereas neuronal apoptosis was monitored through active caspase-3. |
2007-09-26 |
2023-08-12 |
mouse |
| M Kabbaj, C Isgo. Effects of chronic environmental and social stimuli during adolescence on mesolimbic dopaminergic circuitry markers. Neuroscience letters. vol 422. issue 1. 2007-09-26. PMID:17590508. |
no change has been detected in any other dopaminergic markers [d2r, d3r, tyrosine hydroxylase (th) or dopamine transporter (dat) mrnas]. |
2007-09-26 |
2023-08-12 |
rat |
| Heather A Boger, Lawrence D Middaugh, Kennerly S Patrick, Sammanda Ramamoorthy, Emily D Denehy, Haojie Zhu, Alejandra M Pacchioni, Ann-Charlotte Granholm, Jacqueline F McGint. Long-term consequences of methamphetamine exposure in young adults are exacerbated in glial cell line-derived neurotrophic factor heterozygous mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699663. |
two weeks after a methamphetamine binge (4 x 10 mg/kg, i.p., at 2 h intervals), gdnf(+/-) mice had a significantly greater reduction of tyrosine hydroxylase immunoreactivity in the medial striatum, a proportionally greater depletion of dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels in the striatum, and a greater increase in activated microglia in the substantia nigra than wild-type mice. |
2007-09-14 |
2023-08-12 |
mouse |