| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinghong Kou, Jeffrey R Bloomquis. Neurotoxicity in murine striatal dopaminergic pathways following long-term application of low doses of permethrin and MPTP. Toxicology letters. vol 171. issue 3. 2007-09-11. PMID:17597311. |
alterations in the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and alpha-synuclein proteins were analyzed 1 day after the last pm treatment using western blot assay. |
2007-09-11 |
2023-08-12 |
mouse |
| Yuka Morikawa, Fabien D'Autréaux, Michael D Gershon, Peter Cserjes. Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Developmental biology. vol 307. issue 1. 2007-09-10. PMID:17531968. |
to determine whether hand2 regulates noradrenergic differentiation, the levels of the norepinephrine biosynthetic enzymes, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) was examined. |
2007-09-10 |
2023-08-12 |
mouse |
| Marco Cosentino, Anna Maria Fietta, Marco Ferrari, Emanuela Rasini, Raffaella Bombelli, Elena Carcano, Federica Saporiti, Federica Meloni, Franca Marino, Sergio Lecchin. Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop. Blood. vol 109. issue 2. 2007-08-30. PMID:16985181. |
here, we show that human tregs constitutively express tyrosine hydroxylase (th, ec 1.14.16.2), the rate-limiting enzyme in the synthesis of catecholamines, and contain substantial amounts of dopamine, norepinephrine, and epinephrine, which are released upon treatment with reserpine. |
2007-08-30 |
2023-08-12 |
human |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Akemichi Baba, Toshio Matsud. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17429058. |
mptp treatment (10 mg/kg s.c. x 4 with 2-h intervals) decreased dopamine levels and tyrosine hydroxylase immunostaining in the striatum and snc. |
2007-08-30 |
2023-08-12 |
mouse |
| Marc Turiault, Sébastien Parnaudeau, Aude Milet, Rosanna Parlato, Jean-Denis Rouzeau, Monique Lazar, François Tronch. Analysis of dopamine transporter gene expression pattern -- generation of DAT-iCre transgenic mice. The FEBS journal. vol 274. issue 14. 2007-08-30. PMID:17565601. |
the expression profile of tyrosine hydroxylase (an enzyme required for dopamine synthesis) was broader than that of beta-galactosidase in a12 to a15. |
2007-08-30 |
2023-08-12 |
mouse |
| D Eugene Redmond, Kimberly B Bjugstad, Yang D Teng, Vaclav Ourednik, Jitka Ourednik, Dustin R Wakeman, Xuejun H Parsons, Rodolfo Gonzalez, Barbara C Blanchard, Seung U Kim, Zezong Gu, Stuart A Lipton, Eleni A Markakis, Robert H Roth, John D Elsworth, John R Sladek, Richard L Sidman, Evan Y Snyde. Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 29. 2007-08-30. PMID:17586681. |
a small number of hnsc progeny differentiated into tyrosine hydroxylase (th) and/or dopamine transporter (dat) immunopositive cells, suggesting that the microenvironment within and around the lesioned adult host sn still permits development of a da phenotype by responsive progenitor cells. |
2007-08-30 |
2023-08-12 |
human |
| W Michael Caudle, Jason R Richardson, Min Z Wang, Tonya N Taylor, Thomas S Guillot, Alison L McCormack, Rebecca E Colebrooke, Donato A Di Monte, Piers C Emson, Gary W Mille. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652604. |
these changes were associated with decreased striatal dopamine and decreased expression of the dopamine transporter and tyrosine hydroxylase. |
2007-08-20 |
2023-08-12 |
mouse |
| Xingchao Geng, Xuefei Tian, Pengfei Tu, Xiaoping P. Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease. European journal of pharmacology. vol 564. issue 1-3. 2007-08-17. PMID:17359968. |
when administered prior to mptp, echinacoside reduced behavioral deficits, increased striatal dopamine and dopamine metabolite levels, reduced cell death, and led to a marked increase in tyrosine hydroxylase expression relative to mice treated with mptp alone. |
2007-08-17 |
2023-08-12 |
mouse |
| Soojin Ryu, Julia Mahler, Dario Acampora, Jochen Holzschuh, Simone Erhardt, Daniela Omodei, Antonio Simeone, Wolfgang Drieve. Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Current biology : CB. vol 17. issue 10. 2007-08-17. PMID:17481897. |
in fish, overexpression of otp can induce ectopic tyrosine hydroxylase and dopamine transporter expression, indicating that otp can specify aspects of dopaminergic identity. |
2007-08-17 |
2023-08-12 |
mouse |
| Gonzalo Arboleda, Tze-Jen Huang, Catherine Waters, Alex Verkhratsky, Paul Fernyhough, Rosemary M Gibso. Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561816. |
we tested the hypothesis that insulin-like growth factor-1 (igf-1) could mediate a metabolic response in cad cells, a dopaminergic cell line of mesencephalic origin that differentiate into a neuronal-like phenotype upon serum removal, extend processes resembling neurites, synthesize abundant dopamine and noradrenaline and express the catecholaminergic biosynthetic enzymes tyrosine hydroxylase and dopamine beta-hydroxylase, and that this process was phosphatidylinositol 3-kinase (pi 3-k)-akt-dependent and could be inhibited by c(2)-ceramide. |
2007-08-17 |
2023-08-12 |
Not clear |
| Poorvi Kaushik, Fredric Gorin, Shireen Val. Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis. Journal of computational neuroscience. vol 22. issue 2. 2007-08-15. PMID:17053993. |
dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis. |
2007-08-15 |
2023-08-12 |
Not clear |
| Poorvi Kaushik, Fredric Gorin, Shireen Val. Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis. Journal of computational neuroscience. vol 22. issue 2. 2007-08-15. PMID:17053993. |
tyrosine hydroxylase's catalysis of tyrosine to dihydroxyphenylalanine (dopa) is the highly regulated, rate-limiting step catalyzing the synthesis of the catecholamine neurotransmitter dopamine. |
2007-08-15 |
2023-08-12 |
Not clear |
| Keith Hylan. Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids. The Journal of nutrition. vol 137. issue 6 Suppl 1. 2007-08-06. PMID:17513427. |
inherited defects that reduce the concentration of bh4, therefore, in general, lead to phenylketonuria and to deficiencies of dopamine and serotonin, as tyrosine hydroxylase and tryptophan hydroxylase are the rate-limiting enzymes required for the synthesis of these neurotransmitters. |
2007-08-06 |
2023-08-12 |
Not clear |
| Osamu Kitamura, Itsuo Tokunaga, Takako Gotohda, Shin-ichi Kub. Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. International journal of legal medicine. vol 121. issue 3. 2007-07-31. PMID:16622715. |
in this study, we examined the suitability of the immunohistochemical detection of tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter-2 (vmat2) levels, and caspase-3 activation in the striatum to diagnose meth abuse. |
2007-07-31 |
2023-08-12 |
human |
| Qi Li, Gang Lu, G E Antonio, Y T Mak, John A Rudd, Ming Fan, David T Ye. The usefulness of the spontaneously hypertensive rat to model attention-deficit/hyperactivity disorder (ADHD) may be explained by the differential expression of dopamine-related genes in the brain. Neurochemistry international. vol 50. issue 6. 2007-07-26. PMID:17395336. |
in other complimentary studies of the central nervous system, we used real-time pcr to examine the levels of several dopaminergic-related genes, including those coding for the five major subtypes of dopamine receptor (d1, d2, d3, d4 and d5), those coding for enzymes responsible for synthesizing tyrosine hydroxylase and dopamine-beta-hydroxylase, and those coding for the dopamine transporter. |
2007-07-26 |
2023-08-12 |
human |
| Arnaud Jaubert, Guillaume Drutel, Thierry Leste-Lasserre, François Ichas, Laurence Bresson-Bepoldi. Tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis. Endocrinology. vol 148. issue 6. 2007-07-24. PMID:17363452. |
tyrosine hydroxylase and dopamine transporter expression in lactotrophs from postlactating rats: involvement in dopamine-induced apoptosis. |
2007-07-24 |
2023-08-12 |
rat |
| Néstor F Díaz, Christian Guerra-Arraiza, Néstor E Díaz-Martínez, Patricia Salazar, Anayansi Molina-Hernández, Ignacio Camacho-Arroyo, Ivan Velasc. Changes in the content of estrogen alpha and progesterone receptors during differentiation of mouse embryonic stem cells to dopamine neurons. Brain research bulletin. vol 73. issue 1-3. 2007-07-20. PMID:17499639. |
ninety-two percent of dopamine neurons expressed progesterone receptors and only 19% of these neurons co-expressed tyrosine hydroxylase and er-alpha. |
2007-07-20 |
2023-08-12 |
mouse |
| M V Ugriumo. [Brain neurons partly expressing monoaminergic phenotype: distribution, development, and functional significance]. Uspekhi fiziologicheskikh nauk. vol 38. issue 2. 2007-07-16. PMID:17578016. |
most numerous monoenzymatic neurons express individual enzymes of dopamine (da), tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2007-07-16 |
2023-08-12 |
Not clear |
| Jorge Goldstein, Mario Perello, Eduardo A Nilln. PreproThyrotropin-releasing hormone 178-199 affects tyrosine hydroxylase biosynthesis in hypothalamic neurons: a possible role for pituitary prolactin regulation. Journal of molecular neuroscience : MN. vol 31. issue 1. 2007-07-12. PMID:17416971. |
dopamine (da), the main regulator of prolactin secretion, is produced in dopaminergic tyrosine hydroxylase (th)-positive neurons in the hypothalamic arcuate nucleus (arc). |
2007-07-12 |
2023-08-12 |
rat |
| Kensuke Kimura, Masaki Ieda, Hideaki Kanazawa, Takashi Yagi, Makoto Tsunoda, Shin-ichi Ninomiya, Hiroyuki Kurosawa, Kenji Yoshimi, Hideki Mochizuki, Kazuto Yamazaki, Satoshi Ogawa, Keiichi Fukud. Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy. Circulation research. vol 100. issue 12. 2007-07-05. PMID:17495227. |
however, norepinephrine and dopamine content was paradoxically attenuated, and the protein and kinase activity of tyrosine hydroxylase were markedly downregulated in the right ventricle. |
2007-07-05 |
2023-08-12 |
rat |