| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana I Rojo, Celia Montero, María Salazar, Ryan M Close, Javier Fernández-Ruiz, Miguel A Sánchez-González, María Rosa de Sagarra, Vernice Jackson-Lewis, Carmen Cavada, Antonio Cuadrad. Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. The European journal of neuroscience. vol 24. issue 7. 2006-12-21. PMID:17067291. |
c57bl/6 mice, submitted to daily intranasal inoculation with mptp for 30 days, developed motor deficits that correlated with a progressive and severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase and dopamine transporter staining in substantia nigra and striatum. |
2006-12-21 |
2023-08-12 |
mouse |
| Sean M Kearns, Bjorn Scheffler, A Katrin Goetz, Dean D Lin, Harriet D Baker, Steven N Roper, Ronald J Mandel, Dennis A Steindle. A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit. Journal of neuroscience methods. vol 157. issue 1. 2006-12-14. PMID:16704878. |
application of the dopamine specific toxin 6-hydroxy dopamine (6-ohda) induces a significant decline in tyrosine hydroxylase positive cell bodies and fibers. |
2006-12-14 |
2023-08-12 |
mouse |
| Toshiyuki Kawasaki, Kotaro Ishihara, Yukio Ago, Shigeo Nakamura, Soichi Itoh, Akemichi Baba, Toshio Matsud. Protective effect of the radical scavenger edaravone against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. European journal of pharmacology. vol 542. issue 1-3. 2006-12-14. PMID:16784740. |
methamphetamine treatment (4 mg/kg, s.c. x 4 with 2 h intervals) showed striatal dopaminergic degeneration as observed by decreases in dopamine levels and tyrosine hydroxylase immunoreactivity in the striatum. |
2006-12-14 |
2023-08-12 |
mouse |
| K X Jacobsen, M Höistad, W A Staines, K Fux. The distribution of dopamine D1 receptor and mu-opioid receptor 1 receptor immunoreactivities in the amygdala and interstitial nucleus of the posterior limb of the anterior commissure: relationships to tyrosine hydroxylase and opioid peptide terminal systems. Neuroscience. vol 141. issue 4. 2006-12-04. PMID:16820264. |
the distribution of dopamine d1 receptor and mu-opioid receptor 1 receptor immunoreactivities in the amygdala and interstitial nucleus of the posterior limb of the anterior commissure: relationships to tyrosine hydroxylase and opioid peptide terminal systems. |
2006-12-04 |
2023-08-12 |
rat |
| K X Jacobsen, M Höistad, W A Staines, K Fux. The distribution of dopamine D1 receptor and mu-opioid receptor 1 receptor immunoreactivities in the amygdala and interstitial nucleus of the posterior limb of the anterior commissure: relationships to tyrosine hydroxylase and opioid peptide terminal systems. Neuroscience. vol 141. issue 4. 2006-12-04. PMID:16820264. |
discrete cell patches of dopamine d1 receptor and mu-opioid receptor-1 ir were also identified in a distinct region of the extended amygdala, the interstitial nucleus of the posterior limb of the anterior commissure, medial division (ipacm), which displayed sparse tyrosine hydroxylase or enkephalin/beta-endorphin ir nerve terminals. |
2006-12-04 |
2023-08-12 |
rat |
| Takashi Moriguchi, Nakano Takako, Michito Hamada, Atsuko Maeda, Yuki Fujioka, Takashi Kuroha, Reuben E Huber, Susan L Hasegawa, Arvind Rao, Masayuki Yamamoto, Satoru Takahashi, Kim-Chew Lim, James Douglas Enge. Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation. Development (Cambridge, England). vol 133. issue 19. 2006-11-28. PMID:16943277. |
additionally, mrna analyses of purified chromaffin cells from gata3 mutants show that levels of mash1, hand2 and phox2b (postulated upstream regulators of gata3) as well as terminally differentiated sa lineage products (tyrosine hydroxylase, th, and dopamine beta-hydroxylase, dbh) are markedly altered. |
2006-11-28 |
2023-08-12 |
mouse |
| C E Rick, A Ebert, T Virag, M C Bohn, D J Surmeie. Differentiated dopaminergic MN9D cells only partially recapitulate the electrophysiological properties of midbrain dopaminergic neurons. Developmental neuroscience. vol 28. issue 6. 2006-11-24. PMID:17028430. |
the cell line mn9d, a fusion of embryonic ventral mesencephalic and neuroblastoma cells, is extensively used as a model of dopamine (da) neurons because it expresses tyrosine hydroxylase and synthesizes and releases da. |
2006-11-24 |
2023-08-12 |
mouse |
| Daijiro Yanagisawa, Meirigeng Qi, Do-hoon Kim, Yoshihisa Kitamura, Masatoshi Inden, Daiju Tsuchiya, Kazuyuki Takata, Takashi Taniguchi, Kanji Yoshimoto, Shun Shimohama, Akinori Akaike, Shoichiro Sumi, Kazutomo Inou. Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells. Neuroscience letters. vol 407. issue 1. 2006-11-14. PMID:16959414. |
at 15 weeks after transplantation, immunoreactivities for tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum were significantly recovered in rats grafted with es or es-n cells compared to vehicle-injected rats. |
2006-11-14 |
2023-08-12 |
mouse |
| Geeta Ravindran, Harinarayana S Ra. Enriched NCAM-positive cells form functional dopaminergic neurons in the rat model of Parkinson's disease. Stem cells and development. vol 15. issue 4. 2006-11-13. PMID:16978060. |
the predifferentiated cells when analyzed by rt-pcr showed expression of dopaminergic markers such as nurr1, engrailed-1, aromatic amino decarboxylase (aadc), vmat2, tyrosine hydroxylase (th), and dopamine transporter (dat). |
2006-11-13 |
2023-08-12 |
human |
| Maryka Quik, Neeraja Parameswaran, Sarah E McCallum, Tanuja Bordia, Shanshan Bao, Alison McCormack, Amy Kim, Rachel F Tyndale, J William Langston, Donato A Di Mont. Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates. Journal of neurochemistry. vol 98. issue 6. 2006-11-07. PMID:16882311. |
the results showed that levels of striatal tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter, dopamine and nicotinic receptors were greater in nicotine-treated mptp-lesioned primates than in lesioned animals not receiving nicotine. |
2006-11-07 |
2023-08-12 |
monkey |
| Alessandro Martorana, Carmela Giampà, Zena DeMarch, Maria Teresa Viscomi, Stefano Patassini, Giuseppe Sancesario, Giorgio Bernardi, Francesca R Fusc. Distribution of TRPC1 receptors in dendrites of rat substantia nigra: a confocal and electron microscopy study. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930403. |
single-label immunohistochemistry and double-label immunofluorescence were used to study the expression of trpc1 among substantia nigra dopamine neurons and cellular processes using antibodies against tyrosine hydroxylase (th), substance p (sp), enkephalin, synaptophysin, vesicular glutamate transporter-2 (vglut-2), microtubule associated protein-2 and metabotropic glutamate receptor 1 (mglur1). |
2006-11-01 |
2023-08-12 |
rat |
| Jinghong Kou, David C Klorig, Jeffrey R Bloomquis. Potentiating effect of the ATP-sensitive potassium channel blocker glibenclamide on complex I inhibitor neurotoxicity in vitro and in vivo. Neurotoxicology. vol 27. issue 5. 2006-10-31. PMID:16725203. |
western blots of striatal dopamine transporter (dat) and tyrosine hydroxylase (th) proteins demonstrated that 30 mg/kg of glibenclamide alone did not affect the expression of dat and th after two weeks of daily treatments, but it significantly enhanced the reduction of dat and th by a single dose of 20 mg/kg of mptp. |
2006-10-31 |
2023-08-12 |
mouse |
| Hironori Yamazoe, Hiroo Iwat. Efficient generation of dopaminergic neurons from mouse embryonic stem cells enclosed in hollow fibers. Biomaterials. vol 27. issue 28. 2006-10-24. PMID:16766027. |
beta-tubulin type iii positive cells and tyrosine hydroxylase positive cells were efficiently derived in hollow fibers after 16 days in culture, and dopamine release was observed when the hollow fibers containing cells were exposed to 56mm kcl for 15min to induce dopamine release through depolarization of the neurons. |
2006-10-24 |
2023-08-12 |
mouse |
| Michihiro Kawano, Akiko Kawasaki, Hiromi Sakata-Haga, Yoshihiro Fukui, Hitoshi Kawano, Haruo Nogami, Setsuji Hisan. Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain. The Journal of comparative neurology. vol 498. issue 5. 2006-10-18. PMID:16917821. |
using in situ hybridization combined with tyrosine hydroxylase (th) immunostaining, only vglut2 signals were detectable in some th-labeled neurons of a10 dopamine neuron groups, with the highest incidence (20%) in the rostral linear nucleus of the ventral tegmental area. |
2006-10-18 |
2023-08-12 |
rat |
| Keith N Darrow, Emmanuel J Simons, Leslie Dodds, M Charles Liberma. Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers. The Journal of comparative neurology. vol 498. issue 3. 2006-10-03. PMID:16871528. |
immunostaining mouse cochleas for tyrosine hydroxylase (th) and dopamine beta-hydroxylase suggests that there is a rich adrenergic innervation throughout the auditory nerve trunk and a small dopaminergic innervation of the sensory cell areas. |
2006-10-03 |
2023-08-12 |
mouse |
| Jack D Shepard, David T Chuang, Yavin Shaham, Marisela Morale. Effect of methamphetamine self-administration on tyrosine hydroxylase and dopamine transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat. Psychopharmacology. vol 185. issue 4. 2006-09-28. PMID:16555063. |
effect of methamphetamine self-administration on tyrosine hydroxylase and dopamine transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat. |
2006-09-28 |
2023-08-12 |
rat |
| Jack D Shepard, David T Chuang, Yavin Shaham, Marisela Morale. Effect of methamphetamine self-administration on tyrosine hydroxylase and dopamine transporter levels in mesolimbic and nigrostriatal dopamine pathways of the rat. Psychopharmacology. vol 185. issue 4. 2006-09-28. PMID:16555063. |
we studied the effect of methamphetamine self-administration on two key regulators of dopamine transmission, tyrosine hydroxylase (th), and dopamine transporter (dat), in components of the mesolimbic and nigrostriatal dopamine pathways. |
2006-09-28 |
2023-08-12 |
rat |
| Jian-Jun Wang, Ting Zhang, Dong-Bin Niu, Kun Wang, Kai-Rong Li, Bing Xue, Xiao-Min Wan. Doxycycline-regulated co-expression of GDNF and TH in PC12 cells. Neuroscience letters. vol 401. issue 1-2. 2006-09-28. PMID:16584838. |
one is to restore dopamine (da) production by delivering the genes of da-synthesizing enzymes such as tyrosine hydroxylase (th) to the striatum to relieve motor symptoms of pd. |
2006-09-28 |
2023-08-12 |
Not clear |
| Pansiri Phansuwan-Pujito, Parichart Boontem, Banthit Chetsawang, Manuchair Ebadi, Piyarat Govitrapon. Dopamine transporter immunoreactive terminals in the bovine pineal gland. Neuroscience letters. vol 403. issue 1-2. 2006-09-28. PMID:16781060. |
the colocalization of dat with tyrosine hydroxylase (th) or dopamine beta hydroxylase (dbh) immunoreactivities was observed in nerve terminals. |
2006-09-28 |
2023-08-12 |
cattle |
| J W Winkelma. Considering the causes of RLS. European journal of neurology. vol 13 Suppl 3. 2006-09-21. PMID:16930377. |
although iron is necessary for the activity of tyrosine hydroxylase, the rate-limiting step in dopamine synthesis, it is unclear whether this relationship plays a role in the aetiology of rls. |
2006-09-21 |
2023-08-12 |
Not clear |