| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stefan Clemens, David Rye, Shawn Hochma. Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective. Neurology. vol 67. issue 1. 2006-08-08. PMID:16832090. |
excessive locomotor behavior is evident in both sets of animals, and d(3)ko mice exhibit facilitation rather than the expected depression of spinal reflexes in the presence of dopamine as well as a reversal in their circadian expression of the rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase. |
2006-08-08 |
2023-08-12 |
mouse |
| C Bombardi, A Grandis, R Chiocchetti, R Bortolami, H Johansson, M L Lucch. Immunohistochemical localization of alpha(1a)-adrenoreceptors in muscle spindles of rabbit masseter muscle. Tissue & cell. vol 38. issue 2. 2006-08-03. PMID:16510160. |
the sympathetic fibers were visualized by the immunofluorescent labeling of the noradrenaline synthesizing enzymes tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh). |
2006-08-03 |
2023-08-12 |
rabbit |
| A Bairam, V Joseph, Y Lajeunesse, R Kinkea. Developmental pattern of M1 and M2 muscarinic gene expression and receptor levels in cat carotid body, petrosal and superior cervical ganglion. Neuroscience. vol 139. issue 2. 2006-07-31. PMID:16457956. |
mrna expression and protein levels of tyrosine hydroxylase, the rate limiting enzyme for dopamine synthesis, were also assessed. |
2006-07-31 |
2023-08-12 |
cat |
| Marie-Eve Tremblay, Martine Saint-Pierre, Emmanuelle Bourhis, Daniel Lévesque, Claude Rouillard, Francesca Cicchett. Neuroprotective effects of cystamine in aged parkinsonian mice. Neurobiology of aging. vol 27. issue 6. 2006-07-26. PMID:15913845. |
pre-treatment with lower doses of cystamine (10 mg/kg) revealed increased levels of tyrosine hydroxylase (th) positive striatal fiber (p<0.01), increased density of th-immunoreactive cells (p<0.01), increased substantia nigra nurr1 mrna levels (p<0.001), and increased density of substantia nigra cells expressing the dopamine transporter (p<0.001) as compared to mptp treated mice. |
2006-07-26 |
2023-08-12 |
mouse |
| María Nieto, Francisco J Gil-Bea, Esther Dalfó, Mar Cuadrado, Felipe Cabodevilla, Belén Sánchez, Silvia Catena, Teresa Sesma, Elena Ribé, Isidro Ferrer, María J Ramírez, Teresa Gómez-Isl. Increased sensitivity to MPTP in human alpha-synuclein A30P transgenic mice. Neurobiology of aging. vol 27. issue 6. 2006-07-26. PMID:16006012. |
while sensitivity to chronic treatment with rotenone was not enhanced in the tg5093 line, chronic treatment with 80 or 150 mg/kg mptp resulted in increased deterioration of the nigrostriatal dopaminergic system as assessed by quantitation of nigral tyrosine hydroxylase (th) positive neurons and striatal dopamine (da) levels in tg5093 mice when compared to non-transgenic littermate controls. |
2006-07-26 |
2023-08-12 |
mouse |
| Giuseppe Battaglia, Carla L Busceti, Gemma Molinaro, Francesca Biagioni, Anna Traficante, Ferdinando Nicoletti, Valeria Brun. Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 27. 2006-07-25. PMID:16822979. |
phccc treatment (3 or 10 mg/kg) significantly reduced mptp toxicity, as assessed by measurements of the striatal levels of dopamine and its metabolites and by tyrosine hydroxylase, dopamine transporter, and glial fibrillary acidic protein immunostaining in the corpus striatum and substantia nigra. |
2006-07-25 |
2023-08-12 |
mouse |
| Sara González, Camila Scorticati, Moisés García-Arencibia, Rosario de Miguel, José A Ramos, Javier Fernández-Rui. Effects of rimonabant, a selective cannabinoid CB1 receptor antagonist, in a rat model of Parkinson's disease. Brain research. vol 1073-1074. 2006-07-19. PMID:16412990. |
dose-response studies with 6-hydroxydopamine revealed that the application of 200 microg per animal caused hypokinetic signs (decreased ambulatory activity, increased inactivity, and reduced motor coordination), which paralleled several signs of degeneration of nigrostriatal dopaminergic neurons (dopamine depletion in the caudate-putamen, and decreased mrna levels for tyrosine hydroxylase and superoxide dismutase-1 and -2 in the substantia nigra). |
2006-07-19 |
2023-08-12 |
rat |
| Xiaodong Zhang, Kathleen M Klueber, Zhanfang Guo, Jun Cai, Chengliang Lu, Welby I Winstead, Mengsheng Qiu, Fred J Roise. Induction of neuronal differentiation of adult human olfactory neuroepithelial-derived progenitors. Brain research. vol 1073-1074. 2006-07-19. PMID:16455065. |
the application of ra, fn, and shh to nsfcs induced the expression of motoneuronal transcription factors, tyrosine hydroxylase, an indicator of dopamine production, and neurite formation. |
2006-07-19 |
2023-08-12 |
human |
| Eiki Takahashi, Takeshi Nagas. Enhanced expression of Ca2+ channel alpha1A and beta4 subunits and phosphorylated tyrosine hydroxylase in the adrenal gland of N-type Ca2+ channel alpha1B subunit-deficient mice with a CBA/JN genetic background. Comparative medicine. vol 56. issue 3. 2006-07-18. PMID:16774125. |
to examine the expression patterns of the p/q-type alpha1a, l-type alpha1c/alpha1d, and r-type alpha1e, beta1, beta2, beta3, and beta4 subunits, as well as of tyrosine hydroxylase (th), dopamine beta hydroxylase (dbh), and phenylethanolamine-n-methyltransferase (pnmt) in the adrenal gland of alpha1b-deficient mice, we used real-time quantitative reverse transcription-polymerase chain reaction and western blot analyses. |
2006-07-18 |
2023-08-12 |
mouse |
| Philippe Vernier, Frederic Moret, Sophie Callier, Marina Snapyan, Christophe Wersinger, Anita Sidh. The degeneration of dopamine neurons in Parkinson's disease: insights from embryology and evolution of the mesostriatocortical system. Annals of the New York Academy of Sciences. vol 1035. 2006-07-13. PMID:15681811. |
in this respect, mesencephalic dopamine neurons of the substantia nigra and ventral tegmental area are characterized by a molecular combination (tyrosine hydroxylase, aromatic amino acid decarboxylase, monoamine oxidase, vesicular monoamine transporter, dopamine transporter--to name a few), which is not found in other dopamine-containing neurons of the vertebrate brain. |
2006-07-13 |
2023-08-12 |
human |
| Mary Anna Carbone, Katherine W Jordan, Richard F Lyman, Susan T Harbison, Jeff Leips, Theodore J Morgan, Maria DeLuca, Philip Awadalla, Trudy F C Macka. Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila. Current biology : CB. vol 16. issue 9. 2006-07-07. PMID:16682353. |
catecholamines up (catsup), which encodes a negative regulator of tyrosine hydroxylase , the rate-limiting step in the synthesis of the neurotransmitter dopamine, is a pleiotropic quantitative trait gene in drosophila melanogaster. |
2006-07-07 |
2023-08-12 |
drosophila_melanogaster |
| E L Dovedova, D A Khrustalev, I E Mel'nikov. [The peculiarities of long-term amphetamine action on some brain enzyme systems]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 106. issue 4. 2006-06-30. PMID:16737161. |
the enzyme activity of serotonin and dopamine synthesis--tryptophan hydroxylase and tyrosine hydroxylase respectively--as well as content of dihydroxyphenylalanine (dopa) in the brain structures of wistar and august rat strains were studied in normal conditions and during long-term amphetamine administration (21 day) in dosage of 1.0 mg/kg. |
2006-06-30 |
2023-08-12 |
rat |
| Lisbeth Birk Møller, Anne Romstad, Marianne Paulsen, Pia Hougaard, Aida Ormazabal, Mercé Pineda, Nenad Blau, Flemming Güttler, Rafael Artuc. Pre- and postnatal diagnosis of tyrosine hydroxylase deficiency. Prenatal diagnosis. vol 25. issue 8. 2006-06-29. PMID:16049992. |
tyrosine hydroxylase (th) is a key enzyme in the biosynthesis of dopamine, epinephrine and norepinephrine. |
2006-06-29 |
2023-08-12 |
Not clear |
| Claire-Marie Vacher, Martin Gassmann, Sandrine Desrayaud, Etienne Challet, Amyaouch Bradaia, Daniel Hoyer, Peter Waldmeier, Klemens Kaupmann, Paul Pévet, Bernhard Bettle. Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice. Journal of neurochemistry. vol 97. issue 4. 2006-06-22. PMID:16606363. |
tyrosine hydroxylase activity, tissue dopamine content and dopamine metabolism do not appear to be measurably altered. |
2006-06-22 |
2023-08-12 |
mouse |
| Claire-Marie Vacher, Martin Gassmann, Sandrine Desrayaud, Etienne Challet, Amyaouch Bradaia, Daniel Hoyer, Peter Waldmeier, Klemens Kaupmann, Paul Pévet, Bernhard Bettle. Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice. Journal of neurochemistry. vol 97. issue 4. 2006-06-22. PMID:16606363. |
pharmacological and electrophysiological experiments support that the hyperdopaminergic state of gabab1-/- mice is not severe enough to inactivate dopamine d2 receptors and to disrupt d2-mediated feedback inhibition of tyrosine hydroxylase activity. |
2006-06-22 |
2023-08-12 |
mouse |
| Montserrat Royo, S Colette Daubne. Kinetics of regulatory serine variants of tyrosine hydroxylase with cyclic AMP-dependent protein kinase and extracellular signal-regulated protein kinase 2. Biochimica et biophysica acta. vol 1764. issue 4. 2006-06-20. PMID:16503426. |
cyclic amp-dependent kinase was less active in phosphorylating s40 if dopamine was bound to tyrosine hydroxylase, but extracellular signal-regulated kinase 2 phosphorylation at s31 was unaffected by the presence of dopamine. |
2006-06-20 |
2023-08-12 |
rat |
| Xiao-Gang Li, Takashi Okada, Mika Kodera, Yuko Nara, Naomi Takino, Chieko Muramatsu, Kunihiko Ikeguchi, Fumi Urano, Hiroshi Ichinose, Daniel Metzger, Pierre Chambon, Imaharu Nakano, Keiya Ozawa, Shin-Ichi Muramats. Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease. Molecular therapy : the journal of the American Society of Gene Therapy. vol 13. issue 1. 2006-06-12. PMID:16182609. |
treatment with 4-hydroxytamoxifen, a synthetic estrogen receptor modulator, activated cre recombinase within the transduced neurons and induced selective excision of the tyrosine hydroxylase (th) coding sequence flanked by loxp sites, leading to a reduction in transgene-mediated dopamine synthesis. |
2006-06-12 |
2023-08-12 |
rat |
| Yu-Show Fu, Yun-Chih Cheng, Maan-Yuh Anya Lin, Henrich Cheng, Pei-Ming Chu, Shih-Chich Chou, Yang-Hsin Shih, Miau-Hwa Ko, Min-Shan Sun. Conversion of human umbilical cord mesenchymal stem cells in Wharton's jelly to dopaminergic neurons in vitro: potential therapeutic application for Parkinsonism. Stem cells (Dayton, Ohio). vol 24. issue 1. 2006-06-09. PMID:16099997. |
the success rate was 12.7%, as characterized by positive staining for tyrosine hydroxylase (th), the rate-limiting catecholaminergic synthesizing enzyme, and dopamine being released into the culture medium. |
2006-06-09 |
2023-08-12 |
human |
| Norton H Neff, Trina A Wemlinger, Anne-Marie Duchemin, Maria Hadjiconstantino. Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16415089. |
based on its pharmacology and reported enhancing effects on dopamine metabolism and tyrosine hydroxylase activity, we investigated whether it could modulate the activity of aromatic l-amino acid decarboxylase (aaad), the second enzyme for the biosynthesis of catecholamines and indoleamines. |
2006-06-09 |
2023-08-12 |
mouse |
| Norton H Neff, Trina A Wemlinger, Anne-Marie Duchemin, Maria Hadjiconstantino. Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. The Journal of pharmacology and experimental therapeutics. vol 317. issue 2. 2006-06-09. PMID:16415089. |
acute clozapine increased tyrosine hydroxylase activity in striatum but with differing temporal patterns from aaad and heightened dopamine metabolism. |
2006-06-09 |
2023-08-12 |
mouse |