| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Ying Shen, Jin-Cai He, Yumei Wang, Qing-Yuan Huang, Jiang-Fan Che. Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. The Journal of biological chemistry. vol 280. issue 48. 2006-02-03. PMID:16210323. |
neurochemical analysis showed that pretreatment with ga (via intracerebral ventricular injection 24 h prior to mptp treatment) increased residual dopamine content and tyrosine hydroxylase immunoreactivity in the striatum 24 h after mptp treatment. |
2006-02-03 |
2023-08-12 |
mouse |
| Anna J Reynolds, Selma K Kaasinen, Ian A Hendr. Retrograde axonal transport of dopamine beta hydroxylase antibodies by neurons in the trigeminal ganglion. Neurochemical research. vol 30. issue 6-7. 2006-01-30. PMID:16187207. |
in this study we describe a population of neurons in the adult rat trigeminal ganglion (tg) that express dopamine beta-hydroxylase (dbh) and tyrosine hydroxylase (th), and transport anti-dbh from their terminals. |
2006-01-30 |
2023-08-12 |
rat |
| Eberhard Weihe, Burkhard Schütz, Wolfgang Hartschuh, Martin Anlauf, Martin K Schäfer, Lee E Eide. Coexpression of cholinergic and noradrenergic phenotypes in human and nonhuman autonomic nervous system. The Journal of comparative neurology. vol 492. issue 3. 2006-01-23. PMID:16217790. |
adult human sweat gland innervation, however, is not only cholinergic but coexpresses all of the proteins required for full noradrenergic function as well, including tyrosine hydroxylase, aromatic amino acid decarboxylase, dopamine beta-hydroxylase, and the vesicular monoamine transporter vmat2. |
2006-01-23 |
2023-08-12 |
human |
| Michail S Davidoff, Hendrik Ungefroren, Ralf Middendorff, Yvetta Koeva, Mariana Bakalska, Nina Atanassova, Adolf F Holstein, Davor Jezek, Wolfgang Pusch, Dieter Mülle. Catecholamine-synthesizing enzymes in the adult and prenatal human testis. Histochemistry and cell biology. vol 124. issue 3-4. 2006-01-20. PMID:16052322. |
here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (th), aromatic amino acid decarboxylase (aadc), dopamine beta-hydroxylase (dbh) and phenylethanolamine- n-methyltransferase (pnmt), are expressed in leydig cells of the human testis. |
2006-01-20 |
2023-08-12 |
human |
| J Jankovic, S Chen, W D L. The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease. Progress in neurobiology. vol 77. issue 1-2. 2006-01-20. PMID:16243425. |
nurr1 interacts with other factors critical for the survival of mensencephalic dopaminergic neurons and it appears to regulate the expression of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2), and l-aromatic amino acid decarboxylase (aadc), all of which are important in the synthesis and storage of dopamine. |
2006-01-20 |
2023-08-12 |
mouse |
| Leila Kheirandish, David Gozal, Jean-Marc Pequignot, Jacqueline Pequignot, Barry W Ro. Intermittent hypoxia during development induces long-term alterations in spatial working memory, monoamines, and dendritic branching in rat frontal cortex. Pediatric research. vol 58. issue 3. 2006-01-19. PMID:16148079. |
norepinephrine concentrations, dopamine turnover, and tyrosine hydroxylase activity were increased similarly in males and females. |
2006-01-19 |
2023-08-12 |
rat |
| Thomas D Corso, German Torres, Christopher Goulah, Indrajit Roy, Angelo S Gambino, John Nayda, Timothy Buckley, Ewa K Stachowiak, Earl J Bergey, Haridas Pudavar, Purnendu Dutta, David C Bloom, William J Bowers, Michal K Stachowia. Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16039006. |
transfection of tyrosine kinase deleted fgf receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine. |
2006-01-17 |
2023-08-12 |
rat |
| Michael F Salvatore, Brent Fisher, Stewart P Surgener, Greg A Gerhardt, Tracey Rouaul. Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice. Brain research. Molecular brain research. vol 139. issue 2. 2006-01-17. PMID:16051392. |
to further characterize the dopamine (da) systems of irp-2 -/- mice, we harvested cns tissue from age-matched wild type and irp-2 -/- (16-19 months) and analyzed the protein levels of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter (vmat2), and da levels in dorsal striatum, ventral striatum (including the core and shell of nucleus accumbens), and midbrain. |
2006-01-17 |
2023-08-12 |
mouse |
| Montserrat Royo, S Colette Daubner, Paul F Fitzpatric. Effects of mutations in tyrosine hydroxylase associated with progressive dystonia on the activity and stability of the protein. Proteins. vol 58. issue 1. 2006-01-16. PMID:15468323. |
tyrosine hydroxylase (tyrh) catalyzes the conversion of tyrosine to dihydroxyphenylalanine (dopa), the rate-limiting step in the biosynthesis of dopamine. |
2006-01-16 |
2023-08-12 |
cat |
| Virginia Zbarsky, Krishna P Datla, Shabnam Parkar, Deepal K Rai, Okezie I Aruoma, David T Dexte. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free radical research. vol 39. issue 10. 2006-01-10. PMID:16298737. |
unilateral infusion of 6-ohda into the medial forebrain bundle produced a significant loss of tyrosine hydroxylase (th)-positive cells in the substantia nigra (sn) as well as a decreased of dopamine (da) content in the striata in the vehicle-treated animals. |
2006-01-10 |
2023-08-12 |
rat |
| Frank Y Ma, Greg M Anderson, Travis D Gunn, Vincent Goffin, David R Grattan, Stephen J Bun. Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons. Endocrinology. vol 146. issue 12. 2006-01-05. PMID:16123156. |
cultured cells expressing the dopamine synthesizing enzyme tyrosine hydroxylase (th) responded to prolactin with a time-dependent increase in phospho-stat5, but not phospho-stat1 or phospho-stat3, nuclear labeling. |
2006-01-05 |
2023-08-12 |
mouse |
| D M Kuhn, T J Gedde. Molecular footprints of neurotoxic amphetamine action. Annals of the New York Academy of Sciences. vol 914. 2006-01-04. PMID:11085312. |
tryptophan hydroxylase (tph) and tyrosine hydroxylase (th), the initial and rate limiting enzymes in the synthesis of serotonin and dopamine, respectively, are identified targets for the actions of meth and mdma. |
2006-01-04 |
2023-08-12 |
Not clear |
| Wendi S Neckameyer, Bridgette Holt, T J Paradowsk. Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates. Biochemical genetics. vol 43. issue 7-8. 2006-01-04. PMID:16187166. |
fundamental regulation of dopamine occurs via tyrosine hydroxylase (th), the first and rate-limiting enzyme in the catecholamine biosynthetic pathway. |
2006-01-04 |
2023-08-12 |
drosophila_melanogaster |
| Xiangmin Peng, Xiangmin M Peng, Roya Tehranian, Paula Dietrich, Leonidas Stefanis, Ruth G Pere. Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. Journal of cell science. vol 118. issue Pt 15. 2005-12-15. PMID:16030137. |
although the function of alpha-synuclein is not thoroughly elucidated, we found that alpha-synuclein regulates dopamine synthesis by binding to and inhibiting tyrosine hydroxylase, the rate limiting enzyme in dopamine synthesis. |
2005-12-15 |
2023-08-12 |
Not clear |
| Xiangmin Peng, Xiangmin M Peng, Roya Tehranian, Paula Dietrich, Leonidas Stefanis, Ruth G Pere. Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. Journal of cell science. vol 118. issue Pt 15. 2005-12-15. PMID:16030137. |
of these, ser40 contributes significantly to tyrosine hydroxylase activation and dopamine synthesis. |
2005-12-15 |
2023-08-12 |
Not clear |
| B Dass, M M Iravani, C Huang, J Barsoum, T M Engber, A Galdes, P Jenne. Sonic hedgehog delivered by an adeno-associated virus protects dopaminergic neurones against 6-OHDA toxicity in the rat. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 6. 2005-11-22. PMID:15586304. |
following vehicle or aav-lacz administration, 6-ohda caused a marked loss of striatal dopamine content and nigral tyrosine hydroxylase (th) immunopositive cells. |
2005-11-22 |
2023-08-12 |
rat |
| Yan Chen, Yi Ai, John R Slevin, Bruce E Maley, Don M Gas. Progenitor proliferation in the adult hippocampus and substantia nigra induced by glial cell line-derived neurotrophic factor. Experimental neurology. vol 196. issue 1. 2005-11-22. PMID:16112112. |
there was no evidence of neurogenesis in the substantia nigra, with new cells displaying glial features and none of the 1549 brdu-positive cells co-labeled for the dopamine neuronal marker tyrosine hydroxylase (th). |
2005-11-22 |
2023-08-12 |
rat |
| Rui Wang, Mona Boules, Elisa Gollatz, Katrina Williams, William Tiner, Elliott Richelso. Effects of 5 daily injections of the neurotensin-mimetic NT69L on the expression of neurotensin receptors in rat brain. Brain research. Molecular brain research. vol 138. issue 1. 2005-11-14. PMID:15878217. |
on the expression of nt (nts), dopamine 1 and 2 receptors, tyrosine hydroxylase, and dopa decarboxylase using immunohistochemical and real-time pcr were investigated in rats. |
2005-11-14 |
2023-08-12 |
rat |
| Masayuki Ide, Kazuo Yamada, Tomoko Toyota, Yoshimi Iwayama, Yuichi Ishitsuka, Yoshio Minabe, Kazuhiko Nakamura, Nobutaka Hattori, Takashi Asada, Yoshikuni Mizuno, Norio Mori, Takeo Yoshikaw. Genetic association analyses of PHOX2B and ASCL1 in neuropsychiatric disorders: evidence for association of ASCL1 with Parkinson's disease. Human genetics. vol 117. issue 6. 2005-11-10. PMID:16021468. |
we previously identified frequent deletion/insertion polymorphisms in the 20-alanine homopolymer stretch of phox2b (pmx2b), the gene for a transcription factor that plays important roles in the development of oculomotor nerves and catecholaminergic neurons and regulates the expression of both tyrosine hydroxylase and dopamine beta-hydroxylase genes. |
2005-11-10 |
2023-08-12 |
Not clear |
| Akira Nakashima, Nobuhiro Hayashi, Yoko S Kaneko, Keiji Mori, Hiromi Egusa, Toshiharu Nagatsu, Akira Ot. Deletion of N-terminus of human tyrosine hydroxylase type 1 enhances stability of the enzyme in AtT-20 cells. Journal of neuroscience research. vol 81. issue 1. 2005-11-03. PMID:15898085. |
wildtype human tyrosine hydroxylase (th) type 1 and 4 mutants (del-52, a form with the first 52 amino acid residues deleted; del-157, one with the first 157 amino acid residues deleted; rr-ee, one in which arg37-arg38 was replaced by glu37-glu38; and s40d, one in which ser40 was replaced by asp40) were expressed in att-20 mouse neuroendocrine cells in order to clarify how deeply the n-terminus of th is involved in the efficient production of dopamine (da) in mammalian cells. |
2005-11-03 |
2023-08-12 |
mouse |