| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ali Sajadi, Matthias Bauer, Beat Thöny, Patrick Aebische. Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production. Journal of neurochemistry. vol 93. issue 6. 2005-08-02. PMID:15935064. |
however, gdnf overexpression in the dopaminergic pathway leads to a time-dependent down-regulation of tyrosine hydroxylase (th), a key enzyme in dopamine synthesis. |
2005-08-02 |
2023-08-12 |
rat |
| S J López-Pérez, P Vergara, J P Ventura-Valenzuela, M E Ureña-Guerrero, J Segovia, C Beas-Zárat. Modification of dopaminergic markers expression in the striatum by neonatal exposure to glutamate during development. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 4. 2005-08-01. PMID:15927757. |
monosodium l-glutamate (msg) was administered subcutaneously to male neonatal rats, and the effect on developmental profile of tyrosine hydroxylase (th), d1, d2 receptors, and dopamine (da) transporter expression in the striatum was examined using western blot. |
2005-08-01 |
2023-08-12 |
rat |
| F-Q Li, T Wang, Z Pei, B Liu, J-S Hon. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 3. 2005-07-29. PMID:15503194. |
lps-induced damage to dopaminergic neurons was evaluated by uptake capacity for [3h]dopamine and tyrosine hydroxylase (th)-immunocytochemistry. |
2005-07-29 |
2023-08-12 |
rat |
| Xu-Feng Huang, Yinghua Yu, Katerina Zavitsanou, Mei Han, Len Storlie. Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity. Brain research. Molecular brain research. vol 135. issue 1-2. 2005-07-25. PMID:15857678. |
differential expression of dopamine d2 and d4 receptor and tyrosine hydroxylase mrna in mice prone, or resistant, to chronic high-fat diet-induced obesity. |
2005-07-25 |
2023-08-12 |
mouse |
| Xu-Feng Huang, Yinghua Yu, Katerina Zavitsanou, Mei Han, Len Storlie. Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity. Brain research. Molecular brain research. vol 135. issue 1-2. 2005-07-25. PMID:15857678. |
the present study examined brain dopamine d2 and d4 receptor and tyrosine hydroxylase (th) mrna expression in chronic high-fat diet-induced obese (cdio) and obese-resistant (cdr) mice. |
2005-07-25 |
2023-08-12 |
mouse |
| Ivar Mendez, Rosario Sanchez-Pernaute, Oliver Cooper, Angel Viñuela, Daniela Ferrari, Lars Björklund, Alain Dagher, Ole Isacso. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain : a journal of neurology. vol 128. issue Pt 7. 2005-07-18. PMID:15872020. |
the surviving transplanted dopamine neurons were positively identified with phenotypic markers of normal control human substantia nigra (n = 3), such as tyrosine hydroxylase, g-protein-coupled inward rectifying current potassium channel type 2 (girk2) and calbindin. |
2005-07-18 |
2023-08-12 |
human |
| A D Smith, D A Kozlowski, M C Bohn, M J Zigmon. Effect of AdGDNF on dopaminergic neurotransmission in the striatum of 6-OHDA-treated rats. Experimental neurology. vol 193. issue 2. 2005-07-15. PMID:15869944. |
we have previously observed that the delivery of an adenoviral vector encoding for glial cell line-derived neurotrophic factor (adgdnf) into the substantia nigra (sn) 7 days after intrastriatal administration of 6-hydroxydopamine (6-ohda) protects dopamine (da)-dependent behaviors, tyrosine hydroxylase immunoreactive (th+) cells in sn, and amphetamine-induced c-fos induction in striatum. |
2005-07-15 |
2023-08-12 |
rat |
| Isabel Lastres-Becker, Francisco Molina-Holgado, José A Ramos, Raphael Mechoulam, Javier Fernández-Rui. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. Neurobiology of disease. vol 19. issue 1-2. 2005-07-12. PMID:15837565. |
as expected, 2 weeks after the application of this toxin, a significant depletion of dopamine contents and a reduction of tyrosine hydroxylase activity in the lesioned striatum were noted, and were accompanied by a reduction in tyrosine hydroxylase-mrna levels in the substantia nigra. |
2005-07-12 |
2023-08-12 |
mouse |
| Richard Kinkead, Vincent Joseph, Yves Lajeunesse, Aida Baira. Neonatal maternal separation enhances dopamine D(2)-receptor and tyrosine hydroxylase mRNA expression levels in carotid body of rats. Canadian journal of physiology and pharmacology. vol 83. issue 1. 2005-07-11. PMID:15759053. |
neonatal maternal separation enhances dopamine d(2)-receptor and tyrosine hydroxylase mrna expression levels in carotid body of rats. |
2005-07-11 |
2023-08-12 |
rat |
| Richard Kinkead, Vincent Joseph, Yves Lajeunesse, Aida Baira. Neonatal maternal separation enhances dopamine D(2)-receptor and tyrosine hydroxylase mRNA expression levels in carotid body of rats. Canadian journal of physiology and pharmacology. vol 83. issue 1. 2005-07-11. PMID:15759053. |
to begin investigating the mechanisms involved in this gender-specific disruption in cardiorespiratory regulation, we tested the hypothesis that nms alters the expression of dopamine d(2)-receptors and tyrosine hydroxylase mrna in 3 peripheral organs involved in cardio respiratory regulation: the carotid bodies, superior cervical ganglia, and adrenals. |
2005-07-11 |
2023-08-12 |
rat |
| Richard Kinkead, Vincent Joseph, Yves Lajeunesse, Aida Baira. Neonatal maternal separation enhances dopamine D(2)-receptor and tyrosine hydroxylase mRNA expression levels in carotid body of rats. Canadian journal of physiology and pharmacology. vol 83. issue 1. 2005-07-11. PMID:15759053. |
the carotid bodies, superior cervical ganglia, and adrenals were harvested for semi-quantitative analyses of dopamine d(2)-receptors and tyrosine hydroxylase mrna expression using reverse transcription-polymerase chain reaction (carotid bodies only) and northern blot. |
2005-07-11 |
2023-08-12 |
rat |
| J Kaleczyc, J Juranek, J Całka, M Lakom. Immunohistochemical characterization of neurons in the porcine ciliary ganglion. Polish journal of veterinary sciences. vol 8. issue 1. 2005-06-30. PMID:15794476. |
the substances under investigation included markers of "classical" neurotransmitters, choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbetah) as well as neuropeptides, somatostatin (som), galanin (gal), substance p (sp), calcitonin gene-related peptide (cgrp), vasoactive intestinal polypeptide (vip) and neuropeptide y (npy). |
2005-06-30 |
2023-08-12 |
Not clear |
| Ji-Young Choi, Eun-Hee Jang, Chang-Shin Park, Ju-Hee Kan. Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity. Free radical biology & medicine. vol 38. issue 6. 2005-06-28. PMID:15721991. |
eight weeks after a hf or matched normal diet, a severe decrease in the levels of striatal dopamine and of nigral microtubule-associated protein 2, manganese superoxide dismutase, and tyrosine hydroxylase was observed in obese mice treated with subtoxic doses of mptp (20 mg/kg) compared with the matched lean group. |
2005-06-28 |
2023-08-12 |
mouse |
| Jie-Sheng Zheng, Ling-Ling Tang, Shu-Sen Zheng, Ren-Ya Zhan, Yong-Qing Zhou, John Goudreau, David Kaufman, Alex F Che. Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease. Brain research. Molecular brain research. vol 134. issue 1. 2005-06-13. PMID:15790539. |
at the 10th week after gene transfer, the striatal dopamine concentrations were measured by hplc with an electrochemical detector and the number of tyrosine hydroxylase (th)-positive dopamine neurons in the substantia nigra (sn) was determined by immunohistochemistry. |
2005-06-13 |
2023-08-12 |
rat |
| Qin Chen, Yi He, Keyi Yan. Gene therapy for Parkinson's disease: progress and challenges. Current gene therapy. vol 5. issue 1. 2005-05-24. PMID:15638712. |
among the numerous candidate genes that have been tested as therapeutic agents, those encoding tyrosine hydroxylase, guanosine triphosphate cyclohydrolase i and aromatic l-amino acid decarboxylase all boost dopamine production, while glial cell line-derived neurotrophic factor promotes the survival of dopaminergic neurons and is generally believed to possess the greatest potential for successful restoration of the dopaminergic system. |
2005-05-24 |
2023-08-12 |
Not clear |
| Kaori Koike, Kenji Hashimoto, Goro Fukami, Naoe Okamura, Lin Zhang, Shintaro Ohgake, Hiroki Koizumi, Daisuke Matsuzawa, Noriyuki Kawamura, Eiji Shimizu, Masaomi Iy. The immunophilin ligand FK506 protects against methamphetamine-induced dopaminergic neurotoxicity in mouse striatum. Neuropharmacology. vol 48. issue 3. 2005-05-24. PMID:15721171. |
we also examined the immunohistochemistry of dopamine transporter (dat) and tyrosine hydroxylase (th) in the mouse brain. |
2005-05-24 |
2023-08-12 |
mouse |
| Philip E Brandish, Ming Su, Daniel J Holder, Paul Hodor, John Szumiloski, Robert R Kleinhanz, Jaime E Forbes, Mollie E McWhorter, Sven J Duenwald, Mark L Parrish, Sang Na, Yuan Liu, Robert L Phillips, John J Renger, Sethu Sankaranarayanan, Adam J Simon, Edward M Scolnic. Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. Neuron. vol 45. issue 6. 2005-05-19. PMID:15797548. |
previous work has shown that pacap can increase tyrosine hydroxylase (th) activity and dopamine release, and we found that the gene for gtp cyclohydrolase, which effectively regulates th through synthesis of tetrahydrobiopterin, was also upregulated by inositol depletion. |
2005-05-19 |
2023-08-12 |
rat |
| Yossef S Levy, Merav Stroomza, Eldad Melamed, Daniel Offe. Embryonic and adult stem cells as a source for cell therapy in Parkinson's disease. Journal of molecular neuroscience : MN. vol 24. issue 3. 2005-05-11. PMID:15655260. |
to increase the generation of dopamine, researchers have already transplanted non-neuronal cells, without any genetic manipulation or after introduction of genes such as tyrosine hydroxylase, in animal models of pd. |
2005-05-11 |
2023-08-12 |
Not clear |
| Atsushi Mori, Satoshi Ohashi, Masami Nakai, Tetsuji Moriizumi, Yasuhide Mitsumot. Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice. Neuroscience research. vol 51. issue 3. 2005-05-09. PMID:15710490. |
dopamine (da) contents and protein levels of tyrosine hydroxylase and dopamine transporter in the striatum were profoundly decreased in the toxin-treated mice. |
2005-05-09 |
2023-08-12 |
mouse |
| Vânia Gomide, Theo Bibancos, Gerson Chad. Dopamine cell morphology and glial cell hypertrophy and process branching in the nigrostriatal system after striatal 6-OHDA analyzed by specific sterological tools. The International journal of neuroscience. vol 115. issue 4. 2005-05-04. PMID:15804725. |
after behavioral analysis, fats were killed and their brains processed for the immunohistochemistry tyrosine hydroxylase (th), a marker for dopamine cells, as well as glial fibrillary acidic protein (gfap) and ox-42, markers for astrocyte and microglia, respectively. |
2005-05-04 |
2023-08-12 |
rat |