| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideki Mochizuk. [Future of gene therapy for Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651340. |
for enhancing dopamine production, the candidate genes are tyrosine hydroxylase, aadc and/or gtp cyclohydroxylase i. |
2005-03-04 |
2023-08-12 |
mouse |
| W A Luft, P M Iuvone, W K Stel. Spatial, temporal, and intensive determinants of dopamine release in the chick retina. Visual neuroscience. vol 21. issue 4. 2005-02-28. PMID:15579225. |
activation of dopaminergic neurons, labeled for tyrosine hydroxylase (th), was assessed with immunocytochemistry for c-fos, and dopamine release was measured by hplc analysis of dopamine metabolite accumulation in the vitreous body. |
2005-02-28 |
2023-08-12 |
chicken |
| Jesus A Angulo, Nieves Angulo, Jing Y. Antagonists of the neurokinin-1 or dopamine D1 receptors confer protection from methamphetamine on dopamine terminals of the mouse striatum. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542715. |
exposure to meth induces long-term deficits in dopamine transporter (dat) and tyrosine hydroxylase (th) levels as well as induction of glial fibrillary acidic protein (gfap) in the caudate putamen (cpu) and the nucleus accumbens (nac). |
2005-02-18 |
2023-08-12 |
mouse |
| N N Kudriavtseva, M L Filipenko, I V Bakshtanovskaia, D F Avgustinovich, O V Alekseenko, A G Beĭlin. [Changes in the expression of monoaminergic genes under the influence of repeated experience of agonistic interactions: from behavior to gene]. Genetika. vol 40. issue 6. 2005-02-10. PMID:15341265. |
this was accompanied by a decrease in the mrna level of the catechol-o-methyltransferase gene in the midbrain and an increase of the mrna level of the dopamine transporter and tyrosine hydroxylase genes in the ventral tegmental area of aggressive male mice. |
2005-02-10 |
2023-08-12 |
mouse |
| Karen S Rommelfanger, David Weinshenker, Gary W Mille. Reduced MPTP toxicity in noradrenaline transporter knockout mice. Journal of neurochemistry. vol 91. issue 5. 2005-02-10. PMID:15569255. |
net ko and wild-type littermates were administered mptp and striatal dopamine terminal integrity was assessed by hplc of monoamines, immmunoblotting for dopaminergic markers and tyrosine hydroxylase (th) immunohistochemistry. |
2005-02-10 |
2023-08-12 |
mouse |
| Alexander Kuzmin, Johan Sandin, Lars Terenius, Sven Ove Ogre. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors. British journal of pharmacology. vol 141. issue 1. 2005-01-24. PMID:14662736. |
pretreatment with the tyrosine hydroxylase inhibitor h44-68 totally eliminated the motor-stimulatory effects of low doses of nociceptin, probably via dopamine depletion. |
2005-01-24 |
2023-08-12 |
mouse |
| Rumiko Kurosaki, Yasuko Muramatsu, Hiroyuki Kato, Tsutomu Arak. Biochemical, behavioral and immunohistochemical alterations in MPTP-treated mouse model of Parkinson's disease. Pharmacology, biochemistry, and behavior. vol 78. issue 1. 2005-01-07. PMID:15159144. |
the immunohistochemical study has shown that the acute treatment with mptp caused severe loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-immunoreactive dopaminergic neurons and marked increase in glial fibrillary acidic protein (gfap)-immunoreactive astrocytes in the striatum and the substantia nigra. |
2005-01-07 |
2023-08-12 |
mouse |
| R Kurosaki, Y Muramatsu, Y Imai, H Kato, T Arak. Neuroprotective effect of the angiotensin-converting enzyme inhibitor perindopril in MPTP-treated mice. Neurological research. vol 26. issue 6. 2005-01-07. PMID:15327754. |
in our immunohistochemical studies with antibodies against tyrosine hydroxylase (th), microtubule-associated protein 2a, b (map2), dopamine transporter (dat), parvalbumin (pv), glial fibrillary acidic protein (gfap) and cu/zn-superoxide dismutase (cu/zn-sod), the administration of perindopril significantly attenuated mptp-induced substantia nigra and striatal damage. |
2005-01-07 |
2023-08-12 |
mouse |
| K Hyland, S Kasim, K Egami, L A Arnold, H A Jinna. Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease. Journal of inherited metabolic disease. vol 27. issue 2. 2004-12-30. PMID:15159647. |
since bh4 is required as a cofactor for tyrosine hydroxylase in the synthesis of dopamine, any limitation in the supply of gtp could interfere with the synthesis of dopamine. |
2004-12-30 |
2023-08-12 |
mouse |
| Stephanie J Cragg, Jérôme Baufreton, Yi Xue, J Paul Bolam, Mark D Beva. Synaptic release of dopamine in the subthalamic nucleus. The European journal of neuroscience. vol 20. issue 7. 2004-12-22. PMID:15380000. |
we carried out three experiments in rats to explore the function of da in the stn: (i) light and electron microscopic analysis of tyrosine hydroxylase (th)-, dopamine beta-hydroxylase (dbetah)- and da-immunoreactive structures to determine whether da axons form synapses; (ii) fast-scan cyclic voltammetry (fcv) to determine whether da axons release da; and (iii) patch clamp recording to determine whether da, at a concentration similar to that detected by fcv, can modulate activity and synaptic transmission/integration. |
2004-12-22 |
2023-08-12 |
rat |
| Samina S Riaz, Spyridon Theofilopoulos, Eric Jauniaux, Gerald M Stern, Henry F Bradfor. The differentiation potential of human foetal neuronal progenitor cells in vitro. Brain research. Developmental brain research. vol 153. issue 1. 2004-12-21. PMID:15464216. |
positive immunoreactivity to tyrosine hydroxylase (th) and raised levels of dopamine (da) and its metabolite, 3,4-dihydroxyphenylacetic acid (dopac), secreted into culture medium, were used to indicate the presence of the dopaminergic neuronal phenotype, i.e., active th. |
2004-12-21 |
2023-08-12 |
human |
| Benedict T Green, Mark Lyte, Chunsheng Chen, Yonghong Xie, Melissa A Casey, Anjali Kulkarni-Narla, Lucy Vulchanova, David R Brow. Adrenergic modulation of Escherichia coli O157:H7 adherence to the colonic mucosa. American journal of physiology. Gastrointestinal and liver physiology. vol 287. issue 6. 2004-12-20. PMID:15534374. |
nerve fibers immunoreactive for the ne-synthesizing enzymes tyrosine hydroxylase and dopamine beta-hydroxylase appeared to innervate the colonic epithelium. |
2004-12-20 |
2023-08-12 |
Not clear |
| M B Arciszewski, A Zacharko, R Lala. Co-expression of tyrosine hydroxylase, dopamine beta-hydroxylase and neuropeptide Y in the sympathetic neurons projecting to the submandibular gland in the sheep. Anatomy and embryology. vol 208. issue 2. 2004-12-02. PMID:15127299. |
co-expression of tyrosine hydroxylase, dopamine beta-hydroxylase and neuropeptide y in the sympathetic neurons projecting to the submandibular gland in the sheep. |
2004-12-02 |
2023-08-12 |
Not clear |
| M B Arciszewski, A Zacharko, R Lala. Co-expression of tyrosine hydroxylase, dopamine beta-hydroxylase and neuropeptide Y in the sympathetic neurons projecting to the submandibular gland in the sheep. Anatomy and embryology. vol 208. issue 2. 2004-12-02. PMID:15127299. |
antibodies to tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah) and neuropeptide y (npy) were used to determine the immunochemical characteristics of smg-innervating sympathetic neurons. |
2004-12-02 |
2023-08-12 |
Not clear |
| Shun Yu, Xiaohong Zuo, Yaohua Li, Chen Zhang, Ming Zhou, Yu Alex Zhang, Kenji Uéda, Piu Cha. Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells. Neuroscience letters. vol 367. issue 1. 2004-11-24. PMID:15308292. |
although the aberrant expression of alpha-synuclein (alpha-syn) is toxic to dopaminergic neurons, little is known about the correlation between the abnormality of alpha-syn and the expression of tyrosine hydroxylase (th), a rate-limiting enzyme for the synthesis of dopamine neurotransmitter. |
2004-11-24 |
2023-08-12 |
human |
| Anna Zacharko, Marcin Bartłomiej Arciszewski, Krzysztof Wasowic. Origin of the primary efferent neurons projecting to the prostate of the dog. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 186. issue 4. 2004-11-22. PMID:15481842. |
immunohistochemical staining for tyrosine hydroxylase and dopamine beta-hydroxylase was applied to determine the neurochemical character of fast blue-positive efferent neurons. |
2004-11-22 |
2023-08-12 |
dog |
| Anna Zacharko, Marcin Bartłomiej Arciszewski, Krzysztof Wasowic. Origin of the primary efferent neurons projecting to the prostate of the dog. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 186. issue 4. 2004-11-22. PMID:15481842. |
immunohistochemistry revealed that in all tyrosine hydroxylase immunoreactive fast blue-positive neurons immunoreactivity for dopamine beta-hydroxylase was also found (noradrenergic neurons) while all tyrosine hydroxylase-negative fast blue-positive neurons did not express dopamine beta-hydroxylase (non-noradrenergic neurons). |
2004-11-22 |
2023-08-12 |
dog |
| Anna Zacharko, Marcin Bartłomiej Arciszewski, Krzysztof Wasowic. Origin of the primary efferent neurons projecting to the prostate of the dog. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 186. issue 4. 2004-11-22. PMID:15481842. |
in bilateral pelvic plexus ganglia, 26.7% +/- 1.5 of the prostate-supplying efferent neurons did not express either tyrosine hydroxylase or dopamine beta-hydroxylase immunoreactivity which makes discussion of their cholinergic character possible. |
2004-11-22 |
2023-08-12 |
dog |
| N P Murphy, A M Tan, H A Lam, N T Maidmen. Nociceptin/orphanin FQ modulation of rat midbrain dopamine neurons in primary culture. Neuroscience. vol 127. issue 4. 2004-11-16. PMID:15312905. |
immunohistochemical analysis revealed abundant tyrosine hydroxylase- and gaba-immunoreactive neurons, with a strong correlation between tyrosine hydroxylase content and basal endogenous dopamine release. |
2004-11-16 |
2023-08-12 |
rat |
| Laura Ezquerra, Gonzalo Herradón, Trang Nguyen, Thomas F Vogt, Roderick Bronson, Inmaculada Silos-Santiago, Thomas F Deue. Pleiotrophin is a major regulator of the catecholamine biosynthesis pathway in mouse aorta. Biochemical and biophysical research communications. vol 323. issue 2. 2004-11-16. PMID:15369781. |
we identified a dramatic upregulation of expression of tyrosine hydroxylase (th), dopa decarboxylase, and dopamine beta-hydroxylase in aortae of ptn -/- mice in comparison with wt (ptn +/+) mice. |
2004-11-16 |
2023-08-12 |
mouse |