| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elzbieta Lorenc-Koci, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Małgorzata Zapała, Joanna Wierońsk. Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120584. |
effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of cyp2d inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3h]gbr 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. |
2004-07-12 |
2023-08-12 |
rat |
| Elzbieta Lorenc-Koci, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Małgorzata Zapała, Joanna Wierońsk. Effect of 1,2,3,4,-tetrahydroisoquinoline administration under conditions of CYP2D inhibition on dopamine metabolism, level of tyrosine hydroxylase protein and the binding of [3H]GBR 12,935 to dopamine transporter in the rat nigrostriatal, dopaminergic system. Brain research. vol 1009. issue 1-2. 2004-07-12. PMID:15120584. |
twice daily for 14 days) markedly decreased the level of tyrosine hydroxylase protein (th) in the str; however, this effect was not accompanied by reduction of dopamine (da) concentration and [(3)h]gbr 12,935 binding to dopamine transporter (dat). |
2004-07-12 |
2023-08-12 |
rat |
| Guenther Bernert, Harald Hoeger, Wilhelm Mosgoeller, Doris Stolzlechner, Barbara Lube. Neurodegeneration, neuronal loss, and neurotransmitter changes in the adult guinea pig with perinatal asphyxia. Pediatric research. vol 54. issue 4. 2004-07-08. PMID:12867599. |
we tested tyrosine hydroxylase, the vesicular monoamine transporter, and dopamine beta-hydroxylase, representing the monoaminergic system; the vesicular acetylcholine transporter; and the excitatory amino acid carrier 1. |
2004-07-08 |
2023-08-12 |
rat |
| M Murat. Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease. Current pharmaceutical design. vol 10. issue 6. 2004-06-21. PMID:14965331. |
as for its mechanism, we showed that zns increases dopamine contents in the striatum by activating dopamine synthesis and the level of mrna of tyrosine hydroxylase (th) prior to that of th protein. |
2004-06-21 |
2023-08-12 |
Not clear |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. |
2004-06-21 |
2023-08-12 |
mouse |
| Michael W Jakowec, Kerry Nixon, Elizabeth Hogg, Tom McNeill, Giselle M Petzinge. Tyrosine hydroxylase and dopamine transporter expression following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration of the mouse nigrostriatal pathway. Journal of neuroscience research. vol 76. issue 4. 2004-06-21. PMID:15114626. |
the purpose of this study was to analyze proteins and mrna transcripts of genes involved in dopamine biosynthesis (tyrosine hydroxylase; th) and uptake (dopamine transporter; dat) with regard to time course (7-90 days) after mptp lesioning. |
2004-06-21 |
2023-08-12 |
mouse |
| Julian T Pittman, Celia A Dodd, Bradley G Klei. Immunohistochemical changes in the mouse striatum induced by the pyrethroid insecticide permethrin. International journal of toxicology. vol 22. issue 5. 2004-06-14. PMID:14555407. |
dopamine transporter, tyrosine hydroxylase, and glial fibrillary acidic protein immunoreactivities were examined in caudate-putamen to distinguish changes in amount of dopamine transporter immunoreactive protein from degeneration or other damage to dopaminergic neuropil. |
2004-06-14 |
2023-08-12 |
mouse |
| Julian T Pittman, Celia A Dodd, Bradley G Klei. Immunohistochemical changes in the mouse striatum induced by the pyrethroid insecticide permethrin. International journal of toxicology. vol 22. issue 5. 2004-06-14. PMID:14555407. |
the high dose of permethrin did not produce a significant change in dopamine transporter or tyrosine hydroxylase immunostaining, but resulted in a significant increase in glial fibrillary acidic protein immunostaining. |
2004-06-14 |
2023-08-12 |
mouse |
| Matthias J T Kaiser, Gisa Tiegs, Winfried L Neuhube. Close apposition of dynorphin-positive nerve fibres to lymphocytes in the liver suggests opioidergic neuroimmunomodulation. Histochemistry and cell biology. vol 120. issue 3. 2004-06-10. PMID:12904970. |
antibodies directed against dynorphin a, met-enkephalin, endomorphin 1 and 2, mu, kappa- and delta-opioid receptors (mor, kor, dor), tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), cd4, cd8 and macrophages were used. |
2004-06-10 |
2023-08-12 |
mouse |
| Boris Ferger, Andreas Leng, Anna Mura, Bastian Hengerer, Joram Feldo. Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum. Journal of neurochemistry. vol 89. issue 4. 2004-06-04. PMID:15140182. |
partly protected against the mptp-induced dopamine (da) depletion, and tnf-alpha (-/-) mice showed a significant attenuation of striatal da and da metabolite loss as well as striatal tyrosine hydroxylase (th) fiber density, but no difference in nigral th and da transporter immunoreactivity. |
2004-06-04 |
2023-08-12 |
mouse |
| Peter Klivenyi, Noel Y Calingasan, Anatoly Starkov, Irina G Stavrovskaya, Bruce S Kristal, Lichuan Yang, Bé Wieringa, M Flint Bea. Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Neurobiology of disease. vol 15. issue 3. 2004-05-27. PMID:15056469. |
ubmi-ck-deficient mice showed increased sensitivity to 1-methyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced dopamine depletion and loss of tyrosine hydroxylase (th) stained neurons. |
2004-05-27 |
2023-08-12 |
mouse |
| Suzan Dziennis, Beth A Habecke. Ciliary neurotrophic factor suppresses Phox2a in sympathetic neurons. Neuroreport. vol 15. issue 1. 2004-05-27. PMID:15106827. |
in the rat, this includes suppression of the noradrenergic enzymes tyrosine hydroxylase and dopamine beta-hydroxylase. |
2004-05-27 |
2023-08-12 |
mouse |
| Suzan Dziennis, Beth A Habecke. Ciliary neurotrophic factor suppresses Phox2a in sympathetic neurons. Neuroreport. vol 15. issue 1. 2004-05-27. PMID:15106827. |
we found that ciliary neurotrophic factor decreased the transcriptional activator phox2a in neuroblastoma cells and cultured sympathetic neurons, suggesting that the loss of phox2a is part of the mechanism by which cntf suppresses tyrosine hydroxylase and dopamine beta-hydroxylase. |
2004-05-27 |
2023-08-12 |
mouse |
| Chang-Lin Liang, Omar Nelson, Umar Yazdani, Parichehr Pasbakhsh, Dwight C Germa. Inverse relationship between the contents of neuromelanin pigment and the vesicular monoamine transporter-2: human midbrain dopamine neurons. The Journal of comparative neurology. vol 473. issue 1. 2004-05-24. PMID:15067721. |
the immunostaining intensity (isi) was measured for vmat2 and also for the rate-limiting enzyme for the synthesis of dopamine, tyrosine hydroxylase (th). |
2004-05-24 |
2023-08-12 |
human |
| Sung Tae Kim, Jin Woo Chang, Hea Nam Hong, Onyou Hwan. Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain. Neuroscience letters. vol 359. issue 1-2. 2004-05-21. PMID:15050714. |
we report in the present study that bh4 injection into the lateral ventricle leads to degeneration of the dopaminergic terminals in the striatum, evidenced by a loss of tyrosine hydroxylase (th) immunopositive fibers, a decreased amount of th protein, and decreased dopamine content. |
2004-05-21 |
2023-08-12 |
rat |
| Sepill Park, Keum Sil Lee, Young Jae Lee, Hyun Ah Shin, Hwang Yoon Cho, Kyu Chang Wang, Yong Sik Kim, Hoon Taek Lee, Kil Saeng Chung, Eun Young Kim, Jinho Li. Generation of dopaminergic neurons in vitro from human embryonic stem cells treated with neurotrophic factors. Neuroscience letters. vol 359. issue 1-2. 2004-05-21. PMID:15050721. |
in addition, immunostaining and hplc analyses revealed higher levels of tyrosine hydroxylase (20+/-2.3%) and dopamine (265.5+/-62.8 pg/ml) in the bfgf- and tgf-alpha-treated hes cells than in ra- or bdnf-treated hes cells. |
2004-05-21 |
2023-08-12 |
human |
| Marina Romero-Ramos, Jose L Venero, Sonia Garcia-Rodriguez, Antonio Ayala, Alberto Machado, Josefina Can. Semichronic inhibition of glutathione reductase promotes oxidative damage to proteins and induces both transcription and translation of tyrosine hydroxylase in the nigrostriatal system. Free radical research. vol 37. issue 9. 2004-05-20. PMID:14670008. |
we also studied the mrna levels for tyrosine hydroxylase (th) and the dopamine transporter (dat) by in situ hybridization. |
2004-05-20 |
2023-08-12 |
rat |
| Moussa B H Youdim, Galia Stephenson, Dorit Ben Shacha. Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. Annals of the New York Academy of Sciences. vol 1012. 2004-05-19. PMID:15105275. |
desferal alone at the doses studied did not affect striatal tyrosine hydroxylase (th) activity or dopamine (da) metabolism. |
2004-05-19 |
2023-08-12 |
human |
| Margaret E Balfour, Lei Yu, Lique M Coole. Sexual behavior and sex-associated environmental cues activate the mesolimbic system in male rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 4. 2004-05-17. PMID:14694350. |
the next goal was to determine if sexual behavior activates dopamine neurons in the vta, using tyrosine hydroxylase as a marker for dopaminergic neurons and fos-immunoreactivity as a marker for neuronal activation. |
2004-05-17 |
2023-08-12 |
rat |
| M F Salvatore, O Hudspeth, L E Arnold, P E Wilson, J A Stanford, C F MacTutus, R M Booze, G A Gerhard. Prenatal cocaine exposure alters potassium-evoked dopamine release dynamics in rat striatum. Neuroscience. vol 123. issue 2. 2004-05-12. PMID:14698755. |
we also measured total dopamine transporter (dat) and tyrosine hydroxylase protein levels in these offspring by blot immunolabeling and found a small, but significant, decrease in dat protein in striatum from offspring exposed at gd 8-21 and gd 15-21. |
2004-05-12 |
2023-08-12 |
rat |