| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas G Beach, Douglas G Walker, Lucia I Sue, Amanda Newell, Charles C Adler, Jeffrey N Joyc. Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers. Journal of neuropathology and experimental neurology. vol 63. issue 4. 2004-05-12. PMID:15099023. |
marinesco body frequency in elderly control cases correlated significantly, in inverse fashion, with striatal concentrations of the dopaminergic neuron markers dopamine transporter and tyrosine hydroxylase. |
2004-05-12 |
2023-08-12 |
human |
| Jeffrey N Joyce, T C Der, Lynn Renish, Tracy Osredkar, Diane Hagner, Maria Reploge, Shinichi Sakakibara, Shuichi Ued. Loss of D3 receptors in the zitter mutant rat is not reversed by L-dopa treatment. Experimental neurology. vol 187. issue 1. 2004-05-10. PMID:15081599. |
in control sprague-dawley (sd) and zitter heterozygote (zi/-) rats that do not show a loss of d(3) receptors with vehicle treatment, l-dopa produced no change in d(3) receptor number or in da terminal density as measured by dopamine transporter (dat) binding and tyrosine hydroxylase immunoautoradiography (th-ir). |
2004-05-10 |
2023-08-12 |
rat |
| Florence Friggi-Grelin, Magali Iché, Serge Birma. Tissue-specific developmental requirements of Drosophila tyrosine hydroxylase isoforms. Genesis (New York, N.Y. : 2000). vol 35. issue 4. 2004-05-03. PMID:12717737. |
drosophila tyrosine hydroxylase (dth) is a key enzyme in dopamine (da) biosynthesis, which is expressed in neural and hypodermal da-synthesizing cells. |
2004-05-03 |
2023-08-12 |
drosophila_melanogaster |
| Byung Pil Cho, Shuei Sugama, Dong Hoon Shin, Lorraine A DeGiorgio, Sung Soo Kim, Yoon Seong Kim, So Young Lim, Key Chung Park, Bruce T Volpe, Sunghee Cho, Tong H Jo. Microglial phagocytosis of dopamine neurons at early phases of apoptosis. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514015. |
immunohistochemical localization of activated microglia and tyrosine hydroxylase in the axotomized substantia nigra showed that activation of microglia was rapid and ox-6 (mhc-ii marker)-positive and ed1 (lysosomal phagocytic marker)-positive microglia were apposed to structurally intact tyrosine hydroxylase-positive dopamine neurons, indicating microglial phagocytosis of degenerating dopamine neurons. |
2004-04-30 |
2023-08-12 |
rat |
| Ming Yang, Angela E Donaldson, Yubao Jiang, Lorraine Iacovitt. Factors influencing the differentiation of dopaminergic traits in transplanted neural stem cells. Cellular and molecular neurobiology. vol 23. issue 4-5. 2004-04-30. PMID:14514036. |
our previous studies demonstrated that when neural stem cells (nscs) of the c17.2 clonal line are transplanted into the intact or 6-hydroxydopamine (6-ohda) lesioned rat striatum, in most, but not all grafts, cells spontaneously express the dopamine (da) biosynthetic enzymes, tyrosine hydroxylase (th), and aromatic l-amino acid decarboxylase (yang, m., stull, n. d., snyder. |
2004-04-30 |
2023-08-12 |
rat |
| Hijiri Watanabe, Yasuko Muramatsu, Rumiko Kurosaki, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai, Tsutomu Arak. Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 2. 2004-04-19. PMID:15013024. |
it protected against both dopamine depletions and tyrosine hydroxylase (th) positive neuron decreases in the mouse brain. |
2004-04-19 |
2023-08-12 |
mouse |
| Howard T J Mount, Jean-Claude Martel, Paul Fluit, Yingji Wu, Eleanor Gallo-Hendrikx, Cristina Cosi, Marc R Marie. Progressive sensorimotor impairment is not associated with reduced dopamine and high energy phosphate donors in a model of ataxia-telangiectasia. Journal of neurochemistry. vol 88. issue 6. 2004-04-15. PMID:15009646. |
it has been reported that immunoreactive tyrosine hydroxylase and dopamine transporter are reduced in an atm-/- mouse model of a-t. |
2004-04-15 |
2023-08-12 |
mouse |
| J Prieto-Lloret, A I Caceres, A Obeso, A Rocher, R Rigual, M T Agapito, R Bustamante, J Castañeda, M T Perez-Garcia, J R Lopez-Lopez, C Gonzale. Ventilatory responses and carotid body function in adult rats perinatally exposed to hyperoxia. The Journal of physiology. vol 554. issue Pt 1. 2004-04-06. PMID:14678497. |
in comparison with the controls, hyperoxic cbs showed (1) half the size, but comparable percentage area positive to tyrosine hydroxylase (chemoreceptor cells) in histological sections; (2) a twofold increase in dopamine (da) concentration, but a 50% reduction in da synthesis rate; (3) a 75% reduction in hypoxia-evoked da release, but normal high [k+]0-evoked release; (4) a 75% reduction in the number of hypoxia-sensitive csn fibers (although responding units displayed a nearly normal hypoxic response); and (5) a smaller percentage of chemoreceptor cells that increased [ca2+]1 in hypoxia, although responses were within the normal range. |
2004-04-06 |
2023-08-12 |
rat |
| Jason R Richardson, Gary W Mille. Acute exposure to aroclor 1016 or 1260 differentially affects dopamine transporter and vesicular monoamine transporter 2 levels. Toxicology letters. vol 148. issue 1-2. 2004-04-02. PMID:15019086. |
tyrosine hydroxylase expression, a marker of dopamine neuron integrity, was not significantly affected by pcb exposure at any time. |
2004-04-02 |
2023-08-12 |
Not clear |
| Elisa Mengual, Virginia M Picke. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. The Journal of comparative neurology. vol 468. issue 3. 2004-03-26. PMID:14681933. |
regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. |
2004-03-26 |
2023-08-12 |
rat |
| Tessei Kuruma, Meiho Nakayama, Atushi Nakano, Men Dur Wu, Shigeru Inafuku, Guo Gang Fen. [Immunohistochemical study for monoamine neurons in the brain of unilateral inner ear impaired rats]. Nihon Jibiinkoka Gakkai kaiho. vol 106. issue 12. 2004-03-18. PMID:14733122. |
to visualize 5-hydroxytryptamine (5-ht), noradrenaline (na) and dopamine (da) neurons, we used mouse antibodies against 5-ht, na, and da syntheses, i.e., tryptophan hydroxylase (trh), tyrosine hydroxylase (th) and dopamine-beta-hydroxylase (dbh). |
2004-03-18 |
2023-08-12 |
mouse |
| R W P Rodrigues, V C Gomide, G Chad. Astroglial and microglial activation in the wistar rat ventral tegmental area after a single striatal injection of 6-hydroxydopamine. The International journal of neuroscience. vol 114. issue 2. 2004-03-15. PMID:14702208. |
the tyrosine hydroxylase (th) positive dopamine cells, the glial fibrillary acidic protein (gfap) immuno -labeled astrocytes, and the ox42 immunoreactive microglia were visualized by means of immunohistochemistry and quantified by stereologic methods employing the optical dissector and the point intercepts. |
2004-03-15 |
2023-08-12 |
rat |
| M Lonjon, M H Quentien, J J Risso, J F Michiels, E Carre, J C Rostain, O Darbi. Alteration of striatal dopaminergic function induced by glioma development: a microdialysis and immunohistological study in the rat striatum. Neuroscience letters. vol 354. issue 2. 2004-03-11. PMID:14698456. |
immunohistochemistry was performed to investigate changes in neurofilament (nf), tyrosine hydroxylase (th) and dopamine transporter (dat) expression. |
2004-03-11 |
2023-08-12 |
rat |
| Isabel Liste, Beatriz Navarro, Jens Johansen, Carlos Bueno, Ana Villa, Teit E Johansen, Alberto Martínez-Serran. Low-level tyrosine hydroxylase (TH) expression allows for the generation of stable TH+ cell lines of human neural stem cells. Human gene therapy. vol 15. issue 1. 2004-03-10. PMID:14965374. |
human neural stem cells (hnscs) are excellent candidates to serve this role, but, for the case of parkinson's disease, the cells do not normally express the rate-limiting dopamine (da) synthesis enzyme tyrosine hydroxylase (th), and are not equipped with the detoxifying mechanisms needed to prevent the neurotoxicity associated with the da phenotype. |
2004-03-10 |
2023-08-12 |
human |
| Dagmar Galter, Silvia Buervenich, Andrea Carmine, Maria Anvret, Lars Olso. ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678778. |
parallel labeling for gapdh, neuron-specific enolase, tyrosine hydroxylase, dopamine transporter, and dopamine beta-hydroxylase was used to ensure suitability of tissue specimen and to identify all dopamine neurons. |
2004-03-05 |
2023-08-12 |
human |
| Marcin Nowicki, Joanna Wojtkiewicz, Beata Seremak, Magorzata Sulik, Jacek Ostaszewski, Bogdan Lewczuk, Mariusz Majewski, Barbara Przybylska-Gornowic. Specific distribution pattern of nerve fibers containing catecholamine-synthesizing enzymes, neuropeptide Y (NPY) and C-terminal flanking peptide of NPY (CPON) in the pineal gland of the chinchilla (Chinchilla laniger)--an immunohistochemical study. Folia histochemica et cytobiologica. vol 41. issue 4. 2004-03-04. PMID:14677758. |
in this study, immunohistochemical techniques were used to demonstrate the existence and coexistence of tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbetah) as well as npy and cpon in the nerve fibers supplying the chinchilla pineal gland. |
2004-03-04 |
2023-08-12 |
Not clear |
| Cristina Bäckman, YaJun Zhang, Barry J Hoffer, Andreas C Toma. Short interfering RNAs (siRNAs) for reducing dopaminergic phenotypic markers. Journal of neuroscience methods. vol 131. issue 1-2. 2004-03-01. PMID:14659823. |
the effective suppression of nr4a2, cret and tyrosine hydroxylase suggest that the u6 expression cassette could be used to deliver sirna to mammalian cells in vivo and actively suppress the expression of dopamine related mammalian genes. |
2004-03-01 |
2023-08-12 |
human |
| A Kochman, Cz Kośka, D Metodiew. Submolecular adventures of brain tyrosine: what are we searching for now? Amino acids. vol 23. issue 1-3. 2004-02-26. PMID:12373523. |
a signal transduction role, because nitration of tyrosine residues through tyro(*) formation can modulate, as well the phosphorylation (tyrosine kinases activity) and/or tyrosine hydroxylation (tyrosine hydroxylase inactivation), leading to consequent dopamine synthesis failure and increased degradation of target proteins, respectively; 2). |
2004-02-26 |
2023-08-12 |
Not clear |
| Nicolas Cuenca, Ping Deng, Ken A Linberg, Geoffrey P Lewis, Steven K Fisher, Helga Kol. The neurons of the ground squirrel retina as revealed by immunostains for calcium binding proteins and neurotransmitters. Journal of neurocytology. vol 31. issue 8-9. 2004-02-26. PMID:14501205. |
the dopamine cell type ir to tyrosine hydroxylase has the typical morphology of a wide field cell with dendrites in s1 but the "rings" seen in cat or rabbit retina are not as numerous. |
2004-02-26 |
2023-08-12 |
rabbit |
| Rong Chen, Jianning Wei, Stephen C Fowler, Jang-Yen W. Demonstration of functional coupling between dopamine synthesis and its packaging into synaptic vesicles. Journal of biomedical science. vol 10. issue 6 Pt 2. 2004-02-24. PMID:14631117. |
we now report that the rate-limiting enzyme in dopamine (da) biosynthesis, tyrosine hydroxylase (th), is regulated similarly to gad(65). |
2004-02-24 |
2023-08-12 |
Not clear |