| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Oleg S Gorbatyuk, Shoudong Li, Layla F Sullivan, Weijun Chen, Galina Kondrikova, Fredric P Manfredsson, Ronald J Mandel, Nicholas Muzyczk. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 2. 2008-02-06. PMID:18178617. |
there was a significant reduction of dopaminergic neurons in the snc and dopamine (da) and tyrosine hydroxylase (th) levels in the striatum of all s129a-treated rats as early as 4 wk postinjection. |
2008-02-06 |
2023-08-12 |
human |
| Andrej Nikoshkov, Katarina Drakenberg, Xinyu Wang, Monika Cs Horvath, Eva Keller, Yasmin L Hur. Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 2. 2008-02-06. PMID:18184800. |
up-regulation of nac penk in met/met heroin abusers was accompanied by impaired tyrosine hydroxylase (th) mrna expression in mesolimbic dopamine neurons. |
2008-02-06 |
2023-08-12 |
human |
| Mritunjay Pandey, Merina Varghese, Kizhakke M Sindhu, Sen Sreetama, A K Navneet, Kochupurackal P Mohanakumar, Rajamma Ush. Mitochondrial NAD+-linked State 3 respiration and complex-I activity are compromised in the cerebral cortex of 3-nitropropionic acid-induced rat model of Huntington's disease. Journal of neurochemistry. vol 104. issue 2. 2008-02-05. PMID:17953654. |
rats treated with 3-np (10-20 mg/kg i.p., for 4 days) exhibited weight loss, gait abnormalities, and striatal lesions with increased glial fibrillary acidic protein immunostaining on fifth and ninth days, while increase in striatal dopamine and loss of tyrosine hydroxylase immunoreactivity were observed on fifth day following treatment. |
2008-02-05 |
2023-08-12 |
rat |
| Christine A Kirvan, Susan E Swedo, David Kurahara, Madeleine W Cunningha. Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea. Autoimmunity. vol 39. issue 1. 2008-02-01. PMID:16455579. |
antibodies present in acute chorea react with the surface of neuronal cells and signal the induction of calcium calmodulin dependent protein kinase ii with elevation of tyrosine hydroxylase and subsequent dopamine release which may lead to the movement disorder. |
2008-02-01 |
2023-08-12 |
Not clear |
| Aneta Tylec, Marta Stryjecka-Zimmer, Katarzyna Kucharska-Pietur. [Genetic polymorphism of COMT in mental disorders]. Psychiatria polska. vol 41. issue 4. 2008-01-29. PMID:18046978. |
evaluation of genes associated with the dopaminergic system include five well known subtypes of dopaminergic receptors, dopamine transporter and enzymes associated with the synthesis and degradation of dopamine, such as tyrosine hydroxylase, dopa decarboxylase, monoamine oxidase (mao) and catechol o-methyltransferase (comt). |
2008-01-29 |
2023-08-12 |
Not clear |
| Noelia Granado, Isabel Escobedo, Esther O'Shea, Isabel Colado, Rosario Moratall. Early loss of dopaminergic terminals in striosomes after MDMA administration to mice. Synapse (New York, N.Y.). vol 62. issue 1. 2008-01-22. PMID:17960765. |
in this study we examined the long-term effect induced by mdma on tyrosine hydroxylase (th) and dopamine transporter (dat) immunoreactivity in the striosomes and matrix compartments of mouse striatum. |
2008-01-22 |
2023-08-12 |
mouse |
| Ana I Rojo, Carmen Cavada, María Rosa de Sagarra, Antonio Cuadrad. Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats. Experimental neurology. vol 208. issue 1. 2008-01-17. PMID:17880941. |
mptp-treated mice developed motor deficits that correlated with a severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase staining in substantia nigra and striatum. |
2008-01-17 |
2023-08-12 |
mouse |
| A J Fulford, C A Marsde. An intact dopaminergic system is required for context-conditioned release of 5-HT in the nucleus accumbens of postweaning isolation-reared rats. Neuroscience. vol 149. issue 2. 2008-01-16. PMID:17869434. |
we investigated the effect of the tyrosine hydroxylase inhibitor, alpha-methyl-para-tyrosine (ampt) on extracellular dopamine and 5-ht levels in the nucleus accumbens of group- and isolation-reared rats. |
2008-01-16 |
2023-08-12 |
rat |
| C Vadasz, J F Smiley, K Figarsky, M Saito, R Toth, B M Gyetvai, M Oros, K K Kovacs, P Mohan, R Wan. Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes. Neuroscience. vol 149. issue 3. 2008-01-16. PMID:17920205. |
mesencephalic dopamine neuron number and tyrosine hydroxylase content: genetic control and candidate genes. |
2008-01-16 |
2023-08-12 |
mouse |
| M V Ugriumo. [Expression of the enzymes of dopamine synthesis in non-dopaminergic neurons: functional significance and regulation]. Uspekhi fiziologicheskikh nauk. vol 38. issue 4. 2008-01-16. PMID:18064905. |
dopamine(da), the most widely distributed in the nervous system and functionally important chemical signal, is synthesized in da-ergic neurons from l-tyrosine by means of two enzymes, tyrosine hydroxylase (th) and aromatic l-amino acid decarboxylase (aadc). |
2008-01-16 |
2023-08-12 |
Not clear |
| M Mikhaylova, J V Vakhitova, R S Yamidanov, M Kh Salimgareeva, S B Seredenin, T Behnisc. The effects of ladasten on dopaminergic neurotransmission and hippocampal synaptic plasticity in rats. Neuropharmacology. vol 53. issue 5. 2008-01-14. PMID:17854844. |
we found that ladasten differentially regulates tyrosine hydroxylase mrna and protein as well as dopamine and l-dopa content. |
2008-01-14 |
2023-08-12 |
rat |
| Jun Yang, Qingshan Teng, Mary E Garrity-Moses, Shearwood McClelland, Thais Federici, Erin Carlton, Jonathon Riley, Nicholas M Bouli. Reversible unilateral nigrostriatal pathway inhibition induced through expression of adenovirus-mediated clostridial light chain gene in the substantia nigra. Neuromolecular medicine. vol 9. issue 3. 2007-12-27. PMID:17914186. |
tyrosine hydroxylase (th) and dopamine transporter (dat) immunohistochemistry (ihc) showed markedly decreased staining in ipsilateral sn and striatum in 6-ohda but not adlc or adgfp rats. |
2007-12-27 |
2023-08-12 |
rat |
| Monika Cs Horvath, Gabor G Kovacs, Viktor Kovari, Katalin Majtenyi, Yasmin L Hurd, Eva Kelle. Heroin abuse is characterized by discrete mesolimbic dopamine and opioid abnormalities and exaggerated nuclear receptor-related 1 transcriptional decline with age. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 49. 2007-12-27. PMID:18057194. |
we examined mrna expression levels of da transporter (dat), tyrosine hydroxylase (th), dopamine d2 receptor, alpha-synuclein, and nuclear receptor-related 1 (nurr1) in discrete mesocorticolimbic and nigrostriatal subpopulations of heroin users and control subjects. |
2007-12-27 |
2023-08-12 |
human |
| Charles A Ducsay, Kim Hyatt, Malgorzata Mlynarczyk, Brandon K Root, Kanchan M Kaushal, Dean A Myer. Long-term hypoxia modulates expression of key genes regulating adrenomedullary function in the late gestation ovine fetus. American journal of physiology. Regulatory, integrative and comparative physiology. vol 293. issue 5. 2007-12-26. PMID:17699566. |
contrary to our hypothesis, in addition to pnmt, adrenomedullary expression (mrna, protein) of tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) were reduced in the lth fetus. |
2007-12-26 |
2023-08-12 |
Not clear |
| Giovana Seno Di Marco, Carlos P Vio, Oscar Fernando Pav Atilde O Dos Santos, Nestor Schor, Dulce Elena Casarin. Catecholamine production along the nephron. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 20. issue 6. 2007-12-19. PMID:17982274. |
the synthesis enzymes as tyrosine hydroxylase, dopa decarboxylase and dopamine beta-hydroxylase were detected by western blotting. |
2007-12-19 |
2023-08-12 |
Not clear |
| Gennady Dvoryanchikov, Seth M Tomchik, Nirupa Chaudhar. Biogenic amine synthesis and uptake in rodent taste buds. The Journal of comparative neurology. vol 505. issue 3. 2007-12-12. PMID:17879273. |
in contrast, enzymes necessary for ne synthesis, tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) are absent. |
2007-12-12 |
2023-08-12 |
Not clear |
| Lane J Wallac. A small dopamine permeability of storage vesicle membranes and end product inhibition of tyrosine hydroxylase are sufficient to explain changes occurring in dopamine synthesis and storage after inhibition of neuron firing. Synapse (New York, N.Y.). vol 61. issue 9. 2007-11-29. PMID:17559092. |
a small dopamine permeability of storage vesicle membranes and end product inhibition of tyrosine hydroxylase are sufficient to explain changes occurring in dopamine synthesis and storage after inhibition of neuron firing. |
2007-11-29 |
2023-08-12 |
Not clear |
| Laura Grandoso, Sara Ponce, Ivan Manuel, Aurora Arrúe, Jose A Ruiz-Ortega, Isabel Ulibarri, Gorka Orive, Rosa M Hernández, Alicia Rodríguez, Rafael Rodríguez-Puertas, Mercedes Zumárraga, Gurutz Linazasoro, Jose Luis Pedraz, Luisa Uged. Long-term survival of encapsulated GDNF secreting cells implanted within the striatum of parkinsonized rats. International journal of pharmaceutics. vol 343. issue 1-2. 2007-11-27. PMID:17583454. |
no changes in the levels of dopamine and its metabolites or of tyrosine hydroxylase immunoreactivity were detected in the striatum. |
2007-11-27 |
2023-08-12 |
rat |
| Christina H L Teh, Chin Chieh Loh, Kevin K Y Lam, Jia Min Loo, Tie Yan, Tit Meng Li. Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17457889. |
catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (th) is the rate-limiting enzyme. |
2007-11-05 |
2023-08-12 |
mouse |
| Hirohide Sawada, Ryohei Hishida, Yoko Hirata, Kenji Ono, Hiromi Suzuki, Shin-ichi Muramatsu, Imaharu Nakano, Toshiharu Nagatsu, Makoto Sawad. Activated microglia affect the nigro-striatal dopamine neurons differently in neonatal and aged mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Journal of neuroscience research. vol 85. issue 8. 2007-11-05. PMID:17469135. |
tyrosine hydroxylase (th) activity, the levels of dopamine and 3,4-dihydroxyphenylacetic acid (dopac), and the levels of pro-inflammatory cytokines il-1beta and il-6 in the midbrain were elevated in the neonates treated with lps and mptp. |
2007-11-05 |
2023-08-12 |
mouse |