| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ran Barzilay, Inna Kan, Tali Ben-Zur, Shlomo Bulvik, Eldad Melamed, Daniel Offe. Induction of human mesenchymal stem cells into dopamine-producing cells with different differentiation protocols. Stem cells and development. vol 17. issue 3. 2008-08-29. PMID:18513164. |
following cell culture with various combinations of differentiation agents under serum-free defined conditions, different levels of up-regulation were observed in the protein expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2008-08-29 |
2023-08-12 |
human |
| Roberto Chiocchetti, Gemma Mazzuoli, Valeria Albanese, Maurizio Mazzoni, Paolo Clavenzani, Giovanna Lalatta-Costerbosa, Maria L Lucchi, Giovanni Di Guardo, Giuseppe Marruchella, John B Furnes. Anatomical evidence for ileal Peyer's patches innervation by enteric nervous system: a potential route for prion neuroinvasion? Cell and tissue research. vol 332. issue 2. 2008-08-28. PMID:18317812. |
antibodies against protein gene product 9.5, tyrosine hydroxylase, dopamine beta hydroxylase, choline acetyltransferase, calbindin (calb), calcitonin gene-related peptide (cgrp), and nitric oxide synthase were used to characterise the neurons. |
2008-08-28 |
2023-08-12 |
Not clear |
| Jan Haavik, Nenad Blau, Beat Thön. Mutations in human monoamine-related neurotransmitter pathway genes. Human mutation. vol 29. issue 7. 2008-08-28. PMID:18444257. |
the biosynthetic enzymes are tyrosine hydroxylase (th), tryptophan hydroxylases type 1 and 2 (tph1, tph2), aromatic amino acid decarboxylase (aadc), dopamine beta-hydroxylase (dbetah), and phenylethanolamine n-methyltransferase (pnmt), and the specific catabolic enzymes are monoamine oxidase a (mao-a) and catechol o-methyltransferase (comt). |
2008-08-28 |
2023-08-12 |
human |
| Derek B Oien, Greg L Osterhaus, Shaheen A Latif, Jonathan W Pinkston, Jenny Fulks, Michael Johnson, Stephen C Fowler, Jackob Moskovit. MsrA knockout mouse exhibits abnormal behavior and brain dopamine levels. Free radical biology & medicine. vol 45. issue 2. 2008-08-26. PMID:18466776. |
similarly, the expression pattern of tyrosine hydroxylase activating protein correlated with the age-dependent dopamine levels. |
2008-08-26 |
2023-08-12 |
mouse |
| Sirirat Klongpanichapak, Pansiri Phansuwan-Pujito, Manuchair Ebadi, Piyarat Govitrapon. Melatonin inhibits amphetamine-induced increase in alpha-synuclein and decrease in phosphorylated tyrosine hydroxylase in SK-N-SH cells. Neuroscience letters. vol 436. issue 3. 2008-08-25. PMID:18406059. |
the present study was conducted to investigate the effect of amph on alpha-synuclein in regulating tyrosine hydroxylase (th), a rate limiting enzyme for dopamine synthesis, in cultured human dopaminergic sk-n-sh cells. |
2008-08-25 |
2023-08-12 |
human |
| Yoo Jung Yang, Jae Joon Lee, Chun Mei Jin, Sung Cil Lim, Myung Koo Le. Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. European journal of pharmacology. vol 587. issue 1-3. 2008-08-25. PMID:18457825. |
dopamine content, tyrosine hydroxylase (th) activity and th mrna levels were decreased during the first 6 h, maintained for up to 48 h and then gradually recovered at 72 h after exposure to 20 microm harman and 100 microm norharman. |
2008-08-25 |
2023-08-12 |
Not clear |
| Teresa Marie du Bois, Ching-Wen Hsu, Yulin Li, Yean Yeow Tan, Chao Deng, Xu-Feng Huan. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18256931. |
altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mrna expression following perinatal nmda receptor blockade. |
2008-08-20 |
2023-08-12 |
rat |
| Teresa Marie du Bois, Ching-Wen Hsu, Yulin Li, Yean Yeow Tan, Chao Deng, Xu-Feng Huan. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18256931. |
tyrosine hydroxylase mrna expression was also significantly increased by 25% (p < 0.05) in the ventral tegmental area of adult rats, suggesting that this model may produce a long-term increase in dopamine output. |
2008-08-20 |
2023-08-12 |
rat |
| Dongmei Liu, Ling Jin, Hao Wang, Huanying Zhao, Chunli Zhao, Chunli Duan, Lingling Lu, Bo Wu, Shun Yu, Piu Chan, Yaohua Li, Hui Yan. Silencing alpha-synuclein gene expression enhances tyrosine hydroxylase activity in MN9D cells. Neurochemical research. vol 33. issue 7. 2008-08-20. PMID:18357527. |
previous studies have shown that alpha-synuclein is involved in the regulation of dopamine (da) metabolism, possibly by down-regulating the expression of tyrosine hydroxylase (th), the rate-limiting enzyme in da biosynthesis. |
2008-08-20 |
2023-08-12 |
Not clear |
| Niklas Lindgren, Rehana K Leak, Kirsten M Carlson, Amanda D Smith, Michael J Zigmon. Activation of the extracellular signal-regulated kinases 1 and 2 by glial cell line-derived neurotrophic factor and its relation to neuroprotection in a mouse model of Parkinson's disease. Journal of neuroscience research. vol 86. issue 9. 2008-08-20. PMID:18438911. |
gdnf also protected dopamine terminals against the loss of tyrosine hydroxylase immunoreactivity normally associated with the intrastriatal administration of 6-hydroxydopamine (0.5 microg/0.5 microl). |
2008-08-20 |
2023-08-12 |
mouse |
| Mathieu Marella, Byoung Boo Seo, Eiko Nakamaru-Ogiso, J Timothy Greenamyre, Akemi Matsuno-Yagi, Takao Yag. Protection by the NDI1 gene against neurodegeneration in a rotenone rat model of Parkinson's disease. PloS one. vol 3. issue 1. 2008-08-08. PMID:18197244. |
it was clear that the introduction of the ndi1 protein in the substantia nigra rendered resistance to the deleterious effects caused by rotenone exposure as assessed by the levels of tyrosine hydroxylase and dopamine. |
2008-08-08 |
2023-08-12 |
mouse |
| Gaëlle Bouchez, Luc Sensebé, Patrick Vourc'h, Lucette Garreau, Sylvie Bodard, Angélique Rico, Denis Guilloteau, Pierre Charbord, Jean-Claude Besnard, Sylvie Chalo. Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease. Neurochemistry international. vol 52. issue 7. 2008-08-08. PMID:18372079. |
immunoreactive tyrosine hydroxylase, membrane dopamine transporter and vesicular monoamine transporter-2 was significantly higher in group iii as compared with group i. |
2008-08-08 |
2023-08-12 |
rat |
| Eva Hedlund, Jan Pruszak, Thomas Lardaro, Wesley Ludwig, Angel Viñuela, Kwang-Soo Kim, Ole Isacso. Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 26. issue 6. 2008-08-06. PMID:18388307. |
egfp expression overlapped closely with that of pitx3, nurr1, engrailed-1, lmx1a, tyrosine hydroxylase (th), l-aromatic amino acid decarboxylase (aadc), and vesicular monoamine transporter 2 (vmat2), demonstrating that these cells were of a midbrain dopamine neuron character. |
2008-08-06 |
2023-08-12 |
mouse |
| Thomas Gerald Beach, Charles H Adler, Lucia I Sue, Jeffrey B Peirce, Jyothi Bachalakuri, Jessica E Dalsing-Hernandez, Lih Fen Lue, John N Caviness, Donald J Connor, Marwan N Sabbagh, Douglas G Walke. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. Acta neuropathologica. vol 115. issue 4. 2008-08-01. PMID:17985144. |
quantitative elisa measurement of striatal tyrosine hydroxylase (th), the principal enzyme for dopamine synthesis, showed a 49.8% (p = 0.01) reduction in ilbd cases, as compared with control cases. |
2008-08-01 |
2023-08-12 |
human |
| b' Tiina M K\\xc3\\xa4\\xc3\\xa4ri\\xc3\\xa4inen, Marjo Piltonen, Bernardino Ossola, Heli Kekki, S\\xc3\\xa1rka Lehtonen, Terhi Nenonen, Anne Lecklin, Atso Raasmaja, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures. Brain research. vol 1203. 2008-08-01. PMID:18329008.' |
furthermore, no protection was observed in tyrosine hydroxylase positive nigral cell numbers, striatal fiber density or in striatal levels of dopamine. |
2008-08-01 |
2023-08-12 |
rat |
| J C Lewers, I Ceballos-Picot, T L Shirley, L Mockel, K Egami, H A Jinna. Consequences of impaired purine recycling in dopaminergic neurons. Neuroscience. vol 152. issue 3. 2008-07-21. PMID:18313225. |
instead, the loss of dopamine reflected only one aspect of a broad change in the molecular phenotype of the cells affecting mrnas encoding tyrosine hydroxylase, the dopamine transporter, the vesicular monoamine transporter, monoamine oxidase b, catechol-o-methyltransferase, and gtp-cyclohydrolase. |
2008-07-21 |
2023-08-12 |
mouse |
| Michel M M Verheij, Alexander R Cool. Twenty years of dopamine research: individual differences in the response of accumbal dopamine to environmental and pharmacological challenges. European journal of pharmacology. vol 585. issue 2-3. 2008-07-18. PMID:18423601. |
data are summarised demonstrating that individual differences in accumbal dopamine release are due to individual differences in: the functional reactivity of the noradrenergic system, the accumbal concentration of vesicular monoamine transporters and tyrosine hydroxylase as well as in the quantal size of the presynaptic pools of dopamine. |
2008-07-18 |
2023-08-12 |
human |
| Hui-Ling Wang, Marisela Morale. Corticotropin-releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons. The Journal of comparative neurology. vol 509. issue 3. 2008-07-15. PMID:18478589. |
by double in situ hybridization, we determined that vta neurons with crf-bp mrna coexpressed transcripts encoding either tyrosine hydroxylase [th; a marker for dopamine (da) neurons] or glutamic acid decarboxylase [gad; synthesizing enzyme of gamma-aminobutyric acid (gaba)]. |
2008-07-15 |
2023-08-12 |
Not clear |
| Joachim Scholz, Karen Toska, Alexander Luborzewski, Astrid Maass, Volker Schünemann, Jan Haavik, Andreas Mose. Endogenous tetrahydroisoquinolines associated with Parkinson's disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines. The FEBS journal. vol 275. issue 9. 2008-07-09. PMID:18355318. |
we show here that 6,7-dihydroxylated tetrahydroisoquinolines such as n-methyl-norsalsolinol inhibit tyrosine hydroxylase, the key enzyme in dopamine synthesis, by imitating the mechanisms of catecholamine feedback regulation. |
2008-07-09 |
2023-08-12 |
human |
| Kaneyasu Nishimura, Yoshihisa Kitamura, Kiyokazu Agat. [Molecular mechanism of brain regeneration and reconstruction of dopaminergic neural network in planarians]. Brain and nerve = Shinkei kenkyu no shinpo. vol 60. issue 4. 2008-06-26. PMID:18421972. |
recently, we have identified a planarian tyrosine hydroxylase (th) gene, a rate-limiting enzyme for dopamine (da) biosynthesis, and produced th-knockdown planarians by the rna interference technique. |
2008-06-26 |
2023-08-12 |
Not clear |