| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R J Grant, L H L Sellings, S J Crocker, E Melloni, D S Park, P B S Clark. Effects of calpain inhibition on dopaminergic markers and motor function following intrastriatal 6-hydroxydopamine administration in rats. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19007862. |
unexpectedly, dopamine transporter and tyrosine hydroxylase labeling revealed significant neuroprotection, not in the nigrostriatal pathway but rather in the ventral tegmental area. |
2009-04-15 |
2023-08-12 |
rat |
| N Zhang, N Miyamoto, R Tanaka, H Mochizuki, N Hattori, T Urab. Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19032975. |
cilostazol markedly upregulated cyclic amp responsive element binding protein (creb) phosphorylation, increased tyrosine hydroxylase (th) expression in the substantial nigra, and maintained dopamine (84.7+/-2.3 vs. 79.2+/-4.1% control; p=0.0512) and substance p levels (86.6+/-7.9 vs. 73.9+/-6.5% control; p<0.05) in the striatum, compared with the vehicle group. |
2009-04-15 |
2023-08-12 |
rat |
| M T Tadaiesky, P A Dombrowski, C P Figueiredo, E Cargnin-Ferreira, C Da Cunha, R N Takahash. Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience. vol 156. issue 4. 2009-04-14. PMID:18817851. |
the time-course of nigrostriatal damage was evaluated by tyrosine hydroxylase immunohistochemistry and the levels of dopamine, noradrenaline, and 5-ht in various brain regions were analyzed by high performance liquid chromatography (hplc). |
2009-04-14 |
2023-08-12 |
rat |
| Jaya Prasanthi Rantham Prabhakara, Gwen Feist, Sarah Thomasson, Alex Thompson, Eric Schommer, Othman Ghrib. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells. Journal of neurochemistry. vol 107. issue 6. 2009-04-09. PMID:19014385. |
in this study, we incubated the human neuroblastoma sh-sy5y cells for 24 h with 24-ohc, 27-ohc, or a mixture of 24-ohc plus 27-ohc, and have determined effects on tyrosine hydroxylase (the rate-limiting enzyme in dopamine synthesis) levels, alpha-synuclein levels, and apoptosis. |
2009-04-09 |
2023-08-12 |
human |
| Chao Guo, Hai-Yan Qiu, Ming Shi, Ying Huang, Randy L Johnson, Marcelo Rubinstein, Sheng-Di Chen, Yu-Qiang Din. Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 52. 2009-04-08. PMID:19109492. |
we found that mda neurons revealed by tyrosine hydroxylase (th), pitx3, nurr1, and dopamine transporter were indistinguishable from wild-type controls during embryonic development as well as in adulthood in th-cre;lmx1b(flox/-) and dat(cre/+);lmx1b(flox/-) mice, in which lmx1b was selectively deleted in differentiating mda neurons. |
2009-04-08 |
2023-08-12 |
mouse |
| Eduardo Moura, Joana Afonso, Maria Paula Serrão, Maria Augusta Vieira-Coelh. Effect of clonidine on tyrosine hydroxylase activity in the adrenal medulla and brain of spontaneously hypertensive rats. Basic & clinical pharmacology & toxicology. vol 104. issue 2. 2009-04-01. PMID:19067675. |
in the brain of spontaneously hypertensive rats, treatment with clonidine produced a significant decrease in tyrosine hydroxylase activity with lower v(max) values and no changes in k(m) values accompanied by a significant decrease in tyrosine hydroxylase protein expression and of dopamine and noradrenaline levels. |
2009-04-01 |
2023-08-12 |
rat |
| Limin Shi, Ning Song, Hong Jiang, Jun Wang, Zegang Ma, Junxia Xi. Potassium channels are involved in zinc-induced apoptosis in MES23.5 cells. Journal of neuroscience research. vol 87. issue 2. 2009-03-25. PMID:18756520. |
then we observed that the tyrosine hydroxylase (th) protein expression and the dopamine content decreased, as detected by western blots and high-performance liquid chromatography-electrochemical detection (hplc-ecd). |
2009-03-25 |
2023-08-12 |
Not clear |
| Yeong-Gon Choi, Jae-Hyun Park, Sabina Li. Acupuncture inhibits ferric iron deposition and ferritin-heavy chain reduction in an MPTP-induced parkinsonism model. Neuroscience letters. vol 450. issue 2. 2009-03-24. PMID:19056464. |
acupuncture inhibited decreases in the immunoreactivities of tyrosine hydroxylase (th) and dopamine transporter (dat) that occurred as a result of mptp neurotoxicity. |
2009-03-24 |
2023-08-12 |
mouse |
| Shirushi Takahash. Expression levels of mRNAs for catecholamine biosynthetic enzymes as markers of acute response to contusion stress during the early postmortem period. The Tohoku journal of experimental medicine. vol 216. issue 3. 2009-03-11. PMID:18987458. |
real-time quantitative polymerase-chain reaction was performed to quantify relative expression levels of mrnas for catecholamine biosynthetic enzymes in the adrenals and the anterocervical ganglia: tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyltransferase (pnmt). |
2009-03-11 |
2023-08-12 |
rat |
| Jing Liu, Yan-Yong Wang, Li Liu, Quan-Dong Wang, Zhen-Yun Yuan, Zhong-Xia Zhang, Ping Gu, Ming-Wei Wan. Damage to the nigrostriatal system in the MPTP-treated SAMP8 mouse. Neuroscience letters. vol 448. issue 2. 2009-02-27. PMID:18977411. |
in mptp-samp8 mice, the tyrosine hydroxylase (th)-positive neuronal loss at 6h (7.06%), 24h (12.79%), 3 days (22.49%), and 8 days (42.39%), while striatal dopamine (da) levels decreased at 6h by 79.09%, at 24h by 80.33%, at 3 days by 83.86%, and at 8 days by 80.14%. |
2009-02-27 |
2023-08-12 |
mouse |
| J E de Leeuw van Weenen, L Hu, K Jansen-Van Zelm, M G de Vries, J T Tamsma, J A Romijn, H Pij. Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice. Brain research. vol 1250. 2009-02-27. PMID:19028458. |
we monitored in vivo dopamine release in the dorsomedial region of the hypothalamus, and determined hypothalamic gene expression patterns of dopamine receptors 1 and 2 (drd1 and 2), tyrosine hydroxylase (th) and the dopamine transporter (dat) in c57bl6 mice maintained on a high fat diet for 4 weeks. |
2009-02-27 |
2023-08-12 |
mouse |
| Sachiko Saino-Sait. Visualization of spatiotemporal differentiation of dopaminergic interneurons in adult mouse olfactory bulb using transgenic mice. Anatomical science international. vol 83. issue 4. 2009-02-24. PMID:19159350. |
in the adult superficial gr layer transgene expression was found, either enhanced green fluorescent protein or lacz reporter driven by a 9 kb tyrosine hydroxylase (th) promoter, that marked the dopamine (da) phenotype. |
2009-02-24 |
2023-08-12 |
mouse |
| Antoni D'Souza, Eylem Onem, Pranav Patel, Edmund F La Gamma, Bistra B Nankov. Valproic acid regulates catecholaminergic pathways by concentration-dependent threshold effects on TH mRNA synthesis and degradation. Brain research. vol 1247. 2009-02-19. PMID:18976638. |
emerging evidence indicates that brain noradrenergic systems contribute to the symptoms of mood disorders and may involve regulation of tyrosine hydroxylase (th) expression, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine and epinephrine. |
2009-02-19 |
2023-08-12 |
Not clear |
| Valentina Ghisi, Amy J Ramsey, Bernard Masri, Raul R Gainetdinov, Marc G Caron, Ali Salahpou. Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cellular signalling. vol 21. issue 1. 2009-02-06. PMID:18929645. |
this increase in basal pakt levels can be pharmacologically recapitulated by partial dopamine depletion in wt mice treated with the selective tyrosine hydroxylase inhibitor alpha-methyl-para-tyrosine (alpha-mpt). |
2009-02-06 |
2023-08-12 |
mouse |
| S W Kang, B Leclerc, L J Mauro, M E El Halawan. Serotonergic and catecholaminergic interactions with co-localised dopamine-melatonin neurones in the hypothalamus of the female turkey. Journal of neuroendocrinology. vol 21. issue 1. 2009-02-03. PMID:19094089. |
to examine this possible interaction, the retrograde fluorescent tract tracer, 1,1'dioctadecyl-3,3,3'3'-tetramethyleindocarbocyanine perchlorate (dii) was injected into the pmm, and combined with serotonin, tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh) and phenyl n-methyltransferse (pnmt) immunocytochemistry to reveal neuroanatomical connections. |
2009-02-03 |
2023-08-12 |
Not clear |
| Guang-Zhen Jin, Su-Jin Cho, Eu-Gene Choi, Young-S Lee, Xian-Feng Yu, Kap-Seong Choi, Sung-Tae Yee, Jin-Tae Jeon, Myeong-Ok Kim, Il-Keun Kon. Rat mesenchymal stem cells increase tyrosine hydroxylase expression and dopamine content in ventral mesencephalic cells in vitro. Cell biology international. vol 32. issue 11. 2009-01-30. PMID:18778785. |
rat mesenchymal stem cells increase tyrosine hydroxylase expression and dopamine content in ventral mesencephalic cells in vitro. |
2009-01-30 |
2023-08-12 |
rat |
| Maryline Blin, William Norton, Laure Bally-Cuif, Philippe Vernie. NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain. Molecular and cellular neurosciences. vol 39. issue 4. 2009-01-30. PMID:18822380. |
using loss- and gain-of-function experiments in zebrafish, we show that nr4a2 is indeed responsible for the expression of tyrosine hydroxylase (th) in selective subpopulations of dopamine cells in the posterior tuberculum, as well as in the pretectum, preoptic area and telencephalon. |
2009-01-30 |
2023-08-12 |
mouse |
| Ginetta Collo, Silvia Zanetti, Cristina Missale, Pierfranco Span. Dopamine D3 receptor-preferring agonists increase dendrite arborization of mesencephalic dopaminergic neurons via extracellular signal-regulated kinase phosphorylation. The European journal of neuroscience. vol 28. issue 7. 2009-01-30. PMID:18973551. |
in this study, we investigated the effects of the dopamine d3 receptor-preferring agonists quinpirole and 7-hydroxy-n,n-di-propyl-2-aminotetralin (7-oh-dpat), as well as of the indirect agonist amphetamine, on dopaminergic neurons identified by tyrosine hydroxylase immunoreactivity (th-ir). |
2009-01-30 |
2023-08-12 |
mouse |
| b' Patricia Patterson-Buckendahl, Larissa A Pohorecky, Lucia Kubovcakova, Olga Krizanova, R Bruce Martin, Daniel A Martinez, Richard Kvetnansk\\xc3\\xb. Ethanol and stress activate catecholamine synthesis in the adrenal: effects on bone. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120155.' |
plasma osteocalcin, vertebral osteocalcin mrna levels, and adrenomedullary tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine n-methyl transferase (pnmt) mrna levels were quantified. |
2009-01-23 |
2023-08-12 |
rat |
| Louisa C Johnston, Xiaomin Su, Kathleen Maguire-Zeiss, Karen Horovitz, Irina Ankoudinova, Dmitry Guschin, Piotr Hadaczek, Howard J Federoff, Krystof Bankiewicz, John Forsayet. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 8. 2009-01-22. PMID:18545225. |
aav2-hil-10 reduced the 6-ohda-induced loss of tyrosine hydroxylase (th)-positive neurons in the snc, and also reduced loss of striatal dopamine (da). |
2009-01-22 |
2023-08-12 |
human |