| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irmgard Paris, Jorge Lozano, Sergio Cardenas, Carolina Perez-Pastene, Katherine Saud, Patricio Fuentes, Pablo Caviedes, Alexies Dagnino-Subiabre, Rita Raisman-Vozari, Takeshi Shimahara, John P Kostrzewa, David Chi, Richard M Kostrzewa, Raul Caviedes, Juan Segura-Aguila. The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism. Neurotoxicity research. vol 13. issue 3-4. 2008-11-05. PMID:18522901. |
the cell line grows in monolayer and does not require differentiation to express catecholaminergic traits, such as (i) tyrosine hydroxylase; (ii) dopamine release; (iii) dopamine transport; (iv) norepinephrine transport; (v) monoamine oxidase (mao)-a expression, but not mao-b; (vi) formation of neuromelanin; (vii) vmat-2 expression. |
2008-11-05 |
2023-08-12 |
rat |
| Thomas S Guillot, Kennie R Shepherd, Jason R Richardson, Min Z Wang, Yingjie Li, Piers C Emson, Gary W Mille. Reduced vesicular storage of dopamine exacerbates methamphetamine-induced neurodegeneration and astrogliosis. Journal of neurochemistry. vol 106. issue 5. 2008-11-03. PMID:18643795. |
subsequent to meth exposure, the vmat2 lo mice show an exacerbated loss of dopamine transporter and tyrosine hydroxylase (th), as well as enhanced astrogliosis and protein carbonyl formation. |
2008-11-03 |
2023-08-12 |
mouse |
| Jun Mo Kang, Jae-Chul Jung, Heejeong Kim, Heena Lim, Soyong Jang, Seikwan O. Neuroprotective effect of benzylideneacetophenone derivative on the MPTP model of neurodegeneration in mice. Archives of pharmacal research. vol 31. issue 9. 2008-10-28. PMID:18806951. |
immunohistochemistry and western blot were used to determine the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat), ox-42 (a marker of microglial activation), and glial fibrillary acid protein (gfap, a marker of astrocyte activation) in the substantia nigra (sn) and striatum (st). |
2008-10-28 |
2023-08-12 |
mouse |
| Kenta Sato, Chiho Sumi-Ichinose, Ryuji Kaji, Kazuhisa Ikemoto, Takahide Nomura, Ikuko Nagatsu, Hiroshi Ichinose, Masayuki Ito, Wataru Sako, Shinji Nagahiro, Ann M Graybiel, Satoshi Got. Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 34. 2008-10-24. PMID:18713855. |
drd is thought to result from striatal dopamine deficiency due to a reduced synthesis and activity of tyrosine hydroxylase (th), the synthetic enzyme for dopamine. |
2008-10-24 |
2023-08-12 |
mouse |
| Garnik Akopian, Cynthia Crawford, M Flint Beal, Maurand Cappelletti, Michael W Jakowec, Giselle M Petzinger, Ling Zheng, Stacey L Gheorghe, Carmela M Reichel, Robert Chow, John P Wals. Decreased striatal dopamine release underlies increased expression of long-term synaptic potentiation at corticostriatal synapses 24 h after 3-nitropropionic-acid-induced chemical hypoxia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 38. 2008-10-22. PMID:18799690. |
hplc and fast-scan cyclic voltammetry revealed a decrease in dopamine content and release in rats injected 24 h earlier with 3-np, and much like the enhanced ltp, dopamine changes were reversed by 48 h. tyrosine hydroxylase expression was not changed, and there was no evidence of striatal cell loss at 24-48 h after 3-np exposure. |
2008-10-22 |
2023-08-12 |
rat |
| Yan Sai, Qiang Wu, Weidong Le, Feng Ye, Yunpeng Li, Zhaojun Don. Rotenone-induced PC12 cell toxicity is caused by oxidative stress resulting from altered dopamine metabolism. Toxicology in vitro : an international journal published in association with BIBRA. vol 22. issue 6. 2008-10-21. PMID:18579341. |
tyrosine hydroxylase (th) and vesicular monoamine transporter 2 (vmat(2)) were markedly down-regulated, and dopamine transporter (dat) was up-regulated in the cells. |
2008-10-21 |
2023-08-12 |
rat |
| Irene Brunk, Christian Blex, Carles Sanchis-Segura, Jan Sternberg, Stephanie Perreau-Lenz, Ainhoa Bilbao, Heide Hörtnagl, Jens Baron, Judyta Juranek, Gregor Laube, Lutz Birnbaumer, Rainer Spanagel, Gudrun Ahnert-Hilge. Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 10. 2008-10-21. PMID:18606864. |
the lack of behavioral sensitization correlates with reduced dopamine levels in the striatum and decreased expression of tyrosine hydroxylase. |
2008-10-21 |
2023-08-12 |
mouse |
| Patricia Rojas, Norma Serrano-García, José J Mares-Sámano, Omar Noel Medina-Campos, José Pedraza-Chaverri, Sven Ove Ogre. EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice: role of oxidative stress. The European journal of neuroscience. vol 28. issue 1. 2008-10-20. PMID:18662333. |
mptp administration resulted in a significant decrease in striatal dopamine levels and tyrosine hydroxylase immunostaining in the striatum and substantia nigra pars compacta. |
2008-10-20 |
2023-08-12 |
mouse |
| Patricia Rojas, Norma Serrano-García, José J Mares-Sámano, Omar Noel Medina-Campos, José Pedraza-Chaverri, Sven Ove Ogre. EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice: role of oxidative stress. The European journal of neuroscience. vol 28. issue 1. 2008-10-20. PMID:18662333. |
mice receiving egb761 had significantly attenuated mptp-induced loss of striatal dopamine levels and tyrosine hydroxylase immunostaining in the striatum and substantia nigra pars compacta. |
2008-10-20 |
2023-08-12 |
mouse |
| Gaspard Montandon, Aida Bairam, Richard Kinkea. Neonatal caffeine induces sex-specific developmental plasticity of the hypoxic respiratory chemoreflex in adult rats. American journal of physiology. Regulatory, integrative and comparative physiology. vol 295. issue 3. 2008-10-17. PMID:18596110. |
rt-pcr assessment of mrna encoding for adenosine a(1a) and a(2a) receptors, dopamine d(2) receptors, and tyrosine hydroxylase in the rat carotid bodies showed that nct enhanced mrna expression levels of adenosine a(2a), dopamine d(2) receptors, and tyrosine hydroxylase of males but not females. |
2008-10-17 |
2023-08-12 |
rat |
| Chun Mei Jin, Yoo Jung Yang, Hai Shan Huang, Sung Cil Lim, Masaaki Kai, Myung Koo Le. Induction of dopamine biosynthesis by l-DOPA in PC12 cells: implications of L-DOPA influx and cyclic AMP. European journal of pharmacology. vol 591. issue 1-3. 2008-10-15. PMID:18602388. |
l-dopa treatment (20-200 microm) increased the levels of dopamine by 226%-504% after 3-6 h of treatment and enhanced the activities of tyrosine hydroxylase (th) and aromatic l-amino acid decarboxylase (aadc). |
2008-10-15 |
2023-08-12 |
Not clear |
| L I Serova, V Gueorguiev, S-Y Cheng, E L Sabba. Adrenocorticotropic hormone elevates gene expression for catecholamine biosynthesis in rat superior cervical ganglia and locus coeruleus by an adrenal independent mechanism. Neuroscience. vol 153. issue 4. 2008-10-08. PMID:18440707. |
fourteen days post-adx, as expected, plasma acth was elevated, and levels of tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh) and mc2r mrnas in superior cervical ganglia (scg), and th mrna in locus coeruleus (lc) were increased compared with sham-operated animals. |
2008-10-08 |
2023-08-12 |
human |
| G A Oganesian, I V Romanova, E A Aristakesian, V V Kuzik, D M Makina, T Iu Morina, A E Khramenkova, I V Artamokhina, V A Belov. [Diencephalo-telencephalic changes of tyrosine hydroxylase in rats and common frogs (Rana temporaria) after sleep deprivation]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 44. issue 3. 2008-10-07. PMID:18727412. |
based on sleep deprivation-produced changes of electrographic parameters of the wakefulness--sleep cycle (wsc) in rats and common frogs, dynamics of activity of tyrosine hydroxylase, the key enzyme of dopamine synthesis, was studied immunohistochemically in substantia nigra and nigrostriatal pathway in rats and in striatum, paraventricular organ, and extrahypothalamic pathways in frogs. |
2008-10-07 |
2023-08-12 |
rat |
| Hironori Yokoyama, Sho Takagi, Yu Watanabe, Hiroyuki Kato, Tsutomu Arak. Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 6. 2008-10-03. PMID:18235988. |
our immunohistochemical study showed that th (tyrosine hydroxylase) and dat (dopamine transporter) immunoreactivity was decreased significantly in the striatum and substantia nigra 5 days after mptp treatment. |
2008-10-03 |
2023-08-12 |
mouse |
| K Iu Sarkisova, I I Kozlovskiĭ, M M Kozlovskai. [Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 58. issue 2. 2008-09-15. PMID:18661785. |
the neurobiochemical spectrum of selank action combines mechanisms which are characteristics of antidepressants and psychostimulants: activation of the brain monoaminergic systems, dopamine synthesis and turnover, and modulation of the tyrosine hydroxylase activity. |
2008-09-15 |
2023-08-12 |
mouse |
| Sarah L Gordon, Noelene S Quinsey, Peter R Dunkley, Phillip W Dickso. Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites. Journal of neurochemistry. vol 106. issue 4. 2008-09-12. PMID:18513370. |
tyrosine hydroxylase (th), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (ser40). |
2008-09-12 |
2023-08-12 |
human |
| R M Khudoerkov, E L Dovedova, D A Khrustale. [The influence of amphetamine on changes in the brain neuromediator metabolism]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 107. issue 5. 2008-09-09. PMID:18379497. |
specific activity of enzymes involved in dopamine and serotonin metabolism - tyrosine hydroxylase, tryptophan hydroxylase, monoaminooxidase, types a and b - was determined and l-dioxyphenylalanine content measured in brain subfractions (sensomotor cortex and striatum). |
2008-09-09 |
2023-08-12 |
rat |
| Nsikan Akpan, Kacey Caradonna, Marina V Chuenkova, Mercio PereiraPerri. Chagas' disease parasite-derived neurotrophic factor activates cholinergic gene expression in neuronal PC12 cells. Brain research. vol 1217. 2008-09-09. PMID:18502403. |
pdnf also enhances the expression and activity of tyrosine hydroxylase, a rate limiting enzyme in the synthesis of dopamine and other catecholamine neurotransmitters. |
2008-09-09 |
2023-08-12 |
Not clear |
| Patsy S Dickinson, Elizabeth A Stemmler, Andrew E Christi. The pyloric neural circuit of the herbivorous crab Pugettia producta shows limited sensitivity to several neuromodulators that elicit robust effects in more opportunistically feeding decapods. The Journal of experimental biology. vol 211. issue Pt 9. 2008-09-03. PMID:18424677. |
using immunohistochemistry, we found that the distributions of cancer borealis tachykinin-related peptide i (cabtrp i), crustacean cardioactive peptide (ccap), proctolin, red pigment concentrating hormone (rpch) and tyrosine hydroxylase (dopamine) were similar to those of other decapods. |
2008-09-03 |
2023-08-12 |
Not clear |
| Brenda M Geiger, Gerald G Behr, Lauren E Frank, Angela D Caldera-Siu, Margery C Beinfeld, Efi G Kokkotou, Emmanuel N Potho. Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 8. 2008-09-03. PMID:18477764. |
moreover, dopamine impairment in op rats was apparent at birth and associated with changes in expression of several factors regulating dopamine synthesis and release: vesicular monoamine transporter-2, tyrosine hydroxylase, dopamine transporter, and dopamine receptor-2 short-form. |
2008-09-03 |
2023-08-12 |
rat |