| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Chevalier, P Derkinderen, P Gomes, R Thinard, P Naveilhan, P Vanden Berghe, M Neunlis. Activity-dependent regulation of tyrosine hydroxylase expression in the enteric nervous system. The Journal of physiology. vol 586. issue 7. 2008-06-23. PMID:18258664. |
using primary cultures of ens derived from rat embryonic intestine, we have characterized the regulation of tyrosine hydroxylase (th), a key enzyme involved in the synthesis of dopamine. |
2008-06-23 |
2023-08-12 |
rat |
| Julie C Healey, Danny G Winder, Thomas L Kas. Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions. Alcohol (Fayetteville, N.Y.). vol 42. issue 3. 2008-06-23. PMID:18358675. |
using a chronic inhalation model of ethanol exposure in mice, we have begun to investigate the effects of alcohol intake on dopaminergic signaling by examining protein levels of tyrosine hydroxylase and the dopamine transporter, as well as monoamine metabolites in three different target fields of three different dopaminergic nuclei. |
2008-06-23 |
2023-08-12 |
mouse |
| Julie C Healey, Danny G Winder, Thomas L Kas. Chronic ethanol exposure leads to divergent control of dopaminergic synapses in distinct target regions. Alcohol (Fayetteville, N.Y.). vol 42. issue 3. 2008-06-23. PMID:18358675. |
strikingly, we found divergent regulation of tyrosine hydroxylase and dopamine transporter protein levels across these three regions that was dependent upon the means of exposure. |
2008-06-23 |
2023-08-12 |
mouse |
| Trine R Larsen, Ann-Sofi Söderling, Kenneth Caidahl, Peter Roepstorff, Jan Bert Gramsberge. Nitration of soluble proteins in organotypic culture models of Parkinson's disease. Neurochemistry international. vol 52. issue 3. 2008-06-20. PMID:17900761. |
protein nitration due to oxidative and nitrative stress has been linked to the pathogenesis of parkinson's disease (pd), but its relationship to the loss of dopamine (da) or tyrosine hydroxylase (th) activity is not clear. |
2008-06-20 |
2023-08-12 |
mouse |
| Abdelghani El-Yassimi, Aziz Hichami, Philippe Besnard, Naim Akhtar Kha. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18321850. |
reverse transcription-quantitative pcr revealed that the cd36-positive gustatory cells possessed mrna of enzymes like tryptophan hydroxylase-1, l-aromatic amino acid decarboxylase, tyrosine hydroxylase, and dopamine beta-hydroxylase, involved in the synthesis of monoamine neurotransmitters. |
2008-06-17 |
2023-08-12 |
mouse |
| Bin Liu, Jun Xia Xie, Lai Ling Tsang, Dewi Kenneth Rowlands, Lok Sze Ho, Yu Lin Gou, Yiu Wa Chung, Hsiao Chang Cha. Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity. Cell biology international. vol 32. issue 1. 2008-06-12. PMID:17920944. |
in the present study, we have investigated the possible neuroprotective action of bfp upon the nigrostriatal dopaminergic system by examining its effect on the expression patterns of tyrosine hydroxylase (th) and dopamine transporter (dat) in the 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (mptp)-induced parkinson's disease (pd) mouse model. |
2008-06-12 |
2023-08-12 |
mouse |
| P M Aponso, R L M Faull, B Conno. Increased progenitor cell proliferation and astrogenesis in the partial progressive 6-hydroxydopamine model of Parkinson's disease. Neuroscience. vol 151. issue 4. 2008-06-12. PMID:18201835. |
tyrosine hydroxylase immunohistochemistry demonstrated a complete loss of nigrostriatal projections in the striatum and a subsequent progressive loss of dopamine (da) cells in the sn. |
2008-06-12 |
2023-08-12 |
rat |
| Jelena Mijatovic, Outi Patrikainen, Leonid Yavich, Mikko Airavaara, Liisa Ahtee, Mart Saarma, T Petteri Pieppone. Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine. Journal of neurochemistry. vol 105. issue 5. 2008-06-12. PMID:18248620. |
previously, we found that the mice carrying the mutation (men2b mice) have profoundly increased tissue dopamine (da) concentrations in the striatum as well as increased striatal levels of tyrosine hydroxylase (th) and dopamine transporter. |
2008-06-12 |
2023-08-12 |
mouse |
| S A M van Vliet, S A M van Vlieta, E L A Blezer, M J Jongsma, R A P Vanwersch, B Olivier, I H C H M Philippen. Exploring the neuroprotective effects of modafinil in a marmoset Parkinson model with immunohistochemistry, magnetic resonance imaging and spectroscopy. Brain research. vol 1189. 2008-06-02. PMID:18076869. |
tyrosine hydroxylase immunoreactive (th-ir) staining of dopamine neurons of the substantia nigra pars compacta confirmed that modafinil was able to partially prevent the mptp-induced neuronal damage. |
2008-06-02 |
2023-08-12 |
monkey |
| Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamad. Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. Journal of pharmacological sciences. vol 106. issue 2. 2008-05-22. PMID:18277051. |
to investigate the role of tissue plasminogen activator (tpa) in methamphetamine (meth)-induced dopaminergic neurotoxicity, we compared the changes in tyrosine hydroxylase (th) and dopamine transporter (dat) levels in the striatum after repetitive treatment of meth at 4 mg/kg among wild-type, tpa-deficient (tpa-/-), and protease activated receptor-1-deficient (par-1-/-) mice. |
2008-05-22 |
2023-08-12 |
mouse |
| Alessandra Recchia, David Rota, Patrizia Debetto, Daniele Peroni, Diego Guidolin, Alessandro Negro, Stephen D Skaper, Pietro Giust. Generation of a alpha-synuclein-based rat model of Parkinson's disease. Neurobiology of disease. vol 30. issue 1. 2008-05-19. PMID:18313315. |
dopaminergic cell loss was evaluated both by tyrosine hydroxylase immunohistochemistry and by hplc analysis of dopamine and its catabolite 3,4 dihydroxyphenylacetic acid. |
2008-05-19 |
2023-08-12 |
human |
| M Bousquet, M Saint-Pierre, C Julien, N Salem, F Cicchetti, F Calo. Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 4. 2008-05-16. PMID:18032633. |
high n-3 pufa dietary consumption completely prevented the mptp-induced decrease of tyrosine hydroxylase (th)-labeled nigral cells (p<0.01 vs. mptp mice on control diet), nurr1 mrna (p<0.01 vs. mptp mice on control diet), and dopamine transporter mrna levels (p<0.05 vs. mptp mice on control diet) in the substantia nigra. |
2008-05-16 |
2023-08-12 |
mouse |
| Hamid Mostafavi Abdolmaleky, Cassandra L Smith, Jin-Rong Zhou, Sam Thiagalinga. Epigenetic alterations of the dopaminergic system in major psychiatric disorders. Methods in molecular biology (Clifton, N.J.). vol 448. 2008-05-15. PMID:18370235. |
we use the genes of the extended dopaminergic (daergic) system such as membrane-bound catechol-o-methyltransferase (mb-comt), monoamine oxidase a (maoa), dopamine transporter 1 (dat1), tyrosine hydroxylase (th), dopamine (da) receptors1 and 2 (drd1/2), and related genes (e.g., reelin [reln] and brain-derived neurotrophic factor [bdnf]) to illustrate the associations between differential promoter dna methylations and disease phenotype. |
2008-05-15 |
2023-08-12 |
Not clear |
| Gerson Chadi, Camila Silva, Jessica Ruivo Maximino, Kjell Fuxe, Gilberto Ochman da Silv. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain research. vol 1190. 2008-05-06. PMID:18086466. |
seven days after the dopamine lesion, western blot analysis showed a decreased level of tyrosine hydroxylase in the lesioned side of the midbrain, an event that was not altered by adx or corticosterone replacement. |
2008-05-06 |
2023-08-12 |
rat |
| Gerson Chadi, Camila Silva, Jessica Ruivo Maximino, Kjell Fuxe, Gilberto Ochman da Silv. Adrenalectomy counteracts the local modulation of astroglial fibroblast growth factor system without interfering with the pattern of 6-OHDA-induced dopamine degeneration in regions of the ventral midbrain. Brain research. vol 1190. 2008-05-06. PMID:18086466. |
moreover, the degeneration of nigral dopamine neurons, which was confirmed by the disappearance of acidic fgf (fgf-1) mrna and the decrement of tyrosine hydroxylase mrna labeled nigral neurons, was not altered by adx. |
2008-05-06 |
2023-08-12 |
rat |
| Xesús M Abalo, Verona Villar-Cerviño, Begoña Villar-Cheda, Ramón Anadón, M Celina Rodici. Neurochemical differentiation of horizontal and amacrine cells during transformation of the sea lamprey retina. Journal of chemical neuroanatomy. vol 35. issue 2. 2008-05-06. PMID:18242055. |
immunoreactivity for gaba, glycine and serotonin was found at early metamorphic stages, while expression of the markers of catecholaminergic amacrine cells, dopamine and tyrosine hydroxylase, was found to be delayed until intermediate metamorphic stages. |
2008-05-06 |
2023-08-12 |
Not clear |
| Chun-Hung Lin, Jui-Yen Huang, Cheng-Hsin Ching, Jih-Ing Chuan. Melatonin reduces the neuronal loss, downregulation of dopamine transporter, and upregulation of D2 receptor in rotenone-induced parkinsonian rats. Journal of pineal research. vol 44. issue 2. 2008-05-05. PMID:18289173. |
rotenone subcutaneously infused for 14 days induced pd symptoms in rats, as indicated by reduced spontaneous locomotor activity (hypokinesis), loss of tyrosine hydroxylase (th, a marker enzyme for dopamine neurons) immunoreactivity in the substantia nigra and striatum, obvious alpha-synuclein accumulation, downregulated dat protein expression, and upregulated d2r expression. |
2008-05-05 |
2023-08-12 |
rat |
| Rosa Andres, Luis A Herraez-Baranda, Jane Thompson, Sean Wyatt, Alun M Davie. Regulation of sympathetic neuron differentiation by endogenous nerve growth factor and neurotrophin-3. Neuroscience letters. vol 431. issue 3. 2008-05-02. PMID:18162309. |
despite the extensively documented ability of ngf to regulate the noradrenergic phenotype of sympathetic neurons, we found that tyrosine hydroxylase (th) and dopamine beta hydroxylase (dbetah) mrna levels were normal in ngf(-/-) embryos, but significantly reduced in nt3(-/-) embryos. |
2008-05-02 |
2023-08-12 |
mouse |
| Lu Wen, Wei Wei, Wenchao Gu, Peng Huang, Xi Ren, Zheng Zhang, Zuoyan Zhu, Shuo Lin, Bo Zhan. Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental biology. vol 314. issue 1. 2008-04-29. PMID:18164283. |
the gfp positive neurons include the large and pear-shaped tyrosine hydroxylase positive neurons (th populations 2 and 4) in the posterior tuberculum of ventral diencephalon (pt neurons), which are thought to be equivalent to the midbrain dopamine neurons in mammals. |
2008-04-29 |
2023-08-12 |
zebrafish |
| Angela B Lange, Kenny Cha. Dopaminergic control of foregut contractions in Locusta migratoria. Journal of insect physiology. vol 54. issue 1. 2008-04-23. PMID:17953973. |
tyrosine hydroxylase is the rate-limiting enzyme in dopamine biosynthesis, and high-performance liquid chromatography coupled to electrochemical detection was used to confirm the presence of dopamine in the innervation to the foregut. |
2008-04-23 |
2023-08-12 |
Not clear |