| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanja Darmopil, Vilma C Muñetón-Gómez, María L de Ceballos, Miya Bernson, Rosario Moratall. Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA. The European journal of neuroscience. vol 27. issue 3. 2008-04-22. PMID:18279311. |
tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by l-dopa. |
2008-04-22 |
2023-08-12 |
mouse |
| Sanja Darmopil, Vilma C Muñetón-Gómez, María L de Ceballos, Miya Bernson, Rosario Moratall. Tyrosine hydroxylase cells appearing in the mouse striatum after dopamine denervation are likely to be projection neurones regulated by L-DOPA. The European journal of neuroscience. vol 27. issue 3. 2008-04-22. PMID:18279311. |
tyrosine hydroxylase (th)-immunoreactive (ir) neurones are detected in the striatum of animals after dopamine depletion and also in human parkinsonian patients. |
2008-04-22 |
2023-08-12 |
mouse |
| Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Ko Miyoshi, Norio Ogawa, Miho Murat. Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formation. Neuroscience research. vol 60. issue 1. 2008-04-11. PMID:18022268. |
the neurotoxicity of dopamine (da) quinones as dopaminergic neuron-specific oxidative stress is considered to play a role in the pathogenesis and/or progression of parkinson's disease (pd), since da quinones conjugate with several key pd pathogenic molecules (e.g., tyrosine hydroxylase, alpha-synuclein and parkin) to form protein-bound quinone (quinoprotein) and consequently inhibit their functions. |
2008-04-11 |
2023-08-12 |
Not clear |
| Yosuke Ninomiya, Maiko Kurakake, Yasunori Oda, Seiji Tsuzuki, Yoichi Hayakaw. Insect cytokine growth-blocking peptide signaling cascades regulate two separate groups of target genes. The FEBS journal. vol 275. issue 5. 2008-04-11. PMID:18215168. |
gbp also enhances expression of the tyrosine hydroxylase (th, ec 1.14.16.2) and 3,4-dihydroxy-l-phenylalanine (dopa) decarboxylase (ddc, ec 4.1.1.26) genes, which elevate dopamine levels in insect epidermal cells. |
2008-04-11 |
2023-08-12 |
drosophila_melanogaster |
| Masaya Segaw. [Segawa disease]. Brain and nerve = Shinkei kenkyu no shinpo. vol 60. issue 1. 2008-04-11. PMID:18232327. |
polysomnographical examination for evaluating the sleep effects and correlation of the natural course to the age variation of the tyrosine hydroxylase activities in the striatum, these speculated this is a particular disorder caused by non-progressive decrement of the tyrosine hydroxylase at the terminal of the nigrostriatal dopamine neuron. |
2008-04-11 |
2023-08-12 |
Not clear |
| G A Oganesian, E A Aristakesian, I V Romanova, V A Belova, I V Artamokhin. [The effect of dopaminergic nigrostriatal system on sleep deprivation in rats]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 93. issue 12. 2008-04-11. PMID:18318174. |
according to these sleep-wakefulness cycle changes, a quantitative immunohistochemical study of tyrosine hydroxylase: a key enzyme of dopamine synthesis--and d1 and d2 receptors in nigro-striatal projections has been performed. |
2008-04-11 |
2023-08-12 |
rat |
| X Zhang, F Dong, G E Mayer, D C Bruch, J Ren, B Culve. Selective inhibition of cyclooxygenase-2 exacerbates methamphetamine-induced dopamine depletion in the striatum in rats. Neuroscience. vol 150. issue 4. 2008-04-08. PMID:17988800. |
animals receiving ma exhibited an increase in apoptotic cells and notable reductions in dopamine (da) content (63.9%) in immunoreactivity of tyrosine hydroxylase (th) and neuron specific microtubule-associated protein 2 (map2) in striatum. |
2008-04-08 |
2023-08-12 |
rat |
| Elisabet Berglöf, Stefan Plantman, Saga Johansson, Ingrid Strömber. Inhibition of proteoglycan synthesis affects neuronal outgrowth and astrocytic migration in organotypic cultures of fetal ventral mesencephalon. Journal of neuroscience research. vol 86. issue 1. 2008-04-04. PMID:17868150. |
cultures were treated with the pg synthesis inhibitor methyl-umbelliferyl-beta-d-xyloside (beta-xyloside) and analyzed using antibodies against tyrosine hydroxylase (th) to visualize dopamine neurons, s100beta to visualize astrocytes, and neurocan to detect pgs. |
2008-04-04 |
2023-08-12 |
Not clear |
| Kirsten X Jacobsen, Heather MacDonald, Sylvie Lemonde, Mireille Daigle, David A Grimes, Dennis E Bulman, Paul R Alber. A Nurr1 point mutant, implicated in Parkinson's disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription. Neurobiology of disease. vol 29. issue 1. 2008-03-14. PMID:17890097. |
the orphan nuclear receptor nurr1 is critical for the development of mesencephalic dopamine neurons and directly regulates tyrosine hydroxylase (th) via specific ngfi-b response elements (nbre). |
2008-03-14 |
2023-08-12 |
human |
| Jian-Lan Jiang, Yu-Ping Peng, Yi-Hua Qiu, Jian-Jun Wan. Effect of endogenous catecholamines on apoptosis of Con A-activated lymphocytes of rats. Journal of neuroimmunology. vol 192. issue 1-2. 2008-03-14. PMID:17920695. |
our previous studies show that lymphocytes express tyrosine hydroxylase (th) and synthesize catecholamines (cas) including dopamine, epinephrine and norepinephrine, and that the lymphocytes-derived endogenous cas affect function of lymphocytes via autocrine/paracrine pathways. |
2008-03-14 |
2023-08-12 |
rat |
| b' Tiina M K\\xc3\\xa4\\xc3\\xa4ri\\xc3\\xa4inen, J Arturo Garc\\xc3\\xada-Horsman, Marjo Piltonen, Marko Huotari, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral nigral lesions. Basic & clinical pharmacology & toxicology. vol 102. issue 3. 2008-03-14. PMID:17973898.' |
furthermore, striatal dopamine and its metabolites as well as the level of tyrosine hydroxylase were significantly reduced by 6-ohda. |
2008-03-14 |
2023-08-12 |
rat |
| Colin Davidson, Qiang Chen, Xiuwn Zhang, Xueying Xiong, Cindy Lazarus, Tong H Lee, Everett H Ellinwoo. Deprenyl treatment attenuates long-term pre- and post-synaptic changes evoked by chronic methamphetamine. European journal of pharmacology. vol 573. issue 1-3. 2008-03-13. PMID:17651730. |
tyrosine hydroxylase immunostaining in the midbrain was unaffected by methamphetamine, suggesting that dopamine neurotoxicity was localized to the caudate. |
2008-03-13 |
2023-08-12 |
rat |
| Y Chertkow, O Weinreb, M B H Youdim, H Silve. Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 11. 2008-03-11. PMID:17576515. |
haloperidol-fluvoxamine combination, haloperidol, and clozapine treatments increased striatal and frontal cortex dopamine turnover and reduced striatal tyrosine hydroxylase activity at 1.5 h. at 24 h both dopamine turnover and tyrosine hydroxylase activity were reduced. |
2008-03-11 |
2023-08-12 |
rat |
| William H Roden, Jason B Papke, Johnnie M Moore, Anne L Cahill, Heather Macarthur, Amy B Harkin. Stable RNA interference of synaptotagmin I in PC12 cells results in differential regulation of transmitter release. American journal of physiology. Cell physiology. vol 293. issue 6. 2008-03-04. PMID:17913838. |
although expression levels of tyrosine hydroxylase, the rate-limiting enzyme in the dopamine synthesis pathway, was unaffected, expression of the vesicular monoamine transporter 1 was reduced by 50%. |
2008-03-04 |
2023-08-12 |
Not clear |
| Erik J Shank, Patricia K Seitz, Marcy J Bubar, Sonja J Stutz, Kathryn A Cunningha. Selective ablation of GABA neurons in the ventral tegmental area increases spontaneous locomotor activity. Behavioral neuroscience. vol 121. issue 6. 2008-02-29. PMID:18085876. |
a selective loss of vta gaba neurons on day 14 was demonstrated through reduced expression of mrna for glutamic acid decarboxylase-67 and micro-opioid receptor, but not tyrosine hydroxylase (a dopamine neuron marker), in the vta. |
2008-02-29 |
2023-08-12 |
rat |
| Krisztina Hejjas, Judit Vas, Eniko Kubinyi, Maria Sasvari-Szekely, Adam Miklosi, Zsolt Rona. Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves. Mammalian genome : official journal of the International Mammalian Genome Society. vol 18. issue 12. 2008-02-25. PMID:18049838. |
highly variable repetitive sequence regions were found in the tyrosine hydroxylase (th), dopamine transporter (dat), and dopamine beta-hydroxylase (dbh) genes. |
2008-02-25 |
2023-08-12 |
human |
| Izhar A Khan, Peter Thoma. PCB congener-specific disruption of reproductive neuroendocrine function in Atlantic croaker. Marine environmental research. vol 62 Suppl. 2008-02-21. PMID:16690116. |
a previous study in rats has implicated di-ortho-substituted non-coplanar pcb congeners in the inhibition of a similar enzyme, tyrosine hydroxylase, which is the rate-limiting enzyme in dopamine synthesis. |
2008-02-21 |
2023-08-12 |
rat |
| Monica M Davis, Sandra L O'Keefe, David A Primrose, Ross B Hodgett. A neuropeptide hormone cascade controls the precise onset of post-eclosion cuticular tanning in Drosophila melanogaster. Development (Cambridge, England). vol 134. issue 24. 2008-02-20. PMID:18003740. |
together, two enzymes, tyrosine hydroxylase (th, encoded by ple) and dopa decarboxylase (ddc, encoded by ddc), produce the dopamine that is required for tanning. |
2008-02-20 |
2023-08-12 |
drosophila_melanogaster |
| V Klawitter, P Morales, D Bustamante, M Goiny, M Herrera-Marschit. Plasticity of the central nervous system (CNS) following perinatal asphyxia: does nicotinamide provide neuroprotection? Amino acids. vol 31. issue 4. 2008-02-19. PMID:16871361. |
after approximately one month in vitro (div 25), the cultures were treated for immunocytochemistry to characterise neuronal phenotype with markers against the n-methyl-d-aspartate receptor subunit 1 (nr1), the dopamine pacemaker enzyme tyrosine hydroxylase (th), and nitric oxide synthase (nos), the enzyme regulating the bioavailability of no. |
2008-02-19 |
2023-08-12 |
rat |
| M Al-Jarrah, K Pothakos, L Novikova, I V Smirnova, M J Kurz, L Stehno-Bittel, Y-S La. Endurance exercise promotes cardiorespiratory rehabilitation without neurorestoration in the chronic mouse model of parkinsonism with severe neurodegeneration. Neuroscience. vol 149. issue 1. 2008-02-14. PMID:17869432. |
finally, neuronal recovery from the loss of nigrostriatal tyrosine hydroxylase expression and dopamine levels in the severe parkinsonian mice after exercise was not evident. |
2008-02-14 |
2023-08-12 |
mouse |