| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiyuki Kawasaki, Yukio Ago, Tatsuya Kitao, Tetsuaki Nashida, Akiko Takagi, Kazuhiro Takuma, Toshio Matsud. A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18573265. |
mptp treatment also decreased dopamine levels and tyrosine hydroxylase immunostaining in the substantia nigra (snc) and striatum. |
2009-01-15 |
2023-08-12 |
mouse |
| Toshiyuki Kawasaki, Yukio Ago, Tatsuya Kitao, Tetsuaki Nashida, Akiko Takagi, Kazuhiro Takuma, Toshio Matsud. A neuroprotective agent, T-817MA (1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate), prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18573265. |
attenuated these decreases in dopamine levels and tyrosine hydroxylase immunoreactivity, but did not affect brain levels of 1-methyl-4-phenylpyridinium ion, an active metabolite of mptp. |
2009-01-15 |
2023-08-12 |
mouse |
| Noelia Granado, Esther O'Shea, Jordi Bove, Miquel Vila, Ma Isabel Colado, Rosario Moratall. Persistent MDMA-induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18823368. |
acute administration of repeated doses of 3,4-methylenedioxymethamphetamine (mdma, ecstasy) dramatically reduces striatal dopamine (da) content, tyrosine hydroxylase (th), and da transporter-immunoreactivity in mice. |
2009-01-15 |
2023-08-12 |
mouse |
| Claude Wicker-Thomas, Mickael Haman. Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster. Journal of insect physiology. vol 54. issue 10-11. 2009-01-07. PMID:18762189. |
ddc mutants and wild-type female flies treated with tyrosine hydroxylase inhibitors (alpha-methyltyrosine or 3-iodotyrosine) had fewer diene hydrocarbons (female pheromones) and there was a total (ddc), partial (alpha-methyltyrosine) or no (3-iodotyrosine) rescue of hydrocarbon pattern after dopamine ingestion. |
2009-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Claude Wicker-Thomas, Mickael Haman. Interaction of dopamine, female pheromones, locomotion and sex behavior in Drosophila melanogaster. Journal of insect physiology. vol 54. issue 10-11. 2009-01-07. PMID:18762189. |
female locomotion was decreased in flies treated with tyrosine hydroxylase inhibitors and restored by dopamine, showing that decreased mobility of the female has little importance on male courtship. |
2009-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Kevin M Bowling, Zhinong Huang, Dong Xu, Faiza Ferdousy, Christopher D Funderburk, Nirmala Karnik, Wendi Neckameyer, Janis M O'Donnel. Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis. The Journal of biological chemistry. vol 283. issue 46. 2009-01-07. PMID:18801743. |
direct binding of gtp cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis. |
2009-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Kevin M Bowling, Zhinong Huang, Dong Xu, Faiza Ferdousy, Christopher D Funderburk, Nirmala Karnik, Wendi Neckameyer, Janis M O'Donnel. Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis. The Journal of biological chemistry. vol 283. issue 46. 2009-01-07. PMID:18801743. |
a key target of regulation is the enzyme tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, which is activated by phosphorylation and modulated by the availability of its cofactor, tetrahydrobiopterin. |
2009-01-07 |
2023-08-12 |
drosophila_melanogaster |
| Mehmet Cansev, Ismail H Ulus, Lei Wang, Timothy J Maher, Richard J Wurtma. Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease. Neuroscience research. vol 62. issue 3. 2009-01-06. PMID:18761383. |
ump/dha treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (th) activity, th protein and synapsin-1 on the lesioned side. |
2009-01-06 |
2023-08-12 |
rat |
| Maria C Olianas, Simona Dedoni, Marianna Boi, Pierluigi Onal. Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D(1) receptor signaling in rat nucleus accumbens and dorsal striatum. Journal of neurochemistry. vol 107. issue 2. 2008-12-24. PMID:18717817. |
activation of nociceptin/orphanin fq-nop receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine d(1) receptor signaling in rat nucleus accumbens and dorsal striatum. |
2008-12-24 |
2023-08-12 |
rat |
| A Rivera, A Peñafiel, M Megías, L F Agnati, J F López-Téllez, B Gago, A Gutiérrez, A de la Calle, K Fux. Cellular localization and distribution of dopamine D(4) receptors in the rat cerebral cortex and their relationship with the cortical dopaminergic and noradrenergic nerve terminal networks. Neuroscience. vol 155. issue 3. 2008-12-18. PMID:18620029. |
finally, mismatches were observed between d(4) ir and tyrosine hydroxylase and dopamine beta-hydroxylase ir nerve terminal plexuses, indicating that these receptors may be activated at least in part by dopamine and noradrenaline operating as volume transmission signals. |
2008-12-18 |
2023-08-12 |
rat |
| Benedek Erdös, S Remzi Erdem, Aysen Erdem, Christopher S Broxson, Nihal Tüme. Effect of age on angiotensin II-mediated downregulation of adrenomedullary catecholamine biosynthetic enzymes. Experimental gerontology. vol 43. issue 8. 2008-12-16. PMID:18522866. |
expression of catecholamine biosynthesizing enzymes, tyrosine hydroxylase (th) and dopamine beta hydroxylase (dbetah) increase with age in the adrenal medulla, however, the underlying mechanisms are unclear. |
2008-12-16 |
2023-08-12 |
rat |
| V Bagga, S B Dunnett, R A Fricker-Gate. Ascorbic acid increases the number of dopamine neurons in vitro and in transplants to the 6-OHDA-lesioned rat brain. Cell transplantation. vol 17. issue 7. 2008-12-16. PMID:19044203. |
following in vitro differentiation in medium containing ascorbic acid at concentrations ranging from 20 to 100 microm, significantly more neurons were immunopositive for the marker of mesencephalic dopamine neurons, tyrosine hydroxylase (th), when compared to standard differentiation conditions containing no ascorbic acid. |
2008-12-16 |
2023-08-12 |
rat |
| Robert L Arias, Mei-Li A Sung, Dmytro Vasylyev, Mei-Yi Zhang, Kristin Albinson, Katie Kubek, Natasha Kagan, Chad Beyer, Qian Lin, Jason M Dwyer, Margaret M Zaleska, Mark R Bowlby, John Dunlop, Michael Monagha. Amiloride is neuroprotective in an MPTP model of Parkinson's disease. Neurobiology of disease. vol 31. issue 3. 2008-12-15. PMID:18606547. |
amiloride was found to protect substantia nigra (snc) neurons from mptp-induced degeneration, as determined by attenuated reductions in striatal tyrosine hydroxylase (th) and dopamine transporter (dat) immunohistochemistry, as well as smaller declines in striatal dat radioligand binding and dopamine levels. |
2008-12-15 |
2023-08-12 |
mouse |
| Christopher D Herzog, Biplob Dass, Mehdi Gasmi, Roy Bakay, James E Stansell, Mark Tuszynski, Krystof Bankiewicz, Er-Yun Chen, Yaping Chu, Kathie Bishop, Jeffrey H Kordower, Raymond T Bartu. Transgene expression, bioactivity, and safety of CERE-120 (AAV2-neurturin) following delivery to the monkey striatum. Molecular therapy : the journal of the American Society of Gene Therapy. vol 16. issue 10. 2008-12-12. PMID:18728639. |
we report here, for the first time, a dose-related: increase in ntn protein expression within the striatum and substantia nigra (sn) pars compacta of nonhuman primates; increase in nigrostriatal tyrosine hydroxylase (th), (the rate-limited enzyme for dopamine); and activation of phosphorylated signal-regulated kinase (a common neurotrophic signaling event). |
2008-12-12 |
2023-08-12 |
human |
| G A Oganesyan, E A Aristakesyan, I V Romanova, V A Belova, I V Artamokhin. The dopaminergic nigrostriatal system in sleep deprivation in cats. Neuroscience and behavioral physiology. vol 38. issue 8. 2008-12-08. PMID:18802772. |
immunohistochemical studies were performed in relation to changes in the sleep-waking cycle, with the aim of identifying changes in the quantities of immunoreactive dopamine d1 and d2 receptor material and tyrosine hydroxylase, the key enzyme in dopamine synthesis in the nigrostriatal system. |
2008-12-08 |
2023-08-12 |
rat |
| Kelly L Janis, Ryan T Brennan, Robert E Drolet, Bahareh Behrouz, Sarah K Kaufman, Keith J Lookingland, John L Goudrea. Effects of sildenafil on nigrostriatal dopamine neurons in a murine model of Parkinson's disease. Journal of Alzheimer's disease : JAD. vol 15. issue 1. 2008-11-18. PMID:18780970. |
end points of neurotoxicity included dopamine (da) and tyrosine hydroxylase (th) concentrations in nsda axon terminals in the striatum, and stereological cell counts of th immunoreactive neurons in the substantia nigra. |
2008-11-18 |
2023-08-12 |
mouse |
| Tianhong Pan, Wen Zhu, Hongru Zhao, Hao Deng, Wenjie Xie, Joseph Jankovic, Weidong L. Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo. Brain research. vol 1222. 2008-11-12. PMID:18579122. |
at same time, we found that there was a severer loss of tyrosine hydroxylase (th)-positive neurons in substantia nigra (sn) and greater reduction of striatal dopamine (da) levels in nurr1 +/- mice as compared with that in nurr1 +/+ mice. |
2008-11-12 |
2023-08-12 |
mouse |
| Hae Young Lee, Nibedita Naha, Najeeb Ullah, Guang Zhen Jin, Il Keun Kong, Phil Ok Koh, Hwan Hoo Seong, Myeong Ok Ki. Effect of the co-administration of vitamin C and vitamin E on tyrosine hydroxylase and Nurr1 expression in the prenatal rat ventral mesencephalon. The Journal of veterinary medical science. vol 70. issue 8. 2008-11-12. PMID:18772553. |
tyrosine hydroxylase (th) is the rate-limiting enzyme of dopamine (da) biosynthesis, which is up-regulated by vitamin c administration. |
2008-11-12 |
2023-08-12 |
rat |
| Carla Neri, Carla Ghelardini, Bethany Sotak, Richard D Palmiter, Massimo Guarna, George Stefano, Enrica Bianch. Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18643791. |
in this study, we used mice that cannot make dopamine due to a genetic deletion of tyrosine hydroxylase specifically in dopaminergic neurons, to test the hypothesis that endogenous dopamine is necessary to endogenous morphine formation in vivo in mammalian brain. |
2008-11-07 |
2023-08-12 |
mouse |
| Regina C C Kubrusly, Rogerio Panizzutti, Patricia F Gardino, Bernardo Stutz, Ricardo A M Reis, Ana Lucia M Ventura, Maria Christina F de Mello, Fernando G de Mell. Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. Neurochemistry international. vol 53. issue 3-4. 2008-11-06. PMID:18582514. |
finally, cultured avian müller cells display increased expression of tyrosine hydroxylase, under the influence of agents that increase camp levels, which results in higher levels of dopamine synthesized from tyrosine. |
2008-11-06 |
2023-08-12 |
mouse |