| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Padmanabhan, B M Prasa. Sustained depolarization decreases calcium/calmodulin-dependent protein kinase II activity and gene expression in dopamine neurons. Neuroscience. vol 163. issue 1. 2009-12-15. PMID:19555740. |
decreased camkii activity was accompanied by a selective decrease in dopamine transporter (dat) mrna, while tyrosine hydroxylase and actin mrna abundance was unaltered. |
2009-12-15 |
2023-08-12 |
rat |
| Kurt A Jellinge. Formation and development of Lewy pathology: a critical update. Journal of neurology. vol 256 Suppl 3. 2009-12-11. PMID:19711116. |
although some retrospective clinico-pathologic studies have largely confirmed the braak lb staging system, it shows neither correlation to the clinical severity and duration of parkinsonism nor to nigral alpha syn burden and cell loss which significantly correlates with resulting striatal loss of dopamine, dopamine transporter and tyrosine hydroxylase, duration and severity of motor dysfunction. |
2009-12-11 |
2023-08-12 |
human |
| Afsaneh Gaillard, Mickael Decressac, Isabelle Frappé, Pierre Olivier Fernagut, Laetitia Prestoz, Stephan Besnard, Mohamed Jabe. Anatomical and functional reconstruction of the nigrostriatal pathway by intranigral transplants. Neurobiology of disease. vol 35. issue 3. 2009-12-03. PMID:19616502. |
grafted cells integrated within the host mesencephalon and expressed the dopaminergic markers tyrosine hydroxylase, vesicular monoamine transporter 2 and dopamine transporter. |
2009-12-03 |
2023-08-12 |
mouse |
| Amy M Knab, Robert S Bowen, Alicia T Hamilton, Alyssa A Gulledge, J Timothy Lightfoo. Altered dopaminergic profiles: implications for the regulation of voluntary physical activity. Behavioural brain research. vol 204. issue 1. 2009-12-01. PMID:19520120. |
these results indicate that decreased dopaminergic functioning is correlated with increased activity levels in c57l/j mice and suggests that d1-like receptors as well as tyrosine hydroxylase (an indicator of dopamine production), but not d2-like receptors may be associated with the regulation of physical activity in inbred mice. |
2009-12-01 |
2023-08-12 |
mouse |
| E Hedlund, T Perlman. Neuronal cell replacement in Parkinson's disease. Journal of internal medicine. vol 266. issue 4. 2009-12-01. PMID:19765180. |
furthermore, although grafted foetal dopamine neurons can survive in parkinson's patients for more than a decade, the occurrence of lewy bodies within such transplanted cells and reduced dopamine transporter and tyrosine hydroxylase expression levels indicate that grafted cells are associated with pathology. |
2009-12-01 |
2023-08-12 |
Not clear |
| Dingzhen Luo, Quanbin Zhang, Haomin Wang, Yanqiu Cui, Zuoli Sun, Jian Yang, Yan Zheng, Jun Jia, Fen Yu, Xuan Wang, Xiaomin Wan. Fucoidan protects against dopaminergic neuron death in vivo and in vitro. European journal of pharmacology. vol 617. issue 1-3. 2009-11-30. PMID:19545563. |
when administered prior to mptp, fucoidan reduced behavioral deficits, increased striatal dopamine and its metabolites levels, reduced cell death, and led to a marked increase in tyrosine hydroxylase expression relative to mice treated with mptp alone. |
2009-11-30 |
2023-08-12 |
mouse |
| Shizuma Ishikawa, Takahiro Taira, Takeshi Niki, Kazuko Takahashi-Niki, Chinatsu Maita, Hiroshi Maita, Hiroyoshi Ariga, Sanae M M Iguchi-Arig. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. The Journal of biological chemistry. vol 284. issue 42. 2009-11-24. PMID:19703902. |
oxidative status of dj-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-l-phenylalanine (l-dopa) decarboxylase with dj-1. |
2009-11-24 |
2023-08-12 |
human |
| Shizuma Ishikawa, Takahiro Taira, Takeshi Niki, Kazuko Takahashi-Niki, Chinatsu Maita, Hiroshi Maita, Hiroyoshi Ariga, Sanae M M Iguchi-Arig. Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1. The Journal of biological chemistry. vol 284. issue 42. 2009-11-24. PMID:19703902. |
parkinson disease (pd) is caused by loss of dopamine, which is synthesized from tyrosine by two enzymes, tyrosine hydroxylase (th) and 4-dihydroxy-l-phenylalanine decarboxylase (ddc). |
2009-11-24 |
2023-08-12 |
human |
| Justin M Kita, Brian M Kile, Lauren E Parker, R Mark Wightma. In vivo measurement of somatodendritic release of dopamine in the ventral tegmental area. Synapse (New York, N.Y.). vol 63. issue 11. 2009-11-17. PMID:19593821. |
immunohistochemistry experiments with antibodies for tyrosine hydroxylase (th) confirmed that dopamine processes were primarily found below 8 mm. |
2009-11-17 |
2023-08-12 |
rat |
| Lachlan H Thompson, Shane Grealish, Deniz Kirik, Anders Björklun. Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain. The European journal of neuroscience. vol 30. issue 4. 2009-11-17. PMID:19674082. |
using a microtransplantation approach, which allows precise placement of small cell deposits directly into the host substantia nigra, and fetal donor cells that express green fluorescent protein under the control of the tyrosine hydroxylase promoter, we show that dopamine neuroblasts implanted into the substantia nigra of adult mice are capable of generating a new nigrostriatal pathway with an outgrowth pattern that matches the anatomy of the intrinsic system. |
2009-11-17 |
2023-08-12 |
mouse |
| Ljubica Gavrilovic, Natasa Spasojevic, Sladjana Dronja. Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats. Autonomic neuroscience : basic & clinical. vol 150. issue 1-2. 2009-11-16. PMID:19482560. |
in this study we investigated the changes in norepinephrine biosynthetic enzymes tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyltransferase (pnmt) gene expression in the stellate ganglia of naive controls and long-term socially isolated (12 weeks) adult rats and the response of these animals to additional immobilization stress. |
2009-11-16 |
2023-08-12 |
rat |
| Jason R Cannon, J Timothy Greenamyr. NeuN is not a reliable marker of dopamine neurons in rat substantia nigra. Neuroscience letters. vol 464. issue 1. 2009-11-03. PMID:19682546. |
in parkinson's disease models, neun has been widely used to determine if there is actual nigral dopamine neuron loss or simply loss of tyrosine hydroxylase expression, a prominent phenotypic marker. |
2009-11-03 |
2023-08-12 |
rat |
| Theodore A Slotkin, Frederic J Seidle. Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. Brain research bulletin. vol 80. issue 1-2. 2009-11-02. PMID:19539729. |
we directly confirmed bap impairment of neurodifferentiation by measuring markers for the two neurotransmitter phenotypes expressed by pc12 cells: tyrosine hydroxylase (dopamine phenotype) and choline acetyltransferase (acetylcholine phenotype). |
2009-11-02 |
2023-08-12 |
Not clear |
| Rajesh S Yadav, Madhu Lata Sankhwar, Rajendra K Shukla, Ramesh Chandra, Aditya B Pant, Fakhrul Islam, Vinay K Khann. Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicology and applied pharmacology. vol 240. issue 3. 2009-10-26. PMID:19631675. |
the arsenic treated rats also exhibited a decrease in the binding of striatal dopamine receptors (32%) and tyrosine hydroxylase (th) immunoreactivity (19%) in striatum. |
2009-10-26 |
2023-08-12 |
human |
| Seema Singh, Kavita Singh, Satya Prakash Gupta, Devendra Kumar Patel, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. Effect of caffeine on the expression of cytochrome P450 1A2, adenosine A2A receptor and dopamine transporter in control and 1-methyl 4-phenyl 1, 2, 3, 6-tetrahydropyridine treated mouse striatum. Brain research. vol 1283. 2009-10-23. PMID:19520064. |
tyrosine hydroxylase immunoreactivity, levels of dopamine and 1-methyl 4-phenylpyridinium ion (mpp(+)), expressions of cyp1a2, adenosine a(2a) receptor and dat and cyp1a2 catalytic activity were measured in control and treated mouse brain. |
2009-10-23 |
2023-08-12 |
mouse |
| G A Oganesyan, I V Romanova, E A Aristakesyan, V V Kuzik, D M Makina, I Yu Morina, A E Khramenkova, I V Artamokhina, V A Belov. The dopaminergic system of the telencephalo-diencephalic areas of the vertebrate brain in the organization of the sleep-waking cycle. Neuroscience and behavioral physiology. vol 39. issue 8. 2009-10-05. PMID:19779833. |
immunohistochemical studies of tyrosine hydroxylase content, this being the key enzyme in dopamine synthesis, in the striatum, supraoptic and arcuate nuclei, and zona incerta of the hypothalamus of sturgeon and mammals (rats) of three age groups (14 and 30 days and adults), in conditions of tactile and sleep-deprivation stressors. |
2009-10-05 |
2023-08-12 |
rat |
| Rui D S Prediger, Daniel Rial, Rodrigo Medeiros, Cláudia P Figueiredo, Richard L Doty, Reinaldo N Takahash. Risk is in the air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of Parkinson's disease. Annals of the New York Academy of Sciences. vol 1170. 2009-09-25. PMID:19686204. |
such infusion decreased the expression of the enzyme tyrosine hydroxylase in the olfactory bulb and substantia nigra by means of apoptotic mechanisms, reducing dopamine levels in different brain structures, such as the olfactory bulb, striatum, and prefrontal cortex. |
2009-09-25 |
2023-08-12 |
rat |
| Seema Singh, Kavita Singh, Devendra Kumar Patel, Chetna Singh, Chandishwar Nath, Vinod Kumar Singh, Raj Kumar Singh, Mahendra Pratap Sing. The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection. Rejuvenation research. vol 12. issue 3. 2009-09-22. PMID:19594327. |
tyrosine hydroxylase (th)-immunoreactivity in the substantia nigra, the expression of nicotinic acetylcholine receptors (nachrs) alpha6 and alpha4, dopamine content, and 1-methyl-4-phenylpyridinium ion (mpp(+)) level in the striatum were measured to confirm the mptp-induced pd phenotype and nicotine-mediated neuroprotection. |
2009-09-22 |
2023-08-12 |
mouse |
| Miriam Schiff, Birgit Weinhold, Claudia Grothe, Herbert Hildebrand. NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system. Journal of neurochemistry. vol 110. issue 5. 2009-09-21. PMID:19619134. |
as studied by quantitative real-time rt-pcr, mrna profiles of ncam and the polysialyltransferases, st8siaii and st8siaiv, matched the course of tyrosine hydroxylase, dopamine transporter, nur-related factor 1, and paired-like homeodomain transcription factor 3 expression, which were used as marker genes of dopaminergic development. |
2009-09-21 |
2023-08-12 |
mouse |
| Karley Y Little, Eric Ramssen, Ryan Welchko, Vitaly Volberg, Courtney J Roland, Bader Cassi. Decreased brain dopamine cell numbers in human cocaine users. Psychiatry research. vol 168. issue 3. 2009-09-17. PMID:19233481. |
the present experiment involved counting midbrain dopamine neurons utilizing both melanin and tyrosine hydroxylase immunoreactivity. |
2009-09-17 |
2023-08-12 |
human |