| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Argel Aguilar-Valles, Cecilia Flores, Giamal N Luhesh. Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: relevance for schizophrenia. PloS one. vol 5. issue 6. 2010-09-01. PMID:20532043. |
in addition we measured protein levels of tyrosine hydroxylase, and tissue levels of dopamine and its metabolites, in ventral tegmental area, susbtantia nigra, nucleus accumbens, dorsal striatum and medial prefrontal cortex. |
2010-09-01 |
2023-08-12 |
rat |
| Argel Aguilar-Valles, Cecilia Flores, Giamal N Luhesh. Prenatal inflammation-induced hypoferremia alters dopamine function in the adult offspring in rat: relevance for schizophrenia. PloS one. vol 5. issue 6. 2010-09-01. PMID:20532043. |
these behavioral changes were accompanied by increased baseline levels of tyrosine hydroxylase, dopamine and its metabolites, selectively in the nucleus accumbens. |
2010-09-01 |
2023-08-12 |
rat |
| Ayse Ulusoy, Gurdal Sahin, Deniz Kiri. Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA-induced dyskinesia in rats. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 29. 2010-09-01. PMID:20615977. |
here we silenced the nigrostriatal dopamine neurotransmission without affecting the anatomical integrity of the presynaptic terminals using a short-hairpin rna-mediated knockdown of tyrosine hydroxylase enzyme (shth). |
2010-09-01 |
2023-08-12 |
rat |
| Noelia Granado, Sara Ares-Santos, Esther O'Shea, Carlos Vicario-Abejón, M Isabel Colado, Rosario Moratall. Selective vulnerability in striosomes and in the nigrostriatal dopaminergic pathway after methamphetamine administration : early loss of TH in striosomes after methamphetamine. Neurotoxicity research. vol 18. issue 1. 2010-08-31. PMID:19760475. |
we examined the effect of meth on tyrosine hydroxylase (th) and dopamine transporter (dat) immunoreactivity in the different compartments of the striatum and in the nucleus accumbens. |
2010-08-31 |
2023-08-12 |
mouse |
| Z Vucetic, K Totoki, H Schoch, K W Whitaker, T Hill-Smith, I Lucki, T M Reye. Early life protein restriction alters dopamine circuitry. Neuroscience. vol 168. issue 2. 2010-08-19. PMID:20394806. |
iugr offspring have six to eightfold over-expression of dopamine (da)-related genes (tyrosine hydroxylase (th) and dopamine transporter) in brain regions related to reward processing (ventral tegmental area (vta), nucleus accumbens, prefrontal cortex (pfc)) and homeostatic control (hypothalamus), as well as increased number of th-ir neurons in the vta and increased dopamine in the pfc. |
2010-08-19 |
2023-08-12 |
mouse |
| Shirong Wang, Eric E Turne. Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 27. 2010-08-16. PMID:20610757. |
here we show that etv5 expression is not detectable until postnatal stages in the midbrain, well after development of the da system, and that etv5 knock-out and control mice show comparable tyrosine hydroxylase and dopamine transporter expression in the embryonic and adult midbrain. |
2010-08-16 |
2023-08-12 |
mouse |
| Michael C Reed, Anna Lieb, H Frederik Nijhou. The biological significance of substrate inhibition: a mechanism with diverse functions. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 32. issue 5. 2010-07-21. PMID:20414900. |
substrate inhibition of tyrosine hydroxylase results in a steady synthesis of dopamine despite large fluctuations in tyrosine due to meals. |
2010-07-21 |
2023-08-12 |
Not clear |
| Xiangru Xu, Mohamed R Mughal, F Scott Hall, Maria T G Perona, Paul J Pistell, Justin D Lathia, Srinivasulu Chigurupati, Kevin G Becker, Bruce Ladenheim, Laura E Niklason, George R Uhl, Jean Lud Cadet, Mark P Mattso. Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior. Journal of neurochemistry. vol 114. issue 1. 2010-07-19. PMID:20456017. |
the expression of several enzymes involved in dopamine metabolism including tyrosine hydroxylase, monoamine oxidases a and b, and catechol-o-methyltransferase were significantly reduced in obs of mice on the adf diet. |
2010-07-19 |
2023-08-12 |
mouse |
| Béchir Jarraya, Sabrina Boulet, G Scott Ralph, Caroline Jan, Gilles Bonvento, Mimoun Azzouz, James E Miskin, Masahiro Shin, Thierry Delzescaux, Xavier Drouot, Anne-Sophie Hérard, Denise M Day, Emmanuel Brouillet, Susan M Kingsman, Philippe Hantraye, Kyriacos A Mitrophanous, Nicholas D Mazarakis, Stéphane Palf. Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia. Science translational medicine. vol 1. issue 2. 2010-07-12. PMID:20368163. |
in this model, we demonstrated that injection of a tricistronic lentiviral vector encoding the critical genes for dopamine synthesis (tyrosine hydroxylase, aromatic l-amino acid decarboxylase, and guanosine 5'-triphosphate cyclohydrolase 1) into the striatum safely restored extracellular concentrations of dopamine and corrected the motor deficits for 12 months without associated dyskinesias. |
2010-07-12 |
2023-08-12 |
monkey |
| Hong-Ning Zhang, Chun-Na An, Hui-Nan Zhang, Xiao-Ping P. Protocatechuic acid inhibits neurotoxicity induced by MPTP in vivo. Neuroscience letters. vol 474. issue 2. 2010-07-08. PMID:20227465. |
in this study, we demonstrated that pac inhibited the reduction of the latent periods in a rotarod test, and the contents of dopamine (da) and its metabolites in striatum, and furthermore, it ameliorated the pathology in sn and the decreases in the expression of tyrosine hydroxylase (th) in sn of c57bl/6j mice induced by mptp. |
2010-07-08 |
2023-08-12 |
mouse |
| Riccardo Viaro, Matteo Marti, Michele Morar. Dual motor response to l-dopa and nociceptin/orphanin FQ receptor antagonists in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) treated mice: Paradoxical inhibition is relieved by D(2)/D(3) receptor blockade. Experimental neurology. vol 223. issue 2. 2010-07-01. PMID:20122926. |
this impairment was associated with approximately 60% loss of striatal dopamine terminals, as revealed by tyrosine hydroxylase immunohistochemistry, and was attenuated by dopaminergic drugs. |
2010-07-01 |
2023-08-12 |
mouse |
| Pratibha Mehta Luthra, Satendra Sing. Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis. Planta. vol 231. issue 6. 2010-06-29. PMID:20300771. |
tyrosine hydroxylase converted specific monophenols such as l-tyrosine (808.63 microm) and tyramine (k (m) 1.1 mm) to diphenols l-dopa and dopamine, respectively. |
2010-06-29 |
2023-08-12 |
mouse |
| Hyo Won Jung, Hye Young Son, Guang-Zhen Jin, Yong-Ki Par. Preventive role of PD-1 on MPTP-induced dopamine depletion in mice. Cell biochemistry and function. vol 28. issue 3. 2010-06-25. PMID:20186864. |
the mptp administration caused the dopamine neuron loss in the striatum and substantia nigra pars compacta (snpc), which was demonstrated by a depletion of tyrosine hydroxylase (th). |
2010-06-25 |
2023-08-12 |
mouse |
| G Xu, Z Xiong, Y Yong, Z Wang, Z Ke, Z Xia, Y H. Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum. Neuroscience. vol 167. issue 1. 2010-06-17. PMID:20123001. |
instead, catalpol dose dependently raised the tyrosine hydroxylase (th) neuron number in substantia nigra pars compacta (snpc), the striatal dopamine transporter (dat) density and the striatal glial cell derived neurotrophic factor (gdnf) protein level. |
2010-06-17 |
2023-08-12 |
mouse |
| Kei Yamamoto, Jori O Ruuskanen, Mario F Wullimann, Philippe Vernie. Two tyrosine hydroxylase genes in vertebrates New dopaminergic territories revealed in the zebrafish brain. Molecular and cellular neurosciences. vol 43. issue 4. 2010-06-15. PMID:20123022. |
tyrosine hydroxylase (th) is the rate limiting enzyme for dopamine synthesis, catalyzing transformation of l-tyrosine to l-dopa. |
2010-06-15 |
2023-08-12 |
zebrafish |
| André Nobre, Ieva Kalve, Konstantin Cesnulevicius, Daniela Ragancokova, Daniela Rangancokova, Andreas Ratzka, Nina Halfer, Maike Wesemann, Klaus Krampfl, Peter Claus, Claudia Groth. Characterization and differentiation potential of rat ventral mesencephalic neuronal progenitor cells immortalized with SV40 large T antigen. Cell and tissue research. vol 340. issue 1. 2010-06-15. PMID:20177706. |
these cells also expressed low mrna levels of the dopamine transporter and tyrosine hydroxylase (th), although no th-immunopositive neurons were found. |
2010-06-15 |
2023-08-12 |
rat |
| Ana Marcia Delattre, Agata Kiss, Raphael E Szawka, Janete A Anselmo-Franci, Pamela Brambilla Bagatini, Léder Leal Xavier, Paula Rigon, Matilde Achaval, Fabíola Iagher, Cíntia de David, Norma A P Marroni, Anete Curte Ferra. Evaluation of chronic omega-3 fatty acids supplementation on behavioral and neurochemical alterations in 6-hydroxydopamine-lesion model of Parkinson's disease. Neuroscience research. vol 66. issue 3. 2010-06-07. PMID:19941911. |
although omega-3 pufas did not modify the tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area, nor the depletion of dopamine (da) and its metabolites in the striatum, da turnover was increased after omega-3 pufas chronic supplementation. |
2010-06-07 |
2023-08-12 |
rat |
| Min Jeong Kang, Suk Ju Gil, Jeong Eun Lee, Hyun Chul Ko. Selective vulnerability of the striatal subregions of C57BL/6 mice to paraquat. Toxicology letters. vol 195. issue 2-3. 2010-05-27. PMID:20307631. |
we also measured changes in tyrosine hydroxylase (th) immunoreactivity, dopamine (da) and its metabolites, reduced glutathione (gsh), and oxidized glutathione (gssg) in the striatum. |
2010-05-27 |
2023-08-12 |
mouse |
| Ute Mathis, Frank Schaeffe. Transforming growth factor-beta in the chicken fundal layers: an immunohistochemical study. Experimental eye research. vol 90. issue 6. 2010-05-27. PMID:20350541. |
also, colocalization with peptides known to be involved in myopia development in chicks, such as glucagon, or vasointestinal polypeptide and the key enzyme for dopamine synthesis, tyrosine hydroxylase, was not observed. |
2010-05-27 |
2023-08-12 |
chicken |
| Irina N Krasnova, Zuzana Justinova, Bruce Ladenheim, Subramaniam Jayanthi, Michael T McCoy, Chanel Barnes, John E Warner, Steven R Goldberg, Jean Lud Cade. Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098750. |
in addition, there were significant reductions in the levels of striatal dopamine transporter and tyrosine hydroxylase proteins. |
2010-05-20 |
2023-08-12 |
human |