| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ichiro Kawahata, Hirofumi Tokuoka, Hasan Parvez, Hiroshi Ichinos. Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 12. 2010-04-02. PMID:19756365. |
tyrosine hydroxylase (th) is a rate-limiting enzyme for the biosynthesis of catecholamines including dopamine. |
2010-04-02 |
2023-08-12 |
Not clear |
| M S Oh, S J Hong, Y Huh, K-S Ki. Expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter. Gene therapy. vol 16. issue 3. 2010-03-26. PMID:18800154. |
expression of transgenes in midbrain dopamine neurons using the tyrosine hydroxylase promoter. |
2010-03-26 |
2023-08-12 |
rat |
| Monique Coufal, Pietro Invernizzi, Eugenio Gaudio, Francesca Bernuzzi, Gabriel A Frampton, Paolo Onori, Antonio Franchitto, Guido Carpino, Jonathan C Ramirez, Domenico Alvaro, Marco Marzioni, Guido Battisti, Antonio Benedetti, Sharon DeMorro. Increased local dopamine secretion has growth-promoting effects in cholangiocarcinoma. International journal of cancer. vol 126. issue 9. 2010-03-25. PMID:19795457. |
using 4 cholangiocarcinoma cell lines and human biopsy samples, we demonstrated that there was an increase in mrna and protein expression of the dopamine synthesis enzymes tyrosine hydroxylase and dopa decarboxylase in cholangiocarcinoma. |
2010-03-25 |
2023-08-12 |
mouse |
| Yaping Chu, Jeffrey H Kordowe. Lewy body pathology in fetal grafts. Annals of the New York Academy of Sciences. vol 1184. 2010-03-25. PMID:20146690. |
we also found a decline of both dopamine transporter and tyrosine hydroxylase and the formation of lewy body-like inclusions in 14-year-old grafts, which stained positive for alpha-synuclein and ubiquitin proteins. |
2010-03-25 |
2023-08-12 |
Not clear |
| Wenbo Zhou, Young Mook Lee, Vanessa C Guy, Curt R Free. Embryonic stem cells with GFP knocked into the dopamine transporter yield purified dopamine neurons in vitro and from knock-in mice. Stem cells (Dayton, Ohio). vol 27. issue 12. 2010-03-23. PMID:19750538. |
these purified dopamine neurons survived reculture and expressed tyrosine hydroxylase and dat when cocultured with mouse astrocytes or striatal cells. |
2010-03-23 |
2023-08-12 |
mouse |
| Alida Filippi, Julia Mahler, Jörn Schweitzer, Wolfgang Drieve. Expression of the paralogous tyrosine hydroxylase encoding genes th1 and th2 reveals the full complement of dopaminergic and noradrenergic neurons in zebrafish larval and juvenile brain. The Journal of comparative neurology. vol 518. issue 4. 2010-03-23. PMID:20017209. |
th2 expression in the latter two groups resolves a previously reported discrepancy, in which strong dopamine but little tyrosine hydroxylase immunoreactivity had been detected in the caudal hypothalamus. |
2010-03-23 |
2023-08-12 |
zebrafish |
| Michael F Salvatore, Brandon S Pruett, Sandy L Spann, Charles Dempse. Aging reveals a role for nigral tyrosine hydroxylase ser31 phosphorylation in locomotor activity generation. PloS one. vol 4. issue 12. 2010-03-17. PMID:20037632. |
tyrosine hydroxylase (th) regulates dopamine (da) bioavailability. |
2010-03-17 |
2023-08-12 |
Not clear |
| Tomas Björklund, Thomas Carlsson, Erik Ahlm Cederfjäll, Manolo Carta, Deniz Kiri. Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 2. 2010-03-16. PMID:20129936. |
here we utilized high purity recombinant adeno-associated viral vectors serotype 5 coding for tyrosine hydroxylase and its co-factor synthesizing enzyme guanosine-5'-triphosphate cyclohydrolase-1, delivered at an optimal ratio of 5 : 1, to show that the enhanced 3,4-dihydroxyphenylalanine production obtained with this optimized delivery system results in robust recovery of function in spontaneous motor tests after complete dopamine denervation. |
2010-03-16 |
2023-08-12 |
rat |
| Tomas Björklund, Thomas Carlsson, Erik Ahlm Cederfjäll, Manolo Carta, Deniz Kiri. Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease. Brain : a journal of neurology. vol 133. issue Pt 2. 2010-03-16. PMID:20129936. |
the tyrosine hydroxylase plus guanosine-5'-triphosphate cyclohydrolase-1 treated animals were resistant to developing dyskinesias upon peripheral l-3,4-dihydroxyphenylalanine drug challenge, which is consistent with the interpretation that continuous dopamine stimulation resulted in a normalization of the post-synaptic response. |
2010-03-16 |
2023-08-12 |
rat |
| Y T Cho, J L Fudg. Heterogeneous dopamine populations project to specific subregions of the primate amygdala. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19914353. |
to begin understanding how dopamine affects amygdala physiology and pathology in higher primates, we mapped the inputs from the midbrain dopaminergic neurons to various amygdala nuclei in the monkey using retrograde and anterograde tracing techniques, and single and double immunofluorescence histochemistry for tracer and tyrosine hydroxylase, a dopamine marker. |
2010-03-12 |
2023-08-12 |
rat |
| Po-Ling Yu, Ching-I Wu, Tzong-Shyuan Lee, Wynn H T Pan, Paulus S Wang, Shyi-Wu Wan. Attenuation of estradiol on the reduction of striatal dopamine by amphetamine in ovariectomized rats. Journal of cellular biochemistry. vol 108. issue 6. 2010-03-11. PMID:19830701. |
the protein expressions of dopamine transporter (dat), vesicular monoamine transporter 2 (vmat-2), and tyrosine hydroxylase (th) were analyzed by western blotting. |
2010-03-11 |
2023-08-12 |
rat |
| Rui D S Prediger, Aderbal S Aguiar, Argelia Esperanza Rojas-Mayorquin, Claudia P Figueiredo, Filipe C Matheus, Laure Ginestet, Caroline Chevarin, Elaine Del Bel, Raymond Mongeau, Michel Hamon, Laurence Lanfumey, Rita Raisman-Vozar. Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease. Neurotoxicity research. vol 17. issue 2. 2010-03-02. PMID:19629612. |
such infusion decreased the levels of the enzyme tyrosine hydroxylase in the olfactory bulb, striatum, and substantia nigra by means of apoptotic mechanisms, reducing dopamine concentration in different brain structures such as olfactory bulb, striatum, and prefrontal cortex, but not in the hippocampus. |
2010-03-02 |
2023-08-12 |
mouse |
| Lichuan Yang, Kesheng Zhao, Noel Y Calingasan, Guoxiong Luo, Hazel H Szeto, M Flint Bea. Mitochondria targeted peptides protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Antioxidants & redox signaling. vol 11. issue 9. 2010-03-01. PMID:19203217. |
ss-31 produced dose-dependent complete protection against loss of dopamine and its metabolites in striatum, as well as loss of tyrosine hydroxylase immunoreactive neurons in substantia nigra pars compacta. |
2010-03-01 |
2023-08-12 |
mouse |
| Jennifer Barber-Singh, Byoung Boo Seo, Eiko Nakamaru-Ogiso, Yuen-Sum Lau, Akemi Matsuno-Yagi, Takao Yag. Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of Parkinson disorder. Rejuvenation research. vol 12. issue 4. 2010-02-16. PMID:19653878. |
we showed that expression of ndi1 was able to significantly prevent the loss of dopamine and tyrosine hydroxylase as well as the dopaminergic transporters in the striatum of the chronic parkinsonian mice. |
2010-02-16 |
2023-08-12 |
mouse |
| A Nakashima, N Hayashi, Y S Kaneko, K Mori, E L Sabban, Toshiharu Nagatsu, A Ot. Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 11. 2010-02-12. PMID:19396395. |
tyrosine hydroxylase (th) catalyzes the conversion of l: -tyrosine to l: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [ca; dopamine (da), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of ca. |
2010-02-12 |
2023-08-12 |
human |
| Yael Chertkow, Orly Weinreb, Moussa B H Youdim, Henry Silve. Molecular mechanisms underlying synergistic effects of SSRI-antipsychotic augmentation in treatment of negative symptoms in schizophrenia. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 11. 2010-02-12. PMID:19578925. |
thus, the enhanced dopamine release by ssri-antipsychotic treatment is modulated by specific serotonergic receptors and by tyrosine hydroxylase. |
2010-02-12 |
2023-08-12 |
Not clear |
| Min Jung Lee, Chae Ha Yang, Jae-Pil Jeon, Meeyul Hwan. Protective effects of isoliquiritigenin against methamphetamine-induced neurotoxicity in mice. Journal of pharmacological sciences. vol 111. issue 2. 2010-01-28. PMID:19834288. |
repeated injections of methamphetamine cause the loss of striatal dopamine transporter (dat) and tyrosine hydroxylase (th). |
2010-01-28 |
2023-08-12 |
mouse |
| Osamu Kitamur. Detection of methamphetamine neurotoxicity in forensic autopsy cases. Legal medicine (Tokyo, Japan). vol 11 Suppl 1. 2010-01-26. PMID:19269222. |
the tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) levels and glial reactions in the striata of meth abusers were examined using immunohistochemical technique. |
2010-01-26 |
2023-08-12 |
Not clear |
| Sanjay Kasture, Silvia Pontis, Annalisa Pinna, Nicoletta Schintu, Liliana Spina, Rosanna Longoni, Nicola Simola, Mauro Ballero, Micaela Morell. Assessment of symptomatic and neuroprotective efficacy of Mucuna pruriens seed extract in rodent model of Parkinson's disease. Neurotoxicity research. vol 15. issue 2. 2010-01-26. PMID:19384573. |
finally, in a subchronic mice model of 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine hydrochloride (mptp)-induced dopamine neuron degeneration, mp extract did not prove capable of preventing either tyrosine hydroxylase decrease induced by mptp or astroglial or microglial activation as assessed by means of gfap and cd11b immunohistochemistry, supporting the absence of neuroprotective effects by mp. |
2010-01-26 |
2023-08-12 |
mouse |
| Masanori Ookubo, Hironori Yokoyama, Hiroyuki Kato, Tsutomu Arak. Gender differences on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in C57BL/6 mice. Molecular and cellular endocrinology. vol 311. issue 1-2. 2010-01-06. PMID:19631714. |
in the present study, we investigated the time-dependent alterations of dopamine and its metabolites, striatal tyrosine hydroxylase (th) protein, dopamine transporter (dat) protein, glial fibrillary acidic protein (gfap) protein and midbrain th protein and motor function in male and female mice 5h and 1, 3 and 7 days after four administrations of mptp (20mg/kg) at 2-h intervals. |
2010-01-06 |
2023-08-12 |
mouse |