| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irina N Krasnova, Zuzana Justinova, Bruce Ladenheim, Subramaniam Jayanthi, Michael T McCoy, Chanel Barnes, John E Warner, Steven R Goldberg, Jean Lud Cade. Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat. PloS one. vol 5. issue 1. 2010-05-20. PMID:20098750. |
there were also significant decreases in the levels of dopamine, dopamine transporter, and tyrosine hydroxylase in the cortex. |
2010-05-20 |
2023-08-12 |
human |
| A I Davydova, P M Klodt, V S Kudrin, E A Kuznetsova, V B Narkevic. [Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015]. Eksperimental'naia i klinicheskaia farmakologiia. vol 73. issue 3. 2010-05-19. PMID:20408420. |
in contrast to afobazole, ladasten demonstrated the ability to increase the level of l-dopa (a dopamine precursor) in virtually all functional structures of the brain (except for hippocamp), which may support the hypothesis suggestion concerning a predominant action of this drug on the activity of tyrosine hydroxylase. |
2010-05-19 |
2023-08-12 |
rat |
| Mikhail V Ugrumo. [Synthesis of monoamines by non-monoaminergic neurons: illusion or reality?]. Journal de la Societe de biologie. vol 203. issue 1. 2010-05-11. PMID:19358813. |
most monoenzymatic neurons possess one of the enzymes for dopamine (da) synthesis, tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2010-05-11 |
2023-08-12 |
Not clear |
| Diana C Parrish, Eric N Alston, Hermann Rohrer, Paul Nkadi, William R Woodward, Günther Schütz, Beth A Habecke. Infarction-induced cytokines cause local depletion of tyrosine hydroxylase in cardiac sympathetic nerves. Experimental physiology. vol 95. issue 2. 2010-05-06. PMID:19880537. |
to examine the effect of cytokines on tyrosine hydroxylase and na content in cardiac nerves we used gp130(dbh-cre/lox) mice, which have a deletion of the gp130 receptor in neurons expressing dopamine beta-hydroxylase. |
2010-05-06 |
2023-08-12 |
mouse |
| Cindy Casteels, Erwin Lauwers, Abdelbari Baitar, Guy Bormans, Veerle Baekelandt, Koen Van Laer. In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease. Brain research. vol 1316. 2010-05-06. PMID:20026090. |
using the cb1 receptor radioligand [(18)f]mk-9470 and small-animal pet, we investigated for the first time in vivo cerebral changes in [(18)f]mk-9470 binding in the 6-hydroxydopamine (6-ohda) rat model of parkinson's disease (pd), parallel to dopamine transporter (dat) imaging, tyrosine hydroxylase (th) staining, and behavioral measurements. |
2010-05-06 |
2023-08-12 |
rat |
| Jay Hirsh, Thomas Riemensperger, Hélène Coulom, Magali Iché, Jamie Coupar, Serge Birma. Roles of dopamine in circadian rhythmicity and extreme light sensitivity of circadian entrainment. Current biology : CB. vol 20. issue 3. 2010-05-06. PMID:20096587. |
we use gal4;uas-mediated rescue of tyrosine hydroxylase (dth) mutant (ple) flies to study the roles of dopamine in these processes. |
2010-05-06 |
2023-08-12 |
drosophila_melanogaster |
| Roger G Tremblay, Marianna Sikorska, Jagdeep K Sandhu, Patricia Lanthier, Maria Ribecco-Lutkiewicz, Mahmud Bani-Yaghou. Differentiation of mouse Neuro 2A cells into dopamine neurons. Journal of neuroscience methods. vol 186. issue 1. 2010-05-05. PMID:19903493. |
our results showed that n2a cells express nurr-related factor 1 (nurr1) and produce low levels of tyrosine hydroxylase (th) and dopamine. |
2010-05-05 |
2023-08-12 |
mouse |
| Sung Tae Kim, Eun-Mee Kim, Ji Hyun Choi, Hyo Jin Son, In Jung Ji, Tong H Joh, Sun Ju Chung, Onyou Hwan. Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neurons. Neurochemistry international. vol 56. issue 1. 2010-05-04. PMID:19815046. |
dopamine(da)rgic neurons are particularly vulnerable due to the presence of oxidative stress-inducing molecules such as da, tetrahydrobiopterin, iron and tyrosine hydroxylase (th). |
2010-05-04 |
2023-08-12 |
mouse |
| Guang-Zhen Jin, Su-Jin Cho, Young-S Lee, Myeong-Ok Kim, Dong-Woo Cho, Il-Keun Kon. Intrastriatal grafts of mesenchymal stem cells in adult intact rats can elevate tyrosine hydroxylase expression and dopamine levels. Cell biology international. vol 34. issue 1. 2010-05-04. PMID:19947946. |
intrastriatal grafts of mesenchymal stem cells in adult intact rats can elevate tyrosine hydroxylase expression and dopamine levels. |
2010-05-04 |
2023-08-12 |
rat |
| Guang-Zhen Jin, Su-Jin Cho, Young-S Lee, Myeong-Ok Kim, Dong-Woo Cho, Il-Keun Kon. Intrastriatal grafts of mesenchymal stem cells in adult intact rats can elevate tyrosine hydroxylase expression and dopamine levels. Cell biology international. vol 34. issue 1. 2010-05-04. PMID:19947946. |
also, mscs can enhance the th (tyrosine hydroxylase) expression and da (dopamine) content in catecholaminergic cells by in vitro co-culture system. |
2010-05-04 |
2023-08-12 |
rat |
| Li Rebekah Feng, Kathleen A Maguire-Zeis. Gene therapy in Parkinson's disease: rationale and current status. CNS drugs. vol 24. issue 3. 2010-05-04. PMID:20155994. |
the first two therapies discussed in this article focus on increasing dopamine production via direct delivery of genes involved in neurotransmitter synthesis (amino acid decarboxylase, tyrosine hydroxylase and gtp [guanosine triphosphate] cyclohydrolase 1). |
2010-05-04 |
2023-08-12 |
Not clear |
| Ryoichi Sadahiro, Akihito Suzuki, Naoshi Shibuya, Mitsuhiro Kamata, Yoshihiko Matsumoto, Kaoru Goto, Koichi Otan. Association study between a functional polymorphism of tyrosine hydroxylase gene promoter and personality traits in healthy subjects. Behavioural brain research. vol 208. issue 1. 2010-05-03. PMID:19958792. |
tyrosine hydroxylase (th) is the initial and rate-limiting enzyme in the biosynthesis of catecholamines such as dopamine and norepinephrine, which are deeply involved in human mental functions and behaviors. |
2010-05-03 |
2023-08-12 |
human |
| Jianjun Wu, Wenbo Yu, Yan Chen, Yaru Su, Zhengtong Ding, Huimin Ren, Yuping Jiang, Jian Wan. Intrastriatal transplantation of GDNF-engineered BMSCs and its neuroprotection in lactacystin-induced Parkinsonian rat model. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19894114. |
we observed that the intrastriatal transplantation of gdnf-bmscs could significantly rescue the dopaminergic neurons from lactacystin-induced neurotoxicity with regard to behavioral recovery, tyrosine hydroxylase level in nigra and striatum, and striatal dopamine level. |
2010-04-30 |
2023-08-12 |
rat |
| Sarah L Gordon, Julianne K Webb, Jacqueline Shehadeh, Peter R Dunkley, Phillip W Dickso. The low affinity dopamine binding site on tyrosine hydroxylase: the role of the N-terminus and in situ regulation of enzyme activity. Neurochemical research. vol 34. issue 10. 2010-04-23. PMID:19448984. |
the low affinity dopamine binding site on tyrosine hydroxylase: the role of the n-terminus and in situ regulation of enzyme activity. |
2010-04-23 |
2023-08-12 |
Not clear |
| Xiaoli Zhang, Junda Su, Asheebo Rojas, Chun Jian. Pontine norepinephrine defects in Mecp2-null mice involve deficient expression of dopamine beta-hydroxylase but not a loss of catecholaminergic neurons. Biochemical and biophysical research communications. vol 394. issue 2. 2010-04-22. PMID:20193660. |
although deficiency in tyrosine hydroxylase (th) has been demonstrated, it is possible that dopamine beta-hydroxylase (dbh), the critical enzyme converting dopamine to ne, is also affected. |
2010-04-22 |
2023-08-12 |
mouse |
| Miho Murat. [The discovery of an antiparkinsonian drug, zonisamide]. Rinsho shinkeigaku = Clinical neurology. vol 50. issue 2. 2010-04-22. PMID:20196486. |
as the mechanism of antiparkinsonian effects of zns, we showed that zns increases dopamine contents in the striatum by activating dopamine synthesis through increasing the levels of tyrosine hydroxylase (th) mrna and th protein. |
2010-04-22 |
2023-08-12 |
Not clear |
| Maryka Quik, Carla Campos, Neeraja Parameswaran, J William Langston, J Michael McIntosh, Michael Yeluashvil. Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19685015. |
nicotine treatment did not affect the dopamine transporter or the number of tyrosine hydroxylase positive cells in the substantia nigra of lesioned monkeys. |
2010-04-21 |
2023-08-12 |
monkey |
| Aida Bairam, Vincent Joseph, Yves Lajeunesse, Richard Kinkea. Altered expression of adenosine A1 and A2A receptors in the carotid body and nucleus tractus solitarius of adult male and female rats following neonatal caffeine treatment. Brain research. vol 1287. 2010-04-16. PMID:19563784. |
western blot analysis was used to assess the expression of adenosine a(1) and a(2a) receptors and tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis. |
2010-04-16 |
2023-08-12 |
rat |
| Mary K Holder, Maria M Hadjimarkou, Susan L Zup, Tamara Blutstein, Rebecca S Benham, Margaret M McCarthy, Jessica A Mon. Methamphetamine facilitates female sexual behavior and enhances neuronal activation in the medial amygdala and ventromedial nucleus of the hypothalamus. Psychoneuroendocrinology. vol 35. issue 2. 2010-04-16. PMID:19589643. |
in support of this possibility, ovarian hormones significantly increased tyrosine hydroxylase (the rate limiting enzyme in dopamine synthesis) immunoreactivity in the medial amygdala. |
2010-04-16 |
2023-08-12 |
rat |
| Kazuto Sakoori, Niall P Murph. Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice. Neuroscience letters. vol 469. issue 3. 2010-04-12. PMID:20025929. |
three days later, brains were immunohistochemically processed to visualize methamphetamine-induced loss of tyrosine hydroxylase (as a marker of damage to dopamine terminals), glial fibrillary acidic protein (gfap, as a marker of astrocytes), and ionized calcium-binding adapter molecule 1 (lba-1, as a marker of microglia) in the striatum. |
2010-04-12 |
2023-08-12 |
mouse |