| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tian Chen, Wenjie Yang, Yuanyuan Li, Xi Chen, Shunqing X. Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells. Toxicology letters. vol 201. issue 1. 2011-03-30. PMID:21145954. |
during the process of ngf-induced differentiation of the cell line, 4 days of mehp exposure (2.5-250 μm) increased membrane and cytoskeletal protein contents, enhanced ngf-induced neurite outgrowth, up-regulated the choline acetyl transferase (chat) mrna and down-regulated tyrosine hydroxylase (th) mrna levels, which suggested the promoted differentiation towards the acetylcholine (ach) phenotype at the expense of the dopamine (da) phenotype. |
2011-03-30 |
2023-08-12 |
Not clear |
| Merja H Voutilainen, Susanne Bäck, Johan Peränen, Päivi Lindholm, Atso Raasmaja, Pekka T Männistö, Mart Saarma, Raimo K Tuomine. Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease. Experimental neurology. vol 228. issue 1. 2011-03-30. PMID:21185834. |
degeneration of nigrostriatal dopamine nerve tract after toxin injection was assessed by measuring amphetamine-induced rotational behavior, and at the end of the experiment by quantifying tyrosine hydroxylase (th)-positive neurons in the substantia nigra pars compacta (snpc) and th-positive fibers in the striatum. |
2011-03-30 |
2023-08-12 |
rat |
| Ana C Calvo, Angel L Pey, Antonio Miranda-Vizuete, Anne P Døskeland, Aurora Martine. Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. The Biochemical journal. vol 434. issue 1. 2011-03-15. PMID:21087208. |
divergence in enzyme regulation between caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine. |
2011-03-15 |
2023-08-12 |
human |
| Takuya Sato, Yasutomo Shinohara, Daisuke Kaneko, Ikuko Nishimura, Asahi Matsuyam. Fermented soymilk increases voluntary wheel running activity and sexual behavior in male rats. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 35. issue 6. 2011-03-15. PMID:21164545. |
the protein expression of tyrosine hydroxylase (th) increased in the hippocampus by fsm administration and it is suggested that fsm may change norepinephrine or dopamine signaling in the brain. |
2011-03-15 |
2023-08-12 |
rat |
| Lauren A O'Connell, Miles R Fontenot, Hans A Hofman. Characterization of the dopaminergic system in the brain of an African cichlid fish, Astatotilapia burtoni. The Journal of comparative neurology. vol 519. issue 1. 2011-03-14. PMID:21120929. |
to understand better where dopamine acts to regulate social behavior in this species, we have determined the distribution of putative dopaminergic cells and fibers (by tyrosine hydroxylase immunohistochemistry) and dopamine receptors (by in situ hybridization for the d(1a) and d(2) dopamine receptor subtypes) throughout the forebrain and part of the mesencephalon of a. burtoni. |
2011-03-14 |
2023-08-12 |
Not clear |
| Hasna Erazi, Samir Ahboucha, Halima Gamran. Chronic exposure to aluminum reduces tyrosine hydroxylase expression in the substantia nigra and locomotor performance in rats. Neuroscience letters. vol 487. issue 1. 2011-03-09. PMID:20884324. |
the present study was designed to evaluate by means of immunohistochemistry using antibodies against tyrosine hydroxylase (th; the rate-limiting enzyme of dopamine synthesis) the effects of chronic al exposure (0, 3%) in drinking water during 4 months in adulthood or since intra-uterine age in the substantia nigra. |
2011-03-09 |
2023-08-12 |
rat |
| Massimiliano Caiazzo, Luca Colucci-D'Amato, Floriana Volpicelli, Luisa Speranza, Ciro Petrone, Lucio Pastore, Stefano Stifani, Francesco Ramirez, Gian Carlo Bellenchi, Umberto di Porzi. Krüppel-like factor 7 is required for olfactory bulb dopaminergic neuron development. Experimental cell research. vol 317. issue 4. 2011-03-08. PMID:21093432. |
in particular, the tyrosine hydroxylase (th) and dopamine transporter (dat) transcripts are strongly decreased in the olfactory bulbs and ventral midbrain at birth, compared to wild-type littermates. |
2011-03-08 |
2023-08-12 |
mouse |
| Daigo Homma, Chiho Sumi-Ichinose, Hirofumi Tokuoka, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo, Setsuko Katoh, Hiroshi Ichinos. Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21062748. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the biosynthesis of dopamine and requires tetrahydrobiopterin (bh4) as a cofactor. |
2011-03-02 |
2023-08-12 |
mouse |
| Yeong-Gon Choi, Sabina Li. N(ɛ)-(carboxymethyl)lysine linkage to α-synuclein and involvement of advanced glycation end products in α-synuclein deposits in an MPTP-intoxicated mouse model. Biochimie. vol 92. issue 10. 2011-02-16. PMID:20624443. |
results show that the immunoreactivities of the tyrosine hydroxylase and dopamine transporter significantly decreased in the striatum and the substantia nigra (sn) in the mptp model compared to the subjects in the control group. |
2011-02-16 |
2023-08-12 |
mouse |
| Ashutosh Kumar, Israr Ahmad, Smriti Shukla, Brajesh Kumar Singh, Devendra Kumar Patel, Haushila Prasad Pandey, Chetna Sing. Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats. Free radical research. vol 44. issue 8. 2011-02-14. PMID:20553223. |
a significant reduction was observed in spontaneous locomotor activity (sla), striatal dopamine (da) levels, tyrosine hydroxylase (th) immunoreactivity, glutathione reductase (gr) and catalase activity along with increased lipid peroxidation (lpo) and glutathione peroxidase (gpx) activity after zn and/or pq exposure. |
2011-02-14 |
2023-08-12 |
rat |
| Kurt A Jellinge. Interaction between α-synuclein and tau in Parkinson's disease comment on Wills et al.: elevated tauopathy and α-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp Neurol 2010; 225: 210-218. Experimental neurology. vol 227. issue 1. 2011-02-04. PMID:20965169. |
recent neurochemical studies in postmortem brains of patients with parkinson's disease (pd), pd with dementia (pdd) and age-matched controls revealed significant decrease of tyrosine hydroxylase (th) and dopamine transporter (dat) in striatum, confirming previous studies indicating substantial loss of dopaminergic neurons and terminals. |
2011-02-04 |
2023-08-12 |
mouse |
| J W Jahng, V Ryu, S B Yoo, S J Noh, J Y Kim, J H Le. Mesolimbic dopaminergic activity responding to acute stress is blunted in adolescent rats that experienced neonatal maternal separation. Neuroscience. vol 171. issue 1. 2011-02-02. PMID:20828601. |
in nh pups, restraint stress increased dopamine levels not only in the nacb but also in the midbrain dopamine neurons; however, these increases were not observed in ms. gene expression of tyrosine hydroxylase (th) in the ventral tegmental area (vta) was increased by acute restraint in nh pups, but not in ms pups. |
2011-02-02 |
2023-08-12 |
rat |
| Güney Bademci, Todd L Edwards, Andre L Torres, William K Scott, Stephan Züchner, Eden R Martin, Jeffery M Vance, Liyong Wan. A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease. Human mutation. vol 31. issue 10. 2011-01-28. PMID:20809526. |
tyrosine hydroxylase (th) enzyme is a rate limiting enzyme in dopamine biosynthesis. |
2011-01-28 |
2023-08-12 |
Not clear |
| Neil M Richtand, Yanhong Liu, Rebecca Ahlbrand, Juliana R Sullivan, Amy Hauck Newman, Robert K McNamar. Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression. Synapse (New York, N.Y.). vol 64. issue 8. 2011-01-26. PMID:20340170. |
expression of tyrosine hydroxylase (th) mrna, the rate-limiting enzyme in dopamine synthesis, was also determined. |
2011-01-26 |
2023-08-12 |
Not clear |
| Meredith J Ezak, Denise M Ferke. The C. elegans D2-like dopamine receptor DOP-3 decreases behavioral sensitivity to the olfactory stimulus 1-octanol. PloS one. vol 5. issue 3. 2011-01-11. PMID:20209143. |
c. elegans lacking the cat-2 tyrosine hydroxylase enzyme, which is required for dopamine biosynthesis, are hypersensitive in their behavioral avoidance of dilute concentrations of octanol. |
2011-01-11 |
2023-08-12 |
caenorhabditis_elegans |
| Shizuma Ishikawa, Takahiro Taira, Kazuko Takahashi-Niki, Takeshi Niki, Hiroyoshi Ariga, Sanae M M Iguchi-Arig. Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene. The Journal of biological chemistry. vol 285. issue 51. 2011-01-11. PMID:20938049. |
dj-1 has multiple functions, including transcriptional regulation, and one of transcriptional target genes for dj-1 is the tyrosine hydroxylase (th) gene, the product of which is a key enzyme for dopamine biosynthesis. |
2011-01-11 |
2023-08-12 |
mouse |
| Zhishan Li, Marc G Caron, Randy D Blakely, Kara G Margolis, Michael D Gersho. Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 49. 2011-01-07. PMID:21148012. |
subsets of neurons were nevertheless found in the murine ens that express transcripts encoding net, net protein, and dopamine β-hydroxylase; these neurons lack tyrosine hydroxylase (th) and thus are not catecholaminergic. |
2011-01-07 |
2023-08-12 |
Not clear |
| Marta Ibanez, Francisco J Valderrama-Canales, Eva Maranillo, Teresa Vazquez, Arán Pascual-Font, Stephen McHanwell, Jose Sanud. Human laryngeal ganglia contain both sympathetic and parasympathetic cell types. Clinical anatomy (New York, N.Y.). vol 23. issue 6. 2010-12-21. PMID:20821402. |
one population contained chromogranin and tyrosine hydroxylase representing a neurosecretory population possibly secreting dopamine. |
2010-12-21 |
2023-08-12 |
human |
| G Muthian, V Mackey, J King, C G Charlto. Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Neuroscience. vol 169. issue 3. 2010-12-16. PMID:20540993. |
the weights and motor activity of the offspring, high performance liquid chromatography (hplc) striatal dopamine and its metabolites and western blot for tyrosine hydroxylase (th) were determined. |
2010-12-16 |
2023-08-12 |
mouse |
| Fatima Macho Sanchez-Simon, Xiao Xiao Zhang, Horace H Loh, Ping-Yee Law, Raquel E Rodrigue. Morphine regulates dopaminergic neuron differentiation via miR-133b. Molecular pharmacology. vol 78. issue 5. 2010-12-07. PMID:20716624. |
using zebrafish embryos as the model, we demonstrate that morphine decreases mir-133b expression, hence increasing the expression of its target, pitx3, a transcription factor that activates tyrosine hydroxylase and dopamine transporter. |
2010-12-07 |
2023-08-12 |
rat |