| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ann D Cohen, Michael J Zigmond, Amanda D Smit. Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: time course of protection and neurorestoration. Brain research. vol 1370. 2011-11-23. PMID:21062624. |
6-ohda caused a loss of cells in the substantia nigra that expressed both fg and tyrosine hydroxylase (th) and striatal terminals expressing th, the high affinity dopamine transporter (dat), and the vesicular monoamine transporter 2 (vmat2) as assessed 2-8 weeks later. |
2011-11-23 |
2023-08-12 |
Not clear |
| Jennifer M King, Gladson Muthian, Veronica Mackey, Marquitta Smith, Clivel Charlto. L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease. Life sciences. vol 89. issue 17-18. 2011-11-22. PMID:21871902. |
l-dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic l-amino acid decarboxylase, dopamine and its metabolites in an mptp mouse model of parkinson's disease. |
2011-11-22 |
2023-08-12 |
mouse |
| S Parrish-Aungst, E Kiyokage, G Szabo, Y Yanagawa, M T Shipley, A C Puch. Sensory experience selectively regulates transmitter synthesis enzymes in interglomerular circuits. Brain research. vol 1382. 2011-11-15. PMID:21276774. |
gad67 is expressed by sa cells, which also co-express the rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase (th). |
2011-11-15 |
2023-08-12 |
Not clear |
| E-J Shin, J-H Bach, T-T L Nguyen, X-K T Nguyen, B-D Jung, K-W Oh, M J Kim, S K Ko, C G Jang, S F Ali, H-C Ki. Gastrodia elata bl attenuates methamphetamine-induced dopaminergic toxicity via inhibiting oxidative burdens. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886575. |
× 4) resulted in significant decreases in behavioural activity (as shown by locomotor activity and rota rod performance), dopamine level, tyrosine hydroxylase (th) activity, and th protein expression (as evaluated by immunocytochemistry and western blot analysis). |
2011-11-10 |
2023-08-12 |
mouse |
| Andrii Domanskyi, Christin Geissler, Ilya A Vinnikov, Heike Alter, Andreas Schober, Miriam A Vogt, Peter Gass, Rosanna Parlato, Günther Schüt. Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 9. 2011-11-09. PMID:21593433. |
adult mice with da neuron-specific pten deletion exhibit elevated expression of tyrosine hydroxylase, a rate-limiting enzyme in the dopamine biosynthesis pathway, associated with increased striatal dopamine content, and increased mrna levels of foxa2, pitx3, en1, nurr1, and lmx1b-the essential factors for maintaining physiological functions of adult da neurons. |
2011-11-09 |
2023-08-12 |
mouse |
| Nathalie Thiriet, Benjamin Gennequin, Virginie Lardeux, Claudia Chauvet, Mickael Decressac, Thierry Janet, Mohamed Jaber, Marcello Solina. Environmental enrichment does not reduce the rewarding and neurotoxic effects of methamphetamine. Neurotoxicity research. vol 19. issue 1. 2011-11-08. PMID:20143198. |
in addition, contrary to what we found with other toxins such as mptp, ee did not diminish the striatal neurotoxicity induced by meth (4 x 10 mg/kg) as measured by dopamine content, tyrosine hydroxylase protein levels and apoptosis. |
2011-11-08 |
2023-08-12 |
mouse |
| Jesús M López, Ruth Morona, Agustín Gonzále. Immunohistochemical localization of DARPP-32 in the brain and spinal cord of anuran amphibians and its relation with the catecholaminergic system. Journal of chemical neuroanatomy. vol 40. issue 4. 2011-11-07. PMID:20887782. |
the relationship between dopaminergic neuronal structures and dopaminoceptive structures in the amphibian brain and spinal cord are assessed by means of single and double immunohistochemical techniques with antibodies directed against darpp-32 (a phosphoprotein related to the dopamine d(1)-receptor) and tyrosine hydroxylase (th) applied to the brain of the anurans rana perezi and xenopus laevis. |
2011-11-07 |
2023-08-12 |
xenopus_laevis |
| Hui-Di Yang, Qian Wang, Zuoxin Wang, De-Hua Wan. Food hoarding and associated neuronal activation in brain reward circuitry in Mongolian gerbils. Physiology & behavior. vol 104. issue 3. 2011-11-03. PMID:21570992. |
food hoarding was also associated with increases in the number of cells labeled for tyrosine hydroxylase (th-ir), the rate limiting enzyme for dopamine conversion, and the number of cells co-labeled for th-ir/fos-ir in the vta, suggesting that dopamine in the brain reward circuitry may be involved in food hoarding. |
2011-11-03 |
2023-08-12 |
Not clear |
| Hironori Yokoyama, Hayato Kuroiwa, Jiro Kasahara, Tsutomu Arak. Neuropharmacological approach against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine)-induced mouse model of Parkinson's disease. Acta neurobiologiae experimentalis. vol 71. issue 2. 2011-11-03. PMID:21731080. |
furthermore, it is well known that acute treatment with mptp can cause a severe loss of tyrosine hydroxylase and dopamine transporter protein levels and dopamine contents in the striatum of mice, as compared to continuous mptp treatment. |
2011-11-03 |
2023-08-12 |
mouse |
| Eun-Joo Shin, Chu Xuan Duong, Xuan-Khanh Thi Nguyen, Guoying Bing, Jae-Hyung Bach, Dae Hun Park, Keiichi Nakayama, Syed F Ali, Anumantha G Kanthasamy, Jean L Cadet, Toshitaka Nabeshima, Hyoung-Chun Ki. PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment. Neurochemistry international. vol 59. issue 1. 2011-10-27. PMID:21672585. |
there were no ma-induced significant decreases of dopamine (da) content or tyrosine hydroxylase (th) expression in the striatum in rottlerin-treated-, aso-treated- or pkcδ (-/-)-mice. |
2011-10-27 |
2023-08-12 |
mouse |
| Jie Wu, Chen Wang, Jiao Sun, Yang Xu. Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways. ACS nano. vol 5. issue 6. 2011-10-26. PMID:21526751. |
in addition, the in vivo injury of neurochemicals occurred as the sio(2)-nps appeared to induce depleted dopamine in the striatum, and the down-regulation of tyrosine hydroxylase protein was the main contribution. |
2011-10-26 |
2023-08-12 |
Not clear |
| Marcy J Bubar, Sonja J Stutz, Kathryn A Cunningha. 5-HT(2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway. PloS one. vol 6. issue 6. 2011-10-14. PMID:21687728. |
here, we employed double-label fluorescence immunochemistry with the synthetic enzymes for dopamine (tyrosine hydroxylase; th) and gaba (glutamic acid decarboxylase isoform 67; gad-67) and retrograde tract tracing with fluorogold (fg) to uncover whether dopamine and gaba vta neurons that possess 5-ht(2c)r innervate the nucleus accumbens (nac). |
2011-10-14 |
2023-08-12 |
rat |
| Sa Suk Kim, Kyung Rok Moon, Hyun Jin Cho. Interference of alpha-synuclein with cAMP/PKA-dependent CREB signaling for tyrosine hydroxylase gene expression in SK-N-BE(2)C cells. Archives of pharmacal research. vol 34. issue 5. 2011-10-13. PMID:21656370. |
early studies have demonstrated that interaction of α-syn and tyrosine hydroxylase (th), a rate-limiting enzyme in dopamine synthesis, is functionally significant for dopaminergic neurotransmission and the pathophysiology of parkinson's disease. |
2011-10-13 |
2023-08-12 |
Not clear |
| Bastian Zimmer, Stefan Schildknecht, Philipp B Kuegler, Vivek Tanavde, Suzanne Kadereit, Marcel Leis. Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 2. 2011-09-19. PMID:21385734. |
the mixed neuronal cultures that formed within 20 days contained a small subpopulation of tyrosine hydroxylase (th)-positive neurons with specific dopaminergic functions such as dopamine transport (dat) activity. |
2011-09-19 |
2023-08-12 |
Not clear |
| Marie-Josée Wallman, Dave Gagnon, Martin Paren. Serotonin innervation of human basal ganglia. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21375599. |
adjacent sections were immunostained for tyrosine hydroxylase to compare the distribution of 5-ht axons with that of dopamine axons. |
2011-09-16 |
2023-08-12 |
human |
| Tiziana Alberio, Claudia Anchieri, Luca Piacentini, Giovanna Gentile, Maurizio Simmaco, Mara Biasin, Mauro Fasan. Proteomic characterization of Jurkat T leukemic cells after dopamine stimulation: A model of circulating dopamine-sensitive cells. Biochimie. vol 93. issue 5. 2011-09-15. PMID:21300132. |
jurkat cells express both d1- and d2-like dopamine receptors and both membrane and vesicular transporters, while they lack d4 receptor and tyrosine hydroxylase expression. |
2011-09-15 |
2023-08-12 |
human |
| Catherine Bédard, Marie-Josée Wallman, Emmanuelle Pourcher, André Parent, Martin Paren. Intense dopamine innervation of the subventricular zone in Huntington's disease. Neuroreport. vol 21. issue 17. 2011-09-13. PMID:20926973. |
here, we report the presence of an intense dopamine (tyrosine hydroxylase immunoreactive) zone along the ventricular border of the caudate nucleus in patients with huntington's disease, but not in age-matched controls. |
2011-09-13 |
2023-08-12 |
Not clear |
| Anthony P Nichola. Dual immunofluorescence study of citrullinated proteins in Parkinson diseased substantia nigra. Neuroscience letters. vol 495. issue 1. 2011-09-13. PMID:21414385. |
in control sn sections, many tyrosine hydroxylase (th)-immunoreactive dopamine neurons were seen surrounded either by small fibers immunoreactive for deiminated proteins, or large reactive astrocytes, co-localized with glial fibrillary acidic protein (gfap). |
2011-09-13 |
2023-08-12 |
human |
| Danhui Zhang, Arthi Kanthasamy, Vellareddy Anantharam, Anumantha Kanthasam. Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. Toxicology and applied pharmacology. vol 254. issue 2. 2011-09-06. PMID:21310168. |
recently, we showed that pkcδ negatively regulates tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, by enhancing protein phosphatase-2a activity in dopaminergic neurons. |
2011-09-06 |
2023-08-12 |
Not clear |
| Courtney M Keller, Michael F Salvatore, Brandon S Pruett, Glenn F Guerin, Nicholas E Goeder. Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat. Psychopharmacology. vol 215. issue 3. 2011-09-01. PMID:21523347. |
methamphetamine (ma) increases extracellular dopamine (da) and at chronic high doses induces toxicity as indicated by decreased expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2011-09-01 |
2023-08-12 |
rat |