| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lydia M Mexas, Virginia R Florang, Jonathan A Door. Inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Neurotoxicology. vol 32. issue 4. 2012-04-23. PMID:21514317. |
inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. |
2012-04-23 |
2023-08-12 |
Not clear |
| Xiaohong Li, Heng Li, Jianfen Bi, Yana Chen, Sumit Jain, Yong Zha. Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochemical and biophysical research communications. vol 419. issue 1. 2012-04-23. PMID:22330803. |
immunocytochemistry revealed that 48 ± 11% of atra-treated cells were positive for tyrosine hydroxylase (th), and 36 ± 9% of cells were positive for dopamine transporter (dat). |
2012-04-23 |
2023-08-12 |
human |
| Anand Kumar Singh, Manindra Nath Tiwari, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20371137. |
levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum, and tyrosine hydroxylase (th) immunoreactivity and 4',6-diamidino-2-phenylindole (dapi)/fluoro-jade b staining in the substantia nigra were measured to assess dopaminergic neurodegeneration. |
2012-04-19 |
2023-08-12 |
rat |
| Anand Kumar Singh, Manindra Nath Tiwari, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Long term exposure to cypermethrin induces nigrostriatal dopaminergic neurodegeneration in adult rats: postnatal exposure enhances the susceptibility during adulthood. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:20371137. |
the significant reduction in the time of stay on rotarod, spontaneous locomotor activity, dopamine, 3,4-dihydroxyphenylacetic acid, and tyrosine hydroxylase immunoreactivity while an increase in homovanillic acid level and fluoro-jade b-positive cells were observed in cypermethrin treated adult rats. |
2012-04-19 |
2023-08-12 |
rat |
| Matthew D McCoole, Natasha J Atkinson, Devyn I Graham, Elisabeth B Grasser, Andrew L Joselow, Nora M McCall, Alessandra M Welker, Eric J Wilsterman, Kevin N Baer, Andrea R Tilden, Andrew E Christi. Genomic analyses of aminergic signaling systems (dopamine, octopamine and serotonin) in Daphnia pulex. Comparative biochemistry and physiology. Part D, Genomics & proteomics. vol 7. issue 1. 2012-04-17. PMID:22137767. |
among the proteins identified were the biosynthetic enzymes tryptophan-phenylalanine hydroxylase (dopamine, octopamine and serotonin), tyrosine hydroxylase (dopamine), dopa decarboxylase (dopamine and serotonin), tyrosine decarboxylase (octopamine), tyramine β-hydroxylase (octopamine) and tryptophan hydroxylase (serotonin), as well as receptors for each amine and several amine transporters (dopamine and serotonin). |
2012-04-17 |
2023-08-12 |
drosophila_melanogaster |
| Hoa A Lam, Nanping Wu, Ingrid Cely, Rachel L Kelly, Sindalana Hean, Franziska Richter, Iddo Magen, Carlos Cepeda, Larry C Ackerson, Wendy Walwyn, Eliezer Masliah, Marie-Françoise Chesselet, Michael S Levine, Nigel T Maidmen. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein. Journal of neuroscience research. vol 89. issue 7. 2012-03-29. PMID:21488084. |
at 14 months of age, the α-syn mice presented with significantly lower striatal tissue dopamine and tyrosine hydroxylase content relative to wt littermates, accompanied by an l-dopa-reversible sensory motor deficit. |
2012-03-29 |
2023-08-12 |
mouse |
| Brajesh Kumar Singh, Ashutosh Kumar, Israr Ahmad, Vinod Kumar, Devendra Kumar Patel, Swatantra Kumar Jain, Chetna Sing. Oxidative stress in zinc-induced dopaminergic neurodegeneration: implications of superoxide dismutase and heme oxygenase-1. Free radical research. vol 45. issue 10. 2012-03-28. PMID:21777051. |
additionally, zn-induced alterations in the neurobehavioral parameters, lipid peroxidation (lpo), striatal dopamine and its metabolites and tyrosine hydroxylase (th) protein expression were measured to assess their correlations with the oxidative stress. |
2012-03-28 |
2023-08-12 |
rat |
| Hirofumi Tokuoka, Shin-ichi Muramatsu, Chiho Sumi-Ichinose, Hiroaki Sakane, Masayo Kojima, Yoshinori Aso, Takahide Nomura, Daniel Metzger, Hiroshi Ichinos. Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027820. |
compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. |
2012-03-27 |
2023-08-12 |
mouse |
| Hirofumi Tokuoka, Shin-ichi Muramatsu, Chiho Sumi-Ichinose, Hiroaki Sakane, Masayo Kojima, Yoshinori Aso, Takahide Nomura, Daniel Metzger, Hiroshi Ichinos. Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. The Journal of biological chemistry. vol 286. issue 50. 2012-03-27. PMID:22027820. |
the tyrosine hydroxylase (th; ec 1.14.16.2) is a rate-limiting enzyme in the dopamine synthesis and important for the central dopaminergic system, which controls voluntary movements and reward-dependent behaviors. |
2012-03-27 |
2023-08-12 |
mouse |
| Joshua W Vincentz, Nathan J VanDusen, Andrew B Fleming, Michael Rubart, Beth A Firulli, Marthe J Howard, Anthony B Firull. A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 6. 2012-03-27. PMID:22323723. |
finally, we demonstrate that hand1 is dispensable for normal tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) expression in sympathetic neurons, even when hand2 gene dosage is concurrently reduced by half. |
2012-03-27 |
2023-08-12 |
mouse |
| Jung-Hyuck Ahn, Yong Kim, Hee-Sun Kim, Paul Greengard, Angus C Nair. Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046270. |
tyrosine hydroxylase, which plays a critical role in regulation of dopamine synthesis, is known to be controlled by phosphorylation at several critical sites. |
2012-03-26 |
2023-08-12 |
Not clear |
| D Domenger, D Dea, L Theroux, L Moquin, A Gratton, J Poirie. The MPTP neurotoxic lesion model of Parkinson's disease activates the apolipoprotein E cascade in the mouse brain. Experimental neurology. vol 233. issue 1. 2012-03-25. PMID:22155743. |
in the striatum, upregulations of gfap, apoe and lrp mrnas at 1 day post-treatment were associated with marked decreases in dopamine (da) levels, loss in tyrosine hydroxylase protein content, as well as to a compensatory increase in dopaminergic metabolism. |
2012-03-25 |
2023-08-12 |
mouse |
| P Mulcahy, S Walsh, A Paucard, K Rea, E Dow. Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone. Neuroscience. vol 181. 2012-03-16. PMID:21277943. |
the effect of the pesticide on body weight and spontaneous motor function (corridor, stepping and whisker tests) was assessed ante mortem, and its effect on nigrostriatal integrity (quantitative tyrosine hydroxylase immunohistochemistry), α-synuclein expression (quantitative α-synuclein immunohistochemistry), and striatal neurotransmitter content (hlpc for dopamine, gaba and noradrenaline) was assessed post mortem. |
2012-03-16 |
2023-08-12 |
human |
| Beth A Smith, Natalie R S Goldberg, Charles K Meshu. Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. Brain research. vol 1386. 2012-03-12. PMID:21315689. |
we determined the extent of dopamine (da) terminal changes using western immunoblotting [striatal dopamine transporter (dat) and tyrosine hydroxylase (th)] and alterations in the mean number of da cells/section by immunohistochemistry and nissl staining [th-labeled cells and thionin-stained cells in the substantia nigra pars compacta (sn-pc)]. |
2012-03-12 |
2023-08-12 |
mouse |
| Ye Han, Christina E Khodr, Mohan K Sapru, Jyothi Pedapati, Martha C Boh. A microRNA embedded AAV α-synuclein gene silencing vector for dopaminergic neurons. Brain research. vol 1386. 2012-03-12. PMID:21338582. |
in da pc12 cells, neither vector decreased expression of rat snca, tyrosine hydroxylase (th), dopamine transporter (dat) or the vesicular monoamine transporter (vmat). |
2012-03-12 |
2023-08-12 |
human |
| Steven J O'Dell, Bryan A Galvez, Alexander J Ball, John F Marshal. Running wheel exercise ameliorates methamphetamine-induced damage to dopamine and serotonin terminals. Synapse (New York, N.Y.). vol 66. issue 1. 2012-03-07. PMID:21953518. |
[(125) i]rti-55 binding and autoradiography was used to quantify dopamine transporters (dat), and radioimmunocytochemistry was used to quantify striatal tyrosine hydroxylase (th). |
2012-03-07 |
2023-08-12 |
rat |
| Yusuke Sekine, Shuichi Takagahara, Ryo Hatanaka, Takeshi Watanabe, Haruka Oguchi, Takuya Noguchi, Isao Naguro, Kazuto Kobayashi, Makoto Tsunoda, Takashi Funatsu, Hiroshi Nomura, Takeshi Toyoda, Norio Matsuki, Erina Kuranaga, Masayuki Miura, Kohsuke Takeda, Hidenori Ichij. p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors. Journal of cell science. vol 124. issue Pt 17. 2012-02-29. PMID:21878507. |
drosophila tyrosine hydroxylase (th, also known as pale) and dopa decarboxylase (ddc), key enzymes in the dopamine synthesis pathway, underlie the melanin synthesis by providing the melanin precursors dopa and dopamine, respectively. |
2012-02-29 |
2023-08-12 |
drosophila_melanogaster |
| Shih-jei Tsai, Che-yi Chao, Mei-chin Yi. Preventive and therapeutic effects of caffeic acid against inflammatory injury in striatum of MPTP-treated mice. European journal of pharmacology. vol 670. issue 2-3. 2012-02-27. PMID:21970803. |
mptp treatment suppressed mrna expression of brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor and tyrosine hydroxylase (th), and lowered dopamine level (p < 0.05). |
2012-02-27 |
2023-08-12 |
mouse |
| B A Morrow, R H Roth, D E Redmond, J D Elswort. Impact of methamphetamine on dopamine neurons in primates is dependent on age: implications for development of Parkinson's disease. Neuroscience. vol 189. 2012-02-24. PMID:21640165. |
the results indicated that at mid-gestation and in adults, dopamine neurons were susceptible to methamphetamine-induced damage, as indicated by loss of striatal tyrosine hydroxylase (th) immunoreactivity and dopamine concentration. |
2012-02-24 |
2023-08-12 |
monkey |
| K-Y Yeh, C-H Wu, M-Y Tai, Y-F Tsa. Ginkgo biloba extract enhances noncontact erection in rats: the role of dopamine in the paraventricular nucleus and the mesolimbic system. Neuroscience. vol 189. 2012-02-24. PMID:21640798. |
a significant increase in the expression of catecholaminergic neurons in the pvn and the vta was seen by means of tyrosine hydroxylase immunohistochemistry, and tissue levels of dopamine and 3,4-dihydroxyphenylacetic acid in the nac were also markedly increased in the egb 761-treated animals. |
2012-02-24 |
2023-08-12 |
rat |