| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erin F Wolff, Xiao-Bing Gao, Katherine V Yao, Zane B Andrews, Hongling Du, John D Elsworth, Hugh S Taylo. Endometrial stem cell transplantation restores dopamine production in a Parkinson's disease model. Journal of cellular and molecular medicine. vol 15. issue 4. 2011-08-26. PMID:20406327. |
cells expressing cd90, platelet derived growth factor (pdgf)-rβ and cd146 but not cd45 or cd31 were differentiated in vitro into dopaminergic neurons that exhibited axon projections, pyramidal cell bodies and dendritic projections that recapitulate synapse formation; these cells also expressed the neural marker nestin and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2011-08-26 |
2023-08-12 |
mouse |
| Alejandro Higuera-Matas, Fanny Botreau, Nuria Del Olmo, Miguel Miguéns, Oscar Olías, Gonzalo L Montoya, Carmen García-Lecumberri, Emilio Ambrosi. Periadolescent exposure to cannabinoids alters the striatal and hippocampal dopaminergic system in the adult rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 20. issue 12. 2011-08-26. PMID:20655181. |
we evaluated the levels of the dopamine transporter (dat), and the d1- (d1r) and d2-type (d2r) dopaminergic receptors, as well as tyrosine hydroxylase (th) mrna in dopaminergic areas of the adult, cocaine self-administered, rat brain that had been chronically exposed to cp or vehicle (vh) during periadolescence. |
2011-08-26 |
2023-08-12 |
human |
| Gunasingh J Masilamoni, James W Bogenpohl, David Alagille, Kristen Delevich, Gilles Tamagnan, John R Votaw, Thomas Wichmann, Yoland Smit. Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys. Brain : a journal of neurology. vol 134. issue Pt 7. 2011-08-26. PMID:21705423. |
these behavioural observations were consistent with in vivo positron emission tomography dopamine transporter imaging data, and with post-mortem stereological counts of midbrain dopaminergic neurons, as well as striatal intensity measurements of dopamine transporter and tyrosine hydroxylase immunoreactivity, which were all significantly higher in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/3-[(2-methyl-1,3-thiazol-4-yl) ethynyl] pyridine-treated animals than in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/vehicle-treated monkeys. |
2011-08-26 |
2023-08-12 |
monkey |
| Irina N Krasnova, Bruce Ladenheim, Amber B Hodges, Nora D Volkow, Jean Lud Cade. Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain. PloS one. vol 6. issue 4. 2011-08-25. PMID:21547080. |
animals that received toxic meth challenges showed decreases in dopamine levels and reductions in tyrosine hydroxylase protein concentration in the striatum. |
2011-08-25 |
2023-08-12 |
rat |
| Irina N Krasnova, Bruce Ladenheim, Amber B Hodges, Nora D Volkow, Jean Lud Cade. Chronic methamphetamine administration causes differential regulation of transcription factors in the rat midbrain. PloS one. vol 6. issue 4. 2011-08-25. PMID:21547080. |
meth pretreatment protected against loss of striatal dopamine and tyrosine hydroxylase. |
2011-08-25 |
2023-08-12 |
rat |
| Noelia Granado, Sara Ares-Santos, Idaira Oliva, Esther O'Shea, Eduardo D Martin, M Isabel Colado, Rosario Moratall. Dopamine D2-receptor knockout mice are protected against dopaminergic neurotoxicity induced by methamphetamine or MDMA. Neurobiology of disease. vol 42. issue 3. 2011-08-23. PMID:21303698. |
methamphetamine (meth) and 3,4-methylenedioxymethamphetamine (mdma), amphetamine derivatives widely used as recreational drugs, induce similar neurotoxic effects in mice, including a marked loss of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum. |
2011-08-23 |
2023-08-12 |
mouse |
| Chiho Sumi-Ichinose, Hiroshi Ichinose, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kond. Advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals. Journal of pharmacological sciences. vol 114. issue 1. 2011-08-11. PMID:20716859. |
advanced research on dopamine signaling to develop drugs for the treatment of mental disorders: regulation of dopaminergic neural transmission by tyrosine hydroxylase protein at nerve terminals. |
2011-08-11 |
2023-08-12 |
mouse |
| Rui D S Prediger, Aderbal S Aguiar, Eduardo L G Moreira, Filipe C Matheus, Adalberto A Castro, Roger Walz, Andreza F De Bem, Alexandra Latini, Carla I Tasca, Marcelo Farina, Rita Raisman-Vozar. The intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a new rodent model to test palliative and neuroprotective agents for Parkinson's disease. Current pharmaceutical design. vol 17. issue 5. 2011-08-09. PMID:21375482. |
such infusion causes time-dependent loss of tyrosine hydroxylase in the olfactory bulb and snc, resulting in significant dopamine depletion in different brain areas. |
2011-08-09 |
2023-08-12 |
mouse |
| Yao-Hua Li, Nan Gao, Yi-Wen Ye, Xin Li, Shun Yu, Hui Yang, Kenji Uéda, Piu Cha. Alpha-synuclein functions as a negative regulator for expression of tyrosine hydroxylase. Acta neurologica Belgica. vol 111. issue 2. 2011-08-03. PMID:21748932. |
previous studies have shown that over-expression of alpha-synuclein (alpha-syn), a protein whose abnormality is implicated in the pathogenesis of parkinson's disease (pd), reduces tyrosine hydroxylase (th) expression and dopamine synthesis. |
2011-08-03 |
2023-08-12 |
human |
| Jing Yong, Goran Lacan, Hoa Dang, Terry Hsieh, Blake Middleton, Clive Wasserfall, Jide Tian, William P Melega, Daniel L Kaufma. BCG vaccine-induced neuroprotection in a mouse model of Parkinson's disease. PloS one. vol 6. issue 1. 2011-08-02. PMID:21304945. |
we assessed the neuroprotective potential of vaccines containing tyrosine hydroxylase (a neuronal protein involved in dopamine synthesis) or copaxone® in cfa in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of parkinson's disease. |
2011-08-02 |
2023-08-12 |
mouse |
| Margaret I Davis, Henry L Puh. Nr4a1-eGFP is a marker of striosome-matrix architecture, development and activity in the extended striatum. PloS one. vol 6. issue 1. 2011-08-02. PMID:21305052. |
striosomal expression is strong developmentally where nr4a1-egfp expression overlaps with drd1, trkb, tyrosine hydroxylase and phospho-erk, but not phospho-creb, immunoreactivity in "dopamine islands". |
2011-08-02 |
2023-08-12 |
mouse |
| Martin Köllensperger, Florian Krismer, Anton Pallua, Nadia Stefanova, Werner Poewe, Gregor K Wennin. Erythropoietin is neuroprotective in a transgenic mouse model of multiple system atrophy. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 3. 2011-07-29. PMID:21462262. |
immunohistochemistry for tyrosine hydroxylase and dopamine and cyclic adenosine monophosphate-regulated phosphoprotein (darpp-32) was analyzed stereologically. |
2011-07-29 |
2023-08-12 |
mouse |
| Yeong-Gon Choi, Sujung Yeo, Yeon-Mi Hong, Sabina Li. Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis. Cellular and molecular neurobiology. vol 31. issue 3. 2011-07-22. PMID:21107677. |
it was confirmed that acupuncture at these acupoints could inhibit the decrease of tyrosine hydroxylase and dopamine transporter in the nigrostriatal region of the mptp model while acupuncture at the non-acupoints could not counteract this decrease. |
2011-07-22 |
2023-08-12 |
mouse |
| Mohammed Emamussalehin Choudhury, Takashi Moritoyo, Madoka Kubo, Win Thiri Kyaw, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Seiji Matsuda, Masahiro Nomot. Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity. Brain research. vol 1384. 2011-07-19. PMID:21320474. |
mptp-treatment decreased the contents of dopamine as well as the number and area of tyrosine hydroxylase (th)-positive neurons. |
2011-07-19 |
2023-08-12 |
mouse |
| Jonathan Moss, Mark A Ungless, J Paul Bola. Dopaminergic axons in different divisions of the adult rat striatal complex do not express vesicular glutamate transporters. The European journal of neuroscience. vol 33. issue 7. 2011-07-18. PMID:21375596. |
striatal tissue from the adult rat was immunolabelled to reveal tyrosine hydroxylase (th; biosynthetic enzyme of dopamine) and one of the three known vgluts. |
2011-07-18 |
2023-08-12 |
rat |
| Heon-Jeong Lee, Seung-Gul Kang, Jung-Eun Choi, Young-Min Park, Se-Won Lim, Min Kyu Rhee, Seung-Hyun Kim, Leen Ki. No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia. Psychiatry investigation. vol 6. issue 2. 2011-07-14. PMID:20046383. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine biosynthesis. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yangha Kim, Eun-Ha Choi, Miae Doo, Joo-Yeon Kim, Chul-Jin Kim, Chong-Tai Kim, In-Hwan Ki. Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells. Nutrition research and practice. vol 4. issue 4. 2011-07-14. PMID:20827341. |
anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) gene expression in immobilization-stressed rats and pc12 cells. |
2011-07-14 |
2023-08-12 |
rat |
| Yangha Kim, Eun-Ha Choi, Miae Doo, Joo-Yeon Kim, Chul-Jin Kim, Chong-Tai Kim, In-Hwan Ki. Anti-stress effects of ginseng via down-regulation of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) gene expression in immobilization-stressed rats and PC12 cells. Nutrition research and practice. vol 4. issue 4. 2011-07-14. PMID:20827341. |
it is well established that long-term stress leads to the induction of catecholamine biosynthetic enzymes such as tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) in adrenal medulla. |
2011-07-14 |
2023-08-12 |
rat |
| Jean-Luc Dreye. New insights into the roles of microRNAs in drug addiction and neuroplasticity. Genome medicine. vol 2. issue 12. 2011-07-14. PMID:21205279. |
recent studies have identified changes of several specific mirna expression profiles and polymorphisms affecting the interactions between mirnas and their targets in various brain disorders, including addiction: mir-16 causes adaptive changes in production of the serotonin transporter; mir-133b is specifically expressed in midbrain dopaminergic neurons, and regulates the production of tyrosine hydroxylase and the dopamine transporter; mir-212 affects production of striatal brain-derived neurotrophic factor and synaptic plasticity upon cocaine. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jasmin Delic, Herbert Zimmerman. Nucleotides affect neurogenesis and dopaminergic differentiation of mouse fetal midbrain-derived neural precursor cells. Purinergic signalling. vol 6. issue 4. 2011-07-14. PMID:21437012. |
these neurons express tyrosine hydroxylase and the dopamine transporter. |
2011-07-14 |
2023-08-12 |
mouse |