| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yu Luo, Yun Wang, Serena Y Kuang, Yung-Hsiao Chiang, Barry Hoffe. Decreased level of Nurr1 in heterozygous young adult mice leads to exacerbated acute and long-term toxicity after repeated methamphetamine exposure. PloS one. vol 5. issue 12. 2011-07-05. PMID:21151937. |
compared to naïve mice that received meth binge treatment for the first time, mice pretreated with meth in adolescence showed a greater loss of tyrosine hydroxylase (th) immunoreactivity in striatum, loss of thir fibers in the substantia nigra reticulata (snr) as well as decreased dopamine transporter (dat) level and compromised da clearance in striatum. |
2011-07-05 |
2023-08-12 |
mouse |
| H A Boger, P Mannangatti, D J Samuvel, A J Saylor, T S Bender, J F McGinty, A M Fortress, V Zaman, P Huang, L D Middaugh, P K Randall, L D Jayanthi, B Rohrer, K L Helke, A-C Granholm, S Ramamoorth. Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes, brain, and behavior. vol 10. issue 2. 2011-06-15. PMID:20860702. |
dopamine neurotransmitter markers indicated no genotypic difference in striatal tyrosine hydroxylase, da transporter (dat) or vesicular monoamine transporter 2 (vmat2) immunoreactivity at any age. |
2011-06-15 |
2023-08-12 |
mouse |
| T Kato, Y Abe, H Sotoyama, A Kakita, R Kominami, S Hirokawa, M Ozaki, H Takahashi, H Naw. Transient exposure of neonatal mice to neuregulin-1 results in hyperdopaminergic states in adulthood: implication in neurodevelopmental hypothesis for schizophrenia. Molecular psychiatry. vol 16. issue 3. 2011-06-03. PMID:20142818. |
peripheral nrg1 administration activated midbrain erbb4 and elevated the expression, phosphorylation and enzyme activity of tyrosine hydroxylase (th), which ultimately increased dopamine levels. |
2011-06-03 |
2023-08-12 |
mouse |
| B A Sorg, G Stark, A Sergeeva, H T Janse. Photoperiodic suppression of drug reinstatement. Neuroscience. vol 176. 2011-06-01. PMID:21185915. |
in an additional experiment, we examined the photoperiodic regulation of tyrosine hydroxylase (th) and dopamine transporter (dat) proteins in drug-naive rats. |
2011-06-01 |
2023-08-12 |
rat |
| Kiren Ubhi, Edward Rockenstein, Michael Mante, Chandra Inglis, Anthony Adame, Christina Patrick, Eliezer Maslia. Alpha-synuclein deficient mice are resistant to toxin-induced multiple system atrophy. Neuroreport. vol 21. issue 6. 2011-05-31. PMID:20224454. |
the alphasynko mice are resistant to 3np-induced motor deficits and display attenuated loss of tyrosine hydroxylase and dopamine transporter striatal immunoreactivity. |
2011-05-31 |
2023-08-12 |
mouse |
| Naveen Kumar Singhal, Garima Srivastava, Devendra Kumar Patel, Swatantra Kumar Jain, Mahendra Pratap Sing. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse. Journal of pineal research. vol 50. issue 2. 2011-05-26. PMID:20964710. |
locomotor activities along with striatal dopamine content, tyrosine hydroxylase (th) immunoreactivity, number of degenerating neurons, lipid peroxidation and nitrite content were estimated. |
2011-05-26 |
2023-08-12 |
mouse |
| E L Dovedova, D N Voronkov, R M Khudoerko. Effects of short-term exposure to haloperidol and reserpine on dopamine turnover in nigrostriatal system in rat brain. Bulletin of experimental biology and medicine. vol 150. issue 2. 2011-05-20. PMID:21240369. |
spectrophotometric methods were employed to determine activity of dopamine metabolism enzymes, tyrosine hydroxylase and monoamine oxidase b, in nigrostriatal structures of the brain in wistar rats after short-term (60 min) haloperidol or reserpine treatment. |
2011-05-20 |
2023-08-12 |
rat |
| Masaya Segaw. Hereditary progressive dystonia with marked diurnal fluctuation. Brain & development. vol 33. issue 3. 2011-05-19. PMID:21094587. |
because of heterozygous mutation, partial deficiency of tetrahydrobiopterin affects tyrosine hydroxylase (th) rather selectively and causes decrease of th in the terminals of the nigrostriatal dopamine (ns da) neurons, projecting to the d1 receptors on the striosome, the striatal direct pathways and the subthalamic nucleus (stn) and the d4 receptors of the tuberoinfundibular tract. |
2011-05-19 |
2023-08-12 |
Not clear |
| P Panula, Y-C Chen, M Priyadarshini, H Kudo, S Semenova, M Sundvik, V Salline. The comparative neuroanatomy and neurochemistry of zebrafish CNS systems of relevance to human neuropsychiatric diseases. Neurobiology of disease. vol 40. issue 1. 2011-05-16. PMID:20472064. |
zebrafish are sensitive to neurotoxins including mptp, and exposure to this neurotoxin induces a decline in dopamine content and number of detectable tyrosine hydroxylase immunoreactive neurons in distinct nuclei. |
2011-05-16 |
2023-08-12 |
human |
| S Colette Daubner, Tiffany Le, Shanzhi Wan. Tyrosine hydroxylase and regulation of dopamine synthesis. Archives of biochemistry and biophysics. vol 508. issue 1. 2011-05-11. PMID:21176768. |
tyrosine hydroxylase and regulation of dopamine synthesis. |
2011-05-11 |
2023-08-12 |
Not clear |
| Lauren Broom, Lilia Marinova-Mutafchieva, Mona Sadeghian, John B Davis, Andrew D Medhurst, David T Dexte. Neuroprotection by the selective iNOS inhibitor GW274150 in a model of Parkinson disease. Free radical biology & medicine. vol 50. issue 5. 2011-05-06. PMID:21185368. |
administration of the inos inhibitor twice daily for 7 days, beginning 2 days after the 6-ohda lesioning, led to a significant neuroprotection as shown by assessment of the integrity of the nigrostriatal system by tyrosine hydroxylase immunocytochemistry and hplc assessment of striatal dopamine content. |
2011-05-06 |
2023-08-12 |
Not clear |
| Melanie Bousquet, Karl Gue, Vincent Emond, Pierre Julien, Jing X Kang, Francesca Cicchetti, Frederic Calo. Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. Journal of lipid research. vol 52. issue 2. 2011-05-05. PMID:21115966. |
such a limited endogenous production of n-3 pufas in the fat-1 mouse was insufficient to confer neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity as assessed by dopamine levels, tyrosine hydroxylase (th)-positive neurons and fibers, as well as nigral nurr1 and dopamine transporter (dat) mrna expression. |
2011-05-05 |
2023-08-12 |
mouse |
| Pamela J McMillan, Sylvia S White, Allyn Franklin, J Lynne Greenup, James B Leverenz, Murray A Raskind, Patricia Szo. Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease. Brain research. vol 1373. 2011-05-03. PMID:21147074. |
tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) mrna expression in postmortem lc tissue of control and age-matched pd subjects demonstrated a significant reduction in the number of noradrenergic neurons in the lc of pd subjects. |
2011-05-03 |
2023-08-12 |
human |
| James A Miller, Briana R Trout, Kelly A Sullivan, Russell A Bialecki, Ruth A Roberts, Ronald B Tjalken. Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons. Journal of neuroscience research. vol 89. issue 3. 2011-05-03. PMID:21259327. |
in contrast, expression of tyrosine hydroxylase in striatal fibers was reduced at 60 mg/kg mptp, as were levels of dopamine and dopac. |
2011-05-03 |
2023-08-12 |
mouse |
| Lauren A O'Connell, Bryan J Matthews, Michael J Ryan, Hans A Hofman. Characterization of the dopamine system in the brain of the túngara frog, Physalaemus pustulosus. Brain, behavior and evolution. vol 76. issue 3-4. 2011-05-02. PMID:21099197. |
in order to better understand where dopamine acts to regulate social decisions in this species, we have determined the distribution of putative dopaminergic cells (using tyrosine hydroxylase immunohistochemistry) and cells receptive to dopaminergic signaling (using darpp-32 immunohistochemistry) throughout the brain of p. pustulosus. |
2011-05-02 |
2023-08-12 |
Not clear |
| Erika Allen, Kirsten M Carlson, Michael J Zigmond, Jane E Cavanaug. L-DOPA reverses motor deficits associated with normal aging in mice. Neuroscience letters. vol 489. issue 1. 2011-05-02. PMID:21111775. |
following testing, striatal tissue was analyzed for phenotypic markers of dopamine neurons: dopamine, dopamine transporter, and tyrosine hydroxylase. |
2011-05-02 |
2023-08-12 |
mouse |
| Rehana K Leak, Sandra L Castro, Juliann D Jaumotte, Amanda D Smith, Michael J Zigmon. Assaying multiple biochemical variables from the same tissue sample. Journal of neuroscience methods. vol 191. issue 2. 2011-04-26. PMID:20600314. |
dopamine and its metabolite homovanillic acid, serotonin and its metabolite 5-hydroxyindoleacetic acid, tyrosine hydroxylase and its phosphorylation at ser19 and ser31, and the dopamine transporter were unaffected. |
2011-04-26 |
2023-08-12 |
rat |
| Samuel S Shin, Eric R Bray, Cathy Q Zhang, C Edward Dixo. Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats. Brain research. vol 1369. 2011-04-21. PMID:21047500. |
traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats. |
2011-04-21 |
2023-08-12 |
rat |
| Mona Boules, Alfredo Oliveros, Yanqi Liang, Katrina Williams, Amanda Shaw, Jessica Robinson, Paul Fredrickson, Elliott Richelso. A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats. Neuropeptides. vol 45. issue 1. 2011-04-18. PMID:21047685. |
nt69l might modulate dopamine neurotransmission implicated in the reinforcing effects of nicotine by modulating tyrosine hydroxylase and dopamine receptor mrna levels in the pfc and striatum. |
2011-04-18 |
2023-08-12 |
rat |
| Kei Yamamoto, Jori O Ruuskanen, Mario F Wullimann, Philippe Vernie. Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. The Journal of comparative neurology. vol 519. issue 3. 2011-04-11. PMID:21192085. |
although the simultaneous presence of tyrosine hydroxylase (th), aromatic amino acid decarboxylase (aadc), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) is considered as a phenotypic signature of dopamine (da) neurons, it has been suggested that they are not uniformly expressed in all dopaminergic brain nuclei. |
2011-04-11 |
2023-08-12 |
zebrafish |