| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rui Cui, Guoliang Zhang, Yunxiao Kang, Qinglong Cheng, Huibing Tan, Huixian Cui, Geming Sh. Amelioratory effects of testosterone propionate supplement on behavioral, biochemical and morphological parameters in aged rats. Experimental gerontology. vol 47. issue 1. 2012-02-22. PMID:22075531. |
thus, in the present study, the open field motor behavior and adhesive tape removal motor performance as well as the expression of tyrosine hydroxylase (th) and dopamine transporter (dat) of nsda system were examined in aged male rats following chronic subcutaneous injections of testosterone propionate (tp). |
2012-02-22 |
2023-08-12 |
rat |
| Kazuyoshi Kitaoka, Mika Shimizu, Noriyuki Shimizu, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazuo Yoshizaki, Hiroyoshi Sé. Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice. Brain research. vol 1423. 2012-02-17. PMID:22000589. |
western blot analysis revealed a significant decrease in the expression of dopamine d1 receptor (d1dr) in the striatum and tyrosine hydroxylase in the midbrain of mice that were administered le540 for 4weeks. |
2012-02-17 |
2023-08-12 |
mouse |
| Masao Masuda, Masami Miura, Ritsuko Inoue, Michiko Imanishi, Sachiko Saino-Saito, Masahiko Takada, Kazuto Kobayashi, Toshihiko Aosak. Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum. The European journal of neuroscience. vol 34. issue 9. 2012-02-17. PMID:22004548. |
the striatum harbors a small number of tyrosine hydroxylase (th) mrna-containing gabaergic neurons that express th immunoreactivity after dopamine depletion, some of which reportedly resembled striatal medium spiny projection neurons (msns). |
2012-02-17 |
2023-08-12 |
mouse |
| Hidekazu Sotoyama, Yingjun Zheng, Yuriko Iwakura, Makoto Mizuno, Miho Aizawa, Ksenia Shcherbakova, Ran Wang, Hisaaki Namba, Hiroyuki Naw. Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF. PloS one. vol 6. issue 10. 2012-02-17. PMID:22022452. |
here we found that the egf-treated rats exhibited persistent increases in tyrosine hydroxylase levels and dopamine content in the globus pallidus. |
2012-02-17 |
2023-08-12 |
rat |
| Hidekazu Sotoyama, Hiroyuki Naw. [Vulnerability of dopamine circuit development to cytokines from the periphery: implication in schizophrenia]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 5-6. 2012-02-16. PMID:22256609. |
in this review, we introduce neurochemical features of the egf-treated rats and nrg-treated mice, which exhibit persistent increases in tyrosine hydroxylase levels and dopamine release in the globus pallidus and prelimbic cortex (medial prefrontal cortex), respectively. |
2012-02-16 |
2023-08-12 |
mouse |
| Hong Kim, Hong-Im Heo, Dong-Hyun Kim, Il-Gyu Ko, Su-Shin Lee, Sung-Eun Kim, Bo-Kyun Kim, Tae-Woon Kim, Eun-Sang Ji, Jae-Deung Kim, Mal-Soon Shin, Young-Woong Choi, Chang-Ju Ki. Treadmill exercise and methylphenidate ameliorate symptoms of attention deficit/hyperactivity disorder through enhancing dopamine synthesis and brain-derived neurotrophic factor expression in spontaneous hypertensive rats. Neuroscience letters. vol 504. issue 1. 2012-02-14. PMID:21907264. |
immunohistochemistry and western blotting were conducted to examine the levels of tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of dopamine, and bdnf. |
2012-02-14 |
2023-08-12 |
rat |
| Elisabeth Brooks, Elizabeth Waters, Lydia Farrington, Maria Merce Cana. Differential hypothalamic tyrosine hydroxylase distribution and activation by light in adult mice reared under different light conditions during the suckling period. Brain structure & function. vol 216. issue 4. 2012-02-10. PMID:21509614. |
dopamine is thought to be involved in the modulation of photic input within the scn and in tadpoles, the expression of tyrosine hydroxylase (th), a rate-limiting enzyme in the synthesis of dopamine, in the scn is altered by previous light history. |
2012-02-10 |
2023-08-12 |
mouse |
| Naila Rasheed, Ausaf Ahmad, Muneera Al-Sheeha, Abdullah Alghasham, Gautam Pali. Neuroprotective and anti-stress effect of A68930 in acute and chronic unpredictable stress model in rats. Neuroscience letters. vol 504. issue 2. 2012-02-07. PMID:21945949. |
acute (as) and chronic unpredictable (cus) stress models were used to evaluate the effect of a68930 on hpa-axis regulation in relation to the change in the fiber density and number of immunoreactive (ir) neurons of tyrosine hydroxylase (th) and glucocorticoid receptor (gr) in the dopamine (da) and gr rich brain regions in rats. |
2012-02-07 |
2023-08-12 |
rat |
| Emese Prandovszky, Elizabeth Gaskell, Heather Martin, J P Dubey, Joanne P Webster, Glenn A McConke. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PloS one. vol 6. issue 9. 2012-02-03. PMID:21957440. |
the mechanism(s) responsible for behavioral changes in the host is unknown but two lines of published evidence suggest that the parasite alters neurotransmitter signal transduction: the disruption of the parasite-induced behavioral changes with medications used to treat psychiatric disease (specifically dopamine antagonists) and identification of a tyrosine hydroxylase encoded in the parasite genome. |
2012-02-03 |
2023-08-12 |
mouse |
| Emese Prandovszky, Elizabeth Gaskell, Heather Martin, J P Dubey, Joanne P Webster, Glenn A McConke. The neurotropic parasite Toxoplasma gondii increases dopamine metabolism. PloS one. vol 6. issue 9. 2012-02-03. PMID:21957440. |
tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis, was also found in intracellular tissue cysts in brain tissue with antibodies specific for the parasite-encoded tyrosine hydroxylase. |
2012-02-03 |
2023-08-12 |
mouse |
| Sergiu P Paşca, Thomas Portmann, Irina Voineagu, Masayuki Yazawa, Aleksandr Shcheglovitov, Anca M Paşca, Branden Cord, Theo D Palmer, Sachiko Chikahisa, Seiji Nishino, Jonathan A Bernstein, Joachim Hallmayer, Daniel H Geschwind, Ricardo E Dolmetsc. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nature medicine. vol 17. issue 12. 2012-02-02. PMID:22120178. |
in addition, neurons derived from individuals with timothy syndrome show abnormal expression of tyrosine hydroxylase and increased production of norepinephrine and dopamine. |
2012-02-02 |
2023-08-12 |
human |
| Katharina M Iwaniuk, Jessica Schira, Sandra Weinhold, Marc Jung, James Adjaye, Hans Werner Müller, Peter Wernet, Hans-Ingo Trompete. Network-like impact of MicroRNAs on neuronal lineage differentiation of unrestricted somatic stem cells from human cord blood. Stem cells and development. vol 20. issue 8. 2012-01-27. PMID:21067317. |
they show differentiation into neuronal cells of a dopaminergic phenotype, which express neuronal markers such as synaptophysin, neuronal-specific nuclear protein, and neurofilament and release the neurotransmitter dopamine accompanied by expression of dopaminergic key factors tyrosine hydroxylase and nurr1 (nr4a2). |
2012-01-27 |
2023-08-12 |
human |
| Zhe Wang, Faiza Ferdousy, Hakeem Lawal, Zhinong Huang, J Gavin Daigle, Iyare Izevbaye, Olugbenga Doherty, Jerrad Thomas, Dean G Stathakis, Janis M O'Donnel. Catecholamines up integrates dopamine synthesis and synaptic trafficking. Journal of neurochemistry. vol 119. issue 6. 2012-01-26. PMID:21985068. |
we now report a novel association of the membrane protein, catsup, with gtp cyclohydrolase rate-limiting enzyme for tetrahydrobiopterin (bh(4)) biosynthesis and tyrosine hydroxylase, rate-limiting enzyme for dopamine biosynthesis, which requires bh(4) as a cofactor. |
2012-01-26 |
2023-08-12 |
drosophila_melanogaster |
| Michail Pavlidis, Maria Sundvik, Yu-Chia Chen, Pertti Panul. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behavioural brain research. vol 225. issue 2. 2012-01-24. PMID:21875623. |
expression of genes encoding proteins involved in the functioning of the hypothalamus-hypophysis-interrenal axis (corticotropin releasing factor, crf; glucocorticoid receptor, gr; mineralocorticoid receptor, mr); arginine vasotocin, avt), in the biosynthesis and catabolism of catecholamines (tyrosine hydroxylase, th1 and th2; dopa decarboxylase, ddc), dopamine β-hydroxylase, dbh; catechol-o-methyl transferase, comt), in the biosynthesis of histamine (histidine decarboxylase, hdc) and in the general stress response (galanin, gal; hypocretin/orexin, hcrt) was examined. |
2012-01-24 |
2023-08-12 |
zebrafish |
| Lisa L Matragrano, Sara E Sanford, Katrina G Salvante, Keith W Sockman, Donna L Mane. Estradiol-dependent catecholaminergic innervation of auditory areas in a seasonally breeding songbird. The European journal of neuroscience. vol 34. issue 3. 2012-01-23. PMID:21714815. |
in one hemisphere of the brain, we used immunohistochemistry to quantify fibers immunoreactive for tyrosine hydroxylase or dopamine beta-hydroxylase in the auditory forebrain, thalamus and midbrain. |
2012-01-23 |
2023-08-12 |
Not clear |
| Jen-Lin Yang, Jay S C Chen, Yi-Fei Yang, Jyh-Cheng Chen, Ching-Huang Lin, Rong-Seng Chang, Po-Jui Tsao, Fang-Pey Chen, Chang-Ming Chern, Tung-Hu Tsai, Jen-Hwey Chi. Neuroprotection effects of retained acupuncture in neurotoxin-induced Parkinson's disease mice. Brain, behavior, and immunity. vol 25. issue 7. 2012-01-16. PMID:21669281. |
the animals were sacrificed and their brains assayed for dopamine and its metabolites and tyrosine hydroxylase (th) expression by using hplc and immunohistochemistry/western blotting, respectively. |
2012-01-16 |
2023-08-12 |
mouse |
| Jinwoo Park, Pavel Takmakov, R Mark Wightma. In vivo comparison of norepinephrine and dopamine release in rat brain by simultaneous measurements with fast-scan cyclic voltammetry. Journal of neurochemistry. vol 119. issue 5. 2012-01-09. PMID:21933188. |
α-methyl-p-tyrosine, a tyrosine hydroxylase inhibitor, decreased electrically evoked dopamine release faster than norepinephrine. |
2012-01-09 |
2023-08-12 |
rat |
| Gurdeep Marwarha, Turk Rhen, Trevor Schommer, Othman Ghrib. The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease. Journal of neurochemistry. vol 119. issue 5. 2012-01-09. PMID:21951066. |
we showed that the oxysterol 27-hydroxycholesterol (27-ohc) reduces the expression of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, and increases α-synuclein levels in sh-sy5y cells. |
2012-01-09 |
2023-08-12 |
human |
| Anand Kumar Singh, Manindra Nath Tiwari, Anubhuti Dixit, Ghanshyam Upadhyay, Devendra Kumar Patel, Dhirendra Singh, Om Prakash, Mahendra Pratap Sing. Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. Toxicological sciences : an official journal of the Society of Toxicology. vol 122. issue 2. 2011-12-19. PMID:21561882. |
microglial activation, tyrosine hydroxylase immunoreactivity (th-ir), dopamine content, and neurobehavioral changes were measured according to the standard procedures. |
2011-12-19 |
2023-08-12 |
Not clear |
| Stéphanie Vuillermot, Joram Feldon, Urs Meye. Relationship between sensorimotor gating deficits and dopaminergic neuroanatomy in Nurr1-deficient mice. Experimental neurology. vol 232. issue 1. 2011-12-07. PMID:21820432. |
we found that prepulse inhibition deficits in nurr1-deficient mice were paralleled by reduced numbers of substantia nigra dopamine cells expressing tyrosine hydroxylase, and by decreased tyrosine hydroxylase and dopamine transporter immunoreactivity in ventral parts of the striatum. |
2011-12-07 |
2023-08-12 |
mouse |