| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Hagihara, K Fujishiro, A Takahashi, M Naoi, T Nagats. Cyclosporin A, an immune suppressor, enhanced neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice. Neurochemistry international. vol 15. issue 2. 2012-10-02. PMID:20504491. |
on the other hand, cyclosporin a itself did not effect tyrosine hydroxylase activity and dopamine and biopterin contents in the striatum and hypothalamus. |
2012-10-02 |
2023-08-12 |
mouse |
| C Pifl, O Bertel, G Schingnitz, O Hornykiewic. Extrastriatal dopamine in symptomatic and asymptomatic rhesus monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neurochemistry international. vol 17. issue 2. 2012-10-02. PMID:20504626. |
we analyzed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated rhesus monkeys, with and without parkinsonian symptoms, the regional changes in dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva) and tyrosine hydroxylase activity (th). |
2012-10-02 |
2023-08-12 |
monkey |
| M L Vizuete, M Santiago, A J Herrera, A Machado, J Can. Neonatal enucleation alters catecholamine and serotonin metabolism in the lateral geniculate and visual cortex in developing rats. Neurochemistry international. vol 17. issue 3. 2012-10-02. PMID:20504641. |
levels of dopamine, noradrenaline and serotonin and of their metabolites along with tryptophan hydroxylase, tyrosine hydroxylase and monoamine oxidase a and b activities have been determined in lateral geniculate (lg) and visual cortex (vc) after enucleation during postnatal development. |
2012-10-02 |
2023-08-12 |
rat |
| J L Voogt, M J Soares, M C Robertson, L A Arbogas. Rat placental lactogen-I abolishes nocturnal prolactin surges in the pregnant rat. Endocrine. vol 4. issue 3. 2012-10-02. PMID:21153279. |
since lactogenic hormones may inhibit prl by stimulation of dopamine synthesis and release into the hypophysial portal blood vessels leading to the anterior pituitary, the effect of these hormones on tyrosine hydroxylase (th), the rate-limiting enzyme for the synthesis of dopamine activity, was determined. |
2012-10-02 |
2023-08-12 |
human |
| H Ichinose, T Ohye, T Suzuki, H Inagaki, T Nagats. Quantification of tyrosine hydroxylase mRNA. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318774. |
the main biochemical characteristic of parkinson's disease (pd) is reduction of the neurotransmitter dopamine and the dopamine-synthesizing enzyme system, including tyrosine hydroxylase (th, tyrosine 3-monooxygenase, ec 1.14.16.2) and tetrahydrobiopterin (bh(4) co-factor, in nigrostriatal neurons (1). |
2012-10-02 |
2023-08-12 |
Not clear |
| G W Miller, A I Leve. Immunochemical analysis of dopamine transporters in Parkinson's disease. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318775. |
antibodies to dopamine or tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, have been used to identify these neurons. |
2012-10-02 |
2023-08-12 |
human |
| A Detta, P Grabham, E Hitchcoc. Phenotypic plasticity of 'mature' human fœtal mesencephalic dopaminergic neurons and glial cells. Restorative neurology and neuroscience. vol 4. issue 1. 2012-10-02. PMID:21551652. |
immunocytochemical staining for dopamine, tyrosine hydroxylase, neuron-specific enolase and glial fibrillary acid protein, demonstrated that dopaminergic, non-dopaminergic and glial elements responded similarly. |
2012-10-02 |
2023-08-12 |
human |
| M Jakubowski, J L Robert. Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic Acid transcripts from snap-frozen neuroendocrine tissues of individual animals. Journal of neuroendocrinology. vol 4. issue 1. 2012-10-02. PMID:21554581. |
progonadotropin-releasing hormone, proopiomelanocortin, tyrosine hydroxylase, dopamine d2 receptor, prolactin), thus increasing the amount of information obtained from each sample in one assay. |
2012-10-02 |
2023-08-12 |
rat |
| Emma Perez-Costas, Miguel Melendez-Ferro, Matthew W Rice, Robert R Conley, Rosalinda C Robert. Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22509170. |
dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra. |
2012-10-02 |
2023-08-12 |
Not clear |
| Emma Perez-Costas, Miguel Melendez-Ferro, Matthew W Rice, Robert R Conley, Rosalinda C Robert. Dopamine pathology in schizophrenia: analysis of total and phosphorylated tyrosine hydroxylase in the substantia nigra. Frontiers in psychiatry. vol 3. 2012-10-02. PMID:22509170. |
tyrosine hydroxylase (th) is the rate-limiting enzyme for the production of dopamine, and a possible contributor to the anomalies in the dopaminergic neurotransmission observed in schizophrenia. |
2012-10-02 |
2023-08-12 |
Not clear |
| Sebastián Hormigo, José de Anchieta de Castro E Horta Júnior, Ricardo Gómez-Nieto, Dolores E Lópe. The selective neurotoxin DSP-4 impairs the noradrenergic projections from the locus coeruleus to the inferior colliculus in rats. Frontiers in neural circuits. vol 6. 2012-10-02. PMID:22754504. |
the neurochemical nature of this projection is noradrenergic, given that tyrosine hydroxylase (th) and dopamine beta hydroxylase (dbh) colocalize with the bda-labeled fibers from the lc. |
2012-10-02 |
2023-08-12 |
rat |
| Eun-Joo Shin, Chu Xuan Duong, Xuan-Khanh Thi Nguyen, Zhengyi Li, Guoying Bing, Jae-Hyung Bach, Dae Hun Park, Keiichi Nakayama, Syed F Ali, Anumantha G Kanthasamy, Jean Lud Cadet, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22512859. |
furthermore, ma-induced increases in the dopamine (da) turnover rate and decreases in tyrosine hydroxylase (th) activity and the expression of th, dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) were not significantly observed in rottlerin-treated or pkcδ (-/-) mice. |
2012-09-27 |
2023-08-12 |
mouse |
| Kelly A Meulendyke, Mikhail V Pletnikov, Elizabeth L Engle, Patrick M Tarwater, David R Graham, M Christine Zin. Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 2. 2012-09-24. PMID:22198699. |
da decline was not due to direct loss of dopaminergic projections to the basal ganglia as there was no difference in tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter 2 or synaptophysin between minocycline-treated and untreated macaques. |
2012-09-24 |
2023-08-12 |
Not clear |
| Auxiliadora Aracil-Fernández, José M Trigo, María S García-Gutiérrez, Antonio Ortega-Álvaro, Alexander Ternianov, Daniela Navarro, Patricia Robledo, Pere Berbel, Rafael Maldonado, Jorge Manzanare. Decreased cocaine motor sensitization and self-administration in mice overexpressing cannabinoid CB₂ receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22414816. |
dopamine (da) extracellular levels in the nucleus accumbens (nacc), and gene expression of tyrosine hydroxylase (th) and da transporter (dat) in the ventral tegmental area (vta), and μ-opioid and cannabinoid cb₁ receptors in the nacc were also studied in both genotypes. |
2012-09-21 |
2023-08-12 |
mouse |
| Olga Baron, Benjamin Förthmann, Yu-Wei Lee, Christopher Terranova, Andreas Ratzka, Ewa K Stachowiak, Claudia Grothe, Peter Claus, Michal K Stachowia. Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons. The Journal of biological chemistry. vol 287. issue 24. 2012-09-21. PMID:22514272. |
both nurr1 and infs activate expression of neuronal genes, such as tyrosine hydroxylase (th), which is the rate-limiting enzyme in dopamine synthesis. |
2012-09-21 |
2023-08-12 |
mouse |
| Chad R Jackson, Guo-Xiang Ruan, Fazila Aseem, Jane Abey, Karen Gamble, Greg Stanwood, Richard D Palmiter, P Michael Iuvone, Douglas G McMaho. Retinal dopamine mediates multiple dimensions of light-adapted vision. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 27. 2012-09-18. PMID:22764243. |
here, we developed a mouse model on a c57 background in which expression of the rate-limiting enzyme for dopamine synthesis, tyrosine hydroxylase, is specifically disrupted in the retina. |
2012-09-18 |
2023-08-12 |
mouse |
| Miho Murat. [Discovery of an antiparkinsonian drug: zonisamide]. Rinsho shinkeigaku = Clinical neurology. vol 50. issue 11. 2012-09-17. PMID:21921440. |
zns increases dopamine contents in the striatum by activating dopamine synthesis through increasing the levels of tyrosine hydroxylase (th) mrna and th protein. |
2012-09-17 |
2023-08-12 |
Not clear |
| Sang Won Park, Zhi He, Xine Shen, Richard J Roman, Tangeng M. Differential action of methamphetamine on tyrosine hydroxylase and dopamine transport in the nigrostriatal pathway of μ-opioid receptor knockout mice. The International journal of neuroscience. vol 122. issue 6. 2012-09-13. PMID:22329540. |
differential action of methamphetamine on tyrosine hydroxylase and dopamine transport in the nigrostriatal pathway of μ-opioid receptor knockout mice. |
2012-09-13 |
2023-08-12 |
mouse |
| Sang Won Park, Zhi He, Xine Shen, Richard J Roman, Tangeng M. Differential action of methamphetamine on tyrosine hydroxylase and dopamine transport in the nigrostriatal pathway of μ-opioid receptor knockout mice. The International journal of neuroscience. vol 122. issue 6. 2012-09-13. PMID:22329540. |
the present study assessed whether meth-treated μ-or knockout mice exhibit a differential response of the expression of dopamine transporter and tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine synthesis and maintaining dopamine levels. |
2012-09-13 |
2023-08-12 |
mouse |
| Annadurai Anandhan, Kuppusamy Tamilselvam, Thangaiyan Radhiga, Shalinee Rao, Musthafa Mohamed Essa, Thamilarasan Manivasaga. Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease. Brain research. vol 1433. 2012-09-12. PMID:22138428. |
we found that the theaflavin attenuates mptp/p induced apoptosis and neurodegeneration as evidenced by increased expression of nigral tyrosine hydroxylase (th), dopamine transporter (dat) and reduced apoptotic markers such as caspase-3, 8, 9 accompanied by normalized behavioral characterization. |
2012-09-12 |
2023-08-12 |
mouse |