| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jean LeBeau Abel, Emilie F Rissma. Location, location, location: genetic regulation of neural sex differences. Reviews in endocrine & metabolic disorders. vol 13. issue 3. 2012-12-17. PMID:21607612. |
here we focus on three proteins that have well described sexual dimorphisms; calbindin-d28k, a calcium binding protein, tyrosine hydroxylase, the rate limiting enzyme involved in dopamine synthesis and vasopressin, a neuropeptide with central and peripheral sites of action. |
2012-12-17 |
2023-08-12 |
mouse |
| Marcelo M S Lima, Emerson F Martins, Ana Marci Delattre, Mariana B Proenca, Marco A Mori, Bruno Carabelli, Anete C Ferra. Motor and non-motor features of Parkinson's disease - a review of clinical and experimental studies. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483309. |
remarkably, this region consists of approximately 95% of the tyrosine hydroxylase (th)-immunoreactive neurons in both human and rat brains, and consequently this implicates elevated levels of dopamine metabolites, free radicals and other hazard species in these neurons. |
2012-12-03 |
2023-08-12 |
human |
| Marcella Reale, Mirko Pesce, Medha Priyadarshini, Mohammad A Kamal, Antonia Patrun. Mitochondria as an easy target to oxidative stress events in Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483310. |
tyrosine hydroxylase (th) is an important neuronal enzyme that, in the presence of tetrahydrobiopterin, catalyzes the initial and rate-limiting step in the biosynthesis of the catecholamine neurotransmitters dopamine (da) and norepinephrine, and is frequently used as a marker of daergic neuronal loss in animal models of pd. |
2012-12-03 |
2023-08-12 |
Not clear |
| Christopher Tolleson, Daniel Claasse. The function of tyrosine hydroxylase in the normal and Parkinsonian brain. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483314. |
tyrosine hydroxylase (th) is the rate limiting step in the biosynthesis of dopamine and other catecholamines. |
2012-12-03 |
2023-08-12 |
human |
| Robert B White, Meghan G Thoma. Moving beyond tyrosine hydroxylase to define dopaminergic neurons for use in cell replacement therapies for Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22483315. |
the gold standard marker in the identification of dopaminergic neurons is tyrosine hydroxylase (th), the rate limiting enzyme in dopamine synthesis, catalyzing the conversion of l-tyrosine to l-3,4-dihydroxyphenylalanine. |
2012-12-03 |
2023-08-12 |
Not clear |
| Annaik Petithomme Fev. Current status of tyrosine hydroxylase in management of Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22583428. |
tyrosine hydroxylase (th) is the rate limiting enzyme responsible for converting tyrosine to l-dopa in the dopamine synthesis pathway. |
2012-12-03 |
2023-08-12 |
Not clear |
| Wajihullah Khan, Medha Priyadarshini, Haytham A Zakai, Mohammad A Kamal, Qamre Ala. A brief overview of tyrosine hydroxylase and α-synuclein in the Parkinsonian brain. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22583430. |
parkinson's disease (pd) is associated with neurodegeneration of the nigrostriatal tract and is accompanied with loss of tyrosine hydroxylase (th) and dopamine (da). |
2012-12-03 |
2023-08-12 |
Not clear |
| Guney Bademci, Jeffery M Vance, Liyong Wan. Tyrosine hydroxylase gene: another piece of the genetic puzzle of Parkinson's disease. CNS & neurological disorders drug targets. vol 11. issue 4. 2012-12-03. PMID:22583432. |
the tyrosine hydroxylase (th) gene encodes a monoxygenase that catalyzes the rate limiting step in dopamine biosynthesis. |
2012-12-03 |
2023-08-12 |
Not clear |
| I V Romanova, A Iu Chesnokova, A L Mikhrin. [Immunohistochemical study of CART-peptide in striato-nigral projections at dopamine loss]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 98. issue 8. 2012-11-30. PMID:23155622. |
at the same time after in vitro incubation of nigro-accumbal brain slice with ampt (alpha-methyl-paratirosine--dopamine inhibitor) for 4 h the reduction of tyrosine hydroxylase optical density (the enzyme limiting dopamine synthesis) in substantia nigr neurons was found and optical density of cart-peptide in nucleus accumbens and substantia nigra was also revealed. |
2012-11-30 |
2023-08-12 |
rat |
| Mickael Decressac, Stéphanie Pain, Pierre-Yves Chabeauti, Laura Frangeul, Nathalie Thiriet, Herbert Herzog, Jackie Vergote, Sylvie Chalon, Mohamed Jaber, Afsaneh Gaillar. Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease. Neurobiology of aging. vol 33. issue 9. 2012-11-29. PMID:21816512. |
in rat and mice models of pd, striatal injection of npy preserved the nigrostriatal dopamine pathway from degeneration as evidenced by quantification of (1) tyrosine hydroxylase (th)-positive cells in the substantia nigra pars compacta, levels of (2) striatal tyrosine hydroxylase and dopamine transporter, (3) dopamine and 3,4-dihydroxyphenylacetic acid (dopac) as well as (4) rotational behavior. |
2012-11-29 |
2023-08-12 |
mouse |
| Ayse Ulusoy, Tomas Björklund, Kerstin Buck, Deniz Kiri. Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons. Neurobiology of disease. vol 47. issue 3. 2012-11-29. PMID:22659302. |
importantly, silencing the tyrosine hydroxylase enzyme - thereby reducing dopamine content in the nigral neurons - reversed the increased vulnerability back to the baseline level observed in wild-type littermates, but failed to eliminate it completely. |
2012-11-29 |
2023-08-12 |
mouse |
| Shuang-Yong Sun, Chun-Na An, Xiao-Ping P. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats. Brain research bulletin. vol 88. issue 6. 2012-11-23. PMID:22664331. |
we found that dj-1 protein could reduce apomorphine-induced rotations, inhibit reduction of dopamine contents and tyrosine hydroxylase levels in the striatum, and decrease dopaminergic neuron death in the substantia nigra. |
2012-11-23 |
2023-08-12 |
rat |
| Colin A Higgins, Lydia M Vermeer, Jonathan A Doorn, David L Roma. Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli. Protein expression and purification. vol 84. issue 2. 2012-11-21. PMID:22659380. |
tyrosine hydroxylase is the rate-limiting step in the synthesis of dopamine and is tightly regulated. |
2012-11-21 |
2023-08-12 |
human |
| Rafique Islam, Lichuan Yang, Megha Sah, Kavitha Kannan, Denise Anamani, Chibi Vijayan, Jenny Kwok, Marie E Cantino, M Flint Beal, Yih-Woei C Fridel. A neuroprotective role of the human uncoupling protein 2 (hUCP2) in a Drosophila Parkinson's disease model. Neurobiology of disease. vol 46. issue 1. 2012-11-20. PMID:22266335. |
here we show that hucp2 expression in drosophila da neurons under the control of the tyrosine hydroxylase (th) promoter protects those flies against the mitochondrial toxin rotenone-induced da neuron death, head dopamine depletion, impaired locomotor activity and energy deficiency. |
2012-11-20 |
2023-08-12 |
human |
| Jian Yang, Xuan Wang, Yue Wang, Zi-Xuan Guo, Ding-Zhen Luo, Jun Jia, Xiao-Min Wan. Dopaminergic neuronal conversion from adult rat skeletal muscle-derived stem cells in vitro. Neurochemical research. vol 37. issue 9. 2012-11-20. PMID:22723079. |
after the differentiation, these cells expressed tyrosine hydroxylase, dopamine transporter, dopamine d1 receptor and synapse-associated protein synapsin i. |
2012-11-20 |
2023-08-12 |
rat |
| Y-C Chen, M Sundvik, S Rozov, M Priyadarshini, P Panul. MANF regulates dopaminergic neuron development in larval zebrafish. Developmental biology. vol 370. issue 2. 2012-11-19. PMID:22898306. |
nevertheless, the dopamine level of manf morphants was lower than that of the wild type larvae, the expression levels of the two tyrosine hydroxylase gene transcripts were decreased and a decrease in neuron number in certain groups of th1 and th2 cells in the diencephalon region in manf morphants was observed. |
2012-11-19 |
2023-08-12 |
zebrafish |
| Keun Hong Park, Hyun Jin Park, Keon Sung Shin, Hyun Sook Choi, Masaaki Kai, Myung Koo Le. Modulation of PC12 cell viability by forskolin-induced cyclic AMP levels through ERK and JNK pathways: an implication for L-DOPA-induced cytotoxicity in nigrostriatal dopamine neurons. Toxicological sciences : an official journal of the Society of Toxicology. vol 128. issue 1. 2012-11-13. PMID:22539619. |
the low levels of forskolin (0.01 and 0.1 μm)-induced camp increased dopamine biosynthesis and tyrosine hydroxylase (th) phosphorylation, and induced transient phosphorylation of erk1/2 within 1 h. however, at the high levels of forskolin (1.0 and 10 μm)-induced camp, dopamine biosynthesis and th phosphorylation did not increase, but rapid differentiation in neurite-like formation was observed with a steady state. |
2012-11-13 |
2023-08-12 |
Not clear |
| E Danielle Dean, Lydia M Mexas, Natalie L Cápiro, Jeanne E McKeon, Mahlon R DeLong, Kurt D Pennell, Jonathan A Doorn, Vin Tangpricha, Gary W Miller, Marian L Evat. 25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice. PloS one. vol 7. issue 7. 2012-11-13. PMID:22768297. |
we found there was no significant difference between control and 25(oh)d-deficient animals in striatal dopamine levels or dopamine transporter and tyrosine hydroxylase expression after lesioning with mptp. |
2012-11-13 |
2023-08-12 |
mouse |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
investigation of the proteins that regulate dopamine, such as tyrosine hydroxylase (th) protein, th phosphorylation, dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) protein often do not include analysis of dopamine tissue content in the same sample. |
2012-11-02 |
2023-08-12 |
Not clear |
| Wei Song, Hillel Zukor, Shih-Hsiung Lin, Jacob Hascalovici, Adrienne Liberman, Ayda Tavitian, Jeannie Mui, Hojatollah Vali, Xin-Kang Tong, Sanjeev K Bhardwaj, Lalit K Srivastava, Edith Hamel, Hyman M Schippe. Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 32. 2012-10-26. PMID:22875919. |
herein, we demonstrate that selective overexpression of the stress protein heme oxygenase-1 (ho-1) in astrocytes of novel gfap.hmox1 transgenic mice results in subcortical oxidative stress and mitochondrial damage/autophagy; diminished neuronal reelin content (males); induction of nurr1 and pitx3 with attendant suppression of their targeting mirnas, 145 and 133b; increased tyrosine hydroxylase and α-synuclein expression with downregulation of the targeting mir-7b of the latter; augmented dopamine and serotonin levels in basal ganglia; reduced d1 receptor binding in nucleus accumbens; axodendritic pathology and altered hippocampal cytoarchitectonics; impaired neurovascular coupling; attenuated prepulse inhibition (males); and hyperkinetic behavior. |
2012-10-26 |
2023-08-12 |
mouse |